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OIE Collaborating Centre Reports
Activities in 2012
Title of Collaborating Centre:
Address of Collaborating Centre:
Emerging and Re-emerging Zoonotic Diseases
National Center for Emerging and Zoonotic
Infectious Diseases
Centers for Disease Control and Prevention
1600 Clifton Road, MS D-76
Atlanta, Georgia 30333
Tel.:
(1-404) 639.7378
Fax:
(1-404) 639.7090
e-mail address:
[email protected]
website:
http://www.cdc.gov/ncezid/
Name of Director of Institute
(Responsible Official):
Beth Bell, MD, MPH
Name (including Title and
Position) of Head of the
Collaborating Centre (formally
OIE Contact Point):
Carol Rubin, DVM, MPH
Name (including Title and
Position) of writer of this report
(if different from above)
Millie Trotter, M.Ed.
Annual reports of OIE Reference Centres, 2012
Director, One Health Office
Principal Management Official, One
Health Office
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Emerging and Re-emerging Zoonotic Diseases
Summary of activities specifically related to the mandate of
OIE Collaborating Centres
1.
Activities as a centre of research, expertise, standardisation and dissemination of
techniques within the remit of the mandate given by the OIE
The National Center for Emerging and Zoonotic Infectious Diseases (NCEZID) is responsible for the
prevention and control of a wide range of infectious diseases, including rare but deadly diseases like anthrax
and Ebola hemorrhagic fever, and more common illnesses like foodborne diseases. The Center manages a
broad portfolio of science-based programs that promote the identification and control of diseases transmitted
by animals and insects. Select activities as an OIE Collaborating Centre in 2012 include:
 Successfully completed safety and efficacy trial in sheep of live-attenuated Rift Valley fever virus vaccine
candidate. This recombinant vaccine has the potential to be more effective and less teratogenic in animals
than existing vaccines.
 Established a breeding colony of wild-caught fruit bats from Uganda that will be a sustainable resource to
increase understanding of reservoir host and virus dynamics such as viral shedding, mechanisms of virus
transmission, and host immune response to Marburg.
 Activated MicrobeNet to an outward-facing web portal to allow for future beta testing by external partner
public health labs for rapid identification of microbial pathogens.
 Assisted 20 health departments and performed monitoring or rule-out testing for viral hemorrhagic fevers.
 Strain panels for evaluating Burkholderia detection assays were approved by the Department of Homeland
Security-sponsored Stakeholders Panel on Agent Detection Assays committee.
 Provided anthrax diagnostic laboratory support in Sudan and provided guidance on polymerase chain
reaction options for detection of B. anthracis in Kenya.
 Provided melioidosis diagnostic laboratory support for cases or laboratory exposures in the US, Puerto
Rico, Switzerland, and Canada.
 Provided technical assistance to HHS and Department of State in preparing for the 2011 World Health
Assembly discussions on variola virus research review and discussions on virus retention/destruction.
 Provided consultation to USDA on proposed release of a recombinant human adenovirus-rabies vaccine.
 Awarded a U.S. patent on a method of using rabies virus as a cloning and expression vector system.
 Enhanced surveillance, diagnosis and treatment of brucellosis through development of laboratory capacity
in an endemic region of Mexico.
2.
Proposal or development of any procedure that will facilitate harmonisation of international
regulations applicable to the surveillance and control of animal diseases, food safety or
animal welfare
CDC’s Division of Global Disease Detection and Emergency Response (GDDER) has been designated by
WHO as a Collaborating Center for Implementation of the Revised International Health Regulations (IHR
[2005]) National Surveillance and Response Capacity. GDDER coordinates expertise and resources in each
of the WHO regions and assist in the advancement of on-site national core capacities for member states
working to meet the minimum IHR requirements in surveillance and response. NCEZID works with GDDER
to assure that the IHR process will be accommodated during all investigations, surveillance activities and
research when appropriate. Whenever possible, animal and human components are sharing biologic isolates
and epidemiologic data to facilitate the control and containment of disease.
3.
Networking
a)
Maintenance of a network with other OIE Collaborating Centres designated for the same
specialty, and
NCEZID participates at the annual meeting of US OIE Collaborating Centres convened at the US Animal
Health Association Annual Conference to present updates and discuss OIE initiatives that are being
emphasized and key areas of importance to US animal health. Key accomplishments/findings from OIE
collaborative work is presented and planned OIE collaborative work during the next year is discussed,
especially those that might benefit from multi-center involvement.
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Annual reports of OIE Reference Centres, 2012
Title of Collaborating Centre
b)
4.
Should the need arise, maintenance of a network with Collaborating Centres in other
disciplines
Placement of expert consultants at the disposal of the OIE
All CDC subject matter experts are available to the OIE at any time for consultation. This expertise includes,
but is not limited to, epidemiologists, laboratorians, ecologists, veterinarians, microbiologists and virologists.
In 2012, CDC assignee Dr. Kate Glynn completed her 4th year at OIE where she has served as Chargée de
mission in the Scientific and Technical Department, supporting OIE’s activities on the prevention and control
of diseases that pose public health threats at the animal-human interface.
5.
Provision of scientific and technical training, within the remit of the mandate given by the
OIE, to personnel from OIE Member Countries
CDC provides scientific and technical training to both member and non–member countries. Trainings include,
but are not limited to Global Foodborne Infections Network, PulseNet International and Field Epidemiology
and Laboratory Training Program (FELTP). The FELTP training component has been highly successful in
many countries in incorporating veterinarians into the program along with their public health counterparts.
Select scientific and technical training activities conducted by NCEZID in 2012 include:
•
•
•
•
•
6.
Epidemiologic consultations, diagnostic support/training, and health education to Ministry of Agriculture/
Health representatives in 14 different countries.
Training of hospital, clinic, medical and laboratory staff on acute febrile illness surveillance in Uganda.
Enhanced monkeypox surveillance training in French with Ministry of Health personnel in DRC for 59
public health officials.
Provider and public health worker training on appropriate treatment and management of brucellosis as a
human health threat in Mexico.
Two week Arbovirus Diagnostics and Surveillance Training Program conducted by the Division of
Vector-Borne Diseases in Fort Collins, CO. This program is intended to provide training experiences to
international scientists that will improve and strengthen their competencies in methods used for
surveillance and analysis of diseases of public health importance.
Organisation of scientific meetings on behalf of the OIE
None during this reporting period.
7.
Coordination of scientific and technical studies in collaboration with other laboratories,
organisations or collaborating centres
CDC is a supporting partner to USAID’s Emerging Pandemic Threats (EPT) Program. The goal of the EPT
Program is to pre-empt or combat, at their source, the first stages of the emergence of zoonotic diseases that
pose a significant threat to public health. Working with the EPT Program’s coalition of partners, CDC
collaborates on research activities and provides subject-matter expertise and technical assistance.
CDC receives funds from HHS/Office of Global Affairs to support Animal-Human Interface (AHI) Officers
placed in Nigeria, Bangladesh, Vietnam, and Egypt to conduct activities that will improve preparedness,
detection, and response to avian influenza and other zoonotic diseases by working collaboratively with
international, regional and country partners, and human and animal health organizations.
In collaboration with GDDER, NCEZID has placed AHI Officers at GDD centers in Kenya, Thailand, and
Guatemala to work collaboratively with country partners and international human and animal health
organizations to improve global preparedness and response to pandemic threats of zoonotic origin through
multi-disciplinary and multi-sectoral collaborations.
Since 2009 NCEZID has had a veterinary medical officer on assignment at the Food and Agriculture
Organization of the UN to serve as a technical and policy consultant on zoonotic disease surveillance and
epidemiology, the prevention and control of zoonotic diseases, and the integration between veterinary and
public health research and practice.
Annual reports of OIE Reference Centres, 2012
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Emerging and Re-emerging Zoonotic Diseases
NCEZID awarded OIE a three year cooperative agreement to support research and collaborations that will
identify and address gaps between human and animal health activities that can be used to inform the public
health response to infection of humans by animal influenza viruses and other pathogens of zoonotic origin.
8.
Publication and dissemination of any information within the remit of the mandate given by
the OIE that may be useful to Member Countries of the OIE
Emerging Infectious Diseases (EID) Journal – Published monthly by CDC, EID was established to promote
the recognition of new and reemerging infectious diseases around the world and improve the understanding of
factors involved in disease emergence, prevention, and elimination. EID relies on a broad international
authorship base and is rigorously peer-reviewed by independent reviewers from all over the world. The
journal: 1) investigates factors known to influence emergence: microbial adaptation and change, human
demographics and behavior, technology and industry, economic development and land use, international
travel and commerce, and the breakdown of public health measures; 2) reports laboratory and epidemiologic
findings within a broader public health perspective; and 3) provides swift updates of infectious disease trends
and research: new methods of detecting, characterizing, or subtyping pathogens; developments in
antimicrobial drugs, vaccines, and prevention or elimination programs; case reports. [EID Journal Website:
http://www.cdc.gov/ncidod/EID/ ]
In the interest of adhering to the stated page limit of the report, publications have not been included. A full
listing of articles that have been published by CDC in the area of emerging and re-emerging zoonoses during
2012 will be provided upon request.
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Annual reports of OIE Reference Centres, 2012