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This is With Your Host... Glomerulopathies Bloody mess Dirty pipes Fruit medley Glomerulopathies Bloody mess Dirty pipes Fruit medley 100 100 100 100 200 200 200 200 300 300 300 300 400 400 400 400 500 500 500 500 If you meet a patient with rapidly progressive GN and alveolar hemorrhage, suspect this condition marked by antibodies against type IV collagen What is Goodpasture’s syndrome? Patients with this diagnosis have a higher risk of malignancy, especially solid tumors; it is also the most common cause of nephrotic syndrome in adults What is membranous nephropathy? This cause of nephrotic syndrome is frequently associated with HIV and heroin use; the “collapsing” variant is most common among African Americans What is focal segmental glomerulosclerosis? Majority with this disease, marked by hematuria, proteinuria and low complement, are Hepatitis C (+). Don’t forget to look for palpable purpura and skin necrosis. What is mixed cryoglobulinemia? Often heralded by hematuria 1-3 days post-URI, this is the most common cause of GN worldwide most prevalent in Asians and rare in blacks What is IgA nephropathy? What is a hypersegmented neutrophil? (Megaloblastic anemia) What are sickle cells? (Sickle cell anemia) What is a Reed-Sternberg cell? (Hodgkin’s lymphoma) What are Howell-Jolly bodies? (Asplenia; hemolytic, megaloblastic anemia) What are hairy cells? (Hairy cell leukemia) A long latency of about 30-40 years occurs from exposure to this mineral and mesothelioma What is Asbestos? Miners and sandblasters exposed to this crystalline mineral are at high risk for tuberculosis and should have their PPD checked What is Silica? Coal worker’s pneumoconiosis + Rheumatoid arthritis + Multiple pulmonary nodules What is Caplan’s syndrome? First described in fluorescent lamp workers, this disease may present with skin and lung nodules showing noncaseating granuloma What is Berylliosis? A reactive airway disease in textile mill workers exposed to cotton dust, it presents with wheezing and causes “Monday chest tightness” that improves at the end of the work week What is Byssinosis? Strawberry cervix What is Trichomonas vaginalis infection? Apple-core lesion What is colon cancer? Strawberry tongue What is Kawasaki disease? (also Scarlet fever) Cherry red spot on macula What is Tay-Sachs disease? (also Central Retinal Artery occlusion) Watermelon stomach What is Gastric Antral Vascular Ectasia (GAVE)? Rash hour Travel ID Toxicology Pick your node Rash hour Travel ID Toxicology Pick your node 200 200 200 200 400 400 400 400 600 600 600 600 800 800 800 800 1000 1000 1000 1000 What is erythema migrans? (Lyme disease) What is pytiriasis versicolor? What is dermatitis herpetiformis? What is erythema multiforme? What is lichen planus? From pulmonary to disseminated such as in AIDS, this mycosis can be picked up from bird and bat droppings in the Ohio and Mississippi River valleys What is Histoplasmosis? The most common rickettsial infection in the US, it is mainly transmitted by the Dermacentor tick and is prevalent in the Southeast such as North Carolina What is Rocky Mountain Spotted Fever? Attention: this fungal infection that causes Valley Fever is endemic in Arizona, California, New Mexico and yes, West Texas! What is Coccidioidomycosis? Humans handling infected animals, like rabbits and deer, are accidental hosts of this zoonosis caused by a gram-negative bacterium common in the South Central states, primarily Arkansas What is Tularemia? Let’s travel this time to the tropics…this potentially fatal spirochetal infection causes Weil’s syndrome and is acquired by exposure to the urine of infected carrier animals such as rats What is Leptospirosis? Tinnitus, vertigo, respiratory alkalosis and high gap metabolic acidosis…and in kids, Reye’s syndrome What is aspirin toxicity? Xanthopsia, or impaired yellowgreen color perception, is a rare but characteristic adverse effect of toxicity from this oldest cardiac drug What is Digoxin? Chronic intake of this psych drug can cause kidney toxicity and nephrogenic DI What is lithium? Myelosuppression is a well-known hematologic adverse effect of this MRSA-fighting drug, especially when used longer than 2 weeks What is linezolid? Toxicity from this can cause high gap acidosis, high serum osmolality and oxalate crystals in the urine; it is common in antifreeze What is ethylene glycol? Osteoarthritic growth of the proximal interphalangeal joint What is Bouchard’s node? Left supraclavicular lymph node usually suggestive of a gastrointestinal neoplasm What is Virchow’s or Troisier’s node? Tender, red, raised lesions on the hands or feet indicative of subacute bacterial endocarditis What are Osler’s nodes? First lymph node reached by metastasizing cancer cells What is sentinel node? Palpable metastatic node in the umbilicus What is Sister Mary Joseph node? Medical Milestones This Scottish Nobel Prize winner accidentally discovered the world’s first antibiotic named after the fungus from where it was isolated Who is Sir Alexander Fleming? Thank you for playing