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KEY CHAPTER 15 OBJECTIVES: CARDIOVASCULAR SYSTEM 1. List the organs that compose the cardiovascular system and discuss the general functions of this system. ORGANS FUNCTION HEART TO TRANSPORT BLOOD TO AND FROM ALL ORGANS AND TISSUES BLOOD VESSELS 2. Describe the location, size, and orientation of the human heart. THE HEART IS LOCATED IN THE MEDIASTINUM, BEHIND THE STERNUM, WITH THE APEX SLIGHTLY TO THE LEFT OF CENTER ABOVE THE DIAPHRAGM. 3. Define the term cardiology. THE STUDY OF THE HEART 4. Describe the structure of the heart in terms of its coverings, wall layers, chambers, valves, and blood vessels. Please label any of these structures present in the diagram below. Coverings A FIBROUS PERICARDIUM = DENSE REGULAR CT; B PARIETAL PERICARDIUM = SIMPLE SQUAMOUS ET/LOOSE AREOLAR CT Layers C VISCERAL PERICARDIUM = SSET/LACT A EPICARDIUM = SSET/LACT B MYOCARDIUM = CARDIAC MUSCLE Chambers Valves C ENDOCARDIUM = SSET/LACT A ATRIA: RIGHT ATRIUM RECEIVES DEOXYGENATED BLOOD FROM VEINS; LEFT ATRIUM RECEIVES OXYGENATED BLOOD FROM LUNGS B VENTRICLES: RIGHT VENTRICLE PUMPS BLOOD TO LUNGS; LEFT VENTRICLE PUMPS BLOOD TO BODY (AORTA) 1a TRICUSPID LIES BETWEEN THE RIGHT ATRIUM AND RIGHT VENTRICLES. 1b BICUSPID LIES BETWEEN THE LEFT ATRIUM AND LEFT VENTRICLE 2a PULMONARY SEMILUNAR VALVE LIES WITHIN PULMONARY TRUNK 2b AORTIC SEMILUNAR VALVE LIES WITHIN AORTA Blood vessels associated with 1a SUPERIOR VENA CAVA FROM UPPER LIMBS/HEAD EMPTIES INTO RIGHT ATRIUM 1b INFERIOR VENA CAVA FROM TRUNK/LOWER LIMBS EMPTIES INTO RIGHT ATRIUM 1c CORONARY SINUS FROM MYOCARDIUM EMPTIES INTO RIGHT ATRIUM 1d PULMONARY VEINS FROM LUNGS EMPTIES INTI LEFT ATRIUM 2a AORTA FROM LEFT VENTRICLE CARRIES BLOOD TO ARTEIRIES/BODY PARTS 2b PULMONARY TRUNK FROM RIGHT VENTRICLE CARRIES BLOOD TO LUNGS TO BE OXYGENATED 5. Name the function of serous fluid around the heart. LUBRICATION 6. Give another name for epicardium. VISCERAL PERICARDIUM 7. Describe the structure and function of the interventricular septum and label it above. THE IV SEPTUM IS COMPOSED OF THICK MYOCARDIUM ABD IT SEPARATES THE LEFT AND RIGHT VENTRICLES 8. Explain why the atria are passive chambers, while the ventricles are active. ATRIA VENTRICLES THEY ARE PASSIVE, RECEIVING THEY ARE ACTIVE, PUMPING BLOOD FROM VEINS BLOOD INTO ARTERIES 9. Name the function of heart valves. TO PREVENT BACKFLOW OF BLOOD 10. Distinguish between AV and SL valves in terms of location, structure, and when they close. Please label them above. AV VALVES SL VALVES LOCATION BETWEEN ATRIA AND WITHIN MAJOR VENTRICLES ARTERIES STRUCTURE 2 OR 3 CUSPS, 3 CUSPS ANCHORED TO PAPILLARY MUSCLE THROUGH CHORDAE TENDINEAE WHEN CLOSED WHEN VENTRICLES WHEN VENTRICLES CONTRACT RELAX 11. Define/describe the terms chordae tendineae, papillary muscle, and trabeculae carneae, and label each in the diagram above. chordae tendineae papillary muscle trabeculae carneae CORD-LIKE STRUCTURES THAT ANCHOR CUSPS OF AV VALVES TO PAPILLARY MUSCLE COLUMNS OF MUSCLE IN VENTRICLES THAT ANCHOR CUSPS OF AV VALVES CHARACTERISTIC “FLESHY BEANS” APPEARANCE OF INNR VENTRICULAR WALL 12. Name (and locate in the diagram above) the veins that deposit their blood into the atria of the heart (which atria? deox- or oxygenated?). VEIN OXYGENATED OR DEOXYNATED WHICH ATRIA? BLOOD? SVC DEOX RIGHT IVC DEOX RIGHT CS DEOX RIGHT PV OX LEFT 13. Name (and locate in the diagram above) the arteries that take blood away from the heart (from which ventricle? deox-or oxygenated blood?). ARTERY OXYGENATED OR DEOXYNATED FROM WHICH BLOOD? VENTRICLE? AORTA OX LEFT PULMOMARY DEOX RIGHT TRUNK 14. Distinguish between pulmonary, coronary and systemic circulation. PULMONARY CORONARY SYSTEMIC HEART TO LUNGS TO AND FROM TO AND FROM BACK TO HEART MYOCARDIUM BODY PARTS ALL 15. 16. Track a drop of blood through the following circulations: a. pulmonary (heart to lungs and back to heart) RIGHT ATRIUM (RA) TRICUSPID RIGHT VENTRICLE (RV) PULMONARY SEMILUNAR VALVE (PSLV) PULMONARY TRUNK (PT) PULMONARY ARTERIES (PA) LUNG CAPILALLARIES (CAPS) PULMONARY VEINS (PV) LEFT ATRIUM (LA) BICUSPID/MITRAL LEFT VENTRICLE AORTIC SEMILUNAR VALVE (ASLV) AORTA b. coronary (through myocardium) AORTA CORONARY ARTERIES MYOCARDIAL CAPS CARDIAC VEINS CORONARY SINUS RIGHT ATRIUM c. systemic (heart to body and back to the heart, in general). AORTA ARTERIES ARTERIOLES CAPILLARIES VENULES VEINS RIGHT ATRIUM Define the term anastomoses. CONNECTIONS BETWEEN SMALL ARTERIES/ARTERIOLES THAT PROVIDE ALTERNATE ROUTES FOR BLOOD TO FLOW 17. Define the terms ischemia and hypoxia, and explain how they are related to the pathologic conditions of angina pectoris and myocardial infarction. ISCHEMIA REDUCED BLOODFLOW TO A TISSUE HYPOXIA REDUCED OXYGEN TO A TISSUE 18. 19. Discuss what causes reperfusion damage. OXYGEN FREE RADICALS Name the term referring to all of the events associated with one heartbeat. CARDIAC CYCLE 20. Define the terms systole and diastole. SYSTOLE CONTRACTION DIASTOLE RELAXATION 21. Name the two major divisions of the cardiac cycle, and compare them in terms of direction of blood flow, whether valves are opening or closing, and relative pressure within the chambers. Phase VENTRICULAR CONTRACTIO N (SYSTOLE) ATRIAL RELAXATION (diastole) VENTRICULAR RELAXATION (DIASTOLE) ATRIAL CONTRACTION (systole) Blood flow Blood is forced from ventricles into arteries. Atria fill with blood. Ventricles fill with blood. Blood is forced from atria into ventricles. Valves SL open AV closed SL open AV closed AV open SL closed AV open SL closed Pressure V high A low but rises as filling continues V low but rises as filling continues A high 22. Discuss heart sounds in terms of what they represent, how they sound, how they are detected and their significance. HEART WHICH VALVES VENTRICULAR SYSTOLE OR SOUND CLOSING? DIASTOLE? LUB AV VALVES SYSTOLE DUP SL VALVES DIASTOLE INCOMPLETE CLOSING OF CUSPS CAUSESBACKFLOW OF BLOOD; THIS IS HEARD BY STETHOSCOPE AS A “WHOOSHING” SOUND = MURMUR 23. Discuss the physiological stages of cardiac muscle contraction and trace how they appear on graph plotting mV vs. time (i.e. ion channels opening causing what event?) I DON'T HAVE THIS GRAPH IN A FORM TO INCLUDE HERE, BUT REMEMBER WE DID IT IN CLASS ON THE WHITE BOARD. IT STARTS AT -90mV. SA Node fires, opening Na+ ion channels causing rapid depolarization (up to +30mV); Na+ channels close and calcium channels open for a long plateau period (allowing for the contraction mechanism to become activated; the Ca++ channels close and Potassium (K+) channels open causing repolarization. 24. Explain why the refractory period between cardiac muscle contractions is so long. SO THE VENTRICLES CAN FILL WITH ADEQUATE VOLUME OF BLOOD PRIOR TO CONTRACTION 25. Explain the significance of each component of the cardiac conduction system and trace how the cardiac impulse travels through the myocardium. CCS COMPONENT LOCATION SIGNIFICANCE SENDS CARDIAC IMPULSE TO ... Sinoatrial Node right uppermost atrial wall Pacemaker initiates cardiac impulse 60100 times per minute Atrioventricular Node Atrioventricular Node interatrial septum delay signal to allow for ventricular filling Atrioventricular Bundle Atrioventricular Bundle superior interventricular septum only electrical junction between atria & ventricles right and left bundle branches right and left bundle branches lateral interventricular septum passes signals down to apex Purkinje fibers Purkinje fibers in papillary muscles of ventricles conduct impulse to the mass of ventricular myocardium and forces blood out 26. Name the common term for the sinoatrial (SA) node. Pacemaker N/A 27. Trace a typical ECG and label each wave or complex and explain what event of the CCS corresponds to each wave. 28. Outline the phases of the cardiac cycle in terms of what is happening in the ECG trace, mechanical events (contraction or relaxation), atrial pressure, ventricular pressure, ventricular volume, aortic volume and timing. SEE #21ABOVE. 29. Define the terms cardiac output (CO), heart rate (HR), and stroke volume (SV). CO CO is the volume of blood pumped by each ventricle each minute; the volume of blood that is circulating through the systemic (or pulmonary) circuit per minute ; 5 liters/minute is normal adult. HR # of heart beats/minute SV SV is the volume of blood pumped by each ventricle with each contraction (stroke) 30. Discuss the factors that regulate heart rate. HORMONAL FACTORS NEURAL FACTORS