* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download ALSoD Update at MNDA Symposium
Survey
Document related concepts
Gene desert wikipedia , lookup
Community fingerprinting wikipedia , lookup
Promoter (genetics) wikipedia , lookup
Silencer (genetics) wikipedia , lookup
Gene regulatory network wikipedia , lookup
Molecular ecology wikipedia , lookup
Genomic imprinting wikipedia , lookup
Molecular evolution wikipedia , lookup
Ridge (biology) wikipedia , lookup
Artificial gene synthesis wikipedia , lookup
Endogenous retrovirus wikipedia , lookup
Transcript
An update on the ALS Online Genetics Database, ALSoD. Olubunmi Abel ENCALS meeting, Italy 5th December 2013 ALS Online genetics Database (ALSoD) – Originally designed in 1999 for sharing of clinical and genetic data – Publicly available online – Useful for researchers – Links to other genetic information sources Older versions • ALSOD - Amyotrophic Lateral Sclerosis SOD1 • www.alsod.org • 4 genes -SOD1,NEFH,ALS2, VAPB Newer Versions (since 2008) • ALSoD - Amyotrophic Lateral Sclerosis Online genetics Database • 113 ALS-related genes • http://alsod.iop.kcl.ac.uk • Graphical representations • Analysis, collation & integration Overview Brief information of gene Graphs and Statistics Links to external information Animal model publications Key publications on gene Detailed Analysis • Gender Ratio • Family Ratio • Site of Onset Ratio • Population Interactions • GeneMANIA • Select genes • Graphical display Comparing genes • Compares any two genes • Statistical summary • Countries where genes are found Pathogenicity Prediction • Bioinformatics tools: PANTHER, SIFT, PolyPhen • Replicated studies Gene Credibility • Criteria selection • Rank genes according to criteria Displaying genome-wide data Mapped gene variants to genomic coordinates For example SOD1 mutation : A4V Population frequency • 1000 genome, EVS database Animal Models Mobile platform • Summarized version • Mobile website and app • Switchable views • Increased access to data • Encourages collaboration Popularity & Frequency of use Future • Collaboration with PatientsLikeMe • Advanced Integration with external databases • Mobile applications on a wider platform Acknowledgements Previous website designers • Richard Wroe • Ian Gowrie Original idea for ALSoD • Aleks Radunovic • Nigel Leigh Current Co-ordinators • Ammar Al-Chalabi • John Powell • Peter Andersen • Funding – Generous long-term funding from ALSA and MNDA – Additional funding from MNDA Iceland, ALS Society of Canada, ALS Therapy Alliance • Adopted by World Federation of Neurology and European Network for the Cure of ALS