Download Document

Jesus A. Angulo Ph.D.
Affiliation:
Hunter College, CUNY
Biological Sciences
"Neurological Disorders and Mental Health"
Title: Professor of Biology
Rank: Professor
Address:
Room 927 HN, Hunter College, CUNY 695 Park Avenue
New York, NY 10065
Contact:
Email: [email protected]
Telephone: 212 772-5232
Narrative
For nearly two decades my laboratory has investigated the role of dopamine on neuropeptide
expression in the nigrostriatal and mesolimbic pathways of the rodent brain. Our research and that
of others has demonstrated that dopaminergic transmission exerts dynamic regulation on the levels
of expression and utilization of striatal neuropeptides. During the last ten years, we have investigated
the novel hypothesis that neuropeptides modulate the methamphetamine-induced damage to
striatal dopamine terminals and the apoptosis of some striatal neurons. My laboratory has extensive
background in biochemistry, molecular and histochemical methods involving the brains of rats and
mice. The proposed research is an extension of an R01-funded project from NIDA to demonstrate the
role of the neuronal neurokinin-1 receptor (substance P is the natural ligand) on the
methamphetamine-induced production of striatal nitric oxide and the neuroprotection afforded by
neurokinin-1 receptor antagonists on the neuronal apoptosis induced by methamphetamine. This
research has advanced our knowledge of the role played by neuropeptides in the methamphetamineinduced striatal injury. Recently, we are investigating the role of other striatal neuropeptides such as
neuropeptide Y and somatostatin on the cellular mechanisms of methamphetamine-induced neural
damage. Interestingly, we are finding that substance P is pro-damage while neuropeptide Y and
somatostatin are neuroprotective. This research is novel because it is demonstrating that
endogenous neuropeptides play key regulatory roles on survival of neurons in this part of the brain, a
surprising finding with therapeutic potential. It is of high significance to elucidate the involvement of
striatal neuropeptides in the methamphetamine-induced neural damage because these
neuropeptides are expressed and utilized by the healthy brain. In summary, I have extensive
experience and demonstrated productivity in the area of neuropeptides and dopaminergic
transmission in nigrostriatal and mesolimbic pathways. This area of investigation is highly relevant to
the field of drug abuse research and to the mission of the National Institute on Drug Abuse. I am the
Principal Investigator/Program Director of the Research Centers in Minority Institutions (RCMI,
NIMHD) Program at Hunter College. The RCMI Program maintains and expands the research
infrastructure for the researchers of the Center for Translational and Basic Research of Hunter
College. The Center is comprised of 45 faculty researchers in the areas of neuroscience/behavior,
cancer and bioinformatics. The Center researchers are located in the departments of Chemistry,
Biology and Psychology. The Center fosters and develops new generations of minority scientists and
helps to encourage the participation of other ethnic minority groups in the biomedical workforce
pipeline. The research conducted by the Center addresses health disparities in our population. In
addition to the basic/translational research, the Center participates in community engagement
projects in collaboration with the Hunter College School of Nursing, Public Health and the Weill
Cornell CTSC.
Awards and Honors
1989 1991 National Alliance for Research on Schizophrenia and Depression - Young Investigator
Award
1994 1996 City University of New York - Professional Staff Congress of the City University of New
York Research Award
2000 2005 NINDS/NIH - Specialized Neuroscience Research Program
Publications
1.
Tulloch IK, Afanador L, Baker L, Ordonez D, Payne H, Mexhitaj I, Olivares E, PubMed
Chowdhury A, Angulo JA. Methamphetamine induces low levels of neurogenesis in
striatal neuron subpopulations and differential motor performance. Neurotox Res.
2014 Aug; 26(2):115-29.
2.
Afanador L, Mexhitaj I, Diaz C, Ordonez D, Baker L, Angulo JA. The role of the PubMed
neuropeptide somatostatin on methamphetamine and glutamate-induced
neurotoxicity in the striatum of mice. Brain Res. 2013 May 13; 1510:38-47.
3.
Yarosh HL, Angulo JA. Modulation of methamphetamine-induced nitric oxide PubMed
production by neuropeptide Y in the murine striatum. Brain Res. 2012 Nov 5;
1483:31-8.
4.
Afanador L, Yarosh H, Wang J, Ali SF, Angulo JA. Contrasting Effects of the PubMed
Neuropeptides Substance P, Somatostatin, and Neuropeptide Y on the
Methamphetamine-Induced Production of Striatal Nitric Oxide in Mice. J Drug
Alcohol Res. 2012; 1.
5.
Tulloch I, Afanador L, Mexhitaj I, Ghazaryan N, Garzagongora AG, Angulo JA. A PubMed
single high dose of methamphetamine induces apoptotic and necrotic striatal cell
loss lasting up to 3 months in mice. Neuroscience. 2011 Oct 13; 193:162-9.
6.
Tulloch I, Ghazaryan N, Mexhitaj I, Ordonez D, Angulo JA. Role of neurokinin-1 and PubMed
dopamine receptors on the striatal methamphetamine-induced proliferation of new
cells in mice. Brain Res. 2011 Jul 5; 1399:33-9.
7.
Tulloch IK, Afanador L, Zhu J, Angulo JA. Methamphetamine induces striatal cell PubMed
death followed by the generation of new cells and a second round of cell death in
mice. Curr Neuropharmacol. 2011 Mar; 9(1):79-83.
8.
Wang J, Angulo JA. Synergism between methamphetamine and the neuropeptide PubMed
substance P on the production of nitric oxide in the striatum of mice. Brain Res. 2011
Jan 19; 1369:131-9.
9.
Wang J, Angulo JA. Methamphetamine induces striatal neurokinin-1 receptor PubMed
endocytosis primarily in somatostatin/NPY/NOS interneurons and the role of
dopamine receptors in mice. Synapse. 2011 Apr; 65(4):300-8.
10. Zhu J, Xu W, Wang J, Ali SF, Angulo JA. The neurokinin-1 receptor modulates the PubMed
methamphetamine-induced striatal apoptosis and nitric oxide formation in mice. J
Neurochem. 2009 Nov; 111(3):656-68.
11. Wang J, Xu W, Ali SF, Angulo JA. Connection between the striatal neurokinin-1 PubMed
receptor and nitric oxide formation during methamphetamine exposure. Ann N Y
Acad Sci. 2008 Oct; 1139:164-71.
12. Zhu JP, Xu W, Angulo JA. Distinct mechanisms mediating methamphetamine- PubMed
induced neuronal apoptosis and dopamine terminal damage share the neuropeptide
substance p in the striatum of mice. Ann N Y Acad Sci. 2006 Aug; 1074:135-48.
13. Zhu JP, Xu W, Angulo JA. Methamphetamine-induced cell death: selective PubMed
vulnerability in neuronal subpopulations of the striatum in mice. Neuroscience. 2006
Jun 30; 140(2):607-22.
14. Xu W, Zhu JP, Angulo JA. Induction of striatal pre- and postsynaptic damage by PubMed
methamphetamine requires the dopamine receptors. Synapse. 2005 Nov; 58(2):11021.
15. Zhu JP, Xu W, Angulo N, Angulo JA. Methamphetamine-induced striatal apoptosis in PubMed
the mouse brain: comparison of a binge to an acute bolus drug administration.
Neurotoxicology. 2006 Jan; 27(1):131-6.
16. Zhu JP, Xu W, Angulo JA. Disparity in the temporal appearance of PubMed
methamphetamine-induced apoptosis and depletion of dopamine terminal markers
in the striatum of mice. Brain Res. 2005 Jul 12; 1049(2):171-81.
17. Angulo JA, Angulo N, Yu J. Antagonists of the neurokinin-1 or dopamine D1 PubMed
receptors confer protection from methamphetamine on dopamine terminals of the
mouse striatum. Ann N Y Acad Sci. 2004 Oct; 1025:171-80.
18. Yu J, Wang J, Cadet JL, Angulo JA. Histological evidence supporting a role for the PubMed
striatal neurokinin-1 receptor in methamphetamine-induced neurotoxicity in the
mouse brain. Brain Res. 2004 May 8; 1007(1-2):124-31.
19. Loonam TM, Noailles PA, Yu J, Zhu JP, Angulo JA. Substance P and cholecystokinin PubMed
regulate neurochemical responses to cocaine and methamphetamine in the
striatum. Life Sci. 2003 Jun 27; 73(6):727-39.
20. Yu J, Cadet JL, Angulo JA. Neurokinin-1 (NK-1) receptor antagonists abrogate PubMed
methamphetamine-induced striatal dopaminergic neurotoxicity in the murine brain.
J Neurochem. 2002 Nov; 83(3):613-22.
21. Yu J, Allison S, Ibrahim D, Cadet JL, Angulo JA. Ontogeny of neurokinin-1 receptor PubMed
mediation of methamphetamine neurotoxicity in the striatum of the mouse brain.
Ann N Y Acad Sci. 2002 Jun; 965:247-53.
22. Noailles PA, Angulo JA. Neurokinin receptors modulate the neurochemical actions of PubMed
cocaine. Ann N Y Acad Sci. 2002 Jun; 965:267-73.
23. Kraft M, Noailles P, Angulo JA. Substance P modulates cocaine-evoked dopamine PubMed
overflow in the striatum of the rat brain. Ann N Y Acad Sci. 2001 Jun; 937:121-31.
24. Kraft M, Ahluwahlia S, Angulo JA. Neurokinin-1 receptor antagonists block acute PubMed
cocaine-induced horizontal locomotion. Ann N Y Acad Sci. 2001 Jun; 937:132-9.
25. Zhang Y, Loonam TM, Noailles PA, Angulo JA. Comparison of cocaine- and PubMed
methamphetamine-evoked dopamine and glutamate overflow in somatodendritic
and terminal field regions of the rat brain during acute, chronic, and early
withdrawal conditions. Ann N Y Acad Sci. 2001 Jun; 937:93-120.
26. Datta U, Noailles PA, Kraft M, Zhang Y, Angulo JA. Concurrent elevation of the levels PubMed
of expression of striatal preproenkephalin and preprodynorphin mRNA in the rat
brain by chronic treatment with caffeine. Neurosci Lett. 1997 Aug 1; 231(1):29-32.
27. Zhang Y, Landas K, Mueller H, Angulo JA. Progressive augmentation of striatal and PubMed
accumbal preprotachykinin mRNA levels by chronic treatment with
methamphetamine and effect of concurrent administration of the N-methyl-Daspartate receptor antagonist MK-801. Neuropharmacology. 1997 Mar; 36(3):32534.
28. Datta U, Noailles PA, Rodriguez M, Kraft M, Zhang Y, Angulo JA. Accumulation of PubMed
tyrosine hydroxylase messenger RNA molecules in the rat mesencephalon by chronic
caffeine treatment. Neurosci Lett. 1996 Dec 13; 220(2):77-80.
29. Zhang Y, Angulo JA. Contrasting effects of repeated treatment vs. withdrawal of PubMed
methamphetamine on tyrosine hydroxylase messenger RNA levels in the ventral
tegmental area and substantia nigra zona compacta of the rat brain. Synapse. 1996
Nov; 24(3):218-23.
30. Noailles PA, Villegas M, Ledoux M, Lucas LR, McEwen BS, Angulo JA. Acute PubMed
treatment with the N-methyl-D-aspartate receptor antagonist MK-801: effect of
concurrent administration of haloperidol or scopolamine on preproenkephalin
mRNA levels of the striatum and nucleus accumbens of the rat brain. Neurosci Lett.
1996 Jan 5; 202(3):165-68.
31. Villegas M, Angulo JA. Attenuation of neostriatal preproenkephalin and PubMed
preprotachykinin mRNA abundance by chronic treatment with the
kainate/quisqualate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione in
the rat brain. Neurosci Lett. 1995 May 19; 191(1-2):51-4.
32. Angulo JA, Williams A, Ledoux M, Watanabe Y, McEwen BS. Elevation of striatal and PubMed
accumbal preproenkephalin, preprotachykinin and preprodynorphin mRNA
abundance subsequent to N-methyl-D-aspartate receptor blockade with MK-801.
Brain Res Mol Brain Res. 1995 Mar; 29(1):15-22.
33. Angulo JA, McEwen BS. Molecular aspects of neuropeptide regulation and function PubMed
in the corpus striatum and nucleus accumbens. Brain Res Brain Res Rev. 1994 Jan;
19(1):1-28.
THANK YOU FOR USING THE RTRN RESEARCH COLLABORATION AND PROFESSIONAL
NETWORKING SERVICE.
RTRN Data Coordinating Center
Mississippi e-Center @ Jackson State University
1230 Raymond Road, Box 1800, Jackson, Mississippi 39204
Phone: 601-979-0332, Fax: 601-979-0338, e-mail: [email protected]