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PERSONALITY SPECTRUM TM Highly Sensitive 15-20% ? Emotionally balanced 40-45% Insensitive or less sensitive 40% Autistic Spectrum ADH personality DANGER MODEL OF ASSOCIATION TRUSTING MODEL OF ASSOCIATION Insecure Attachment: Secure Childhood Attachment: Anxious & Inconsistent Collected & Consistent DISTANT MODEL OF ASSOCIATION Insecure Attachment: Distant & Evasive IN-PERSON & AMONG PERSONS Collected from multiple sources & integrated by SOVEREIGN RESEARCH, LLC 2011 INCREASED VULNERABILITY TO ENVIRONMENTAL TOXINS INCREASE INFLAMMATION & FURTHER WEAKEN MUCOUS MEMBRANES TOXIC BYPRODUCTS, IMMUNE & INFLAMMATORY MEDIATORS MAY BLOCK CORTISOL PRODUCTION eg. DEFENSINS INDUCE STRESS RESPONSE CRH corticotropin releasing hormone TOXIN ACQUISITION BY INGESTION OR INHALATION INFLAMMATION IN MUCUS MEMBRANES & REDUCED DEFENSIVE & FILTERING CAPACITY RECRUITMENT OF IMMUNE MEDIATORS COPYRIGHT SOVEREIGN RESEARCH, LLC 2011 WHY DOES AUTISTIC PERSONALITY EMERGE AT A VARIABLE AGE? Increased innate reactivity to stress (genetic predisposition) MAGNITUDE OF STRESS (OVERWHELMING VS. STIMULATIVE) REPETITIVE EXPOSURE TO STRESS (MISHANDLING, TOXINS, PARENTAL FEUDING...) STAGE OF LIFE 1st 2 YRS..TODDLER..SCHOOL YRS..PUBERTY..COLLEGE..ADULTHOOD COPYRIGHT SOVEREIGN RESEARCH, LLC 2011 BEHAVIORAL CURVE-BALL TRADITION SENSITIVES & INSENSITIVES VARY WIDELY IN BASAL AROUSABILITY SENSITIVES ARE MORE EMOTIONALLY AROUSABLE BY MODERATE STRAIN INSENSITIVES: CHOKE UNDER PRESSURE SENSITIVES: THRIVE UNDER PRESSURE COURTESY SMITH, BD (1983); EXTRAVERSION & ELECTRODERMAL ACTIVITY; AROUSABILITY & THE INVERTED U; Personality & Individual Differences, Vol 4; p 411-420 COPYRIGHT SOVEREIGN RESEARCH, LLC 2011 MAGNITUDE OF STRESS RESPONSE SENSORY OVERLOAD: THE AFTERMATH ABSENCE OF STIMULATION [IDLENESS] IS MORE STRESSFUL THAN ANY TANGIBLE CHALLENGE Decreasing perceived stress DISTRESS Increasing perceived stress Stimulation (eustress) DISTRESS COPYRIGHT SOVEREIGN RESEARCH, LLC 2011 IMPACT OF NEUTRAL, PLEASANT & UNPLEASANT EXPERIENCES ON STRESS RESPONSE FROM STRESS WITHOUT DISTRESS, BY HANS SELYE COPYRIGHT SOVEREIGN RESEARCH, LLC 2011 TRANSIENT SENSORY OVERLOAD VS. PROLONGED BURNOUT HANS SELYE'S GENERAL ADAPTATION SYNDROME “THE STRESS OF LIFE” COPYRIGHT SOVEREIGN RESEARCH, LLC 2011 CENTRAL REALIZATION OF THREAT OR STRAIN LHPA AXIS (HYPOTHALAMUS /PITUITARY) CRH & ACTH LHPA AXIS (ADRENALS) CORTISOL HYPOCRETINS ? CENTRAL SYMPATHETIC (LOCUS CERULEUS) NOREPINEPHRINE PERIPHERAL SYMPATHETIC GANGLIA & ADERNALS EPINEPHRINE ALARM, MOTIVATION & RECRUITMENT MESSAGE DISTRIBUTED COPYRIGHT SOVEREIGN RESEARCH, LLC 2011 Neg hi mood: irritable, creative Neg lo mood: thought synthesis Pos hi mood: Enron exec. Pos lo mood: follower INSENSITIVE POSITIVE MOOD NEGATIVE MOOD HIGH MOOD SENSITIVE LOW MOOD COPYRIGHT SOVEREIGN RESEARCH, LLC 2011 Change Effect 1- Increase hypothalamic CRH production Increase stress reactivity and anxiety 2- Increase amygdala CRH production Increase stress reactivity and fear learning 3- Decrease cortisol receptors in hippocampus and hypothalamus Increase difficulty terminating stress response 4- Decrease GABAA receptors in hippocampus Increase difficulty terminating the stress response 5- Increase brain noradrenalin activity Increase reactivity to stress and irritability 6- Increase serotonin availability and utilization Difficulty gaining dominance over personal life All these effects cumulatively result in limiting the baby’s potential later in life. These effects often result in a life marred by desperation, perpetual failure and loss of selfesteem. Target tissue or system Liver Liver Biologic effect Increased glucose synthesis Decrease HDL production Functional/clinical correlate Increase blood sugar levels Increase cholesterol in blood Muscle and fat Glycogen and protein breakdown to form glucose Fat breakdown and mobilization to blood Increase blood sugar levels Muscle and fat Decrease sensitivity to insulin actions Heart and blood vessels Increase heart rate and blood vessel tone Facilitate insulin resistance – a precursor to diabetes Increase blood pressure, blood vessel wall thickening and risk of blood clots Growth axis Decrease GH release*, tissue sensitivity Delay in growth and development in to GH, IGF1 and IGF2 children; bony frame; reduced tissue regeneration Inhibition of reproductive hormones Sexual maturity problems at puberty, including LH, progesterone and cycle irregularities, premenstrual testosterone; render target tissues cramping, reduced fertility, hot flashes, resistant low libido Decrease triiodothyronine, the active Delay in growth and development in thyroid hormone; children; decrease metabolic rate Inhibition of TSH, short-term only Reduced new bone formation Osteopenia and osteoporosis – both genders equally Muscle and fat Reproductive system Thyroid axis Skeleton Gastrointestinal Gastrointestinal Childhood stress Enhanced reliance on fatty acids for fuel – facilitator of obesity and aging Inhibit stomach acid; reduce movement Bloating, food fermentation, loose of food along; stools, constipation, irritable bowel, pain, weaken gut immune defenses; increase free access of ingested toxins and food permeability (leaky gut); weaken additives to rest of body; succumbing to friendly bacteria in colon microbes including yeast and parasites. Further sensitizes stress pathways Increase likelihood of anxiety and SOY CRUCIFEROUS VEGETABLES Broccoli, Cauliflower, Brussels, kholrabi… All soy containing foods (including soy milk) facilitate the disposition of thyroid hormone from the body All crucifers contain a chemical (isothiocyanate) which is a toxin for the thyroid gland GLUTEN CONTAINING GRAINS RYE, BARLEY, WHEAT… Gluten sensitive individuals of all ages show a deterioration in thyroid function while consuming grains; and an improvement on gluten-free diet CORTAID CREAM & OTHER OVER THE COUNTER STEROID CREAMS Cortisol (hydrocortisone), a naturally occurring steroid, in excess amounts may lower active thyroid hormone in the body Synthetic variants of cortisol show a more accentuated effect compared to cortisol an herb commonly used to help with sleep may reduce thyroid function Melatonin and other sleep aids also may lower levels of active thyroid hormone May lower levels of active thyroid hormone in body ASTHMA INHALERS & OTHER PHARMACEUTICAL STEROIDS LEMON BALM (Melissa Officinalis) Melatonin supplements Low carbohydrate diets MALES BETTER FEMALES BETTER Spatial abilities including mental rotations, route learning, and visualization of spatial relationships Verbal skills including fluency, rate of speech acquisition, spelling, and grammar Mathematical reasoning and problem Computational accuracy and solving procedural knowledge of arithmetic and mathematics Gross motor skills that involve Fine motor skills and finger dexterity strength Short term memory including memory for object locations