Download bio 342 human physiology

1Quiz #9 for 10:30
Choose two of the following false or misleading statements and make the
appropriate corrections. Be sure to write the number of the questions you choose.
1)
Thyroid hormones are stored in intracellularly in secretory vesicles before they
are release from a stimulated follicular endocrine cell.
2)
In the form of thyrotoxicosis called Grave’s Disease, excessive secretion of TSH
stimulates thyroid follicular cells to release too much of the thyroid hormones
into the bloodstream.
3)
Basal levels of epinephrine must be present so that cell can be appropriately
responsive to thyroid hormone.
4)
All hormones released from the pituitary are produced by cell bodies in the
hypothalamus.
Note: next Monday’s quiz will include material from Frog Reflex Lab
1Quiz #9 for 11:30
Choose two of the following false or misleading statements and make the
appropriate corrections. Be sure to write the number of the questions you choose.
1)
Thyroid hormones are stored in intracellularly in secretory vesicles before they
are release from a stimulated follicular endocrine cell.
2)
In the form of thyrotoxicosis called Grave’s Disease, excessive secretion of TSH
stimulates thyroid follicular cells to release too much of the thyroid hormones
into the bloodstream.
3)
Basal levels of epinephrine must be present so that cell can be appropriately
respond to thyroid hormone.
4)
Goiters are enlarged thyroid glands that occur because of excess stimulation by
thyroid hormone.
Note: next Monday’s quiz will include material from Frog Reflex Lab.
S1
Another Endocrine Disorder
Age 16
33
52
Disorder =Acromegaly
S2
• Excessive growth of
bones and soft tissues
of face and hands, and
feet.
• Hypersecretion of
Growth Hormone from
adenohypophysis or
ectopic tumor in adults
• Treatment?
• Somatostatin analogs
• GH receptor blockers
• Transphenoidal
resection/ablation with
focal radiation
GHRH SS
GH
IGF-1
Compare to Pituitary Gigantism
Acromegaly in Merck Manual
Classification of
Endocrine Disorders
• Hypersecretion
– Primary
– Secondary
• Hyposecretion
Try to classify:
Endemic Goiter
Grave’s Disease
Acromegaly
Diabetes mellitus Type 1
Diabetes mellitus Type 2
– Primary
– Secondary
• Hyper-responsive target
• Hypo-responsive target
S3
Lab Next Week:
Case Studies in Endocrinology
Look at the on-line Merck Manual before your lab day.
http://www.merckmanuals.com/professional/index.html
Follow Link to Endocrine and Metabolic Disorders
S5
Vasopressin
Cytokines
from
immune cells
CRH from Hypothalamus
Physical trauma
Prolonged exposure to cold
Prolonged intense exercise
Infection
Sleep deprivation
Pain
Fright
Emotional distress
ACTH from Ant. Pit
Clinical example: treatment of chronic inflammation
(e.g. arthritis) can lead to Cushing’s Syndrome!
⇧Cortisol
secretion from
Adrenal Cortex
Mobilize fuel from muscle & adipose tissue
Suppress non-essential functions
(reproduction & growth)
Suppress inflammatory &
immune responses
Potentiates response to EPI (vascular
smooth muscle)
Cushing’s Syndrome
Excess Cortisol from
1) adrenal cortex tumor (primary) or
2) hypersecretion of ACTH from anterior pituitary (secondary)
S6
Why are NSAIDs preferable to
Glucocorticoids for treating inflammation and
arthritis?
Consider the HPA axis and the effects of
long-term dosing with cortisol on ACTH
secretion and the Adrenal Cortex.