Download Virus 1+2-summary+quiz2017-03-04 06:551.4 MB

‫‪Lecture : viruses 1+2‬‬
‫‪SUMMARY + QUIZ + helpful videos‬‬
‫"ال حول وال قوة إال باهلل العلي العظيم" وتقال هذه الجملة إذا دهم اإلنسان أمر عظيم ال‬
‫يستطيعه ‪ ،‬أو يصعب عليه القيام به ‪.‬‬
V1
Viral Infections of the Respiratory System
Influenza Virus (A, B, C)
Avian flu:
Avian influenza type A virus
(H5N1)
Family
orthomyxoviridae
orthomyxoviridae
Structure
Enveloped virus with 2
projecting glycoprotein spikes
(H & N)
Genome
8 segmented - polarity ssRNA
I.P.
1 – 4 days
Symptoms
Fever, malaise, headache, cough, Range from typical flu to severe
chills, sore throat, and
respiratory disease. Diarrhea,
generalized pain
abdominal pain, nose bleed.
Lab diagnosis Routine testing
PCR, detection of viral RNA in
throat swap
Treatment
Amantadine (A only)
Rimantadine, Oseltamivir, or
Zanamivir (A & B)
Oseltamivir
Zanamivir
(should be started within 48 hrs)
Prevention
1. Flu shot vaccine
2. Nasal spray flue vaccine
Routine testing = direct detection of
virus from sputum, nasopharyngeal
swab, aspirate (NPA), or respiratory
secretion by direct
immunofluorescent essay (IFA)
Transmission is always through
inhalation of infectious aerosol
droplets.
V1
Viral Infections of the Respiratory System
Viral Parainfluenza
Respiratory Syncytial Virus &
Human metapneumovirus
Measeles
Mumps virus
Family
Paramyxoviridae
Paramyxoviridae
Paramyxoviridae
Paramyxoviridae
Structure
Enveloped virus
Enveloped virus
Enveloped virus
Enveloped virus covered with two
glycoprotein spikes (H & N)
Genome
– polarity ssRNA
– polarity ssRNA
– polarity ssRNA
– polarity ssRNA
7 – 14 days
18 – 21 days
I.P.
Symptoms
Fever, harsh cough,
difficult inspiration.
(Croup, bronchiolitis,
pneumonia)
Bronchiolitis (<6months)
Pneumonia
Fever, cough, conjunctivitis, runny
nose, koplik’s spot, rash
Moderate fever, malaise, pain on chewing
or swallowing, particularly acidic liquids.
Sudden onset of fever and painful
swelling of parotid gland
Lab diagnosis
Routine testing
Tissue culture
PCR
Routine testing
Cell culture (with CPE)
PCR
Serology by detection of IgM Ab
using ELISA
in case of SSPE detection of
measles antibodies in CSF
or detection of viral NA using PCR.
Serology by detection of IgM Ab using
ELISA,
cell culture and isolation of the virus from
saliva or detection of viral NA using PCR
Treatment
No specific treatment
(only supportive
treatment)
Ribavirin (for infants)
No specific treatment
No specific treatment
Prevention
No vaccine available
No vaccine available (passive
immunization immunoglobulin
given for infected premature
infants)
MMR Vaccine
MMR Vaccine
V1
Videos
Influenza:
https://www.youtube.com/watch?v=U17Rbx1AmN4
Measles:
https://www.youtube.com/watch?v=YBceTQ97FnM
Mumps:
https://www.youtube.com/watch?v=s3ACcn8IWFc
SAQ:
An 8 year old child is presented with fever, malaise and cough he visits an E.R doctor in the hospital , the doctor
suspects a viral infection he later diagnosed him with influenza. Based on this info answer the following…
1- if the influenza was type B what is the treatment?
ANS: Rimatidine , Oseltamivir , Zanamivir
2- what are the currently circulating strains of influenza?
ANS: H1N1 , H3N2
3- what is the most common complication that could arise in children duo to influenza?
ANS: Reyes syndrome
Direct questions:
1- What is the treatment for Respiratory syntical virus and human metapneumoviruse in infants?
ANS: Ribavirin
2- What is the virus that is presented with Kopliks spot?
ANS: Measels
3- What is the most common cause of common cold?
ANS: Rhinovirus
4- what virus has ocnogenic (cancer) properties?
ANS: Epstien Barr Virus (EBV)
5- What are the viruses that can be detected using serology detection of IgM antibodies using ELISA?
ANS : Measels , Mumps , EBV
ZOOM to see the answers ;)
MCQs:
1.Which one of the following is considered as first cause of common cold?
a. Rhinovirus
b. Coronavirus
c. Adenovirus
2.Which one of the following is structurally non-enveloped?
a. Parainfluenza
b. Coronavirus
c. Rhinovirus
3.Which one of the following is the only virus with dsDNA?
a. Adenovirus
b. Influenza
c. Respiratory Syncitial
4.Avian flu do not usually infect humans.
a. T
b. F
1- a
2- c
3- a
4- a
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