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6th Course Basic and Translational Endocrinology: “Emerging Technologies in Endocrine Research” Also as a precursor for the JNCE conference 27 & 28 October in Leiden Monday 24-Wednesday 26 October, 2016 web version 160623 (NB most speakers still to be invited!) Organizers: Erica van den Akker, Leo Hofland, Joop Janssen, Robin Peeters, Jenny Visser, Frank van Vliet Participants: Research Master students, Postgraduates, Post docs and other interested participants of the Postgraduate Schools MolMed and MGC and from other Universities The Erasmus Postgraduate School Molecular Medicine has two main activities: the organization of education for postgraduate students, and the stimulation of cooperation between several departments with regards to translational research. The aim of this course and workshop is to offer a comprehensive, interactive introduction to the field of basic and translational Endocrinology, including the paediatric aspects. The course aims at a small and specialised audience of PhD students working in this field, who like to gain in-depth knowledge. We cooperate with the JNVE conference on the 2 following days, 27 & 28 October in Leiden. This JNVE conference will again take place at the Holiday Inn Hotel in Leiden at October 27 and 28. The conference will offer a varied programme with a workshop on the history of hormone preparations (dr. Toine Pieters, VUMC/UMCU) and furthermore several talks by renowned Dutch senior researchers that do research on obesity in children (dr. Erica van den Akker, EMC), FGF-23 and Klotho (dr. Marc Vervloet, VUMC), thyroid carcinoma (dr. Thera Links, UMCG) and HPA axis in young delinquents (dr. Lucres Nauta, VUMC). Furthermore, this year's foreign guest speaker is drs. Christoph Thaiss (Weizmann Institute of Science, Tel Aviv, Israel), with his talk 'Microbiome time'. See: http://www.nve.nl/jnve-conference-2016. This course at Erasmus MC is primarily organized for PhD students and postdocs of the Postgraduate Schools MolMed and MGC. Other participants, such as Research Master students, young MD’s and research technicians, as well as other researchers in this field are welcome on ‘first come first served’ basis. The total number of participants is limited to 25. All 6 themes that we cover will start with an overview given by the moderator in a Q&A form by the participants themselves, as a ‘refreshments class’. The morning and afternoon sessions of the Monday, Tuesday and Thursday are each dedicated to one of the 6 specific themes of this course & workshop. 1 We expect that the participants study previously some chapters from the recommended textbook of this course: Boron en Boulpaep; Medical Physiology, Second Edition HOMEWORK BEFORE START OF COURSE (FROM TEXTBOOK Boron en Boulpaep) A] Introduction 1. Biosynthesis of hormones 2. Storage and secretion 3. Hormones in blood 4. Autocrine/paracrine secretion 5. Hormone degradation B] Mechanisms of hormone action 1. Hormonal actions mediated by intracellular receptors 2. Hormonal actions mediated by surface receptors C] Regulation of hormone secretion 1. Positive feedback 2. Negative feedback 3. Feed forward 4. Integration with central nervous system D] Measurements of Hormones 1. Principles of Radioimmunoassay 2. Day and night rhythms of blood hormone levels We do not expect that you can reproduce it, but you should know the principles and the terminology. The chapters are: Chapter Chapter Chapter Chapter Chapter Chapter Chapter 3 Signal transduction pp 48-74 47 Organization of endocrine control pp 1011-1027 48 Regulation of growth and body mass 49 The thyroid gland pp 1044-1056 50 The adrenal gland pp 1057-1073 51 The endocrine pancreas pp 1074-1093 55 The female reproductive system pp 1146-1169 Subscription fees: see below. Please subscribe as soon as possible via the website of MolMed: www.molmed.nl. 2 First Day, Monday October 24th. Room XXX Morning session: Opening & refreshment, thyroid gland Moderator: Robin Peeters, Erasmus MC <Robin benadert hen, Frank> Time Speaker Title Keywords 09:00-09:30 Registration & coffee 09:30-10:10 Robin Peeters & Marcel Refreshment class Endocrine control, hormone Meima, Erasmus MC synthesis, signal transduction, G-protein coupled receptor 10:10-10:50 t.b.d. Nuclear hormone receptors Steroid receptors; Regulatory Response Elements; Ligand induced transcription regulation; Co-activation/represssion; Transcriptional clock; Signal transduction; Anti-hormone action; 3D-modelling/conformational changes; orphan receptors 10:50-11:05 Coffee break 11:05-11:45 Robin Peeters & Marcel Thyroid hormone resistance THRA, THRB, ligand binding Meima, Erasmus MC due to mutations in thyroid domain, thyroid response hormone receptors element, tissue-specificity 11:45-12:25 Edward Visser, Erasmus Local regulation of thyroid MC, Rotterdam hormone activity 12:25-13.15 Lunch break in … First Day, Monday October 24th. Room XXX Afternoon session: Adrenal Moderator: Leo Hofland, Erasmus MC <Leo benadert hen, Frank> Time Speaker Title 13:15-13:55 Leo Hofland, Erasmus G-protein coupled receptors MC 13:55-14:35 Richard Feelders, Adrenal gland hyper- and Erasmus MC hypofunction 14:35-14:50 Coffee break 14:50-15:30 Hans Hofland, Erasmus Local regulation of cortisol MC activity 15:30-16:10 Liesbeth van Rossum, Cortisol, a hairy business Erasmus MC Keywords Second Day, Tuesday October 25th. Room xxx Morning session: Reproduction & refreshment Moderator: Jenny Visser, Erasmus MC <Jenny benadert hen, is vrijwel rond; Frank> Time Speaker Title Keywords 09:30-10:10 Jenny Visser, Erasmus Refreshment class Sex differentiation, gonadal MC development, hormonal regulation 10:10-10:50 Esther Baart, Erasmus Ovarian stimulation and MC effects on oocyte quality 10:50-11:05 Coffee break 11:05-11:45 Joop Laven, Erasmus MC Female reproductive aging Genetics, ovarian reserve, aging 11:45-12:25 Jenny Visser, Erasmus Role of AMH in ovarian Ovary, follicle selection, FSH MC function sensitivity, TGFβ family members 12:25-13.15 Lunch break in … 3 Second Day, Tuesday October 25th. Room xxx Afternoon session: Endocrine aspects of Obesity Moderator: Erica van den Akker with Jenny Visser, Erasmus MC <Erica benadert hen, Frank> Time Speaker Title Keywords 13:15-13:55 Hein Raat MGZ, Erasmus Prevention of obesity MC/ Amy van Grieken, Anne Wytzes MGZ 13:55-14:35 Erica van den Akker, Satiety and weight Neuroendocrine regulation, Ped. endocrinologist, regulation hypothalamus, satiety, weight Erasmus MC regulation, food intake, syndromal and monogenic obesity 14:35-14:50 Coffee break 14:50-15:30 Aldo Grefhorst, Role of brown adipose tissue Brown adipose tissue, White Erasmus MC in obesity adipose tissue, Brite adipose tissue, FDG PET scanning, obesity, insulin sensitivity, thermoneutrality 15:30-16:10 Mieke van Haelst, Titel? Key words? Clinical geneticist, UMCU Third Day, Wednesday October 26th . Room xxx Morning session: Bone; refreshment (?) Moderator: Bram van der Eerden <Bram, wil je ze vragen? Frank> Time Speaker Title 09:30-10:10 Bram van der Eerden, Calcium and phosphate Erasmus MC minerals make up bone: how are they regulated? 10:10-10:50 10:50-11:05 11:05-11:45 11:45-12:25 12:25-13.15 Keywords Bone metabolism, calcium, phosphate, vitamin D, parathyroid hormone, energy metabolism Carola Zillikens, Erasmus The genetic background of Osteoporosis, fractures, MC osteoporosis, a common and heritability, GWAS, exome complex disease sequencing, RANKL, sclerostin, Wnt signalling Coffee break Marjolein van Driel, Bone and cancer, a vicious Bone metastases, osteoblasts, Erasmus MC circle? prostate tumor cells, cocultures t.b.d. Bone stem cells …? Lunch break in … Third Day, Wednesday October 26th. Room xxx Afternoon session: Glucose, Insulin, IGF Moderator: Joop Janssen <Frank benadert hen, OK? Frank> Time Speaker Title 13:15-13:55 Joop Janssen, Erasmus Gut hormones and control of MC insulin action - to be determined/ The delicate interplay be-tween GH, IGFI and Insulin <1 praatje> 13:55-14:35 14:35-14:50 14:50-15:30 15:30-16:10 Patrick Delhanty, Erasmus MC Coffee break Anton Scheurink, RUG, Groningen Aart Jan van der Lelij, Erasmus MC Keywords Incretins, GLP-1, diabetes mellitus en/of Incretins, glucagon-like-peptide-1, glucose-dependent insulinotropic peptide, insulin, glucagon and bariatric surgery Ghrelin and its role in glucose homeostasis Individual differences in the development and treatment of insuline resistance Are we addicted to sugar? 4 Insuline resistance Attendance fees The subscription fee of non-commercial participants for the Course is € 550. Discounts are handled as followed: All PhD students and all members of the JNVE get a discount of 50 % and pay € 275,-. All participants from the MolMed school get a discount of 100 % and pay € 0. If these financial requirements pose a problem but you wish to attend the Course and Workshops, please contact Frank van Vliet, managing director of the Erasmus Postgraduate School Mol Med, at: [email protected]. Invoice Fees can be paid upon an INVOICE. Shortly after your registration you will receive the INVOICE per mail. Payment per bank can be done on account: 43.47.01.408 / Erasmus MC, (IBAN code bank: NL86ANBA0434701408; SWIFT code bank: ABNANL2A), together with the number on your INVOICE. Late participants can also pay in cash upon signing in for the Course. Cancellations The fees are for all the days of the Course. There is no discount for partaking only in part of the Course. Our cancellation policy is that cancellation is possible up to one week before the start of the Course. Later cancellation will not be accepted, but you are allowed to send a substitute. Commercial participants & sponsors Companies are invited to inquire for participation and sponsoring. 5