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6th Course Basic and Translational Endocrinology:
“Emerging Technologies in Endocrine Research”
Also as a precursor for the JNCE conference 27 & 28 October in Leiden
Monday 24-Wednesday 26 October, 2016
web version 160623
(NB most speakers still to be invited!)
Organizers:
Erica van den Akker, Leo Hofland, Joop Janssen, Robin Peeters, Jenny
Visser, Frank van Vliet
Participants: Research Master students, Postgraduates, Post docs and other
interested participants of the Postgraduate Schools MolMed and MGC
and from other Universities
The Erasmus Postgraduate School Molecular Medicine has two main activities: the
organization of education for postgraduate students, and the stimulation of
cooperation between several departments with regards to translational research.
The aim of this course and workshop is to offer a comprehensive, interactive
introduction to the field of basic and translational Endocrinology, including the
paediatric aspects. The course aims at a small and specialised audience of PhD
students working in this field, who like to gain in-depth knowledge.
We cooperate with the JNVE conference on the 2 following days, 27 & 28
October in Leiden. This JNVE conference will again take place at the Holiday Inn Hotel
in Leiden at October 27 and 28. The conference will offer a varied programme with a
workshop on the history of hormone preparations (dr. Toine Pieters, VUMC/UMCU) and
furthermore several talks by renowned Dutch senior researchers that do research on
obesity in children (dr. Erica van den Akker, EMC), FGF-23 and Klotho (dr. Marc Vervloet,
VUMC), thyroid carcinoma (dr. Thera Links, UMCG) and HPA axis in young delinquents
(dr. Lucres Nauta, VUMC). Furthermore, this year's foreign guest speaker is drs.
Christoph Thaiss (Weizmann Institute of Science, Tel Aviv, Israel), with his talk
'Microbiome time'. See: http://www.nve.nl/jnve-conference-2016.
This course at Erasmus MC is primarily organized for PhD students and
postdocs of the Postgraduate Schools MolMed and MGC. Other participants, such as
Research Master students, young MD’s and research technicians, as well as other
researchers in this field are welcome on ‘first come first served’ basis. The total number
of participants is limited to 25.
All 6 themes that we cover will start with an overview given by the moderator in a Q&A
form by the participants themselves, as a ‘refreshments class’. The morning and
afternoon sessions of the Monday, Tuesday and Thursday are each dedicated to one of
the 6 specific themes of this course & workshop.
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We expect that the participants study previously some chapters from the
recommended textbook of this course:
Boron en Boulpaep; Medical Physiology, Second Edition
HOMEWORK BEFORE START OF COURSE (FROM TEXTBOOK Boron en Boulpaep)
A] Introduction
1. Biosynthesis of hormones
2. Storage and secretion
3. Hormones in blood
4. Autocrine/paracrine secretion
5. Hormone degradation
B] Mechanisms of hormone action
1. Hormonal actions mediated by intracellular receptors
2. Hormonal actions mediated by surface receptors
C] Regulation of hormone secretion
1. Positive feedback
2. Negative feedback
3. Feed forward
4. Integration with central nervous system
D] Measurements of Hormones
1. Principles of Radioimmunoassay
2. Day and night rhythms of blood hormone levels
We do not expect that you can reproduce it, but you should know the principles
and the terminology. The chapters are:
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Chapter
Chapter
Chapter
Chapter
Chapter
Chapter
Chapter
3 Signal transduction pp 48-74
47 Organization of endocrine control pp 1011-1027
48 Regulation of growth and body mass
49 The thyroid gland pp 1044-1056
50 The adrenal gland pp 1057-1073
51 The endocrine pancreas pp 1074-1093
55 The female reproductive system pp 1146-1169
Subscription fees: see below.
Please subscribe as soon as possible via the website of MolMed: www.molmed.nl.
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First Day, Monday October 24th. Room XXX
Morning session: Opening & refreshment, thyroid gland
Moderator: Robin Peeters, Erasmus MC <Robin benadert hen, Frank>
Time
Speaker
Title
Keywords
09:00-09:30
Registration & coffee
09:30-10:10
Robin Peeters & Marcel
Refreshment class
Endocrine control, hormone
Meima, Erasmus MC
synthesis, signal
transduction, G-protein
coupled receptor
10:10-10:50
t.b.d.
Nuclear hormone receptors
Steroid receptors; Regulatory
Response Elements; Ligand
induced transcription regulation; Co-activation/represssion; Transcriptional clock;
Signal transduction;
Anti-hormone action;
3D-modelling/conformational
changes; orphan receptors
10:50-11:05
Coffee break
11:05-11:45
Robin Peeters & Marcel
Thyroid hormone resistance THRA, THRB, ligand binding
Meima, Erasmus MC
due to mutations in thyroid
domain, thyroid response
hormone receptors
element, tissue-specificity
11:45-12:25
Edward Visser, Erasmus Local regulation of thyroid
MC, Rotterdam
hormone activity
12:25-13.15
Lunch break in …
First Day, Monday October 24th. Room XXX
Afternoon session: Adrenal
Moderator: Leo Hofland, Erasmus MC <Leo benadert hen, Frank>
Time
Speaker
Title
13:15-13:55
Leo Hofland, Erasmus
G-protein coupled receptors
MC
13:55-14:35
Richard Feelders,
Adrenal gland hyper- and
Erasmus MC
hypofunction
14:35-14:50
Coffee break
14:50-15:30
Hans Hofland, Erasmus
Local regulation of cortisol
MC
activity
15:30-16:10
Liesbeth van Rossum,
Cortisol, a hairy business
Erasmus MC
Keywords
Second Day, Tuesday October 25th. Room xxx
Morning session: Reproduction & refreshment
Moderator: Jenny Visser, Erasmus MC <Jenny benadert hen, is vrijwel rond; Frank>
Time
Speaker
Title
Keywords
09:30-10:10
Jenny Visser, Erasmus
Refreshment class
Sex differentiation, gonadal
MC
development, hormonal
regulation
10:10-10:50
Esther Baart, Erasmus
Ovarian stimulation and
MC
effects on oocyte quality
10:50-11:05
Coffee break
11:05-11:45
Joop Laven, Erasmus MC Female reproductive aging
Genetics, ovarian reserve,
aging
11:45-12:25
Jenny Visser, Erasmus
Role of AMH in ovarian
Ovary, follicle selection, FSH
MC
function
sensitivity, TGFβ family
members
12:25-13.15
Lunch break in …
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Second Day, Tuesday October 25th. Room xxx
Afternoon session: Endocrine aspects of Obesity
Moderator: Erica van den Akker with Jenny Visser, Erasmus MC <Erica benadert hen, Frank>
Time
Speaker
Title
Keywords
13:15-13:55
Hein Raat MGZ, Erasmus Prevention of obesity
MC/ Amy van Grieken,
Anne Wytzes MGZ
13:55-14:35
Erica van den Akker,
Satiety and weight
Neuroendocrine regulation,
Ped. endocrinologist,
regulation
hypothalamus, satiety, weight
Erasmus MC
regulation, food intake,
syndromal and monogenic
obesity
14:35-14:50
Coffee break
14:50-15:30
Aldo Grefhorst,
Role of brown adipose tissue Brown adipose tissue, White
Erasmus MC
in obesity
adipose tissue, Brite adipose
tissue, FDG PET scanning,
obesity, insulin sensitivity,
thermoneutrality
15:30-16:10
Mieke van Haelst,
Titel?
Key words?
Clinical geneticist, UMCU
Third Day, Wednesday October 26th . Room xxx
Morning session: Bone; refreshment (?)
Moderator: Bram van der Eerden <Bram, wil je ze vragen? Frank>
Time
Speaker
Title
09:30-10:10
Bram van der Eerden,
Calcium and phosphate
Erasmus MC
minerals make up bone:
how are they regulated?
10:10-10:50
10:50-11:05
11:05-11:45
11:45-12:25
12:25-13.15
Keywords
Bone metabolism, calcium,
phosphate, vitamin D,
parathyroid hormone, energy
metabolism
Carola Zillikens, Erasmus The genetic background of
Osteoporosis, fractures,
MC
osteoporosis, a common and heritability, GWAS, exome
complex disease
sequencing, RANKL,
sclerostin, Wnt signalling
Coffee break
Marjolein van Driel,
Bone and cancer, a vicious
Bone metastases, osteoblasts,
Erasmus MC
circle?
prostate tumor cells, cocultures
t.b.d.
Bone stem cells
…?
Lunch break in …
Third Day, Wednesday October 26th. Room xxx
Afternoon session: Glucose, Insulin, IGF
Moderator: Joop Janssen <Frank benadert hen, OK? Frank>
Time
Speaker
Title
13:15-13:55
Joop Janssen, Erasmus
Gut hormones and control of
MC
insulin action - to be
determined/ The delicate
interplay be-tween GH, IGFI and Insulin <1 praatje>
13:55-14:35
14:35-14:50
14:50-15:30
15:30-16:10
Patrick Delhanty,
Erasmus MC
Coffee break
Anton Scheurink, RUG,
Groningen
Aart Jan van der Lelij,
Erasmus MC
Keywords
Incretins, GLP-1, diabetes
mellitus en/of Incretins,
glucagon-like-peptide-1,
glucose-dependent
insulinotropic peptide, insulin,
glucagon and bariatric surgery
Ghrelin and its role in
glucose homeostasis
Individual differences in the
development and treatment
of insuline resistance
Are we addicted to sugar?
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Insuline resistance
Attendance fees
The subscription fee of non-commercial participants for the Course is € 550.
Discounts are handled as followed:


All PhD students and all members of the JNVE get a discount of 50 % and
pay € 275,-.
All participants from the MolMed school get a discount of 100 % and pay €
0.
If these financial requirements pose a problem but you wish to attend the Course and Workshops,
please contact Frank van Vliet, managing director of the Erasmus Postgraduate School Mol Med, at:
[email protected].
Invoice
Fees can be paid upon an INVOICE. Shortly after your registration you will receive
the INVOICE per mail. Payment per bank can be done on account: 43.47.01.408 /
Erasmus MC, (IBAN code bank: NL86ANBA0434701408; SWIFT code bank:
ABNANL2A), together with the number on your INVOICE.
Late participants can also pay in cash upon signing in for the Course.
Cancellations
The fees are for all the days of the Course. There is no discount for partaking only
in part of the Course. Our cancellation policy is that cancellation is possible up
to one week before the start of the Course. Later cancellation will not be
accepted, but you are allowed to send a substitute.
Commercial participants & sponsors
Companies are invited to inquire for participation and sponsoring.
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