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Jeffrey V. May, PhD Associate Professor Executive Director, H.L. Snyder Medical Res. Inst. Office: 438 Hubbard Hall Phone:(316) 978-6177 Fax: (316) 978-3772 Email:[email protected] Education: Institution Degree Year Field of Study University of Maine B.S. 1970 Biochemistry University of Rhode Island Ph.D. 1979 Biochemistry 19791983 Reproductive Biology Duke University Medical Postdocoral Center Fellowship Research Interests: Endocrine disruptors (EDs) represent an expanding group of environmental compounds that can markedly affect biological processes in animals and humans. These include pesticides, herbicides, solvents, plasticizers, prescription drugs, and naturally occurring compounds such as isoflavones. Whereas EDs can potentially affect biological systems during any phase of life, specific concern has been raised with respect to their damaging effects upon developing organ systems following fetal and/or neonatal exposure. Among the potential developmental targets of EDs, the reproductive system warrants special attention based upon the estrogenic nature of many EDs. Whereas much emphasis has been placed upon the toxic effects of EDs to fetal outcome in terms of overt birth defects, it is becoming evident that the effects of fetal/neonatal exposure to these compounds may be subtle and may impair but not totally attenuate biological function in the adult. My research interests are currently focused upon the impact of EDs upon the developing ovary in terms of the onset of reproductive function, infertility/subfertility, and reproductive aging. My laboratory utilizes numerous techniques including immunoblotting for protein detection, reverse transcription/polymerase chain reaction (RT/PCR), fluorescence differential gene display, RNA and DNA isolation, and immunocytochemistry and in situ hybridization. Figure: Induction of polyovular follicles in the hamster ovary following neonatal exposure to diethylstilbestrol (DES) at 0.01 (B), 1.0 (C) , and 100 µg/animal (D. A control is illustrated in (A). Grant Funding: "Neonatal Endocrine Disruption and Ovarian Senescence", NIH Grant HD R15 ES012182-01, 5/1/03 - 4/30/05 Representative publications: Hendry, WJ III, Sheehan, DM, Khan, SA, May, JV (2002) Developing a laboratory model for perinatal endocrine disruption: The hamster chronicles. Soc Exptl Biol Med 227:709-723 May, JV, Rueda, BR, Hendry, WJ III (2003) Differential ovarian disuption following neonatal exposure of hamsters to diethylstilbestrol versus estradiol 17ß. Biol Reprod (In revision) Mau Y-HL and May JV (2003) Ovarian cell-specific TGF-ß1 autoexpression in the porcine follicle (In preparation.) Courses Taught: Developmental Biology Molecular and Cell Biology Endocrinology Immunobiology Biol. 420. Molecular Cell Biology. (4). 3R; 2L. Concerned primarily with the molecular biology of eukaryotic cells. Covers individual cellular components (organelles) and processes includes the plasma membrane, mitochondrion and energy conversion, intracellular sorting, the cell nucleus and genetic mechanisms, control of gene expression, cell signalling, cell growth and division, cancer, and cellular mechanisms of development. Reviews and demonstrates current techniques and experimental approaches for studying cells. Prerequisites: Biol. 204 or 211 and Chem. 112.