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Jeffrey V. May, PhD
Associate Professor
Executive Director, H.L. Snyder Medical Res. Inst. Office: 438 Hubbard Hall
Phone:(316) 978-6177
Fax: (316) 978-3772
Email:[email protected]
Education:
Institution
Degree
Year
Field of Study
University of Maine
B.S.
1970
Biochemistry
University of Rhode
Island
Ph.D.
1979
Biochemistry
19791983
Reproductive
Biology
Duke University Medical Postdocoral
Center
Fellowship
Research Interests:
Endocrine disruptors (EDs) represent an expanding group of environmental compounds that can
markedly affect biological processes in animals and humans. These include pesticides,
herbicides, solvents, plasticizers, prescription drugs, and naturally occurring compounds such as
isoflavones. Whereas EDs can potentially affect biological systems during any phase of life,
specific concern has been raised with respect to their damaging effects upon developing organ
systems following fetal and/or neonatal exposure. Among the potential developmental targets of
EDs, the reproductive system warrants special attention based upon the estrogenic nature of
many EDs. Whereas much emphasis has been placed upon the toxic effects of EDs to fetal
outcome in terms of overt birth defects, it is becoming evident that the effects of fetal/neonatal
exposure to these compounds may be subtle and may impair but not totally attenuate biological
function in the adult. My research interests are currently focused upon the impact of EDs upon
the developing ovary in terms of the onset of reproductive function, infertility/subfertility, and
reproductive aging. My laboratory utilizes numerous techniques including immunoblotting for
protein detection, reverse transcription/polymerase chain reaction (RT/PCR), fluorescence
differential gene display, RNA and DNA isolation, and immunocytochemistry and in situ
hybridization.
Figure: Induction of polyovular follicles in the hamster ovary following neonatal exposure to
diethylstilbestrol (DES) at 0.01 (B), 1.0 (C) , and 100 µg/animal (D. A control is illustrated in
(A).
Grant Funding:
"Neonatal Endocrine Disruption and Ovarian Senescence", NIH Grant HD R15 ES012182-01,
5/1/03 - 4/30/05
Representative publications:
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Hendry, WJ III, Sheehan, DM, Khan, SA, May, JV (2002) Developing a laboratory
model for perinatal endocrine disruption: The hamster chronicles. Soc Exptl Biol Med
227:709-723
May, JV, Rueda, BR, Hendry, WJ III (2003) Differential ovarian disuption following
neonatal exposure of hamsters to diethylstilbestrol versus estradiol 17ß. Biol Reprod (In
revision)
Mau Y-HL and May JV (2003) Ovarian cell-specific TGF-ß1 autoexpression in the
porcine follicle (In preparation.)
Courses Taught:
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Developmental Biology
Molecular and Cell Biology
Endocrinology
Immunobiology
Biol. 420. Molecular Cell Biology. (4). 3R; 2L. Concerned primarily with the molecular
biology of eukaryotic cells. Covers individual cellular components (organelles) and processes
includes the plasma membrane, mitochondrion and energy conversion, intracellular sorting, the
cell nucleus and genetic mechanisms, control of gene expression, cell signalling, cell growth and
division, cancer, and cellular mechanisms of development. Reviews and demonstrates current
techniques and experimental approaches for studying cells. Prerequisites: Biol. 204 or 211 and
Chem. 112.