Download 與細胞核內受器蛋白結合的激素Hormones That Bind to Nuclear

內分泌系統-3
激素的作用機制
Mechanisms of Hormone Action

Hormones of same chemical class have similar
mechanisms of action.

Location of cellular receptor proteins.

Target cell must have specific receptors for that
hormone (specificity).

Hormones bind to receptors with high bond strength
(affinity).

Low capacity of receptors (saturation).
2
摘自 新編生理學 永大出版社
3
與細胞核內受器蛋白結合的激素
Hormones That Bind to Nuclear Receptor Proteins
4
Receptor of steroid hormone
5
Mechanisms of thyroid hormone action
6
7
利用第二傳訊者的激素
Hormones That Use Second Messengers

Cannot pass through plasma membrane.

Catecholamines, polypeptides, and
glycoproteins bind to receptor proteins on
the target cell membrane.

Actions are mediated by 2nd messengers
(signal-transduction mechanisms).

Extracellular hormones are transuded into intracellular
second messengers.
8
利用第二傳訊者的激素
Hormones That Use Second Messengers

3 classes of 2nd messenger systems:

Adenylate cyclase (腺苷酸環化酶)- cAMP, cGMP.

Phospholipase C (磷脂酶)- IP3, DAG.

Tyrosine kinase (酪胺酸激酶).
9
10
11
利用第二傳訊者的激素
Hormones That Use Second Messengers

3 classes of 2nd messenger systems:

Adenylate cyclase (腺苷酸環化酶)- cAMP, cGMP.

Phospholipase C (磷脂酶)- IP3, DAG.

Tyrosine kinase (酪胺酸激酶).
12
DAG
13
14
(DAG)
15
利用第二傳訊者的激素
Hormones That Use Second Messengers

3 classes of 2nd messenger systems:

Adenylate cyclase (腺苷酸環化酶)- cAMP, cGMP.

Phospholipase C (磷脂酶)- IP3, DAG.

Tyrosine kinase (酪胺酸激酶).
16
17