Download **** 1 - School of Life Sciences

Bionanoscience for Innovative Global
Healthcare Research & Technology (BIGHEART)
Speaker : Luke P. Lee, Ph.D
Department of Bioengineering, University of California
It is critical time to solve the problems of current qualitative biomedical science and
healthcare system. In the first part of lecture, I will discuss nanosatellites that have
multiple functions in living systems: targeting, imaging, gene delivery and regulations.
Magnetic nanosatellites are being developed as new classes of smart MRI contrast agents,
molecular diagnostic probes, magnetic cell labeling and separation tools. New paradigm of
molecular optogenetics by nanosatellites is not only for the on-demand remote control of
gene regulations, but also to create transcriptional pulses for systematic digital biology
and translational medicine. Molecular imaging methods of wireless nanosatellites provide
us a new opportunity to explore inner life of living cells for understanding signaling
pathways and cellular dynamics. Capturing the dynamics of epigenetic landscape via
nanosatellites might give us insights for the rational cell reprogramming in regenerative
medicine.
In the second part of lecture, I will discuss my vision for precision biology and preventive
personalized medicine via cellular BASICs* (Biologic Application Specific Integrated
Circuits). As an example of BASICs, I will present a Self-powered Integrated Microfluidic
Blood Analysis System (SIMBAS) that does not require any external connections, tethers, or
tubing to deliver and analyze a raw whole-blood sample. By integrating these cellular
BASICs platforms and nanoplasmonic optical antenna array, we are developing Optofluidic
Application Specific Integrated System (OASIS) for label-free bioassays. The OASIS
platform allows highly multiplexed nucleic acid and protein analysis. In summary, I will
discus the critical role of 21st precision biology for nanomedicine, molecular diagnostics,
and low-cost integrative healthcare systems.
When: 3:00 PM on May. 26 (Thu.)
Where: Engineering Building 1, E104
Contact: Prof. Yoon Kyoung Cho(2511) / [email protected]
School of Nano-Bioscience & Chemical Engineering
UNIST