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Tutorial
Topics: Lymph node syndrome/Dengue & other hemorrhagic fevers
Block: Hematology (HEM)
MBBS Year 1 Semester 2
Session 2011/2012
Lecturer-in-charge: HK/PS
4th June 2012
1.
The following statements are TRUE/FALSE:
F
A.
F
B.
T
C.
T
D.
F
E.
Chronic fatigue syndrome is primarily a disorder of
elderly males.
Cytomegalovirus and herpes simplex virus are usually
implicated in chronic fatigue syndrome.
Patients with chronic fatigue syndrome tend to
develop paradoxical bradycardia and syncope.
Impairment in short-term memory is one of the
presentations of chronic fatigue syndrome.
Blood culture helps in the diagnosis of chronic fatigue
syndrome.
2.
The following statements are TRUE/FALSE:
T
A.
T
B.
T
C.
F
D.
T
E.
Kawasaki syndrome is an acute vasculitis that primarily
affects infants and young children.
Staphylococcal enterotoxins may be associated with
Kawasaki syndrome.
Strawberry tongue with small haemorrhagic fissures
are the clinical manifestations of Kawasaki syndrome.
Diagnosis of Kawasaki syndrome is based on the
decreased levels of bilirubin and alkaline phosphatase.
Aspirin is used in the treatment of acute phase of
Kawasaki syndrome.
3.
T
T
The following statements are TRUE/FALSE:
A.
B.
T
C.
F
D.
T
E.
Transfusion-transmitted cytomegalovirus disease is
usually seen in immunocompromised hosts.
The clinical presentations of neonatal cytomegalovirus
infections include hepatomegaly, petechiae and
thrombocytopenia.
Guillain-Barre syndrome and Bell’s palsy are among
the complications of CMV mononucleosis.
CMV infection is diagnosed based on positive
heterophile antibody.
Ganciclovir is used in the treatment of CMV infections.
4.
The following statements are TRUE/FALSE:
T
A.
EBV replicates in epithelial cells of the oropharynx.
T
B.
Infectious mononucleosis usually presents with
lymphadenopathy and fever.
Autoimmune hemolytic anemia is one of the
complications of infectious mononucleosis.
Detection of pp65 in circulating lymphocytes is used
as a diagnostic tool for infectious mononucleosis.
Treatment of infectious mononucleosis includes the
administration of anti-viral agents.
T
F
F
C.
D.
E.
5.
The following statements are TRUE/FALSE:
T
A.
EBV infection is usually transmitted through contact of
saliva from an infected person.
T
B.
Patients with infectious mononucleosis may develop
distinct diffuse maculopapular rash following
administration of ampicillin.
C.
Oral hairy leukoplakia is one of the complications of
EBV infections in HIV positive patients.
D.
Tissues infected with EBV exhibit a typical enlarged cell
with “owl’s eye” basophilic nuclear inclusion.
E.
The presence of large atypical lymphocytes with
abundant, basophilic, vacuolated cytoplasm is a
hallmark of infectious mononucleosis.
T
F
T
6.
The following statements are TRUE/FALSE:
F
A.
T
B.
T
C.
F
D.
T
E.
Chikungunya hemorrhagic fever is caused by a
flavivirus and is transmitted by rat bites.
Rats are the reservoirs of Hantaan virus.
Hantaan virus is the causative agent of Korean
hemorrhagic fever.
Marburg and Ebola viruses which belong to the
genus Arenavirus cause self-limiting disease.
Both dengue and yellow fever are caused by
flaviviruses and are transmitted by mosquitoes.
7.
T
T
The following statements are TRUE/FALSE:
A.
Dengue virus consists of more than one serotype.
B.
The principal vector of dengue fever in the rural and
urban areas are different.
Fever, retro-orbital pain and myalgia with deep bone
pain are clinical features of dengue fever.
Dengue virus replicates in hepatocytes and also in
vascular endothelium.
After an earlier attack of dengue, antibodies formed
against one serotype are protective against all other
serotypes.
T
C.
F
D.
F
E.
8.
The following statements are TRUE/FALSE:
F
A.
T
B.
T
C.
T
D.
E.
F
Antibody to dengue virus serotype 1 binds to dengue
virus serotype 2 and thus neutralize the infection by
serotype 2.
Vascular damage, shock and hemorrhage are due to
an increased release of cytokines into the circulation.
Saddleback pattern of fever is observed in dengue
fever.
Gastrointestinal bleeding is one of the manifestations
of dengue hemorrhagic fever.
Leucocytosis with predominant polymorphs is a
feature of dengue fever.
9.
The following statements are TRUE/FALSE:
T
A.
T
B.
C.
T
F
F
D.
E.
Dengue hemorrhagic fever occurs following
reinfection with a dengue virus of different serotype
after the primary attack.
A narrow pulse pressure of less than 20mm Hg is a
feature of dengue shock syndrome.
Dengue virus can be isolated by intracerebral
inoculation of the clinical specimen in Aedes
albopictus larvae.
In secondary infection, IgG is significantly raised and
IgM is always negative.
Dengue and yellow fever viruses are antigenically
related and usually provide cross-immunity.
10. The following statements are TRUE/FALSE:
T
A.
T
B.
T
C.
F
D.
F
E.
Yellow fever virus is a flavirus with one antigenic
type.
Jungle yellow fever is transmitted from infected
monkeys to human by bites of Haemogogus sp.
Live attenuated 17D yellow fever vaccine provides
95% protection for 10 years.
Hantavirus pulmonary syndrome is caused by
Prospect Hill virus and is usually a self-limiting
disease.
Hemorrhagic complications of Chikungunya fever are
more commonly seen among Europeans.