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LED Light Skin-care Product and Special Cream I. Background Everyone tries to reverse the natural process of aging. Major cosmetics companies still use the “mystery of beauty” to sell their skin-care products. Even with huge advances in medical discovery and human genome exploration, no serious scientists have tackled this field. Using biotechnology to guide skin-care product development is Oulian’s mission. Two major methods exist to reduce wrinkles and rejuvenate skin on the market: 1) Chemical methods: the main products are creams with popular active ingredients, such as Vitamin A, C, or E, their derivatives, alpha lipoic acid, dimethylaminoethanol, or other anti-oxidant, etc.. 2) Physical methods: mechanical surface skin removal or laser surgery. It is known that Type I collagen (later abbreviated as collagen) increases skin elasticity and firmness. The traditional methods mentioned above all strive to increase collagen production under the skin. However, all the traditional methods missed out on one caveat in collagen increase. Collagen increase by outside force tilts the delicate balance of our body, thus increasing the production of collagenase, which degrades collagen. This natural phenomenon eventually takes the level of collagen back to the original state. Oulian’s product solves this dilemma. II. Oulian’s Product We have successfully developed a novel skin-care product (patent pending). Our LED (light-emitting diode) device (CollaLightTM) is made up of 800 LED bulbs of specific wavelength, specific light emitting angle, specific light strength, and specific light frequency. The final light output is less than 10mw/cm 2. The mild light does not hurt the skin, yet LED light can still penetrate into theepidermis to activate cells. Our patented product has another necessary companion, our CollaCreamTM skin-firming cream, applied at the area illuminated by the CollaLightTM. The active ingredient in CollaCreamTM is a specific small molecule collagenase inhibitor that is lipid soluble. Theory CollaLightTM induces collagen production under the skin. Increased collagen concentration in turn increases collagenase activity. Oulian’s CollaCreamTM specifically inhibits collagenase, and thus achieves a high level of collagen under the skin. Other active ingredients in CollaCreamTM, such as Vitamin A, C, and anti-oxidants additionally induce collagen content in the skin. Experimental Results Oulian’s quantitative cell line experiment shows the additive effect of our programmed LED light and special collagenase inhibitor (the active ingredient in CollaCreamTM) in increasing collagen. Using a 35year-old female skin cell line as experimental material and Type I collagen antibody and western blot as the detection method , we observed no obvious Type I collagen increase using programmed LED light alone, 10 times Type I collagen increase using collagenase inhibitor alone, and 50 times Type I collagen increase using both LED light and collagenase inhibitor, compared with the collagen content in skin cells without external disturbance (shown in Figure below). The programmed LED light and specific collagenase inhibitor together have an additive effect in increasing collagen production in skin cells. Actin protein amount is used as total protein concentration control. Procollagen I (Type I collagen) in the skin cells is measured using Type I collagen antibody. C --no LED light, no inhibitor; RH5 --LED light alone for 5 minutes; OL-1 --Specific collagenase inhibitor alone; RH5 +OL-1: LED light 5 minutes first, then addition of specific collagenase inhibitor (Figure adapted from Oulian’s patent) Oulian’s human testing using the CollaLightTM and CollaCreamTM also showed positive results. We have conducted human testing in 6 beauty salons in Beijing, Guangzhou, and Jiangsu province on our products. 50% of the women saw their wrinkles diminish after 4-10 times of use; 80% of women saw their skin have increasing elasticity after 311 times of use; 70% of women saw their dark circles and eye bags diminish after 1-10 times of use. After each treatment, the tested subject and beautician each wrote down skin changes, with no communication involved. Only when we see consistent observation from the tested subject and beautician do we consider the observation real. Current prototype goggles are made by hand, shown in the figure at right. We are in the process of updating the goggle design. III. Competitors Laser Surgery Compared with Laser surgery, Oulian’s product CollaLightTM is superior. CollaLightTM uses very low energy, thus it does not cause injury to skin. It is small, easy to use, very safe, and inexpensive. It is designed and suited for home use, while Laser treatment is not. Additionally, CollaLightTM and CollaCreamTM can achieve results similar to Laser surgery. LED Light Products We have two competitors in the US with LED light skin-care products in development. However, their designs are simpler than ours, yet their prices are 10-100 times more than ours. Their products are bulky, thus can only be used at beauty salons or doctors’ offices. In addition, no company has included any special cream in its usage. As shown in our cell line results, without collagenase inhibitor present, the LED light effect is quite minimal. Thus their products do not achieve as positive a result as ours. In China we have no competitors. IV. Timeline for the product launch in China Dec. 2003 Chinese patent applied. Dec. 2003 Better design and model frame design for CollaLightTM. Jan. 2004 2 L CollaCreamTM made for approval in China. Feb. 2004 50 CollaLightTM made with new design. Feb. 2004 CollaCreamTM approved in China for sale. Mar. 2004 CollaLightTM approved in China for sale. Mar. 2004 Cosmetic Product National Meeting in Guangzhou, China. May 2004 Cosmetic Product National Meeting in Shanghai, China. Jun. 2004 TV commercials, and collaboration for marketing in China. V. China Market We are aiming for beauty salons and high-income middle age urban women (28-59 years old, home use) in the China market. Of this group in China, at least 5 million women can afford our product. If we can capture 20% of the market (1 million users), charging $250 USD for each device, Oulian’s revenue might reach $250 million. It could take 1 year of commercial development and promotion to reach that figure. In addition, CollaCreamTM is a consumable good, thus it can generate constant revenues of around $10 million USD a year. The uniqueness, effectiveness, and ease of use will be the selling points of Oulian’s product. The company requires $300K to roll-out this product in the Chinese market.