Vitreous and Developmental Vitreoretinopathies
... detach the posterior cortical vitreous from the retina, resulting in surgical complications such as retinal breaks. The interface between vitreous and retina consists of a complex formed by the posterior vitreous cortex and the internal limiting lamina (ILL), which includes the basal lamina of Mülle ...
... detach the posterior cortical vitreous from the retina, resulting in surgical complications such as retinal breaks. The interface between vitreous and retina consists of a complex formed by the posterior vitreous cortex and the internal limiting lamina (ILL), which includes the basal lamina of Mülle ...
Vitreous Anatomy and Pathology
... hydrophilic hyaluronan.11 Rheological observations also suggest the existence of an important interaction between hyaluronan and collagen.12 Balazs has hypothesized that the hydroxylysine amino acids of ...
... hydrophilic hyaluronan.11 Rheological observations also suggest the existence of an important interaction between hyaluronan and collagen.12 Balazs has hypothesized that the hydroxylysine amino acids of ...
Separate Functions of Gelsolin Mediate Sequential Steps of
... When creating actin filament severing mutants of gelsolin, the choice of altered residues was directed by the following considerations: the aminoterminal half of gelsolin is largely responsible for severing and capping activities and is regulated by phosphoinositides (Janmey and Stossel, 1987; Yin, ...
... When creating actin filament severing mutants of gelsolin, the choice of altered residues was directed by the following considerations: the aminoterminal half of gelsolin is largely responsible for severing and capping activities and is regulated by phosphoinositides (Janmey and Stossel, 1987; Yin, ...
Dua`s Layer: its discovery, characteristics and applications
... starts as two or more small bubbles at the periphery which enlarge centrally to meet and coalesce. At times both Type 1 and Type 2 BB can appear in the same sclero-corneal disc. These are termed “Mixed bubbles” (Figure 3C). The two bubbles in mixed-BB can be in various combinations, a complete Type ...
... starts as two or more small bubbles at the periphery which enlarge centrally to meet and coalesce. At times both Type 1 and Type 2 BB can appear in the same sclero-corneal disc. These are termed “Mixed bubbles” (Figure 3C). The two bubbles in mixed-BB can be in various combinations, a complete Type ...
The cuticle
... The cuticle surrounding the main body of the animal can be sub-divided into the broad dorsal and ventral regions overlying the dorsal and ventral hypodermis and the narrow lateral regions overlying the seam cells where longitudinal ridges termed alae are positioned on the cuticle of the L1 and dauer ...
... The cuticle surrounding the main body of the animal can be sub-divided into the broad dorsal and ventral regions overlying the dorsal and ventral hypodermis and the narrow lateral regions overlying the seam cells where longitudinal ridges termed alae are positioned on the cuticle of the L1 and dauer ...
Type XIII collagen. Structural and functional characterization of the
... Type XIII collagen is a transmembrane protein consisting of a short intracellular portion, a transmembrane anchor, and a long extracellular domain with a mainly collagenous sequence. Histochemical and cell biological studies have revealed that type XIII collagen has a wide distribution in various ti ...
... Type XIII collagen is a transmembrane protein consisting of a short intracellular portion, a transmembrane anchor, and a long extracellular domain with a mainly collagenous sequence. Histochemical and cell biological studies have revealed that type XIII collagen has a wide distribution in various ti ...
RefectoCil Eyelash Perm
... wonderful curl, letting the eyes appear lager and more expressive. At the same time the eyelashes are nourished. Unlike mechanical lash curlers RefectoCil Eyelash Perm gently forms the eyelashes with the curl lasting up to 6 weeks. Collagen is one of the commonly occurring structural proteins in the ...
... wonderful curl, letting the eyes appear lager and more expressive. At the same time the eyelashes are nourished. Unlike mechanical lash curlers RefectoCil Eyelash Perm gently forms the eyelashes with the curl lasting up to 6 weeks. Collagen is one of the commonly occurring structural proteins in the ...
Published version
... the suggestion that some mutations may interfere with biological interactions involving collagen and that interaction mutations could be particularly severe or even non-viable (7, 18). Type I collagen interacts with many matrix and cell receptor proteins, including the integrin cell receptors (␣21, ...
... the suggestion that some mutations may interfere with biological interactions involving collagen and that interaction mutations could be particularly severe or even non-viable (7, 18). Type I collagen interacts with many matrix and cell receptor proteins, including the integrin cell receptors (␣21, ...
Collagen in the Human Lung
... Quantitation of the rates of in vitro collagen and noncollagen protein synthesis. Fetal and adult lungs were rinsed in PBS (4°C) and finely minced in the incubation medium described above. For each lung, the lung mince was divided into three (fetal) or four (adult) equal portions which were incubate ...
... Quantitation of the rates of in vitro collagen and noncollagen protein synthesis. Fetal and adult lungs were rinsed in PBS (4°C) and finely minced in the incubation medium described above. For each lung, the lung mince was divided into three (fetal) or four (adult) equal portions which were incubate ...
Simvastatin Reduces MMP1 Expression in Human Smooth Muscle
... Objective—Activation of collagen receptors expressed by smooth muscle cells induces matrix metalloproteinase (MMP) expression. The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have been shown to interfere with integrin signaling, but their effects on collagen receptor-mediate ...
... Objective—Activation of collagen receptors expressed by smooth muscle cells induces matrix metalloproteinase (MMP) expression. The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have been shown to interfere with integrin signaling, but their effects on collagen receptor-mediate ...
A Comparative Study of Collagen Matrix Density Effect on
... environmental factors, and successful signal transduction. These complex vascular networks exhibit dynamic behavior including endothelial cell migration, proliferation, elongation, and branching.14 As endothelial cells migrate into the extracellular matrix (ECM), they undergo cell-type specific speci ...
... environmental factors, and successful signal transduction. These complex vascular networks exhibit dynamic behavior including endothelial cell migration, proliferation, elongation, and branching.14 As endothelial cells migrate into the extracellular matrix (ECM), they undergo cell-type specific speci ...
Elastin
... Some of the lysyl side chains of the tropoelastin polypeptides are oxidatively deaminated by lysyl oxidase, forming allysine residues. Three of the allysyl side chains plus one unaltered lysyl side chain from the same or neighboring polypeptides form a desmosine cross-link .THIS PRODUCES ELASTIN— a ...
... Some of the lysyl side chains of the tropoelastin polypeptides are oxidatively deaminated by lysyl oxidase, forming allysine residues. Three of the allysyl side chains plus one unaltered lysyl side chain from the same or neighboring polypeptides form a desmosine cross-link .THIS PRODUCES ELASTIN— a ...
Isolated Osteoclasts Resorb the Organic and Inorganic Components
... electron microscopy, these cells were seen to have the abundant mitochondria and the extensive membrane ruffling characteristic of osteoclasts (Fig. 2). Binding of osteoclast-specific antibody confirmed that the cells were osteoclasts (Fig. 3). Isolated osteoclasts, incubated with 45Ca o r L-[5-aH]p ...
... electron microscopy, these cells were seen to have the abundant mitochondria and the extensive membrane ruffling characteristic of osteoclasts (Fig. 2). Binding of osteoclast-specific antibody confirmed that the cells were osteoclasts (Fig. 3). Isolated osteoclasts, incubated with 45Ca o r L-[5-aH]p ...
Fibrous proteins
... the walls of large arteries, and elastic ligaments. They can be stretched to several times their normal length, but recoil to their original shape when the stretching force is relaxed. ...
... the walls of large arteries, and elastic ligaments. They can be stretched to several times their normal length, but recoil to their original shape when the stretching force is relaxed. ...
Collagen Diversity, Synthesis and Assembly
... any amino acid. This motif allows the chains to form a right-handed triple-helical structure (Fig. 2.1), with all glycine residues buried within the core of the protein, and residues X and Y exposed on the surface. Depending on the genetic type of collagen, this triple-helical motif can be a major o ...
... any amino acid. This motif allows the chains to form a right-handed triple-helical structure (Fig. 2.1), with all glycine residues buried within the core of the protein, and residues X and Y exposed on the surface. Depending on the genetic type of collagen, this triple-helical motif can be a major o ...
(ECM) Binding Sites on the Basal Surface of Embryonic Corneal
... L-[2,3aH]proline, 23.7 Ci/mmol, New England Nuclear, Boston, MA) or [3H]leucine (30 ~Ci/ml, L-[2,3,4,5-3H]leucine, 120 Ci/mmol, ICN Biomedicals Inc., Irvine, CA). After a 16-24-h incubation, the tissue and media were harvested in 0.01 M Tris (pH 7.4) with 2 mM EDTA and EGTA and protease inhibitors, ...
... L-[2,3aH]proline, 23.7 Ci/mmol, New England Nuclear, Boston, MA) or [3H]leucine (30 ~Ci/ml, L-[2,3,4,5-3H]leucine, 120 Ci/mmol, ICN Biomedicals Inc., Irvine, CA). After a 16-24-h incubation, the tissue and media were harvested in 0.01 M Tris (pH 7.4) with 2 mM EDTA and EGTA and protease inhibitors, ...
Antibiotic-loaded silica nanoparticleâcollagen composite
... bacteria. The effect of gentamicin and rifamycin were evaluated on P. aeruginosa and S. aureus, respectively. Antibiograms were carried out using the disk diffusion method as described in United States Pharmacopeia. Briefly, a bacterial suspension (culture dilution 1:100) was spread on an agar petri ...
... bacteria. The effect of gentamicin and rifamycin were evaluated on P. aeruginosa and S. aureus, respectively. Antibiograms were carried out using the disk diffusion method as described in United States Pharmacopeia. Briefly, a bacterial suspension (culture dilution 1:100) was spread on an agar petri ...
Jelly Facts - Institute of Food Research
... the helical protein chains: Image from www.3dchem.com ...
... the helical protein chains: Image from www.3dchem.com ...
Micropreparation of tissue collagenase fragments of type I collagen
... when the peptidic moieties were extracted from the gel while the CNBr series of peptides had never been brought into the contact with SDS. Consequently a separation based on the hydrophobicity of the polypeptide–SDS complex resulting from slab gel electrophoresis appeared likely. When the sample was ...
... when the peptidic moieties were extracted from the gel while the CNBr series of peptides had never been brought into the contact with SDS. Consequently a separation based on the hydrophobicity of the polypeptide–SDS complex resulting from slab gel electrophoresis appeared likely. When the sample was ...
The Structure of Collagen within Parchment
... Collagen molecules have the prerequisite of repeating arnino acid sequences of Gly-X-Y, where Gly is the amino acid residue glycine and X and Y are any amino acid residues; most commonly X and Y are proline and hydroxyproline34. Hy-droxylysine is another residue that commonly takes the X or Y posit ...
... Collagen molecules have the prerequisite of repeating arnino acid sequences of Gly-X-Y, where Gly is the amino acid residue glycine and X and Y are any amino acid residues; most commonly X and Y are proline and hydroxyproline34. Hy-droxylysine is another residue that commonly takes the X or Y posit ...
Production of fibronectin and collagen types I and III by chick embryo
... substrates consisting of one or two extracellular matnx components (type I. III, or IV collagen, fJbronectin and several glycosamlnoglycans (GAGs): hyaluronate. chondroitin-4, chondroltin-5. dermatan and heparan sulfates). The effect of these substrates on the production of flbronectln. of types I. ...
... substrates consisting of one or two extracellular matnx components (type I. III, or IV collagen, fJbronectin and several glycosamlnoglycans (GAGs): hyaluronate. chondroitin-4, chondroltin-5. dermatan and heparan sulfates). The effect of these substrates on the production of flbronectln. of types I. ...
A domain-specific usherin/collagen IV interaction may be required
... fibronectin type III repeats. These domains, of approximately 100 amino acids, are shared with at least 45 different families of molecules ranging from cytokine receptors to cell surface binding proteins. Different type III domains may be almost completely dissimilar at the amino acid level and as m ...
... fibronectin type III repeats. These domains, of approximately 100 amino acids, are shared with at least 45 different families of molecules ranging from cytokine receptors to cell surface binding proteins. Different type III domains may be almost completely dissimilar at the amino acid level and as m ...
Mapping the Heparin-binding Sites on Type I Collagen Monomers
... may consist of a highly basic triple helical domain, including several amino acids known sometimes to function as disaccharide acceptor sites. We propose that the heparin-binding site of type I collagen may play a key role in cell adhesion and migration within connective tissues, or in the cell-dire ...
... may consist of a highly basic triple helical domain, including several amino acids known sometimes to function as disaccharide acceptor sites. We propose that the heparin-binding site of type I collagen may play a key role in cell adhesion and migration within connective tissues, or in the cell-dire ...
Characterization of Type I and IV Collagens by Raman
... chain is characterized by a Gly-X-Y sequence where X corresponds frequently to proline and Y to hydroxyproline [11]. For each Gly-X-Y tripeptide unit, there is only one direct intrachain hydrogen bond between the N–H group of glycine and the C=O group of X residue. In addition, stabilizing interacti ...
... chain is characterized by a Gly-X-Y sequence where X corresponds frequently to proline and Y to hydroxyproline [11]. For each Gly-X-Y tripeptide unit, there is only one direct intrachain hydrogen bond between the N–H group of glycine and the C=O group of X residue. In addition, stabilizing interacti ...
Collagen
Collagen /ˈkɒlədʒɨn/ is the main structural protein in the extracellular space in the various connective tissues in animals. As the main component of connective tissue, it is the most abundant protein in mammals, making up from 25% to 35% of the whole-body protein content.Collagen, in the form of elongated fibrils, is mostly found in fibrous tissues such as tendons, ligaments and skin. It is also abundant in corneas, cartilage, bones, blood vessels, the gut, intervertebral discs and the dentin in teeth. In muscle tissue, it serves as a major component of the endomysium. Collagen constitutes one to two percent of muscle tissue, and accounts for 6% of the weight of strong, tendinous muscles. The fibroblast is the most common cell that creates collagen.Gelatin, which is used in food and industry, is collagen that has been irreversibly hydrolyzed. Collagen also has many medical uses in treating complications of the bones and skin.The name collagen comes from the Greek κόλλα (kólla), meaning ""glue"", and suffix -γέν, -gen, denoting ""producing"". This refers to the compound's early use in the process of boiling the skin and sinews of horses and other animals to obtain glue.