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EMBL – Beyond Molecular Biology
Physics
Computational Biology
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Chemistry
Modelling and Simulation
Medicine
Collaborations between EMBL research groups
2006-2009
EMBL Research Units
Director’s Research
Developmental Biology Unit
Cell Biology and Biophysics Unit
Structural and Computational Biology Unit
Grenoble
EMBL-EBI
Hamburg
Monterotondo
Genome Biology Unit
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EMBL Scientific Core Facilities
• Advanced Light Microscopy
• Chemical Biology
• Electron Microscopy
• Flow Cytometry
• Protein Expression & Purification
• Genomics
• Proteomics
• Monoclonal Antibodies
• Transgenics
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Research Directions
Imaging
• Bridging scales of biological organisation: combine low- and highresolution techniques
• Biology in four dimensions: live imaging to study dynamic
processes in space and time
• Generate quantitative data
Computational Biology
• Analysing, integrating and exploiting quantitative data
• Build predictive networks and models of biological processes
Utilising Next Generation Sequencing
• Inter-species variation: comparative sequence analysis to study
evolution
• Intra-species variation: link genetic variation to phenotype
Disease Models and Mechanisms
• Decipher the molecular basis of genetic and infectious diseases
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4
06/06/11
with the help of animal and cellular models
Human microbiome
• Human body consists 1013 human
cells (10 trillion)
• It harbors 1014 microbial cells –
human microbiome (100 trillion)
• Role and influence in human health
not fully understood
• Recent focus: International studies
to investigate their role in human
development and health
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Human intestinal tract - gut microbiome
• Composition of gut microbiome varies from person to person
• Roles of gut flora: help digestion, produce vitamins, break
down toxins, protect from invadors
• MetaHIT
Consortium:
metagenomics
approach to study
the gut microbiome
• Metagenomics:
sequence and
analyse the genetic
material of the entire
gut microbiome
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Humans can be classified into 3 types based on
their gut microbes
• Microbial genetic markers (abundant genes or functional modules, not
species) are related to age, gender and body-mass index
• Investigate applicability for diagnosis and prediction of outcomes for diseases
like colo-rectal cancer
• Information about a
person’s gut type
could help inform
treatment or predict
aspects of drug
response
Arumugam, M. et al. Enterotypes
of the human gut microbiome.
Nature 473
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Technology Development
• EMBL develops a broad spectrum of technology and
instrumentation for life science research
• Cross-fertilisation between research activities and
technology development
Imaging
technology
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Software
development
Synchrotron instrumentation
EMBL Technology Transfer
EMBL*
Idea
EMBLEM**
Discovery
Licensing
Protect
ETF***
* European Molecular Biology Laboratory (http://www.embl.org)
** EMBLEM Technology Transfer GmbH (http://www.embl-em.de)
*** EMBL Technology Fund (http://www.embl-ventures.com)
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Start Up
Company