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Course 5 Case 19 Kas 5-19E: Heart failure and shock. Pavel Stanka, MD. Patient: male, 53 years. History of presenting complaint. A 53 years old, so far healthy, warehouseman comes to emergency for progressive dyspnoea. For the last 3 weeks, he is observing dyspnoea on minimal effort and sometimes also at rest and at nights. Furthermore, he is complaining of an intermittent dull pressure behind the lower sternum without radiation. No complaints of palpitation, sporadically nausea. Since introduction of therapy by general practitioner, he has experienced some improvement of symptoms. Past history: never seriously ill Approximately 10 years ago, in-hospital observation for dyspepsia (nausea) Social habits: Former smoker, twenty cigarettes a day since his 17, nonsmoker for the last 6 years, alcohol- 5 pints of beer and two shots of liqueur a day Medication: furosemide 40mg 1-0-0 tbl, spironolacton 25mg 1-1-1 tbl, B-vitamins Family history: father unknown, mother died at 69 of stroke, brother died at 68 of lung disease. He does not know any details. Physical examination: 72 kg, 165 cm, no resting dyspnoea, no cyanosis, whole body tremor, head: chronic stomatitis, pharyngitis, jugular vein distension reaching up to one half of the neck, breathing with medium inspiratory crackles over both lung bases. HR 140/min, gallop, soft abdomen, liver 1 cm bellow right costal margin, no peripheral edemas, BP 120/80mmHg ECG: at admission, sin rhythm, 136/min, horizontal axis, PQ 0,16, flat negat. T aVL, T+V4,V5 After treatment, sinus 84/min, flat negat. T aVL, T+-V3-V5 Course 5 Case 19 Course 5 Case 19 Chest X-ray: lungs without infiltration, heart is dilated to the left Course 5 Case 19 Echocardiography (normal values in parentheses: left ventricle 73mm (within 60mm), EF 30% (over 55%), septum thickness 11mm (within 12mm), posterior wall 10-11mm (within 12mm), left atrium 44mm (within 43mm), right ventricle 26mm (within 30mm), diffuse hypokinesis of the left ventricle, pericardium without effusion Spirometry: Normal Coronary and left ventricular angiography: Intermediate LAD stenosis (60%), diffuse hypokinesis EF 30%, performed ad hoc PCI with stent implantation in LAD Sonography of abdomen: Diffuse liver lesion of steatosis type, right liver lobe is of uppernormal size. Blood tests: elevated liver enzymes (ALT 2,3 ukat/l, AST 1,47 ukat/L), slightly elevated plasma ammonia Questions 1. Make a list of admission diagnoses arranged in order by priority. 2. What is a likely cause of patient disease? 3. What therapeutic measures would you suggest to treat the acute phase and to prevent the progression of the disease? 4. What causes of heart failure do you know? 5. Types of cardiomyopathy 6. Etiology of tremor