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King Abdulaziz University (KAU)
Faculty of Science- Biochemistry Department
Second semester 2014
Hormones- BIOC 313
Midterm exam
Wednesday 9-6-1435/9-4-2014
Dr. Ayat B. Al-Ghafari
Student Name
Computer Number
Total Mark
20
Bonus (in blue)
3
1
Question (1): In the following table, complete the missing word in column (A) by
choosing what matching it from column (B) (0.5 for each point) (16.5 marks).
Answer
Column (A)
1- The thyroid gland has thousands of follicles.
E
Each follicle is filled with pink-staining
proteinaceous material called (………..).
2- A deficiency of vasopressin leads to excessive
G
loss of urine, a condition known as (………….).
3- In males, Interstitial cell-stimulating hormone
M
(ICSH) is another name for (……………..).
4- Calcitonin has the ability to decrease blood
S
calcium levels in (……..).
5- The (……..) gland is considered the largest
A
endocrine gland.
6- Vasopressin hormone has another name
I
(……….).
7- Follicle-stimulating hormone (FSH) is a hormone
H
found in humans and other animals and it is
produced by the (…….) pituitary lobe.
8- (……) is a mammalian hormone that acts
L
primarily as a neurotransmitter in the brain and is
important for the contractions of epithelial cells
in many organs.
9- When the thyroid gland is active, the follicle size
B
is (……….).
10- In females, an acute rise of LH called the
Y
(………..) triggers ovulation and development of
the corpus luteum.
11- (………) is an important mineral in the formation
F
of thyroid hormones.
12- Prolactin stimulates the mammary glands to
J
produce milk in a process called (…………).
13- The thyroid gland contains two lobes (Right &
BB
Left), that are connected by band of tissue called
(…………).
14- When calcium concentration is high, it can
W
deposit in the kidney and form (………).
15- Cl- -I- co-transporter has another name, which is (
AA
……).
16- Vitamin D is important for the maintenance of
CC
(………) in blood and bones.
2
Column (B)
A. Thyroid
B. Small
C. Lung and intestinal
tract
D. Calcitonin
E. Colloid
F. Iodine
G. Diabetes insipidus
H. Anterior
I. ADH
J. Lactation
K. TRH
L. Oxytocin
M. LH
N. Chief cells
O. Na+ - K+ ATPase
P. Lysosomes
FF
N
X
P
Q
V
U
O
C
Z
R
GG
D
DD
EE
T
K
17- Thyroid hormones are derivatives of the amino
acid (………).
18- The parathyroid hormone (PTH) is secreted from
(……..).
19- During the synthesis of thyroid hormones,
thyroglobulin (Tg) is synthesized in these cells
(……..).
20- The endocytosed vesicle containing colloid is
fused with (………..).
21- Overexpression of prolactin is clinically known
as (……).
22- Inadequate production of parathyroid hormone,
typically results in decreased concentrations of
calcium and increased concentrations of
phosphorus in blood, which results in (……….).
23- (……..) stimulates the production and release of
melanin (melanogenesis) by melanocytes in skin
and hair.
24- Na+-I- co-transporter has another name, which is
(…….).
25- Calcitonin is secreted from C cells in the thyroid
gland as well as from (……..).
26- It is a gland, which contains four small glands
located in the neck.
27- The follicular cells and (……) cells are two
major cells that formed the thyroid gland.
28- In sexually mature males, (…..) acts on
spermatogonia stimulating (with the aid of
testosterone) the production of sperms.
29- (……..) is a marker for thyroid gland cancer.
Q. Hyperprolactenemia
30- Follicle stimulating hormone (FSH) is produced
from specialized cells known as (……..).
31- Other iodinated molecules are similar structurally
to thyroid hormones but have little or no
biological activity; so called (……….).
32- PTH stimulates the absorption of calcium from
the small intestine indirectly under the effect of
(………..).
33- Hypothalamus (…….) has a stimulatory effect on
prolactin release.
3
R. C cells
S. Bone and kidney
T. Vitamin D
U. MSH
V. Tetany
W. Kidney stones
X. Follicular cells
Y. LH surge
Z. Parathyroid glands
AA.
Pendrin channel
BB.
Isthmus
CC.
Calcium
DD.
Gonadotrophs
EE.
Reverse T3
FF.
Tyrosine
GG.
FSH
Question (2): Put (T) or (F) for the following sentences and correct the false one (0.25
for each correct point and 0.5 for the false one) (6.5 marks)
Answer
Sentence
Correction if the
sentence is wrong
T
1- Thyroid hormones are highly insoluble in water.
T
2- Highly elevated levels of prolactin decrease the levels
of sex hormones .
3- H2O2 is transported from the follicular cells to the
lumen by the action of thyroid peroxidase (TPO).
4- FSH needs to work with other hormones to produce its
effect.
5- Transthyrein is the major carrier for thyroid hormones.
6- The thyroid gland is well vascularized.
7- FSH signals to the brain have effects on appetite and
sexual arousal.
8- LH levels are normally low during childhood and, in
women, high after menopause.
F
T
F
T
F
T
F
9- Dopamine stimulates prolactin secretion.
F
10- Thyroid hormones synthesis begins with the uptake of
chloride mineral from the blood.
11- H2O2 is produced as a result of the O2 interaction with
intermediates of pentose phosphate pathway.
12- When the levels of T3 and T4 are low, the production
of TSH from the pituitary gland is decreased.
13- The number and position of iodine is important in the
structure and function of thyroid gland hormones.
14- In the synthesis of thyroid gland hormones, every time
one sodium ion and two iodide ions are transported
into the follicular cells.
15- Thyroid peroxidase is an important enzyme that
catalyzes three major steps in the synthesis of thyroid
gland hormones. These are respectively oxidation,
iodination, and conjugation.
16- The iodinated and conjugated thyroglobulin is then
endocytosed back into follicular cells, initiated by
pendrin channel.
17- luteotropic hormone (LTH) is another name for
prolactin hormone.
18- Vasopressin structure contains specialized amino acid
(arginine).
T
F
T
F
T
F
T
T
Dual Oxidase 2
Thyroglobulin
MSH
TRH/ Inhibition
Iodide
Increased
2 sodium and 1
iodide
Megalin receptors
Good Luck ,,,
4