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LHRH Agonists Antagonists
LHRH Agonists Antagonists

... of the Endocrine Society in San Francisco in 1971. Porcine LHRH was shown to be a decapeptide with the following structure: Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 (
clinical endocrinology - Nakladatelství KAROLINUM
clinical endocrinology - Nakladatelství KAROLINUM

... 1.6.7 Septo-optic dysplasia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65 1.6.8 Hypoplasia of the pituitary gland . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...
Hypophysis and Hypothalamus
Hypophysis and Hypothalamus

... 1.2 Physiology and Function....................................................... ...
MRI features of growth hormone deficiency in children with short
MRI features of growth hormone deficiency in children with short

... occupying and in some cases we detected extension to suprasellar region. Usually this condition is observed in females (15). MRI results revealed low, equal or high signal on T1 and high signal on T2. No enhancement was found in capsule wall and content in case of enhancement scanning conducted by a ...
Serum Concentrations of Luteinizing Hormone, Growth Hormone
Serum Concentrations of Luteinizing Hormone, Growth Hormone

... Increased secretion of LH following treatment of luteal-phase gilts with NMA is most likely a consequence of NMA-induced release of GnRH from the hypothalamus. Administration of GnRH antisera to ovariectomized gilts abolished the ability of the compound to increase LH secretion (Sesti and Britt, 199 ...
Altered functional resting-state hypothalamic connectivity and
Altered functional resting-state hypothalamic connectivity and

... problems and hyperphagia, indicating hypothalamic-pituitary dysfunction. However, few studies have explored the underlying neurobiology of the hypothalamus and its functional connectivity with other brain regions. Thus, the aim of this study was to examine the anatomical differences of the hypothala ...
Dynamic contrast-enhanced MR imaging of the
Dynamic contrast-enhanced MR imaging of the

... hypothalamic hormones. We also used pituitary length and width and the product of the three parameters as measures of pituitary size with similar results. Observed changes were only small and inconsistent, although the matching procedure was accurate and the reproducibility of MRI scans was high, as ...
Andrew V. Schally - Nobel Lecture
Andrew V. Schally - Nobel Lecture

... It has long been known that the reproductive activity of animals is influenced by seasonal and external environmental factors such as nutrition, light and temperature and that aberrations in the menstrual cycles of women can occur as a result of adverse environmental and psychological stimuli and em ...
pituitary gland – an overview
pituitary gland – an overview

... 25- 150ng/ml - prolactinoma, stalk effect, drugs , Hypothyroid > 150ng/ml - prolactinoma(pure or mixed) > 1000 ng/ml - invasive prolactinomas ...
Induction of the Secretion of LH and GH by Orexin A and Ghrelin is
Induction of the Secretion of LH and GH by Orexin A and Ghrelin is

... 2012; Towhidi et al., 2007; Wójcik-Gładysz et al., 2009). Subcutaneous administration of leptin in wethers with estradiol implants increases LH concentrations reduced by 78-h dietary restrictions (Nagatani et al., 2000). In the same animal model, Miller et al. (2002) observed that ICV infusion of le ...
Thyrotropin releasing hormone interactions with growth hormone
Thyrotropin releasing hormone interactions with growth hormone

... water (Sticker et al., 2001). The aspartate solutions were made to 1.427 M, pH of 7.3 to 7.4, and were infused at 2 mL/kg BW. Samples of jugular blood (5 mL) were collected at −30, −15, and 0 min relative to saline or TRH treatment. Aspartate infusion was started immediately following the 0-min samp ...
Secretion of neuron-specific enolase, prolactin, growth hormone
Secretion of neuron-specific enolase, prolactin, growth hormone

... were defined by measurement of prolactin, growth hormone, luteinising hormone (LH) and follicle stimulating hormone (FSH) secretion rates in vitro and the corresponding plasma hormone levels. Measurement of prolactin secretion provided a clear distinction between true prolactinomas and "functionless ...
Fetal tissue containing the suprachiasmatic nucleus restores
Fetal tissue containing the suprachiasmatic nucleus restores

... Fetal tissue containing either the SCN (n 5 23) or a comparable amount of cerebellar tissue (controls, n 5 5) was implanted into the third ventricle of those animals. Two other control groups received fetal SCN grafts. They were included to examine possible interactions between the healthy host SCN ...
Hypothalamo-Pituitary Disorders
Hypothalamo-Pituitary Disorders

... on chromosome 11 has been cloned and its common mutations resulting in MEN-1 have been identified. A constitutively active mutation of the stimulatory G protein (gsp) has been postulated as the cause of GH-secreting adenomas in up to 40% of cases. Rare familial cases of acromegaly have been recorded ...
The Endocrine System, Second Edition
The Endocrine System, Second Edition

... active hormone is ‘seen’ by the body but the bound hormone is effectively hidden. This is one factor that must be considered when measuring circulating concentrations of hormones: some assays measure total hormone (bound and free) while others measure only the biologically active hormone. You really ...
Ectopic posterior pituitary gland
Ectopic posterior pituitary gland

... hypersignal on T1-weighted and enhances after gadolinium injection ...
The Sella and Parasellar Region
The Sella and Parasellar Region

... • A large percentage of these (approximately 75%) are functioning and result in endocrine abnormalities. ...
MALDI mass spectrometry imaging analysis of
MALDI mass spectrometry imaging analysis of

... generate a broad range of endocrine disturbances and comorbidities related to the specific hormone being secreted in excess (5–9). Transsphenoidal surgical approaches are the most common first-line treatment for pituitary adenomas that require surgical intervention. These procedures relieve the comp ...
Vestibular modulation of endocrine secretions
Vestibular modulation of endocrine secretions

... Vestibular system regulates sympathetic nerve activity in humans [82]. Numerous animal studies have shown functional interactions between vestibular and autonomic systems. However, relatively few studies have examined vestibularautonomic interactions in humans. In response to electrical activation o ...
30 Overview of Endocrine System, Pituitary gland
30 Overview of Endocrine System, Pituitary gland

... Intestines and other organs ...
The Hypothalamic pituitary axis part 1
The Hypothalamic pituitary axis part 1

... The posterior pituitary secretes 2 peptide hormones which are synthesised respectively in the supraoptic and paraventricular nuclei of the hypothalamus: 1) Antidiuretic Hormone (ADH) 2) Oxytocin These hormones are then transported to the posterior pituitary from where they are released into the circ ...
About Pituitary Tumors What Are Pituitary Tumors?
About Pituitary Tumors What Are Pituitary Tumors?

... The smaller, back part of the pituitary gland, known as the posterior pituitary, is really an extension of brain tissue from the hypothalamus. The posterior pituitary is where hormones made by the hypothalamus (vasopressin and oxytocin) are stored and released into the bloodstream. ...
Author`s personal copy
Author`s personal copy

... Between 1910 and 1930, workers were so dazzled by the effects of the newly discovered anterior pituitary hormones that many considered the gland to be autonomous e “the conductor of the endocrine orchestra”.1 However, earlier findings by Bramwell (1888) and Fröhlich (1901) regarding the effect of h ...
Chapter 1 Gener and outline of this thesis
Chapter 1 Gener and outline of this thesis

... Hormones released by the pituitary gland influence the endocrine systems in the body and also have a feedback on the hypothalamus. The communication between the hypothalamus and anterior pituitary is via the portal system that runs through the pituitary stalk. Hormones released by the hypothalamus a ...
Pathology of Hypophysis
Pathology of Hypophysis

... distinct components: • 1. Anterior lobe (adenohypophysis, 80% of gland) production of the most pituitary hormones is controlled predominantly by positive-acting releasing factors from the hypothalamus delivered via portal vascular system (exceptions: prolactin- only inhibitory signals; growth hormon ...
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Vasopressin

Vasopressin, also known as arginine vasopressin (AVP), antidiuretic hormone (ADH), or argipressin, is a neurohypophysial hormone found in most mammals. Its two primary functions are to retain water in the body and to constrict blood vessels. Vasopressin regulates the body's retention of water by acting to increase water reabsorption in the kidney's collecting ducts, the tubules which receive the very dilute urine produced by the functional unit of the kidney, the nephrons. Vasopressin is a peptide hormone that increases water permeability of the kidney's collecting duct and distal convoluted tubule by inducing translocation of aquaporin-CD water channels in the plasma membrane of collecting duct cells. It also increases peripheral vascular resistance, which in turn increases arterial blood pressure. It plays a key role in homeostasis, by the regulation of water, glucose, and salts in the blood. It is derived from a preprohormone precursor that is synthesized in the hypothalamus and stored in vesicles at the posterior pituitary. Most of it is stored in the posterior pituitary to be released into the bloodstream. However, some AVP may also be released directly into the brain, and accumulating evidence suggests it plays an important role in social behavior, sexual motivation and pair bonding, and maternal responses to stress. It has a very short half-life between 16–24 minutes.
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