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NERVOUS SYSTEM NERVOUS TISSUE Nervous System - General Control System Regulator of Homeostasis Electrical Impulses Rapid & Transient Effects Nervous System - Functions Sensory - Monitors Internal & External Environments Integrative - Analyzes Sensory Information - Stores - Makes Decisions Regarding Appropriate Responses Motor – Controls muscles & glands; responds to sensory information Nervous System Divisions Central Nervous System (CNS) - Brain, Spinal Cord - Dorsal Body Cavity - Integration & Command Center Peripheral Nervous System (PNS) - All Neural Tissue outside CNS Nerves (Cranial & Spinal) Carries Info. Between CNS & Rest of Body Sensory & motor Peripheral Nervous System Sensory - Afferent - Conveys sensory information to CNS Motor - Efferent - Conveys motor commands to muscles & glands PNS Motor Divisions Somatic Nervous System (SNS) - Voluntary Control of Skeletal Muscles Autonomic Nervous System (ANS) - Involuntary Control of Smooth Muscle, Cardiac Muscle & Glands - Sympathetic Division - Parasympathetic Division Cells of Nervous System Neurons - Basic Unit of Nervous System - Most Specialized Cell in Body - Conduct Impulses Neuroglia (“Nerve Glue”) - Support, Framework (fill spaces) & Phagocytes - Most Numerous - Can Divide & Multiply Neurons - Structure Cell Body (Soma) - Nucleus & Various Organelles * Nissl Bodies (Rough ER) * Neurofibrils (Cytoskeletal) Dendrites - Numerous, Short, Branched Processes - Receive Impulse from other Neurons or Receptors - Carry Impulse Towards Cell Body (Afferent) Fig. 8.3 Neurons – Structure continued Axon - Long, Usually Singular Process - Many Mitochondria, Neurofibrils - Carries Impulse Away from Cell Body (Efferent) - Carries Impulse Towards: * ANOTHER NEURON * MUSCLE FIBER * GLAND CELL Neurons – Axon continued - Axon Hillock (Joins Cell Body & Axon) - Collaterals (Axon Branches) - Axon/Synaptic Terminals *Numerous, Fine Processes at end of Axon & Axon Collaterals *Some with Synaptic Knobs Neurons – Axon continued - Myelination *Most Axons *Enclosed in Schwann Cells (Neurolemmocyte) Myelin Sheath – Multilayered, Inner, Fatty Neurolemma – Outer Schwann Cell Membrane & Cytoplasm Fig. 8.6 Neurons – Axon Myelination continued *Insulates & Increases Speed of Conduction *Nodes of Ranvier Occur Along Axon Between Schwann Cells No Myelin Neurons – Functional Classification Sensory - Afferent - Connect Receptors & CNS Motor - Efferent - Carry Commands from CNS to Effectors Interneurons (Association) - CNS - Integrate Sensory & Motor - Most Numerous Neurons – Structural Classification Unipolar - One Process (Dendrites & Axon Fused) - Sensory Bipolar - Two Processes: One Dendrite, One Axon - Rare (Special Senses) Multipolar - Several Dendrites, One Axon - Common - Motor & Interneurons Neurons - Terminology Gray Matter – Unmyelinated Fibers & Cell Bodies White Matter – Myelinated Axons Nerve – Bundle of Fibers (Axons) in PNS Tract – Bundle of Fibers in CNS Ganglia – Clusters of Neuron Cell Bodies in PNS Nuclei – Clusters of Neuron Cell Bodies in CNS Neuroglia CNS - Astrocytes * Large, Star-shaped * Link Neurons & Blood Vessels; Help form Blood-brain Barrier - Oligodendrocytes * Form Myelin Sheath - Microglia * Derived from WBCs, Phagocytes Fig. 8.5abc Neuroglia continued - Ependymal Cells * Epithelium * Line Ventricles & Central Canal * Produce & Help Circulate CSF PNS - Schwann Cells (Neurolemmocytes) * Form Myelin Sheath - Satellite Cells * Support, Cushion Ganglia Nerve Impulse Transmission Two mechanisms involved - Transmission along a neuron *An electrical process - Transmission between neurons *A chemical process *Occurs at synapse Neuron Physiology Transmission Requirements: - Resting Membrane Potential (Cell Membrane is Polarized) - Ion Channels in Cell Membrane (Allow Ions to Cross When Open) - Delivery of Threshold Stimulus Conduction Along Neuron Resting Membrane Potential (+/Na+ outside, -/K+ inside Appropriate Threshold Stimulus Opens Na+ Channels Na+ Diffuses into Neuron, Results in Depolarization Depolarization wave spreads from dendrite to axon Fig. 8.11 Conduction Along Neuron continued Na+ Channels Close, K+ Channels Open & K+ Diffuses Out of Neuron Results In Repolarization Action Potential = Depolarization + Repolarization (dendrite to axon) Repolarization Required before another Action Potential Sodium-Potassium Pump moves Na+ out & K+ in (Requires Energy) Conduction continued All-or-None Principle - Neurons respond to stimuli by generating an impulse (action potential), or don’t respond at all Refractory Period - Neurons must repolarize their cell membranes before they respond to subsequent stimuli Types of Conduction Continuous - Typical of Unmyelinated Neurons (Slower) - Steps as Previously Described Saltatory - Occurs along Myelinated Neurons - No Current where Myelin occurs - Action Potential Leaps from Node of Ranvier to Node - Faster! Fig. 8.12 Synaptic Transmission Arriving Action Potential Depolarizes Synaptic Knob Ca++ Enters Cytoplasm of Presynaptic Neuron Exocytosis of Synaptic Vesicles, Releasing Neurotransmitter Neurotransmitter Diffuses across Synaptic Cleft & Binds to Receptors on Postsynaptic Membrane Na+ Channels Open, Postsynaptic Membrane Depolarizes Fig. 8.13 Neurotransmitters Excitatory – Cause Depolarization/Na+ ions channels open (Dopamine) Inhibitory – Raise the Threshold/ K+ or Clion channels open (Serotonin & GABA) Removed by Specific Enzymes