Download 499 Med Chem Chap 6 problems

Patrick: An Introduction to Medicinal Chemistry 5e
Chapter 06
01) Match the following structures to their names.
a.
b.
c.
d.
02) Name the following structures (i) – (iv)
i)
ii)
NH2
N
N
HO
HO
O
H H
H H
H
OH H
H
O
N
HO
O
H H
H
OH H
N
N
HO
O
H
O
NH2
CH3
HN
N
N
iv)
O
N
HN
N
N
iii)
O
H
O
H H
H
OH H
a. Deoxyadenosine =
b. Deoxyguanosine =
c. Deoxythymidine =
d. Deoxycytidine =
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H
H
OH H
Patrick: An Introduction to Medicinal Chemistry 5e
Chapter 06
03) Consider the following representation of DNA. What is the blue region called?
a. The carbohydrate backbone.
b. The phosphate backbone.
c. The sugar-phosphate backbone.
d. The nucleic acid base backbone.
04) Consider the following representation of DNA. What are the groups shown in black?
a. Nucleic acid bases.
b. Deoxyribose.
c. Nucleosides.
d. Nucleotides.
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Patrick: An Introduction to Medicinal Chemistry 5e
Chapter 06
05) Consider the following representation of DNA. What is the term used to describe the
end of the chain marked J?
a. The 2’ end.
b. The 3’ end.
c. The 4’ end.
d. The 5’ end.
06) Consider the following representation of DNA. What type of DNA structure is shown
here?
a. Primary.
b. Secondary.
c. Tertiary.
d. Quaternary.
© Oxford University Press, 2013. All rights reserved.
Patrick: An Introduction to Medicinal Chemistry 5e
Chapter 06
07) What type of structure is the double helix of DNA?
a. Primary.
b. Secondary.
c. Tertiary.
d. Quaternary.
08) What does the following diagram demonstrate?
a. Dimerisation.
b. Receptor binding.
c. Base pairing.
d. Polymerisation.
09) Which of the following statements is not true about DNA secondary structure?
a. There is a minor groove and a major groove.
b. A purine base pairs up with a pyrimidine base.
c. The phosphate groups are positioned to the inside of the structure.
d. The base pairs are stacked.
10) What non-covalent bonding interactions do the nucleic acid bases form in DNA
secondary structure?
a. Ionic bonds only.
b. Hydrogen bonds only.
c. Van der Waals interactions only.
d. Hydrogen bonds and van der Waals interactions.
11) What is the significance of base pairing to the function of DNA?
a. It neutralises basic groups and controls the cell pH.
b. It means that the chains of DNA are complementary allowing replication.
c. It stabilises the molecule such that its lifetime in the cell is increased.
d. It prevents water interacting with the nucleic acid bases.
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Patrick: An Introduction to Medicinal Chemistry 5e
Chapter 06
12) Which of the following is not true when RNA is compared with DNA?
a. RNA contains ribose and not deoxyribose.
b. RNA contains uracil and not adenine.
c. RNA does not form a double helix.
d. RNA is smaller than DNA.
13) Which of the following mutations is most likely to be disruptive to protein synthesis or
function?
a. UAU to UAC.
b. UAU to UUU.
c. UAU to UAA.
d. UAU to CAU.
14) Match the structure to the process described.
a. The organelle in the cell’s cytoplasm where protein synthesis occurs.
b. The structure where transcription occurs.
c. The structure which catalyses protein synthesis and which is sometimes called the
protein factory.
d. The structure which is responsible for modifying newly transcribed mRNA prior to
translation.
15) What is the term for the portion of messenger RNA that is excised when the molecule
undergoes a splicing modification?
a. Intron.
b. Exon.
c. Exclusion.
d. Inclusion.
16) Which of the following molecules is not a nucleotide?
a. Adenosine.
b. Adenosine monophosphate.
c. Adenosine diphosphate.
d. Adenosine triphosphate.
17) Which of the following structures is uracil?
a. Structure A.
b. Structure B.
c. Structure C.
d. Structure D.
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Patrick: An Introduction to Medicinal Chemistry 5e
Chapter 06
18) Which of the following structures is a purine structure?
a. Structure A.
b. Structure B.
c. Structure C.
d. Structure D.
19) Which of the following structures is a pyrimidine structure?
a. Structure A.
b. Structure B.
c. Structure C.
d. Structure D.
20) Which of the following structures is adenosine?
a. Structure A.
b. Structure B.
c. Structure C.
d. Structure D.
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Patrick: An Introduction to Medicinal Chemistry 5e
Chapter 06
21) Which of the following structures is a nucleotide building block for DNA?
a. Structure A.
b. Structure B.
c. Structure C.
d. Structure D.
22) Which of the following structures is guanosine?
a. Structure A.
b. Structure B.
c. Structure C.
d. Structure D.
23) Which of the following structures is a nucleotide building block for DNA?
a. Structure A.
b. Structure B.
c. Structure C.
d. Structure D.
© Oxford University Press, 2013. All rights reserved.
Patrick: An Introduction to Medicinal Chemistry 5e
Chapter 06
24) To which of the following does adenine form hydrogen bonds in DNA?
a. Adenine.
b. Thymine.
c. Cytosine.
d. Guanine.
25) To which of the following does cytosine form hydrogen bonds in DNA?
a. Adenine.
b. Thymine.
c. Cytosine.
d. Guanine.
26) Which of the following statements is not true about DNA secondary structure?
a. There is a minor groove and a major groove.
b. Purine bases pair up with each other.
c. The phosphate groups are positioned to the outside of the structure.
d. The base pairs are stacked.
27) Which of the following is not true when RNA is compared with DNA?
a. RNA contains ribose and not deoxyribose.
b. RNA contains uracil and not thymine.
c. RNA does not form a double helix.
d. RNA is larger than DNA.
28) Match the processes to their descriptions.
a. The process by which DNA is copied to two daughter DNA molecules.
b. The process by which a segment of DNA is copied to produce a molecule of messenger
RNA.
c. The process by which proteins are synthesised from a genetic code.
d. The overall physiological process by which new progeny are produced in a particular
species.
29) Which of the following descriptions applies to the process of translation?
a. The process by which DNA is copied to produce two daughter DNA molecules.
b. The process by which a segment of DNA is copied to produce a molecule of messenger
RNA.
c. The process by which proteins are synthesised from a genetic code.
d. The overall physiological process by which new progeny are produced in a particular
species.
30) Match the type of RNA to its function.
a. The RNA which catalyses protein synthesis.
b. The RNA which provides the genetic blueprint for a protein.
c. The RNA which is responsible for translating the triplet code into a specific amino acid.
d. The RNA which participates in modifying mRNA prior to protein synthesis.
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Patrick: An Introduction to Medicinal Chemistry 5e
Chapter 06
31) Which of the following types of RNA helps to catalyse the synthesis of proteins?
a. rRNA.
b. mRNA.
c. tRNA.
d. snRNA.
32) Which of the following types of RNA translates the genetic code for the synthesis of
proteins?
a. rRNA.
b. mRNA.
c. tRNA.
d. snRNA.
33) What expression is given for the three nucleic acid bases present on transfer RNA that
base pair with a triplet of bases on messenger RNA?
a. Anticodon.
b. Triplet.
c. Codon.
d. Translation factor.
34) How many nucleic acid bases on messenger RNA are responsible for the coding of
one amino acid?
a. 1
b. 2
c. 3
d. 4
35) What amino acid is coded by the triplet of bases UUU?
a. Phenylalanine.
b. Serine.
c. Tyrosine.
d. Cysteine.
36) Which of the following mutations is most likely to be disruptive to protein synthesis or
function?
a. GAG to GAA.
b. GAG to GAC.
c. GAG to GAU.
d. GAG to UAG.
37) What sort of reaction is catalysed by a restriction enzyme in recombinant DNA
technology?
a. The hydrolysis of an ester group.
b. The cleavage of a sugar phosphate bond.
c. The reduction of a ketone.
d. The formation of a sugar phosphate bond.
© Oxford University Press, 2013. All rights reserved.
Patrick: An Introduction to Medicinal Chemistry 5e
Chapter 06
38) Match the enzyme to the reaction catalysed.
a. The hydrolysis of an ester group.
b. The cleavage of a sugar phosphate bond
c. The reduction of a ketone.
d. The formation of a sugar phosphate bond.
39) Which amino acid in the enzyme topoisomerase II is responsible for cleaving a
phosphate-sugar link in a DNA strand?
a. Tyrosine.
b. Threonine.
c. Serine.
d. Cysteine.
40) What role does the enzyme topoisomerase II have?
a. It catalyses the formation of protective units at the end of chromosomes.
b. It catalyses the synthesis of DNA.
c. It catalyses the unwinding of the DNA double helix.
d. It catalyses crossing over of DNA strands to relieve the tension created in DNA when
the DNA double helix is unravelled.
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