Download Iron(II) chloride tetrahydrate Product Code 22029-9 - Sigma

Iron(II) chloride tetrahydrate
Product Code 22,029-9
Store at Room Temperature
Replacement for Product No. F 2130
Product Description
Molecular Formula: FeCl2 • 4H2O
Molecular Weight: 198.8
CAS Number: 13478-10-9
Synonym: ferrous chloride tetrahydrate
Ferrous chloride occurs in nature as the mineral
lawrencite. Its applications include its use in
metallurgy as an electrolytic agent and as a mordant in
dyeing.1 FeCl2 has been used in the synthesis of
pentasubstituted acylferrocenes.2
In biological research, ferrous chloride is used as a
source of Fe2+ ion. Studies of oxidative stress in
biology have utilized FeCl2 with hydrogen peroxide to
general hydroxyl radicals via the Fenton reaction.3,4
FeCl2 has been shown to block calcium influx through
N-methyl-D-aspartate receptor channels in immature
cultured rat cortical neurons.5 It has also been used in
a study of the interaction between hypoxia-inducible
factor (HIF-α) and the von Hippel-Lindau ubiquitylation
complex.6
Precautions and Disclaimer
For Laboratory Use Only. Not for drug, household or
other uses.
Storage/Stability
Aqueous solutions of FeCl2 are readily oxidized.1
References
1. The Merck Index, 12th ed., Entry# 4091.
2. Norinder, J., et al., An efficient route to
pentasubstituted acylferrocenes. J. Org. Chem.,
67(25), 9096-9098 (2002).
3. Shoker, A. S., et al., Inhibition of human
lymphocyte function by organic solvents. Mol.
Cell. Biochem., 171(1-2), 49-58 (1997).
4. Yu, T. W., and Anderson, D., Reactive oxygen
species-induced DNA damage and its
modification: a chemical investigation. Mutat.
Res., 379(2), 201-210 (1997).
5. Nakamichi, N., et al., Blockade by ferrous iron of
Ca2+ influx through N-methyl-D-aspartate receptor
channels in immature cultured rat cortical neurons.
J. Neurochem., 83(1), 1-11 (2002).
6. Jaakkola, P., et al., Targeting of HIF-α to the von
Hippel-Lindau ubiquitylation complex by O2regulated prolyl hydroxylation. Science,
292(5516), 468-472 (2001).
GCY/RXR 10/03
Preparation Instructions
This product is soluble in 7% HNO3 (50 mg/ml), with
heat as needed, yielding a clear, light green solution.
It is soluble in water and alcohol.1
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