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The target of sympathetic neurons determines neurotransmitter phenotype. Sympathetic neurons are initially specified with a noradrenergic transmitter phenotype. Most sympathetic neurons, including those that innervate cardiac muscle cells, retain this transmitter phenotype, and their terminals are packed with the dense-core vesicles in which norepinephrine is stored. But the sympathetic neurons that innervate sweat gland targets are induced to switch to a cholinergic transmitter phenotype; their terminals become filled with the small clear vesicles in which acetylcholine (ACh) is stored. Sweat gland cells direct the switch in transmitter phenotype by secreting members of the interleukin cytokine family. Several members of this family, including leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF), are potent inducers of cholinergic phenotype in sympathetic neurons grown in cell culture. Source: Differentiation and Survival of Nerve Cells, Principles of Neural Science, Fifth Editon (Micrographs reproduced, with permission, courtesy of S. Landis.) Citation: Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ, Mack S. Principles of Neural Science, Fifth Editon; 2012 Available at: http://mhmedical.com/ Accessed: May 02, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved
