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12/13/2016 Cell Specialization Cell Specialization • Scientists estimate there are between 75 and 100 trillion cells in the body of an adult human • Three factors influence differentiation in animal cells – Contents of cell’s cytoplasm – Environmental conditions – Influence of neighbouring cells Effects of Cytoplasm • Mitosis ensures that daughter cells receive identical sets of chromosomes • Cytoplasmic contents may differ – More storage vacuoles will allow the cell to use more energy as it grows Effects of Neighbouring Cells • One of the biggest influences on what a cell will become • Substances produced by one cell can diffuse through a neighbouring cell’s membrane – Changes the expression of DNA Effects of Environment • Temperature and presence of nutrients can explain why cells with identical genes will develop differently • Example: Siamese cats Stem Cells • Recall: Meristematic cells in plants • Animals have similar cells called stem cells – An unspecialized cell that can produce various specialized cells 1 12/13/2016 Stem Cells Stem Cells • Embryos have totipotent stem cells • Human stem cells become less versatile as they become more specialized – Can become any kind of cell • As the embryo develops, stem cells become pluripotent – Can produce many but not all cell types Adult Stem Cells • Only adult skin stem cells can give rise to new skin cells • Only bone stem cells can replace bone Ethics of Embryonic Stem Cells Medical Potential of Stem Cells • Canadian researchers Dr. Ernest McCulloch and Dr. James Till found that marrow transplanted from a healthy animal could restore blood cells in an animal that had undergone radiation therapy Ethics of Embryonic Stem Cells • Embryonic stem cells are found in embryos that are less than a week old • In the lab these totipotent stem cells are able to keep dividing for up to a year without differentiating – Can make any one of the 300 cell types found in an adult human • To harvest these cells the embryo must be sacrificed 2 12/13/2016 Ethics of Embryonic Stem Cells • Where should we draw the line between – “Harvesting” embryonic stem cells which could save thousands, if not millions, of lives and – Murdering a developing person cells – tissues – organs – organ systems • Our faith teaches us that the Holy Spirit is present from the time of conception (egg meet sperm) LEVELS OF ORGANIZATION Levels of Organization in a multicellular organism Levels of Organization • Tissue – A group of similar cells that perform similar functions – Blood, nervous tissue • Organ – A group of tissues that work together to perform a specific function – Muscles, eyes Levels of Organization in a multicellular organism • Organ Systems – A group of organs that perform closely related functions – There are 11 organ systems in the human body – Can you name them? Human Organ Systems • • • • • • Integumentary Muscular Circulatory Digestive Reproductive Endocrine Skeletal Nervous Respiratory Excretory Immune 3 12/13/2016 Organ System Organs Involved Basic Function Integumentary Skin, hair, nails, glands • Covers and protects body • Glands help control body temperature Skeletal Bones, cartilage • Supports body • Allows movement • Protects the body Muscular Skeletal muscle, smooth muscle, cardiac muscle, tendons, ligaments • Works with skeletal system to provide movement • Moves materials within body Digestive Mouth, esophagus, stomach, pancreas, gall bladder, liver, intestines, rectum • Ingestion • Digestion • Absorption of nutrients • Elimination of solid wastes Respiratory Nose, mouth, trachea, lungs, bronchi, bronchioles, alveoli, diaphram • Exchange of gases Circulatory Heart, blood vessels, blood • Transportation of materials (such as oxygen, nutrients, hormones, and wastes within the body) Nervous Brain, nerves, spinal cord • Controls body functions • Coordinates responses Endocrine Glands (pituitary, hypothalamus, thyroid, adrenals, pancreas, ovaries, testes) • Controls growth and development • Controls metabolism Excretory Skin, kidney, bladder, ureter, urethra • Elimination of wastes Reproductive Ovaries, fallopian tubes, vagina, uterus Testes, epididymis, vas deferens, penis, urethra • Reproduction Lymphatic White blood cells, thymus, spleen, lymph nodes, lymph vessels • Protects body from disease • Circulates fluid called lymph • Absorbs and transports fats 4