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Butler Community College Science, Technology, Engineering, and Math Division Alan R. Brown New Spring 2016 Implement Fall 2016 Textbook Update Fall 2016 COURSE OUTLINE Majors Biology I (Cell) Course Description BI 215. Majors Biology I (Cell). 5 hours credit. This course will enable the student to develop an understanding of basic biological chemistry; cell structure and function; cell metabolism, including cellular respiration and photosynthesis; classical genetics, including cell reproduction and inheritance processes; molecular genetics, including nucleic acid and protein processes and regulation; and the evolutionary processes of cells. The learning outcomes and competencies detailed in this course outline meet or exceed the learning outcomes and competencies specified by the Kansas Core Outcomes Groups project for this course as approved by the Kansas Board of Regents. (Transfers as BIO1020). Required Materials Brooker, R. J., Widmaier, E. P., Graham, L. E., & Stiling, P. D. Biology. New York: McGraw Hill Education. *For complete material(s) information, refer to https://bookstore.butlercc.edu Butler-assessed Outcomes The intention is for the student to be able to: 1. Describe the relationship of cell structures to specific cellular functions. 2. Describe the molecular processes for cellular metabolism. 3. Apply the principles of genetics to patterns of inheritance. 4. Identify the molecular mechanisms for cellular evolution. Learning PACT Skills that will be developed and documented in this course Through involvement in this course, the student will develop ability in the following PACT skill area(s): Analytical Thinking Skills Problem solving - Through analytical thinking, experimental design, calculations, and the statistical analysis of data, the student will develop skills in experimental biology. Technology Skills Discipline-specific technology – Through the use of computer software and biotechnology equipment, the student will develop an understanding of biologic principles and the ability to execute experimental protocols. Communication Skills Creation and delivery of messages- Through a written report on up-to-date research on the functioning of a cellular organelle or of a cellular metabolic BI 215 Majors Biology I (Cell) 1 pathway, the student will develop abilities to search, comprehend, and write about the biology of cells. Major Summative Assessment Task(s) These Butler-assessed Outcome(s) and the Learning PACT skill(s) will be demonstrated by: 1. Designing and executing an experiment that demonstrates a sound scientific process and reporting the results in a scientific paper format. (A skill) 2. Demonstrating technical expertise in using computer software and biotechnology laboratory equipment in biology. (T skill) 3. Searching biology literature, organizing content, and writing an up-to-date review about a cell organelle or metabolic pathway. (C skill) Skills and Competencies These actions are essential to achieve the course outcomes: 1. Apply the scientific process to and recognize the variables in experimental design. 2. Recognize basic chemical and biochemical molecules and their bonding properties. 3. Describe the molecular and cellular basis of life and the connection between cell structure and function. 4. Identify the chemical basis of metabolism, physiological processes, cell respiration and protein synthesis. 5. Describe the classical and molecular basis of genetics. 6. Demonstrate a comprehension of the molecular processes of evolution. Learning Units I. Scientific process and biologic chemistry A. Describe the steps in the scientific process and how each relates to a specific area in a scientific paper B. Describe the differences between a hypothesis, fact, and interpretation C. Design an experiment in which you can identify the control, independent and dependent variables, state the hypothesis in a predictive form, and null and alternative hypotheses D. Describe the steps of Koch’s postulates for proving causation in biology E. Diagram the structural formula from the empirical formula for a given molecule F. Recognize the structural formulas of the following kinds of molecules: glucose, fructose, sucrose, maltose, starch, fat or triglyceride (saturated and unsaturated), amino acid, protein (primary, secondary, and tertiary structure), peptide bond, and the structures of nucleic acids and nucleotides G. Describe the difference between an ionic and covalent bond II. Cell structures and functions A. Describe the following cellular parts: cell wall, cell membrane, nucleus, centriole, ribosome, endoplasmic reticulum (smooth and rough), golgi body, mitochondria, chloroplast, flagella, and cilia B. Describe the three major points of the cell theory and the significance of each BI 215 Majors Biology I (Cell) 2 C. Describe the structure of the cell membrane and the roles the double phospholipid layer and proteins play in its operation D. Describe the direction of flow across a differentially permeable membrane in hypotonic, hypertonic, and isotonic solutions E. Describe the difference between diffusion, osmosis, and active transport F. Distinguish the differences between prokaryotic and eukaryotic cells III. Cellular Metabolism A. Describe the laws of thermodynamics in the context of living cells. B. Identify the general structure and function of enzymes C. Describe the effects of pH, solute, and temperature on enzyme activity D. Describe the characteristics of reduction-oxidation reactions by electrons E. Describe energy production of cells by glycolysis, Krebs (Citric Acid) cycle, and electron transport processes F. Describe the differences in the reactions and products between aerobic and anaerobic respiration G. Describe the energy generation and macro molecule synthesis processes of photosynthesis IV. Genetics A. Describe the meaning of the terms: chromosome, chromatid, centromere, mitosis, mitotic cell division, cytokinesis, zygotes, and gametes B. Describe the major events that occur during the various phases of mitosis C. Describe and diagram the major events that occur during meiosis D. Describe major differences between mitosis and meiosis E. Describe the difference between homologous and non-homologous chromosomes F. Describe the meaning of genotype, phenotype, homozygous, heterozygous, dominant, recessive, allele, gene, and co-dominant G. Solve genetic problems for crosses between individuals heterozygous for one trait and for two traits H. Identify the kinds of gametes the following genotypes can produce: DdTt, DDTt, ddTT I. Describe how Mendel’s work proved that genes behave as particles J. Describe the principles of dominance, recessiveness, and gene segregation K. Describe the kinds of inheritance and molecular basis of human genetic diseases like: cystic fibrosis, galactosemia, phenylketonuria (PKU), sickle cell anemia, and Huntington’s Chorea L. Describe the inheritance of blood types – ABO and Rh M. Describe the inheritance of maleness or femaleness in humans N. Describe how Down’s syndrome occurs and relate this with non-disjunction O. Describe the structure of nucleic acids P. Describe the structural differences between DNA and RNA Q. Describe how DNA replicates R. Describe the steps involved in transcription and translation BI 215 Majors Biology I (Cell) 3 S. Describe the roles or meaning of the following: codon, anti-codon, amino acid, protein, messenger RNA, transfer RNA, ribosome, and nucleolus V. Cell molecular processes A. Describe how DNA functions as genetic material B. Describe DNA replication and repair processes in eukaryote and prokaryotic cells C. Describe transcription processes in cells D. Describe translation of RNA to protein E. Describe and contrast the transcriptional regulation of prokaryote and eukaryote cells F. Describe the intracellular regulation and recycling of cellular proteins VI. Molecular genetic technology A. Describe the processes of DNA isolation B. Describe the enzymatic cleave of DNA and the analysis/recovery of DNA fragments C. Describe the general structure of DNA plasmids and their application to cell transformation D. Describe the principles of the polymerase chain reaction E. Describe the processes of DNA sequencing F. Describe the comparative sizes of prokaryotic and various eukaryotic organisms G. Describe the influence of alterations in DNA sequences and transposon insertions on cell evolution Learning Activities Learning activities will be assigned to assist the student to achieve the intended learning outcome(s) through lecture, instructor and student-led class discussion, student presentation of current biology news, group laboratory activities, practicing with laboratory equipment, unit questions to answer, and other activities at the discretion of the instructor. These activities may either be face-to-face or online. Grade Determination The student will be graded on learning activities and assessment tasks. Grade determinants may include the following: daily work, quizzes, unit tests, laboratory research projects, presentations, class participation, and other methods of evaluation at the discretion of the instructor. BI 215 Majors Biology I (Cell) 4