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PhD Studentship in the Leeds Institute of Biomedical and Clinical Sciences Faculty of Medicine and Health University of Leeds Statistical genetic association analysis of gestational diabetes in a population with high levels of consanguineous marriage Supervisors: Dr Mark Iles, Professor Eamonn Sheridan Funding: Alan and Joan Webster Studentship A PhD studentship is available for UK and EU citizens only. The studentship will attract an annual tax-free stipend of £14,296 for up to 3 years, subject to satisfactory progress and will cover the UK/EU tuition fees. You should hold a first degree equivalent to at least a UK upper second class honours degree in a relevant subject. This project would suit a student with a strong background in statistics or a related computational field and an interest in the application of genomics to the benefit of human health. Candidates whose first language is not English must provide evidence that their English language is sufficient to meet the specific demands of their study, the Faculty minimum requirements are: • • British Council IELTS - score of 6.5 overall, with no element less than 6.0 TOEFL iBT - overall score of 92 with the listening and reading element no less than 21, writing element no less than 22 and the speaking element no less than 23. Research Project: Gestational diabetes is far more common in British mothers of Pakistani descent than in other ethnic groups1. Part of this may be due to environmental exposures (diet, exercise, etc.) but these do not fully explain the risk and it is believed that genetic variation is an important factor. This project aims to identify the genetic variants increasing risk of gestational diabetes by utilising both genotype and genetic sequence data from over 3,000 mothers of Pakistani descent from the Born in Bradford cohort2. There has been little work on the effect of common genetic variants in ethnic minorities, who are typically underrepresented in genetic epidemiological studies. This population is of particular genetic interest given its distinct genetic structure into clans (known as biraderis) and tradition of consanguineous marriage. The project is potentially wide-ranging and offers a variety of possible avenues to follow. Candidates should have a good first degree in a relevant scientific discipline with a strong grasp of statistical analysis (either through formal qualification or experience). An interest in genetics is important, but no prior knowledge is required. Environment: The Section of Epidemiology and Biostatistics has an international reputation in the field of genetic epidemiology. Members of the section lead GenoMEL, the world’s largest melanoma genetics consortium and are part of large consortia studying the genetics of diseases such as testis cancer, colorectal cancer and rheumatoid arthritis. The Section of Genetics has a major interest in inherited disorders, in particular neurological conditions. Most rare paediatric neurological disease has a genetic basis. The risk of congenital anomalies in the local population in Bradford is about twice the average for England and Wales. Genetic data indicate that a considerable element of this is due to autosomal recessive disorders3. We have a longstanding interest in these disorders and in the identification and characterisation of novel disease genes. Reference: 1. Farrar, D., Fairley, L., Santorelli, G., Tuffnell, D., Sheldon, T.A., Wright, J., van Overveld, L., and Lawlor, D.A. (2015). Association between hyperglycaemia and adverse perinatal outcomes in south Asian and white British women: analysis of data from the Born in Bradford cohort. The lancet Diabetes & endocrinology 3, 795-804. 2. Narasimhan, V.M., Hunt, K.A., Mason, D., Baker, C.L., Karczewski, K.J., Barnes, M.R., Barnett, A.H., Bates, C., Bellary, S., Bockett, N.A., et al. (2016). Health and population effects of rare gene knockouts in adult humans with related parents. Science. 3. Sheridan, E., Wright, J., Small, N., Corry, P.C., Oddie, S., Whibley, C., Petherick, E.S., Malik, T., Pawson, N., McKinney, P.A., et al. (2013). Risk factors for congenital anomaly in a multiethnic birth cohort: an analysis of the Born in Bradford study. Lancet 382, 1350-1359. How to apply: To apply for this studentship applicants should complete a Faculty Scholarship Application form and send this alongside a full academic CV, degree transcripts (or marks so far if still studying) and degree certificates to the Faculty Graduate School [email protected] We also require 2 academic references to support your application. Please ask your referees to send these references on your behalf, directly to [email protected] by no later than Thursday 16 March 2017 Potential applicants are welcome to contact Dr Mark Iles with informal enquiries about this research project [email protected] Any queries regarding the application process should be directed to [email protected] Closing date for this studentship is Thursday 16 March 2017