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MEDIA STORY BANK: PROPOSALS TO RECEIVE FUNDING FROM THE GSK-SINGAPORE GREEN AND SUSTAINABLE MANUFACTURING PARTNERSHIP Projects Novel approach Story opportunity Activation of alcohols Alcohol activation by hydrogen The activation of alcohols, a readily available and nonhazardous Developing sustainable technologies to convert borrowing strategy: Alcohols as feedstock, for useful transformations without functional group readily available nontoxic feedstock would electrophiles in C-N and C-C bond interconversions is a challenge in organic and process chemistry. In a greatly impact the way in which APIs are forming reactions classic synthesis, the less active alcohols are converted to the active manufactured in the future. forms which are generally genotoxic and the process would generate hazardous waste raising environmental concerns. We approach this problem by using the novel catalytic “hydrogen borrowing strategy” that converts the alcohols in situ to an active intermediate that react with another suitable molecule to form the desired product. In this project, we target to design cost-effective catalysts and greener technologies for batch and continuous process for the alkylation of amines using non-hazardous and readily available alcohols. Principal investigator: Dr. Abdul Majeed Seayad Scientist Institution: Institute of Chemical & Engineering Sciences, A*STAR Email: [email protected] 1