Download ID_4420_Standartization of drugs_English_sem_9

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According to the pharmacological action antibiotics belong to the:
Antispasmodic means
Antiseptic means
Chemical-therapeutic means
Antimicrobial means
Anti-inflammatory means
Medical drug tetracycline belongs to the antibiotics of:
Tetracycline row
Penicillin row
Aminoglycoside row
Alicyclic row
Cephalosporin row
Antibiotics of tetracycline row are used for the treatment of:
Pneumonia
Dysenteria
Allergy
Fractures
CNS diseases
To the antibiotics of aromatic row the following compound belongs:
Tetracycline
Streptomycin sulfate
Lincomycin hydrochloride
Laevomycetin
Rondomycin
What gas evaporated after the heating of tablet laevomycetin with NaOH solution?
CO2
N2
NH3
H2S
NO2
Quantitative determination of substance of the laevomycetin according to the requirements of MCQ
after the reduction of nitro-group to amino-group is conducted by the following method:
Acidimetry
Alkalimetry
Argentometry
Iodometry
Nitritometry
Laevomyctin is used in the medical practice for the treatment of:
Dysentery
Fungal diseases
Dermatoses
Typhoid
Allergy
By the action on microorganisms and human organism all antibiotics can be divided into two main
groups:
General and individual
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Main and reserve
Correct and incorrect
Main and auxiliary
Forward and backward
What antibiotics in their core have naphthalene nucleus?
Aromatic
Penicillin’s row
Glycosidic row
Polyene antibiotics
Tetracycline row
Substance of doxycycline hydrochloride belongs to the antibiotics of the following row:
Cephalosporin
Aminoglycoside
Alicyclic
Penicillin
Macrolide
Tetracycline has acidic properties due to the presence in its structure:
4-dimethylamino-group, 1-oxogroup
1-oxogroup, 10-phenol hydroxyl
10-phenol hydroxyl, 3- and 12-enol hydroxyls
4-dimethylamino-group, 11-oxogroup
11-oxogroup, 3- and 12-enol hydroxyls
Methacycline hydrochloride used in the medical practice in the form of:
Ampoule solutions
Tablets
Ointments
Capsules
Suppositories
Laevomycetin the following international unpatented name:
Methanedion
Rondomycin
Vibramycin
Chloramphenicol
Oletetrin
What indicator can be used to establish the equivalent point in the quantitative determination of
laevomycetin by nitritometry?
Starch
Phenolphtalein
Methyl orange
Litmus paper
Iodinestarch paper
Laevomycetin at the long-term treatment may cause:
Habituation
Temperature decreasing
Dysfunction of blood-forming organs
Detrimental effect on the organs of hearing
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Improve appetite
The biological activity of antibiotics can be expressed in:
Kilograms
Units of weight
Units of action (activity)
G/ml
G/mol
Methacycline hydrochloride is also called:
Chloramphenicol
Vibramycin
Ampicillin
Rondomycin
Phenoxymethylpenicillin
Anhydrous derivative of tetracycline can be obtained by the action of:
Concentrated alkali solution
Diluted sulfate acid
Concentrated sulfate acid
Concentrated phosphate acid
Methyl alcohol
Doxycycline hydrochloride used in the medical practice for the treatment of:
Dysentery
Upper respiratory tract infections
Allergy
Rhinitis
Meningitis
Which drug of the listed below has the chemical name of
D(-)-threo-1-p-nitrophenyl-2-dichloroacetylaminopropanediol-1,3:
Tetracycline
Laevomycetin
Benzylpenicillin
Streptomycin
Cefalexin
What physical and physico-chemical methods are not used for tablets of laevomycetin identification?
Determination of the melting point
TLC
UV-spectroscopy
Determination of the refractive index
IR-spectroscopy
What is the molecular mass of tablets of the laevomycetin equivalent at its quantitative determination
by the nitritometry method?
2 М.m
1/2 М.m
1/5 М.m
1/4 М.m
М.m
In clinical pediatric practice are used instead of chloramphenicol stearate, because it:
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Is not hygroscopic
Has no bitter taste
Is better soluble in water
Does not dissolve in water
Has a fragrant odor
At the determination of the antibiotics’ quality biological tests are conducted. What animals
according to SPhU are used to determine abnormal toxicity?
White mice
Rabbits
Guinea pigs
Dogs
It is not studied on animals
What acid is in the base of penicillin molecule?
7-aminocephalosporanic acid
p-aminobenzoic acid
7- aminodesacetoxycephalosporanic acid
6-aminopenicillanic acid
Penicillanic acid
Chemical name sodium (2S 5R 6R)-3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo
[3,2,0] heptane-2-carboxylate the following compound has:
Ampicillin sodium salt
Oxacilline sodium salt
Benzylpenicillin sodium salt
Carbenicillin sodium salt
Azlocillin sodium salt
To the ampiox content the following compounds belong:
Benzylpenicillin sodium salt, oxacillin sodium salt
Benzylpenicillin sodium salt, ampicillin sodium salt
Cefalexin, cefalotin
Ampicillin and oxacillin sodium salts
Laevomycetin, ampicillin sodium salt
To the penicillins of the firs generation the following preparation belongs:
Oxacilline sodium salt
Ampicillin sodium salt
Amoxicillin
Amoxiclav
Phenoxymethylpenicillin
What indicator is used for the equivalent point detection at the penicillin’s sum assay of the hemi
synthetic penicillin antibiotics?
Starch
Methyl orange
Methyl red
Methyl blue
Phenolphthalein
What side effect is characteristic for penicillin antibiotics?
Hearing loss
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Partial loss of memory
reduction of visual acuity
Gastrointestinal disorders
Violation of the vestibular apparatus
Determine the difference in the structural formulas of 7-ACA and 7-ADCA?
Presence of ethoxy-group
Absence of ethoxy-group
Presence acethoxy-group
Abesence acethoxy-group
Absence of keto-group
What reagent can be used for the sodium-ion (Nа+) identification in substens of benzylpenicillin
sodium salt molecule?
Methoxyphenylacetic acid
Diphenylamine
Potassium permanganate, sulfuric acid
Silver nitrate
Tartaric acid
One of the distinctive reactions of heterocyclic antibiotics is interaction with:
Hydroxylamine hydrochloride
Concentrated sulfuric acid
Formaldehyde
Formaldehyde in the presence of concentrated sulfuric acid
Copper (II) sulfate solution
7-aminocefalosporanic acid consists from the following cycles:
Thiazolidine and β-lactame
Thiazine and α-lactame
Furan and β-lactame
Dihydrothiazine and β-lactame
Phenothiazine and α-lactame
In the base of cephalosporin antibiotics is:
6-aminopenicillanic acid
aminocephalosporanic acid
p-aminobenzoic acid
7-aminodesacetoxycephalosporanic acid
cephalosporanic acid
Chemical name sodium (2S, 5R, 6R)-6-[(2
R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo [3,2,0]
heptane-2-carboxylate the following compound has:
Oxacillin
Azlocillin
Ampicillin
Carbenicilline
Carfecillin
What reagent can be used for the potassium-ion (K+) identification in substance of benzylpenicillin
potassium salt molecule?
Tartaric acid
Potassium hexacyanoferrate (II)
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Ammonium oxalate
Potassium hexacyanoferrate (III)
Sodium hexanitrocobaltate (III)
To the penicillins of the second generation the following preparation belongs:
Bicillin-1
Bicillin-5
Benzylpenicillin Novocain salt
Amoxicillin
Phenoxymethylpenicillin
What structural element in the penicillin’s antibiotics cases their pharmacological action?
Thiazolidine cycle
Amino-group
Carboxylic group
Lactame cycle
Methyl group
?-lactame cycle in the structure of cephalosporin antibiotics can be detected with the reaction of:
Schiff bases formation
Indophenol formation
Aurine dye formation
Iodoform frmation
Hydroxamates of Сu and Fe
What side effect is characteristic for cephalosporin antibiotics?
Convulsions
Lowering of the blood pressure
Headache
Allergic complications
Brittle bones
What reagent can be used for organic bounded sulfur in the bicillin-1 molecule?
Pb(CH3COO)2
NaOH solution
HNO3 conc.
HNO3 dil.
NaOH (solid), Pb(CH3COOH)2
Which of the following antibiotics has hygroscopic properties?
Bicillin-1, phenoxymethylpenicillin
Ampicillin sodium salt, benzylpenicillin sodium salt
Benzylpenicillin potassium salt, benzylpenicillin sodium salt
Cefazolin, ceftriaxone
Bicillin-5, benzylpenicillin Novocain salt
Biological activity of the natural penicillins is be expressed in:
DUA
RUA
CUA
UA
FUA
Which of the following antibiotics can be detected with ninhydrine solution?
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Ampicillin, oxacillin
Amoxicillin, benzylpenicillin sodium salt
Ampicillin, amoxicillin
Cefalotin, cefalexin
Amoxiclav, bicillin-1
To the penicillins of the third generation the following preparation belongs:
Ceftriaxone
Amoxicillin
Amoxiclav
Ampicillin sodium salt
Oxacillin sodium salt
To the cephalosporin’s derivatives of 7-ADAC the following antibiotic belongs:
Cefalotin
Cephapirin
Cefuroxime
Cefaloridine
Cefaloglycine
Amoxiclav consists of:
Ampicillin, clavulanic acid
Amoxicillin, clavulanic acid
Amoxicillin, tienam
Amoxicillin, imipenem
Clavulanic acid, tienam
What reagent can be used for the carboxylic group detection?
NaOH
NH4OH
NaHCO3
Felling liquid
K3KFe(CN)6F
Antibiotic kefzol can be also named as:
Bicilllin-1
Bicillin-5
Cefazolin
Cefalexin
Cefaloridine
Which of the following preparations does belong to antibiotics-glycosides?
Gentamycin sulfate
Monomycin sulfate
Neomycin sulfate
Doxorubicin hydrochloride
Streptomycin sulfate
Medical drug amikacin sulfate belongs to the following antibiotic’s type:
?-lactamide
Aminoglycoside
Macrolide
Polypeptide
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Polyene
Choose aglycone in the streptomycin sulfate molecule:
2-deoxistreptamine
3-deoxistreptamine
streptidine
2-deoxisreptidine
3-deoxisreptidine
One of the methods of quantitative determination of powder of streptomycin is the following one:
Argentometry
Complexonometry
Cerimetry
Acidimetry
Iodochlorometry
Which of the following medical drugs has synonym cifran?
Ciprofloxacin hydrochloride
Norfloxacin
Lomefloxacin
Ofloxacin
Pefloxacin
Oleandomycin phosphate can be detected with silver nitrate solution. What fragment does silver
nitrate detect in the antibiotic molecule structure?
Alcoholic hydroxyl
Tertiary amine
Shugar part
Phosphate-ions
Lactone cycle
Solution of gentamicin sulfate is not used for the treatment of:
Infection diseases of urinary ways
Sepsis, tuberculosis
Hormonal disorders
Gastrointestinal tract diseases
Infection diseases of the skin
Peptide bond in the gramicidin molecule connects residues of:
Esters
Ethers
Lactones
D-Aminoacids
Glycosides
Choose antitumor antibiotic, tetracycline derivative:
Doxycycline hydrochloride
Bruneomycin
Rubomycin
Doxorubicin hydrochloride
Olivomycin А
Streptomycin sulfate belongs to the following antibiotics:
Cephalosporins
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Polyenes
Glycosides
Polypeptides
Anzamycins
Which of the following preparations does belong to antibiotics-polypeptides?
Nystatin
Kanamycin
Erythromycin
Gramicidin
Olivomycin
Chemical name 1,3-diguanidino-2,4,5,6-tetraoxicyclohexane the following compound has:
2-deoxistreptidine
2-deoxistreptamine
3-deoxistreptamine
streptidine
3-deoxistreptidine
Presence of L-streptose in the streptomycin cases formation of:
Azo-dye
Schiff bases
Azomethyne dye
D-Naphthalene
Maltol
What is the molecular mass of substance of streptomycin at the quantitative determination by
cerimetric method?
2 М2m
ММm
М.m./2
М.m./4
М.m./8
In the molecule of medical preparations 6-fluoroquinoline derivatives in the position number 7 is the
following heterocyclic connection:
Pyperidine
Pyrrolidine
Pyrrole
Piperazine
Thiazole
Which of the following sugars is in the erythromycin structure?
Glucose
L-streptose
Cladinose
Fructose
Arabinose
Monomycin is not used for the treatment of:
Infection diseases of urinary ways
Infection diseases of the skin
Virus diseases
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Sepsis
Tuberculosis
Antitumor antibiotic olivomycin A according to its chemical structure belongs to the derivatives of:
Quinoline
Fluoroquinoline
Quiniline-5,8-dione
Quinoline-3-carboxylic acid
Aurelia acid
Aliphatic amino-group in the kanamycin molecule can be identified by the usage of the following
reagent:
Alkaline solution of A-naphthalene
Nessler’s reagent
Bromine water
Sodium nitrite, НСl
Ninhydrine
Which of the following medical preparations does belong to antibiotics-aminoglycosides?
Streptomycin sulfate
Griseofulvin
Lincomycin hydrochloride
Erythromycin
Kanamycin monosulfate
Medical drug clindamycin (dalacyn) according to its chemical structure belongs to the following type
of antibiotics:
Glycosides
Macrolides
Polyenes
Lincomycins
Anzamycins
What two residues are in the structure of streptidine?
Urea
Guanidine
Streptose
Glucose
Glucoseamine
What indicator is used for fixation of the equivalent point at the streptomycin assay by cerimetry
method?
Phenolphthalein
Starch
Solution FeCl3
Methyl orange
Litmus
Choose chemical name of norfloxacine:
1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinoline
carboxylic acid
1-Ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxo-3-quinoline carboxylic acid
1-Cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-4-oxo-1,4-dihydro-3-quinoline carboxylic acid
hydrochloride
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3-Methyl-7-oxo-9-fluoro-10-(4-methyl-1-piperazinyl)-2,3-dihydro-7Н-pyrido-1,4-benzoxazine-6-car
boxylic acid
1-Ethyl-1,4-dihydro-4-oxo-7-(4-pyridinyl)-3-carboxylic acid
Oleandomycin phosphate in capsulas can be identified with molybdenum-vanadium reagent. What
fragment does this reagent detect in the antibiotic molecule structure?
Tertiary amine
Alcoholic hydroxyl
Sugar part
Lactone cycle
Phosphate-ions
Neomycin and gramicidin belong to the following eyes drops:
Sulfacyl-sodium
Levamisole
Sofradex
Amracin
Taufonum
Which of the following antitumor antibiotics is anthracycline derivative?
Doxycycline hydrochloride
Bruneomycin
Rubomycin
Doxorubicin hydrochloride
Olivomycin А
What reagent can be used for sulfate-ion detection in the powder of monomycin sulfate?
NaCl
H2SO4 dil.
I2
КОН
КВr
Thyroid hormone is produced by one of the endocrine glands:
Adrenals cortex
Pancreas
Cerebral layer of adrenals cortex
Thyroid gland
Hvpophysis pituitary gland
Protein portion of the thyroidin molecule is revealed by the following reagents:
NaOH
HCl
Marky reagent
K[Sb(OH)6]
KMnО4
Insulin is used to treat:
Diathesis
Muscular dystrophy
Diabetes
Intestines atony
Hemophilia
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85.
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86.
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87.
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88.
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E.
89.
A.
Which indicator is used to fix the equivalence point for quantifying thyroidine according to the
requirements of the MCQ:
Phenolphthalein
Crystal violet
KI
Starch
Sodium eosin
Parent material for the adrenaline synthesis is:
Pyrogallol
Phenol
Methylamine
Ethyl alcohol
Pyrocatechol
Quantitative determination of adrenaline hydrotartrate according to the MCQ requirements is held by
the method of:
Argentometry
Permanganatometry
Acidimetry in non-aqueous medium
Gravimetry
Acidimetry in aqueous medium
Solution of noradrenaline hydrotartrate in medical practice is used as a treatment:
Antiadrenergic
Antihistaminic
Adrenomimetic
Anticholinesterase
Cholinomimetic
Noradrenaline base has its synonymous name:
Epinephrine
Phenylephrine
Naphtizine
Gelsolin
Levarterenol
Chemical name of 1 - (3,4-Dioxyphenyl)-2-Isopropylaminoetanol Hydrochloride is:
Mesaton hydrochloride
Ephedrine hydrochloride
Isoproterenol hydrochloride
Adrenaline hydrochloride
Papaverine hydrochloride
What reagents must be used to confirm the identity of solution of mesaton:
AgNO3, HNO3, NH4OH
AgNO3, H3PO4, NH4OH
CuSO4, NaOH, ether
AgNO3, HCl, NH4OH
K[Sb(OH)6], HCl
Thyroidin contains the following hormones:
Adrenaline, L-Thyroxine
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90.
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91.
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92.
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93.
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94.
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95.
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96.
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B.
C.
L-Thyroxine, 3,5,3Ttriiodothyronine
Noradrenaline, Corticosterone
3,5,3- Triiodothyronine, Adrenaline
Corticosterone, 3,5,3- Triiodothyronine
At boiling thyroidin with a solution of NaOH one observes:
Decolouration of the solution
Sendimentation of white color
The formation of yellow color
Isolation of NH3
Separation of CO2
In accordance with the MCQ requirements in quantitative determination of thyroidin at first one
conducts mineralization with the help of:
KNO3, Na2CO3
K2Cr2O7, NaOH
KMnО4, H2O
H2O2, H2SO4 dilluted
H2O2, H2SO4 concentrated
The adrenaline hormone is produced by:
Female sex glands
Cortical layer of adrenals
Cerebral layer of adrenals
Male sex glands
Thyroid gland
With the help of what reagents one can find tartrate ion in the adrenaline tartrate molecule?
FeCl3, KCl
KCl, CuSO4
CuSO4,CH3COONa
CH3COONa, KCl
Resorcin, concentrated sulfate acid, KCl
Parent material for obtaining noradrenaline hydrotartrate is:
Benzene
Aniline
Catechin
Pyrocatechol
Phenol
Nordrenaline hydrotartrate is issued as:
Pills of 0,2 g
Ointment 0,2%
Suppository of 0,2 g
Spray 0,2%
0,2% ampullaceous solution
Quantitative determination of solution of mesaton according to the requirements of MCQ is carried
out by methods of:
Acidimetry in non-aqueous medium, bromometry
Permanganatometry, nitritometry
Bromometry, gravimetry
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97.
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98.
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C. *
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99.
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B.
C.
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100.
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101.
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C.
D.
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102.
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B.
C. *
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E.
103.
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B.
C.
D. *
E.
Nitritometry, cerimetry
Gravimetry, nitritometry
Isoproterenol in medical practice is used to treat:
Rhinitis
Bronchial asthma
Spasm of brain vessels
Dermatitis
Diabetes
Constituent part of thyroidin is:
Tyrosine
Bethanidine
L-Thyroxine
Cortisone
Phenylephrine
Protein portion of the thyroidin molecule is determined by boiling it with a solution of NaOH. When
one adds H2SO diluted the solution decolorizes and:
There is a smell of ammonium
Leaves black sendiment
Sends off free I2
Leaves yellow colloidal sendiment
Leaves white colloidal sendiment
After thyroidin mineralization the solution of KMnO4 is added to the reaction mixture to:
Restore iodides to iodates
Oxidation of iodides to periodates
Oxidation of iodide to iodates
Oxidation of iodides to iodates
Restore iodides to free iodine
Thyroidin in medical practice is used to treat:
Thyroid gland cancer
Breast Cancer
Dermatitis
Pellagra
Scurvy
FeCl3 solution is added to adrenaline tartrate solution and appears emerald green coloration. What
kind of analytical and functional groups can be detected by this reagent?
Alcoholic hydroxyl
Tartrate ion
Phenolic hydroxyl
Methyl group
Aromatic system
To stabilize the injection solution of adrenaline hydrotartrate one adds:
3% solution of hydrogen peroxide
1% solution of sodium benzoate
Antifebrin
0,1% solution of sodium metabisulfite
0, 1% solution of potassium permanganate
104.
A.
B.
C.
D.
E. *
105.
A.
B.
C.
D. *
E.
106.
A.
B.
C.
D. *
E.
107.
A.
B.
C. *
D.
E.
108.
A.
B. *
C.
D.
E.
109.
A. *
B.
C.
D.
E.
110.
A.
B.
C.
D. *
E.
111.
A.
B.
During the oxidation of noradrenaline in iodine at a pH of -6.5 there is produced:
Adrenochrome
Adrenaline
Adrenolytics
Noradrenochrome
3,4-dihydroxyacetophenone
Methods of quantifying mesaton according to the requirements of MCQ are:
Methods of iodinechlorometry, Folgard
Methods of complexometry, permangatometry
Methods of permanganatometry, Folgard
Methods of cerimetry, permanganatometry
Methods of Folgard, complexometry
With the help of what reagent one cannot conduct the reaction of isoproterenol identification:
HNO3
NH4OH
AgNO3
NaNO2
FeCl3
Structural basis of steroid hormones is:
Phenothiazine
6 Aminopenicilline acid
Cyclopentaneperhydrophenanthrene
Naphthacene
Furanose
To glucocorticosteroids refers:
Deoxycorticosterone acetate
Prednisolone
Synestrol
Pregnenolone
Progesterone
What reagent does not reveal ketogroup in position 3 in the molecules of corticosteroids?
H2SO4 concentrated
Phenylhydrazine
2,4-Dinitrophenylhydrazine
Hydroxylamine hydrochloride
Isoniazid
Quantitative determination of solution of desoxycorticosterone acetate in accordance with the
requirements of MCQ is carried out by the method of:
PMR
NMR
Refractometry
UV-spectrometry
Thin layer chromatography
Which of the listed preparations belongs to the fluorderived corticosteroids?
Desoxycorticosteronacetate
Cortisone acetate
C. *
D.
E.
112.
A.
B.
C.
D. *
E.
113.
A.
B.
C.
D. *
E.
114.
A.
B. *
C.
D.
E.
115.
A.
B.
C. *
D.
E.
116.
A.
B.
C. *
D.
E.
117.
A.
B.
C. *
D.
E.
118.
A. *
B.
C.
D.
E.
Triamcinolone
Thyroidin
Hydrocortisone acetate
Natural gestagen is:
Cortisone acetate
Pregnenolone
Cortisol
Progesterone
Toremifene
Quantitative determination of tablets of pregnenolone according to the MCQ requirements is carried
out by the method of:
Acidimetry in non-aqueous medium
Kjeldal
Direct alkalimetry
Substitution alkalimetry
Acidimetry method
Deoxycorticosterone acetate is obtained in the industry from:
Cortisone
Cholesterol
Chlorophyll
Hydrocortisone
Pregnenolone
Steroid system in the corticosteroids molecule can be detected by the reaction of:
Legal
Pellagri
Boskott
Sakaguchy
Vitaly-Moren
Corticosteroid hormones are produced in the body by:
Cerebral part of adrenals
Thyroid gland
Cortical layer of adrenals
Hypophysis pituitary gland
Pancreas
Which of the following preparations does not apply to glucocorticosteroids:
Cortisone acetate
Hydrocortisone acetate
Deoxycorticosterone acetate
Prednisolone
Dexamethasone
What physicochemical methods are used for corticosteroids identification:
UV-spectroscopy, infared spectroscopy
Potentiometry, infared spectroscopy
Refractometry, potentiometry
Infared spectroscopy, conductometry
Conductometry, UV-spectroscopy
119.
A.
B. *
C.
D.
E.
120.
A. *
B.
C.
D.
E.
121.
A.
B.
C.
D. *
E.
122.
A.
B.
C. *
D.
E.
123.
A.
B.
C.
D. *
E.
124.
A.
B.
C.
D.
E. *
125.
A. *
B.
C.
D.
E.
126.
A.
Chemical name of Meso-3 ,4-di-(N-Hydroxyphenyl)-Hexane corresponds to:
Diethylstilbestrole
Synestrol
Ethinylestradiol
Estradiol
Pregnenolone
Chemical name of 16 alpha -Methyl-9 alpha-Fluorprednisolone corresponds to:
Dexamethasone
Triamcinolone
Mesaton
Desoxycorticosteronacetate
Prednisolone
Gestagens are derived from:
Androstane
Gestanon
Estrone
Pregnanolone
Propylpregnan
Chemical name of progesterone is:
Pregnano-4-lone-20-diol-17 beta-ic-3
Pregnanolone-4-triol-11 alpha, 17 alpha,21-dione-3.20-21-acetate
Pregnanolone-4-dione-3,20
Pregnanolone-4-diol-21-dione-3,20-21-acetate
Pregnanolone-4-dione-17 alpha ,21-trione-3 ,11,20-21-acetate
Difluorderived corticosteroids include:
Cortisone acetate
Prednisolone
Triamcinolone
Fluocinolone acetonide
Dexamethasone
Quantitative determination of synestrol in oil solution is carried out after extraction with NaOH
solution by the method of:
Iodometry
Acidimetry
Permanganatometry
Cerimetry
Reverse titration bromatometry
What functional group in the corticosteroids molecule can be determined by the reaction of Boskott?
Steroid cycle
Ketogroup in position 3
Methyl radical
Estar group
Double bond in position 4
One of the diethylstilbestrole identification reactions according to the requirements of MCQ is
interaction with:
Formalin
B.
C.
D. *
E.
127.
A.
B.
C. *
D.
E.
128.
A.
B.
C.
D. *
E.
129.
A.
B.
C.
D.
E. *
130.
A.
B.
C. *
D. *
E.
131.
A.
B.
C. *
D.
E.
132.
A.
B.
C.
D.
E. *
133.
A.
B. *
C.
D.
Н2SO4 dilluted
НNO3 concentrated
(СН3СО)2О
СН3СОН
What prednisolone properties condition the reaction with the Feling reagent?
Acid
Main
Restoration
Oxidative
Amphoteric
Natural corticosteroids and their synthetic analogues are derived from:
Androstane
Estrone
Adamantane
Pregnanolone
Purine
Chemical name of Pregnenolone-4-diol-17alpha, 21-trione 3,11,20-21-acetate corresponds to:
Hydrocortisone acetate
Deoxycorticosterone acetate
Tocopherol acetate
Retinol acetate
Cortisone acetate
Mineralcorticosteroids affect in the body:
Exchange of hormones
Exchange of enzymes
Mineral metabolism
Exchange of insulin
Brain
The quantitative content of hydrocortisone acetate in a substance according to the requirements of
MCQ is determined by:
The acidimetry method
The gravimetric method
The method of gas liquid chromatography
UV-spectrometry
The method of diffusion in agar agar
Equivalence point for quantifying synestrol in substance is determined by:
Potassium chromate
Potassium dichromate
Phenolphthalein
Methylene blue
Methyl orange
Which of the listed products belongs to difluorderived corticosteroids?
Dexamethasone
Triamcinopone
Fluocinolone pivalate
Desoxycorticosteronacetate
E.
134.
A.
B.
C.
D.
E. *
135.
A. *
B.
C.
D.
E.
136.
A.
B. *
C.
D.
E.
137.
A.
B. *
C.
D.
E.
138.
A. *
B.
C.
D.
E.
139.
A.
B.
C.
D.
E. *
140.
A.
B. *
C.
D.
E.
141.
Mesaton
Hormones of the corpus luteums have a joint name:
Anabolics
Tranquilizers
Estrogens
Androgens
Gestagens
Hormones of pregnancy are produced in:
Cortical layer of adrenals
Cerebral layer of adrenals
Ovaries
Testicles
Corpus luteums
Steroid cycle in corticosteroids molecule can be determined by :
H2SO4 concentrated
HNO3 concentrated
H2SO4 diluted
HCl
NH4OH
At heating prednisolone with the alcoholic solution of phenylhydrazine sulfate a yellow color is
obtained. What functional group in the prednisolone molecule is revealed by that reaction?
Double bond in position 1
Ketogroup in position 3
Steroid cycle
Double bond in position 4
Alcoholic hydroxyl in position 11
The basis of male sex hormones is:
Estrone
Pregnanolone
Ethane
Androstan
Propane
Natural estrogen hormone is:
Diethylstilbestrol
Ergocalciferol
Synestrol
Androstan
Estrone
The chemical name of Androsten-4, 3-ol-17 beta corresponds to:
Methanandrostenolone
Testosterone
Methylandrostenediol
Phenobolinan
Rhetabolile
Quantitative determination of methylandrostenediol in substance as required by AND is conducted
by the method of:
A. *
B.
C.
D.
E.
142.
A. *
B.
C.
D.
E.
143.
A.
B.
C.
D.
E. *
144.
A.
B.
C. *
D.
E.
145.
A.
B.
C.
D. *
E.
146.
A.
B.
C.
D.
E. *
147.
A.
B.
C.
D.
E. *
148.
A.
B.
UV-spectroscopy
Gravimetry
Infared spectroscopy
TLC
Polarimetry
The chemical name of Trans-3, 4-di-(N-Hydroxyphenyl)-Hexanone-3 corresponds to:
Synestrol
Estradiol
Methanandrostenolone
Phenobolinan
Diethylstilbestrol
Quantitative determination of oil solution of synestrol according to the requirements of MCQ is
carried out by:
Acidimetry
Iodometry
Acetylation
Complexometry
Bromatometry
In the quantitative determination of diethylstilbestrol by the photometric method one uses azo
coupling reaction with:
Azo dyes
Auramine dye
Sodium nitrite in the alkaline medium
Sodium nitrite in the acid medium
Dinitrogenase sulfanilic acid
With the help of what reagent according to the MCQ requirements one may identify
diethylstilbestrol?
Glucose
KOH solid
Bromine water
NaOH solid
Phenol
To the anabolic steroids belong:
Synestrol
Diethylstilbestrol
Estrone
Phenobolinan
Testosterone propionate
Steroid cycle in the methandrostenolone molecule is determined by:
NaOH concentrated
NaOH dilluted
Mixture of concentrated HCl and HNO3
H2SO4 dilluted
H2SO4 concentrated
In the basis of female sex hormones is:
Cyclopenthaneperhydrophenanthrene
Androstan
C.
D.
E. *
149.
A.
B. *
C.
D.
E.
150.
A.
B.
C.
D.
E. *
151.
A.
B.
C.
D.
E. *
152.
A.
B.
C. *
D.
E.
153.
A. *
B.
C.
D.
E.
154.
A. *
B.
C.
D.
E.
155.
A.
B. *
C.
D.
E.
Pregnanolone
Acetylene
Estrone
Natural hormones of estrogen is:
Thyroidin
Estradiol
Cortisone acetate
Hydrocortisone
Prednisolone
Testosterone propionate corresponds to such chemical name:
Estratriene -1, 3,5 (10)-Diol-3, 17 - beta Dipropionate
B.17 beta-Propionoxy-2-alpha-Mehylandrostanol-3
C.17 alpha-Ethynyltestosterone
Androst-4-ene-3-diol-17-beta-Propionate
17 alpha-Allele-17-beta-Oxyestrone-4
The remainder of propionate acid in the estradiol dipropionate molecule according to the MCQ
requirements is determined by the reaction of:
Formation of azo dye
Constitution of oxime
With the cast-iron solution
With ammonia solution
Formation of ethyl ester of propionate acid
Diethylstilbestrol corresponds to such chemical name:
Meso-3 ,4-Di-(N-Hydroxyphenyl)-Hexenal
17-alpha-Ethynylestrenolone-1, 3,5 (10)-diol-3, 17 - beta
Estrenolone-1, 3,5 (10)-diol-3, 17 - beta-Dipropionate
17-alpha-Methylandroethane-5-diol 3 beta, 17 beta
Trans-3 ,4-di-(N-Hydroxyphenyl)-hexane-3
What indicator is used to fix the equivalence point for quantifying sinoestrol by the acetylation
method:
Starch
Methyl orange
Phenolphthalein
Methylene blue
Potassium chromate
Diethylstilbestrol is used in medical practice to treat cancer in:
Lungs
Brain
Prostate
Skin
Blood
Ketogroup in position 3 in the methyltestosterone molecule can be detected by:
Hydroxylamine hydrochloride
H2SO4 concentrated
HCl concentrated
Concentrated alkaline solution
Alcoholic alkaline solution
156.
A.
B.
C.
D. *
E.
157.
A.
B.
C. *
D.
E.
158.
A.
B.
C. *
D.
E.
159.
A.
B.
C.
D.
E. *
160.
A.
B.
C.
D.
E. *
161.
A.
B.
C.
D. *
E.
162.
A.
B.
C.
D. *
E.
163.
A.
Synestrol belongs to the synthetic compounds of:
Anabolic effects
Androgenous action
Neuroleptic action
Estrogen action
Antipyretic action
One of the reactions of solution of diethylstilbestrole identification according to the MCQ
requirements is the interaction with:
Formalin
Н2SO4 dilluted
Н2SO4 concentrated
СН3СООСН3
СН3СОН
Natural androgen is:
Estradiol dipropionate
Strophanthin
Testosterone
Methyltestosterone
Methandrostenolone
To synthetic estrogens belong:
Methyltestosterone
Progesterone
Estradiol
Estrone
Synoestrol
Methyltestosterone corresponds to such chemical name:
Androst-4-ene-3-diol
17-alpha-Methylandrostane-5-diol-3-beta -17 beta
17-alpha-Methylandrostan-1 ,4-diol-17-beta-diene-3
17-alpha-Ethynylestrenolone-1, 3,5 (10)-diol-3, 17 - beta
17-alpha-methylandrost-4-ene-17-beta-ene-3
Quantitative determination of estradiol dipropionate in substance is conducted by the method of:
Alkalimetry
Acidimetry in non-aqueous medium
Argentometry
Reverse alkalimetry
Complexometry
Phenolic hydroxyl in the synestrol molecule according to the MCQ requirements is determined by:
Br2
HNO3
NaOH
FeCl3
KNO3
Quantitative determination of diethylstilbestrole in accordance with the requirements of MCQ is
conducted by the method of :
Acidimetry in non-aqueous medium
B.
C.
D. *
E.
164.
A.
B.
C.
D. *
E.
165.
A.
B.
C.
D. *
E.
166.
A.
B.
C.
D. *
E.
167.
A.
B.
C.
D. *
E.
168.
A.
B.
C. *
D.
E.
169.
A.
B. *
C.
D.
E.
170.
A.
B. *
Acidimetry in the aqueous medium
Cerimetry
Acetylation
Argentometry
When the forecast uncertainty of sample preparation, which was carried out before the
spectrophotometric definition, taking into account the uncertainty of everything except:
Chemical glassware
Pipettes
Scales
Spectrophotometer
volumetric flask
If the forecast uncertainty of sample preparation, which was carried out before the chromatographic
determination, taking into account the uncertainty of everything except:
Chemical glassware
pipettes
scales
chromatograph
volumetric flask
If the forecast uncertainty of sample preparation, which was carried out before the chromatographic
determination, taking into account the uncertainty of everything except:
Chemical glassware
pipettes
scales
Cuvettes
volumetric flask
Measurement accuracy - is:
Good vidtvoryuvalnist measurements
No failures
The lack of random errors
Maximum output proximity to the true value of measured value
No gross errors
Standardization - an activity aimed at achieving:
Minimum measurement errors;
Optimal measurement errors;
Optimal degree of conformity of production of functional purpose;
Optimal conditions;
Satisfactory degree of compliance products - functionality.
Validation of analytical methods - is experimental evidence that the method .:
Very nice and easy
Suitable for solving the tasks
Characterized necessary metrological characteristics
In theory, science-based
Practical and rational
Validated the correctness of description is a typical test:
Only assay
Quantitative determination and quantitative tests for impurities
C.
D.
E.
171.
A. *
B.
C.
D.
E.
172.
A.
B.
C. *
D.
E.
173.
A. *
B.
C.
D.
E.
174.
A.
B. *
C.
D.
E.
175.
A.
B.
C. *
D.
E.
176.
A.
B.
C.
D.
E. *
177.
A. *
B.
C.
Identification
Identification and quantification determination
Identification and testing limit impurities
Learning the correct analytical procedure is carried out by:
Introduced-found
least squares
Fisher
Student
Variance and kurtosis
Accuracy and correctness - a metrological characteristics are investigated in test validation:
Identification by chemical methods
Identification of physical and physico-chemical methods
Quantitative determination of active pharmaceutical ingredients and additives
Marginal tests for impurities
Quantification only biological methods
Linearity - a metrological characteristic is studied:
In order to establish the degree of connection measured parameters and quantitative content
Only for analytical methods performed by physical methods of analysis
Only for analytical methods using chemical analysis methods
For methods that use physical, chemical and physico-chemical methods of analysis
For analytical methods to determine the specificity of verifying the identity of drugs
In the study of linear equations calculations analytical techniques hold the line method:
Administration found
Least squares
Fisher
Student
Asymmetry and kurtosis
In the tests for enteric dissolving dosage form of aspirin on the release of hydrochloric acid for 2
hours shall not exceed 10%, in alkaline solution after 3 h of release should reach at least 90%. What
range should have a method of determination of acetylsalicylic acid?
80-100% of the nominal content
70-130% of the nominal content
0-110% of the nominal content
from almost 0% to 120% of the normalized content
85-115% of the nominal content
If the forecast uncertainty final analytical operations pursued in spectrophotometric defined
uncertainty:
Chemical
glassware
pipettes
scales
volumetric flask
Spectrophotometer
In studying the metrological characteristics of the "linearity" calculated the correlation coefficient
whose value should be:
From -1 to +1
From -3 to +3
Less 1
D.
E.
From -2 to +2
More 2