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1. A. B. C. * D. E. 2. A. B. C. D. * E. 3. A. * B. C. D. E. 4. A. B. C. D. * E. 5. A. B. C. * D. E. 6. A. B. C. D. E. * 7. A. * B. C. D. E. 8. A. According to the pharmacological action antibiotics belong to the: Antispasmodic means Antiseptic means Chemical-therapeutic means Antimicrobial means Anti-inflammatory means Medical drug tetracycline belongs to the antibiotics of: Tetracycline row Penicillin row Aminoglycoside row Alicyclic row Cephalosporin row Antibiotics of tetracycline row are used for the treatment of: Pneumonia Dysenteria Allergy Fractures CNS diseases To the antibiotics of aromatic row the following compound belongs: Tetracycline Streptomycin sulfate Lincomycin hydrochloride Laevomycetin Rondomycin What gas evaporated after the heating of tablet laevomycetin with NaOH solution? CO2 N2 NH3 H2S NO2 Quantitative determination of substance of the laevomycetin according to the requirements of MCQ after the reduction of nitro-group to amino-group is conducted by the following method: Acidimetry Alkalimetry Argentometry Iodometry Nitritometry Laevomyctin is used in the medical practice for the treatment of: Dysentery Fungal diseases Dermatoses Typhoid Allergy By the action on microorganisms and human organism all antibiotics can be divided into two main groups: General and individual B. * C. D. E. 9. A. B. C. D. E. * 10. A. B. C. * D. E. 11. A. B. C. * D. E. 12. A. B. C. D. * E. 13. A. B. C. D. * E. 14. A. B. C. D. E. * 15. A. B. C. * D. Main and reserve Correct and incorrect Main and auxiliary Forward and backward What antibiotics in their core have naphthalene nucleus? Aromatic Penicillin’s row Glycosidic row Polyene antibiotics Tetracycline row Substance of doxycycline hydrochloride belongs to the antibiotics of the following row: Cephalosporin Aminoglycoside Alicyclic Penicillin Macrolide Tetracycline has acidic properties due to the presence in its structure: 4-dimethylamino-group, 1-oxogroup 1-oxogroup, 10-phenol hydroxyl 10-phenol hydroxyl, 3- and 12-enol hydroxyls 4-dimethylamino-group, 11-oxogroup 11-oxogroup, 3- and 12-enol hydroxyls Methacycline hydrochloride used in the medical practice in the form of: Ampoule solutions Tablets Ointments Capsules Suppositories Laevomycetin the following international unpatented name: Methanedion Rondomycin Vibramycin Chloramphenicol Oletetrin What indicator can be used to establish the equivalent point in the quantitative determination of laevomycetin by nitritometry? Starch Phenolphtalein Methyl orange Litmus paper Iodinestarch paper Laevomycetin at the long-term treatment may cause: Habituation Temperature decreasing Dysfunction of blood-forming organs Detrimental effect on the organs of hearing E. 16. A. B. C. * D. E. 17. A. B. C. D. * E. 18. A. B. C. * D. E. 19. A. B. * C. D. E. 20. A. B. * C. D. E. 21. A. B. C. D. * E. 22. A. B. C. D. E. * 23. Improve appetite The biological activity of antibiotics can be expressed in: Kilograms Units of weight Units of action (activity) G/ml G/mol Methacycline hydrochloride is also called: Chloramphenicol Vibramycin Ampicillin Rondomycin Phenoxymethylpenicillin Anhydrous derivative of tetracycline can be obtained by the action of: Concentrated alkali solution Diluted sulfate acid Concentrated sulfate acid Concentrated phosphate acid Methyl alcohol Doxycycline hydrochloride used in the medical practice for the treatment of: Dysentery Upper respiratory tract infections Allergy Rhinitis Meningitis Which drug of the listed below has the chemical name of D(-)-threo-1-p-nitrophenyl-2-dichloroacetylaminopropanediol-1,3: Tetracycline Laevomycetin Benzylpenicillin Streptomycin Cefalexin What physical and physico-chemical methods are not used for tablets of laevomycetin identification? Determination of the melting point TLC UV-spectroscopy Determination of the refractive index IR-spectroscopy What is the molecular mass of tablets of the laevomycetin equivalent at its quantitative determination by the nitritometry method? 2 М.m 1/2 М.m 1/5 М.m 1/4 М.m М.m In clinical pediatric practice are used instead of chloramphenicol stearate, because it: A. B. * C. D. E. 24. A. * B. C. D. E. 25. A. B. C. D. * E. 26. A. B. C. * D. E. 27. A. B. C. D. * E. 28. A. B. C. D. E. * 29. A. B. C. D. E. * 30. A. Is not hygroscopic Has no bitter taste Is better soluble in water Does not dissolve in water Has a fragrant odor At the determination of the antibiotics’ quality biological tests are conducted. What animals according to SPhU are used to determine abnormal toxicity? White mice Rabbits Guinea pigs Dogs It is not studied on animals What acid is in the base of penicillin molecule? 7-aminocephalosporanic acid p-aminobenzoic acid 7- aminodesacetoxycephalosporanic acid 6-aminopenicillanic acid Penicillanic acid Chemical name sodium (2S 5R 6R)-3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo [3,2,0] heptane-2-carboxylate the following compound has: Ampicillin sodium salt Oxacilline sodium salt Benzylpenicillin sodium salt Carbenicillin sodium salt Azlocillin sodium salt To the ampiox content the following compounds belong: Benzylpenicillin sodium salt, oxacillin sodium salt Benzylpenicillin sodium salt, ampicillin sodium salt Cefalexin, cefalotin Ampicillin and oxacillin sodium salts Laevomycetin, ampicillin sodium salt To the penicillins of the firs generation the following preparation belongs: Oxacilline sodium salt Ampicillin sodium salt Amoxicillin Amoxiclav Phenoxymethylpenicillin What indicator is used for the equivalent point detection at the penicillin’s sum assay of the hemi synthetic penicillin antibiotics? Starch Methyl orange Methyl red Methyl blue Phenolphthalein What side effect is characteristic for penicillin antibiotics? Hearing loss B. C. D. * E. 31. A. B. C. D. E. * 32. A. * B. C. D. E. 33. A. B. C. D. * E. 34. A. B. C. D. * E. 35. A. B. C. D. * E. 36. A. B. C. * D. E. 37. A. * B. Partial loss of memory reduction of visual acuity Gastrointestinal disorders Violation of the vestibular apparatus Determine the difference in the structural formulas of 7-ACA and 7-ADCA? Presence of ethoxy-group Absence of ethoxy-group Presence acethoxy-group Abesence acethoxy-group Absence of keto-group What reagent can be used for the sodium-ion (Nа+) identification in substens of benzylpenicillin sodium salt molecule? Methoxyphenylacetic acid Diphenylamine Potassium permanganate, sulfuric acid Silver nitrate Tartaric acid One of the distinctive reactions of heterocyclic antibiotics is interaction with: Hydroxylamine hydrochloride Concentrated sulfuric acid Formaldehyde Formaldehyde in the presence of concentrated sulfuric acid Copper (II) sulfate solution 7-aminocefalosporanic acid consists from the following cycles: Thiazolidine and β-lactame Thiazine and α-lactame Furan and β-lactame Dihydrothiazine and β-lactame Phenothiazine and α-lactame In the base of cephalosporin antibiotics is: 6-aminopenicillanic acid aminocephalosporanic acid p-aminobenzoic acid 7-aminodesacetoxycephalosporanic acid cephalosporanic acid Chemical name sodium (2S, 5R, 6R)-6-[(2 R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo [3,2,0] heptane-2-carboxylate the following compound has: Oxacillin Azlocillin Ampicillin Carbenicilline Carfecillin What reagent can be used for the potassium-ion (K+) identification in substance of benzylpenicillin potassium salt molecule? Tartaric acid Potassium hexacyanoferrate (II) C. D. E. 38. A. B. C. D. * E. 39. A. B. C. D. * E. 40. A. B. C. D. E. * 41. A. B. C. D. * E. 42. A. B. C. D. E. * 43. A. B. C. * D. E. 44. A. B. C. D. * E. 45. Ammonium oxalate Potassium hexacyanoferrate (III) Sodium hexanitrocobaltate (III) To the penicillins of the second generation the following preparation belongs: Bicillin-1 Bicillin-5 Benzylpenicillin Novocain salt Amoxicillin Phenoxymethylpenicillin What structural element in the penicillin’s antibiotics cases their pharmacological action? Thiazolidine cycle Amino-group Carboxylic group Lactame cycle Methyl group ?-lactame cycle in the structure of cephalosporin antibiotics can be detected with the reaction of: Schiff bases formation Indophenol formation Aurine dye formation Iodoform frmation Hydroxamates of Сu and Fe What side effect is characteristic for cephalosporin antibiotics? Convulsions Lowering of the blood pressure Headache Allergic complications Brittle bones What reagent can be used for organic bounded sulfur in the bicillin-1 molecule? Pb(CH3COO)2 NaOH solution HNO3 conc. HNO3 dil. NaOH (solid), Pb(CH3COOH)2 Which of the following antibiotics has hygroscopic properties? Bicillin-1, phenoxymethylpenicillin Ampicillin sodium salt, benzylpenicillin sodium salt Benzylpenicillin potassium salt, benzylpenicillin sodium salt Cefazolin, ceftriaxone Bicillin-5, benzylpenicillin Novocain salt Biological activity of the natural penicillins is be expressed in: DUA RUA CUA UA FUA Which of the following antibiotics can be detected with ninhydrine solution? A. B. C. * D. E. 46. A. B. C. * D. E. 47. A. B. C. D. * E. 48. A. B. * C. D. E. 49. A. B. C. * D. E. 50. A. B. C. * D. E. 51. A. B. C. D. * E. 52. A. B. * C. D. Ampicillin, oxacillin Amoxicillin, benzylpenicillin sodium salt Ampicillin, amoxicillin Cefalotin, cefalexin Amoxiclav, bicillin-1 To the penicillins of the third generation the following preparation belongs: Ceftriaxone Amoxicillin Amoxiclav Ampicillin sodium salt Oxacillin sodium salt To the cephalosporin’s derivatives of 7-ADAC the following antibiotic belongs: Cefalotin Cephapirin Cefuroxime Cefaloridine Cefaloglycine Amoxiclav consists of: Ampicillin, clavulanic acid Amoxicillin, clavulanic acid Amoxicillin, tienam Amoxicillin, imipenem Clavulanic acid, tienam What reagent can be used for the carboxylic group detection? NaOH NH4OH NaHCO3 Felling liquid K3KFe(CN)6F Antibiotic kefzol can be also named as: Bicilllin-1 Bicillin-5 Cefazolin Cefalexin Cefaloridine Which of the following preparations does belong to antibiotics-glycosides? Gentamycin sulfate Monomycin sulfate Neomycin sulfate Doxorubicin hydrochloride Streptomycin sulfate Medical drug amikacin sulfate belongs to the following antibiotic’s type: ?-lactamide Aminoglycoside Macrolide Polypeptide E. 53. A. B. C. * D. E. 54. A. B. C. * D. E. 55. A. * B. C. D. E. 56. A. B. C. D. * E. 57. A. B. C. * D. E. 58. A. B. C. D. * E. 59. A. B. C. D. * E. 60. A. Polyene Choose aglycone in the streptomycin sulfate molecule: 2-deoxistreptamine 3-deoxistreptamine streptidine 2-deoxisreptidine 3-deoxisreptidine One of the methods of quantitative determination of powder of streptomycin is the following one: Argentometry Complexonometry Cerimetry Acidimetry Iodochlorometry Which of the following medical drugs has synonym cifran? Ciprofloxacin hydrochloride Norfloxacin Lomefloxacin Ofloxacin Pefloxacin Oleandomycin phosphate can be detected with silver nitrate solution. What fragment does silver nitrate detect in the antibiotic molecule structure? Alcoholic hydroxyl Tertiary amine Shugar part Phosphate-ions Lactone cycle Solution of gentamicin sulfate is not used for the treatment of: Infection diseases of urinary ways Sepsis, tuberculosis Hormonal disorders Gastrointestinal tract diseases Infection diseases of the skin Peptide bond in the gramicidin molecule connects residues of: Esters Ethers Lactones D-Aminoacids Glycosides Choose antitumor antibiotic, tetracycline derivative: Doxycycline hydrochloride Bruneomycin Rubomycin Doxorubicin hydrochloride Olivomycin А Streptomycin sulfate belongs to the following antibiotics: Cephalosporins B. C. * D. E. 61. A. B. C. D. * E. 62. A. B. C. D. * E. 63. A. B. C. D. E. * 64. A. B. C. * D. E. 65. A. B. C. D. * E. 66. A. B. C. * D. E. 67. A. B. C. * Polyenes Glycosides Polypeptides Anzamycins Which of the following preparations does belong to antibiotics-polypeptides? Nystatin Kanamycin Erythromycin Gramicidin Olivomycin Chemical name 1,3-diguanidino-2,4,5,6-tetraoxicyclohexane the following compound has: 2-deoxistreptidine 2-deoxistreptamine 3-deoxistreptamine streptidine 3-deoxistreptidine Presence of L-streptose in the streptomycin cases formation of: Azo-dye Schiff bases Azomethyne dye D-Naphthalene Maltol What is the molecular mass of substance of streptomycin at the quantitative determination by cerimetric method? 2 М2m ММm М.m./2 М.m./4 М.m./8 In the molecule of medical preparations 6-fluoroquinoline derivatives in the position number 7 is the following heterocyclic connection: Pyperidine Pyrrolidine Pyrrole Piperazine Thiazole Which of the following sugars is in the erythromycin structure? Glucose L-streptose Cladinose Fructose Arabinose Monomycin is not used for the treatment of: Infection diseases of urinary ways Infection diseases of the skin Virus diseases D. E. 68. A. B. C. D. E. * 69. A. B. C. D. E. * 70. A. B. C. D. E. * 71. A. B. C. D. * E. 72. A. B. * C. D. E. 73. A. B. C. * D. E. 74. A. B. * C. Sepsis Tuberculosis Antitumor antibiotic olivomycin A according to its chemical structure belongs to the derivatives of: Quinoline Fluoroquinoline Quiniline-5,8-dione Quinoline-3-carboxylic acid Aurelia acid Aliphatic amino-group in the kanamycin molecule can be identified by the usage of the following reagent: Alkaline solution of A-naphthalene Nessler’s reagent Bromine water Sodium nitrite, НСl Ninhydrine Which of the following medical preparations does belong to antibiotics-aminoglycosides? Streptomycin sulfate Griseofulvin Lincomycin hydrochloride Erythromycin Kanamycin monosulfate Medical drug clindamycin (dalacyn) according to its chemical structure belongs to the following type of antibiotics: Glycosides Macrolides Polyenes Lincomycins Anzamycins What two residues are in the structure of streptidine? Urea Guanidine Streptose Glucose Glucoseamine What indicator is used for fixation of the equivalent point at the streptomycin assay by cerimetry method? Phenolphthalein Starch Solution FeCl3 Methyl orange Litmus Choose chemical name of norfloxacine: 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinoline carboxylic acid 1-Ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxo-3-quinoline carboxylic acid 1-Cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-4-oxo-1,4-dihydro-3-quinoline carboxylic acid hydrochloride D. E. 75. A. B. C. D. E. * 76. A. B. C. * D. E. 77. A. B. C. * D. E. 78. A. B. C. * D. E. 79. A. B. C. D. * E. 80. A. * B. C. D. E. 81. A. B. C. * D. E. 3-Methyl-7-oxo-9-fluoro-10-(4-methyl-1-piperazinyl)-2,3-dihydro-7Н-pyrido-1,4-benzoxazine-6-car boxylic acid 1-Ethyl-1,4-dihydro-4-oxo-7-(4-pyridinyl)-3-carboxylic acid Oleandomycin phosphate in capsulas can be identified with molybdenum-vanadium reagent. What fragment does this reagent detect in the antibiotic molecule structure? Tertiary amine Alcoholic hydroxyl Sugar part Lactone cycle Phosphate-ions Neomycin and gramicidin belong to the following eyes drops: Sulfacyl-sodium Levamisole Sofradex Amracin Taufonum Which of the following antitumor antibiotics is anthracycline derivative? Doxycycline hydrochloride Bruneomycin Rubomycin Doxorubicin hydrochloride Olivomycin А What reagent can be used for sulfate-ion detection in the powder of monomycin sulfate? NaCl H2SO4 dil. I2 КОН КВr Thyroid hormone is produced by one of the endocrine glands: Adrenals cortex Pancreas Cerebral layer of adrenals cortex Thyroid gland Hvpophysis pituitary gland Protein portion of the thyroidin molecule is revealed by the following reagents: NaOH HCl Marky reagent K[Sb(OH)6] KMnО4 Insulin is used to treat: Diathesis Muscular dystrophy Diabetes Intestines atony Hemophilia 82. A. B. C. D. * E. 83. A. B. C. D. E. * 84. A. B. C. * D. E. 85. A. B. C. * D. E. 86. A. B. C. D. E. * 87. A. B. C. * D. E. 88. A. * B. C. D. E. 89. A. Which indicator is used to fix the equivalence point for quantifying thyroidine according to the requirements of the MCQ: Phenolphthalein Crystal violet KI Starch Sodium eosin Parent material for the adrenaline synthesis is: Pyrogallol Phenol Methylamine Ethyl alcohol Pyrocatechol Quantitative determination of adrenaline hydrotartrate according to the MCQ requirements is held by the method of: Argentometry Permanganatometry Acidimetry in non-aqueous medium Gravimetry Acidimetry in aqueous medium Solution of noradrenaline hydrotartrate in medical practice is used as a treatment: Antiadrenergic Antihistaminic Adrenomimetic Anticholinesterase Cholinomimetic Noradrenaline base has its synonymous name: Epinephrine Phenylephrine Naphtizine Gelsolin Levarterenol Chemical name of 1 - (3,4-Dioxyphenyl)-2-Isopropylaminoetanol Hydrochloride is: Mesaton hydrochloride Ephedrine hydrochloride Isoproterenol hydrochloride Adrenaline hydrochloride Papaverine hydrochloride What reagents must be used to confirm the identity of solution of mesaton: AgNO3, HNO3, NH4OH AgNO3, H3PO4, NH4OH CuSO4, NaOH, ether AgNO3, HCl, NH4OH K[Sb(OH)6], HCl Thyroidin contains the following hormones: Adrenaline, L-Thyroxine B. * C. D. E. 90. A. B. C. * D. E. 91. A. B. C. D. E. * 92. A. B. C. * D. E. 93. A. * B. C. D. E. 94. A. B. C. D. * E. 95. A. B. C. D. E. * 96. A. * B. C. L-Thyroxine, 3,5,3Ttriiodothyronine Noradrenaline, Corticosterone 3,5,3- Triiodothyronine, Adrenaline Corticosterone, 3,5,3- Triiodothyronine At boiling thyroidin with a solution of NaOH one observes: Decolouration of the solution Sendimentation of white color The formation of yellow color Isolation of NH3 Separation of CO2 In accordance with the MCQ requirements in quantitative determination of thyroidin at first one conducts mineralization with the help of: KNO3, Na2CO3 K2Cr2O7, NaOH KMnО4, H2O H2O2, H2SO4 dilluted H2O2, H2SO4 concentrated The adrenaline hormone is produced by: Female sex glands Cortical layer of adrenals Cerebral layer of adrenals Male sex glands Thyroid gland With the help of what reagents one can find tartrate ion in the adrenaline tartrate molecule? FeCl3, KCl KCl, CuSO4 CuSO4,CH3COONa CH3COONa, KCl Resorcin, concentrated sulfate acid, KCl Parent material for obtaining noradrenaline hydrotartrate is: Benzene Aniline Catechin Pyrocatechol Phenol Nordrenaline hydrotartrate is issued as: Pills of 0,2 g Ointment 0,2% Suppository of 0,2 g Spray 0,2% 0,2% ampullaceous solution Quantitative determination of solution of mesaton according to the requirements of MCQ is carried out by methods of: Acidimetry in non-aqueous medium, bromometry Permanganatometry, nitritometry Bromometry, gravimetry D. E. 97. A. B. * C. D. E. 98. A. B. C. * D. E. 99. A. B. C. D. E. * 100. A. B. C. * D. E. 101. A. * B. C. D. E. 102. A. B. C. * D. E. 103. A. B. C. D. * E. Nitritometry, cerimetry Gravimetry, nitritometry Isoproterenol in medical practice is used to treat: Rhinitis Bronchial asthma Spasm of brain vessels Dermatitis Diabetes Constituent part of thyroidin is: Tyrosine Bethanidine L-Thyroxine Cortisone Phenylephrine Protein portion of the thyroidin molecule is determined by boiling it with a solution of NaOH. When one adds H2SO diluted the solution decolorizes and: There is a smell of ammonium Leaves black sendiment Sends off free I2 Leaves yellow colloidal sendiment Leaves white colloidal sendiment After thyroidin mineralization the solution of KMnO4 is added to the reaction mixture to: Restore iodides to iodates Oxidation of iodides to periodates Oxidation of iodide to iodates Oxidation of iodides to iodates Restore iodides to free iodine Thyroidin in medical practice is used to treat: Thyroid gland cancer Breast Cancer Dermatitis Pellagra Scurvy FeCl3 solution is added to adrenaline tartrate solution and appears emerald green coloration. What kind of analytical and functional groups can be detected by this reagent? Alcoholic hydroxyl Tartrate ion Phenolic hydroxyl Methyl group Aromatic system To stabilize the injection solution of adrenaline hydrotartrate one adds: 3% solution of hydrogen peroxide 1% solution of sodium benzoate Antifebrin 0,1% solution of sodium metabisulfite 0, 1% solution of potassium permanganate 104. A. B. C. D. E. * 105. A. B. C. D. * E. 106. A. B. C. D. * E. 107. A. B. C. * D. E. 108. A. B. * C. D. E. 109. A. * B. C. D. E. 110. A. B. C. D. * E. 111. A. B. During the oxidation of noradrenaline in iodine at a pH of -6.5 there is produced: Adrenochrome Adrenaline Adrenolytics Noradrenochrome 3,4-dihydroxyacetophenone Methods of quantifying mesaton according to the requirements of MCQ are: Methods of iodinechlorometry, Folgard Methods of complexometry, permangatometry Methods of permanganatometry, Folgard Methods of cerimetry, permanganatometry Methods of Folgard, complexometry With the help of what reagent one cannot conduct the reaction of isoproterenol identification: HNO3 NH4OH AgNO3 NaNO2 FeCl3 Structural basis of steroid hormones is: Phenothiazine 6 Aminopenicilline acid Cyclopentaneperhydrophenanthrene Naphthacene Furanose To glucocorticosteroids refers: Deoxycorticosterone acetate Prednisolone Synestrol Pregnenolone Progesterone What reagent does not reveal ketogroup in position 3 in the molecules of corticosteroids? H2SO4 concentrated Phenylhydrazine 2,4-Dinitrophenylhydrazine Hydroxylamine hydrochloride Isoniazid Quantitative determination of solution of desoxycorticosterone acetate in accordance with the requirements of MCQ is carried out by the method of: PMR NMR Refractometry UV-spectrometry Thin layer chromatography Which of the listed preparations belongs to the fluorderived corticosteroids? Desoxycorticosteronacetate Cortisone acetate C. * D. E. 112. A. B. C. D. * E. 113. A. B. C. D. * E. 114. A. B. * C. D. E. 115. A. B. C. * D. E. 116. A. B. C. * D. E. 117. A. B. C. * D. E. 118. A. * B. C. D. E. Triamcinolone Thyroidin Hydrocortisone acetate Natural gestagen is: Cortisone acetate Pregnenolone Cortisol Progesterone Toremifene Quantitative determination of tablets of pregnenolone according to the MCQ requirements is carried out by the method of: Acidimetry in non-aqueous medium Kjeldal Direct alkalimetry Substitution alkalimetry Acidimetry method Deoxycorticosterone acetate is obtained in the industry from: Cortisone Cholesterol Chlorophyll Hydrocortisone Pregnenolone Steroid system in the corticosteroids molecule can be detected by the reaction of: Legal Pellagri Boskott Sakaguchy Vitaly-Moren Corticosteroid hormones are produced in the body by: Cerebral part of adrenals Thyroid gland Cortical layer of adrenals Hypophysis pituitary gland Pancreas Which of the following preparations does not apply to glucocorticosteroids: Cortisone acetate Hydrocortisone acetate Deoxycorticosterone acetate Prednisolone Dexamethasone What physicochemical methods are used for corticosteroids identification: UV-spectroscopy, infared spectroscopy Potentiometry, infared spectroscopy Refractometry, potentiometry Infared spectroscopy, conductometry Conductometry, UV-spectroscopy 119. A. B. * C. D. E. 120. A. * B. C. D. E. 121. A. B. C. D. * E. 122. A. B. C. * D. E. 123. A. B. C. D. * E. 124. A. B. C. D. E. * 125. A. * B. C. D. E. 126. A. Chemical name of Meso-3 ,4-di-(N-Hydroxyphenyl)-Hexane corresponds to: Diethylstilbestrole Synestrol Ethinylestradiol Estradiol Pregnenolone Chemical name of 16 alpha -Methyl-9 alpha-Fluorprednisolone corresponds to: Dexamethasone Triamcinolone Mesaton Desoxycorticosteronacetate Prednisolone Gestagens are derived from: Androstane Gestanon Estrone Pregnanolone Propylpregnan Chemical name of progesterone is: Pregnano-4-lone-20-diol-17 beta-ic-3 Pregnanolone-4-triol-11 alpha, 17 alpha,21-dione-3.20-21-acetate Pregnanolone-4-dione-3,20 Pregnanolone-4-diol-21-dione-3,20-21-acetate Pregnanolone-4-dione-17 alpha ,21-trione-3 ,11,20-21-acetate Difluorderived corticosteroids include: Cortisone acetate Prednisolone Triamcinolone Fluocinolone acetonide Dexamethasone Quantitative determination of synestrol in oil solution is carried out after extraction with NaOH solution by the method of: Iodometry Acidimetry Permanganatometry Cerimetry Reverse titration bromatometry What functional group in the corticosteroids molecule can be determined by the reaction of Boskott? Steroid cycle Ketogroup in position 3 Methyl radical Estar group Double bond in position 4 One of the diethylstilbestrole identification reactions according to the requirements of MCQ is interaction with: Formalin B. C. D. * E. 127. A. B. C. * D. E. 128. A. B. C. D. * E. 129. A. B. C. D. E. * 130. A. B. C. * D. * E. 131. A. B. C. * D. E. 132. A. B. C. D. E. * 133. A. B. * C. D. Н2SO4 dilluted НNO3 concentrated (СН3СО)2О СН3СОН What prednisolone properties condition the reaction with the Feling reagent? Acid Main Restoration Oxidative Amphoteric Natural corticosteroids and their synthetic analogues are derived from: Androstane Estrone Adamantane Pregnanolone Purine Chemical name of Pregnenolone-4-diol-17alpha, 21-trione 3,11,20-21-acetate corresponds to: Hydrocortisone acetate Deoxycorticosterone acetate Tocopherol acetate Retinol acetate Cortisone acetate Mineralcorticosteroids affect in the body: Exchange of hormones Exchange of enzymes Mineral metabolism Exchange of insulin Brain The quantitative content of hydrocortisone acetate in a substance according to the requirements of MCQ is determined by: The acidimetry method The gravimetric method The method of gas liquid chromatography UV-spectrometry The method of diffusion in agar agar Equivalence point for quantifying synestrol in substance is determined by: Potassium chromate Potassium dichromate Phenolphthalein Methylene blue Methyl orange Which of the listed products belongs to difluorderived corticosteroids? Dexamethasone Triamcinopone Fluocinolone pivalate Desoxycorticosteronacetate E. 134. A. B. C. D. E. * 135. A. * B. C. D. E. 136. A. B. * C. D. E. 137. A. B. * C. D. E. 138. A. * B. C. D. E. 139. A. B. C. D. E. * 140. A. B. * C. D. E. 141. Mesaton Hormones of the corpus luteums have a joint name: Anabolics Tranquilizers Estrogens Androgens Gestagens Hormones of pregnancy are produced in: Cortical layer of adrenals Cerebral layer of adrenals Ovaries Testicles Corpus luteums Steroid cycle in corticosteroids molecule can be determined by : H2SO4 concentrated HNO3 concentrated H2SO4 diluted HCl NH4OH At heating prednisolone with the alcoholic solution of phenylhydrazine sulfate a yellow color is obtained. What functional group in the prednisolone molecule is revealed by that reaction? Double bond in position 1 Ketogroup in position 3 Steroid cycle Double bond in position 4 Alcoholic hydroxyl in position 11 The basis of male sex hormones is: Estrone Pregnanolone Ethane Androstan Propane Natural estrogen hormone is: Diethylstilbestrol Ergocalciferol Synestrol Androstan Estrone The chemical name of Androsten-4, 3-ol-17 beta corresponds to: Methanandrostenolone Testosterone Methylandrostenediol Phenobolinan Rhetabolile Quantitative determination of methylandrostenediol in substance as required by AND is conducted by the method of: A. * B. C. D. E. 142. A. * B. C. D. E. 143. A. B. C. D. E. * 144. A. B. C. * D. E. 145. A. B. C. D. * E. 146. A. B. C. D. E. * 147. A. B. C. D. E. * 148. A. B. UV-spectroscopy Gravimetry Infared spectroscopy TLC Polarimetry The chemical name of Trans-3, 4-di-(N-Hydroxyphenyl)-Hexanone-3 corresponds to: Synestrol Estradiol Methanandrostenolone Phenobolinan Diethylstilbestrol Quantitative determination of oil solution of synestrol according to the requirements of MCQ is carried out by: Acidimetry Iodometry Acetylation Complexometry Bromatometry In the quantitative determination of diethylstilbestrol by the photometric method one uses azo coupling reaction with: Azo dyes Auramine dye Sodium nitrite in the alkaline medium Sodium nitrite in the acid medium Dinitrogenase sulfanilic acid With the help of what reagent according to the MCQ requirements one may identify diethylstilbestrol? Glucose KOH solid Bromine water NaOH solid Phenol To the anabolic steroids belong: Synestrol Diethylstilbestrol Estrone Phenobolinan Testosterone propionate Steroid cycle in the methandrostenolone molecule is determined by: NaOH concentrated NaOH dilluted Mixture of concentrated HCl and HNO3 H2SO4 dilluted H2SO4 concentrated In the basis of female sex hormones is: Cyclopenthaneperhydrophenanthrene Androstan C. D. E. * 149. A. B. * C. D. E. 150. A. B. C. D. E. * 151. A. B. C. D. E. * 152. A. B. C. * D. E. 153. A. * B. C. D. E. 154. A. * B. C. D. E. 155. A. B. * C. D. E. Pregnanolone Acetylene Estrone Natural hormones of estrogen is: Thyroidin Estradiol Cortisone acetate Hydrocortisone Prednisolone Testosterone propionate corresponds to such chemical name: Estratriene -1, 3,5 (10)-Diol-3, 17 - beta Dipropionate B.17 beta-Propionoxy-2-alpha-Mehylandrostanol-3 C.17 alpha-Ethynyltestosterone Androst-4-ene-3-diol-17-beta-Propionate 17 alpha-Allele-17-beta-Oxyestrone-4 The remainder of propionate acid in the estradiol dipropionate molecule according to the MCQ requirements is determined by the reaction of: Formation of azo dye Constitution of oxime With the cast-iron solution With ammonia solution Formation of ethyl ester of propionate acid Diethylstilbestrol corresponds to such chemical name: Meso-3 ,4-Di-(N-Hydroxyphenyl)-Hexenal 17-alpha-Ethynylestrenolone-1, 3,5 (10)-diol-3, 17 - beta Estrenolone-1, 3,5 (10)-diol-3, 17 - beta-Dipropionate 17-alpha-Methylandroethane-5-diol 3 beta, 17 beta Trans-3 ,4-di-(N-Hydroxyphenyl)-hexane-3 What indicator is used to fix the equivalence point for quantifying sinoestrol by the acetylation method: Starch Methyl orange Phenolphthalein Methylene blue Potassium chromate Diethylstilbestrol is used in medical practice to treat cancer in: Lungs Brain Prostate Skin Blood Ketogroup in position 3 in the methyltestosterone molecule can be detected by: Hydroxylamine hydrochloride H2SO4 concentrated HCl concentrated Concentrated alkaline solution Alcoholic alkaline solution 156. A. B. C. D. * E. 157. A. B. C. * D. E. 158. A. B. C. * D. E. 159. A. B. C. D. E. * 160. A. B. C. D. E. * 161. A. B. C. D. * E. 162. A. B. C. D. * E. 163. A. Synestrol belongs to the synthetic compounds of: Anabolic effects Androgenous action Neuroleptic action Estrogen action Antipyretic action One of the reactions of solution of diethylstilbestrole identification according to the MCQ requirements is the interaction with: Formalin Н2SO4 dilluted Н2SO4 concentrated СН3СООСН3 СН3СОН Natural androgen is: Estradiol dipropionate Strophanthin Testosterone Methyltestosterone Methandrostenolone To synthetic estrogens belong: Methyltestosterone Progesterone Estradiol Estrone Synoestrol Methyltestosterone corresponds to such chemical name: Androst-4-ene-3-diol 17-alpha-Methylandrostane-5-diol-3-beta -17 beta 17-alpha-Methylandrostan-1 ,4-diol-17-beta-diene-3 17-alpha-Ethynylestrenolone-1, 3,5 (10)-diol-3, 17 - beta 17-alpha-methylandrost-4-ene-17-beta-ene-3 Quantitative determination of estradiol dipropionate in substance is conducted by the method of: Alkalimetry Acidimetry in non-aqueous medium Argentometry Reverse alkalimetry Complexometry Phenolic hydroxyl in the synestrol molecule according to the MCQ requirements is determined by: Br2 HNO3 NaOH FeCl3 KNO3 Quantitative determination of diethylstilbestrole in accordance with the requirements of MCQ is conducted by the method of : Acidimetry in non-aqueous medium B. C. D. * E. 164. A. B. C. D. * E. 165. A. B. C. D. * E. 166. A. B. C. D. * E. 167. A. B. C. D. * E. 168. A. B. C. * D. E. 169. A. B. * C. D. E. 170. A. B. * Acidimetry in the aqueous medium Cerimetry Acetylation Argentometry When the forecast uncertainty of sample preparation, which was carried out before the spectrophotometric definition, taking into account the uncertainty of everything except: Chemical glassware Pipettes Scales Spectrophotometer volumetric flask If the forecast uncertainty of sample preparation, which was carried out before the chromatographic determination, taking into account the uncertainty of everything except: Chemical glassware pipettes scales chromatograph volumetric flask If the forecast uncertainty of sample preparation, which was carried out before the chromatographic determination, taking into account the uncertainty of everything except: Chemical glassware pipettes scales Cuvettes volumetric flask Measurement accuracy - is: Good vidtvoryuvalnist measurements No failures The lack of random errors Maximum output proximity to the true value of measured value No gross errors Standardization - an activity aimed at achieving: Minimum measurement errors; Optimal measurement errors; Optimal degree of conformity of production of functional purpose; Optimal conditions; Satisfactory degree of compliance products - functionality. Validation of analytical methods - is experimental evidence that the method .: Very nice and easy Suitable for solving the tasks Characterized necessary metrological characteristics In theory, science-based Practical and rational Validated the correctness of description is a typical test: Only assay Quantitative determination and quantitative tests for impurities C. D. E. 171. A. * B. C. D. E. 172. A. B. C. * D. E. 173. A. * B. C. D. E. 174. A. B. * C. D. E. 175. A. B. C. * D. E. 176. A. B. C. D. E. * 177. A. * B. C. Identification Identification and quantification determination Identification and testing limit impurities Learning the correct analytical procedure is carried out by: Introduced-found least squares Fisher Student Variance and kurtosis Accuracy and correctness - a metrological characteristics are investigated in test validation: Identification by chemical methods Identification of physical and physico-chemical methods Quantitative determination of active pharmaceutical ingredients and additives Marginal tests for impurities Quantification only biological methods Linearity - a metrological characteristic is studied: In order to establish the degree of connection measured parameters and quantitative content Only for analytical methods performed by physical methods of analysis Only for analytical methods using chemical analysis methods For methods that use physical, chemical and physico-chemical methods of analysis For analytical methods to determine the specificity of verifying the identity of drugs In the study of linear equations calculations analytical techniques hold the line method: Administration found Least squares Fisher Student Asymmetry and kurtosis In the tests for enteric dissolving dosage form of aspirin on the release of hydrochloric acid for 2 hours shall not exceed 10%, in alkaline solution after 3 h of release should reach at least 90%. What range should have a method of determination of acetylsalicylic acid? 80-100% of the nominal content 70-130% of the nominal content 0-110% of the nominal content from almost 0% to 120% of the normalized content 85-115% of the nominal content If the forecast uncertainty final analytical operations pursued in spectrophotometric defined uncertainty: Chemical glassware pipettes scales volumetric flask Spectrophotometer In studying the metrological characteristics of the "linearity" calculated the correlation coefficient whose value should be: From -1 to +1 From -3 to +3 Less 1 D. E. From -2 to +2 More 2