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Stefan Stamm
The long-term aim of my research is to understand the regulation and
function of alternative splicing. The sequencing of the human genome has
demonstrated the existence of only 22-35,000 genes, far less than previously
anticipated. Since the transcriptome consists of at least 250,000 molecules,
pre-mRNA processing events in humans contribute more significantly to
human gene expression and regulation than previously thought. Recent array
data show that more than 90% of all human genes are alternatively spliced.
Changes in alternative splice site selection are often characteristic for
developmental stages or certain cell types, such as neurons or cells derived
from the immune system. Alternative splicing pathways are not static, but can
change according to environmental cues. Therefore, alternative splicing
emerges as one of the most important mechanism to regulate gene
expression. In order to understand this regulatory function, I am connecting
results obtained by molecular biological techniques and bioinformatics with
physiological events.
Stefan Stamm studied Biochemistry in Hannover and received his Ph.D. in
1992 from the University of Hannover. The work for the PH.D. thesis was
performed in the United States, at the Mount Sinai Hospital in New York City
(1989-91) and Cold Spring Harbor (1991-1992). His stay in the United States
was sponsored by the Gottlieb Daimler and Karl Benz Stiftung. He continued
his post doctoral studies in Cold Spring Harbor, NY, from 1992-1994 in the
laboratory of David Helfmanm which was financed by a stipend from the
Deutsche Forschungsgemeinschaft. He then accepted the position of an
independent group leader (“Nachwuchsgruppenleiter”) at the Max-Planck
Institute for Neurobiology in Martinsried/Munich, where he worked from
1995-2001. In 2001 he became Professor for Biochemistry and molecular
medicine at the University of Erlangen-Nuremberg. In 2007 he moved to the
University of Kentucky, where is now Associate Professor.
Stefan Stamm authored more than 105 papers in peer reviewed journals
(including senior authorships in Science, and Proc. Natl. Acd. Sci. USA). In
addition, he obtained or applied for 5 patents. He co-organized many
international conferences and was invited keynote speaker. He is reviewer for
the Deutsche Forschungsgemeinschaft (DFG), the Human Frontier Science
Program
(HFSP),
the
National
Science
Foundation
(NSF),,
the
Volkswagenstiftung, the Israel Science Foundation (ISF), the Medical Resarch
Council (MRC), The Wellcome Trust, the Alzheimer's Association and the Cystic
Fibrosis Research Foundation. He serves on the editorial board of the FEBS
Journal and is ad hoc reviewer for more than 30 leading jounals. He
coordinated several internationally funded projects among them: European
Network of Excellence on alternative splicing (EURASNET), where he was cocoordinator and a German-Israeli Project (alternative splicing of ion channels).
Stefan Stamm short CV
Address:
Department of Molecular & Cellular Biochemistry
Biomedical Biological Sciences Research Building
University of Kentucky
741 S. Limestone, B278
Lexington, Ky 40536-0298
e-mail:
[email protected]
Phone:
+1 859 323 0896
Fax:
+1 859 257 2283
www:
http://www.stamms-lab.net
Place of Birth:
Saarbrücken, Germany
Family status:
3 children, married
Education:
1983
Abitur in Saarbrücken (1.0, on a scale from 1 to 6)
1983-1988
Study of Biochemistry at the University of Hannover, Germany
1988
Masters (=Diplom), (sehr gut=summa cum laude)
1992
Dr. rer. nat. (sehr gut =summa cum laude), University of Hannover,
Work for the Ph.D. was performed at Mount Sinai Hospital, New York and
Cold Spring Harbor, New York
Postdoctoral Training:
1992-1994
Postdoctoral Fellow at the Cold Spring Harbor Laboratory
Academic Appointments:
1995-2001
Independent group leader at the Max-Planck Institute for Neurobiology
2001-2007
Associate Professor (C3) at the University of Erlangen-Nürnberg
2007- Associate Professor University of Kentucky