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Teaching Plan
by
School of Basic Medicine
Peking Union Medical College
Department:
Pharmacology
Lesson:
Pharmacology
Name of Teacher: Dechang Zhang
Professional Title:
1
Professor
Teaching
topic：
Introduction to Pharmacology
Pharmacodynamics
Teaching
subjects：
Hours：
Medical Students
Teaching
aims:
1.
3 hours
2.
3.
To master the conception, the basic rule and affecting factors of
pharmacodynamics; excitation and inhibition；Local action and
general action；Selectivity；Clinical effect including therapeutic
action and untoward reaction; parameter of graded and quantal
response.
To be familiar with conception of graded and quantal response；
dose-response curve of graded and quantal ones; parameters of
graded and quantal response.
To understand Drug receptor conception; parameters of
competitive antagonism; the conception, interaction and parameters
of competitive antagonism.
Teaching
content:
Chapter 2 Pharmacodynamics
Emphases:
1.
2.
3.
4.
5.
The conception of pharmacodynamics
Untoward reaction of drug
The parameter of graded and quantal response
The theory and parameter of drug-receptor interaction
The parameters(pA2) of competitive antagonism
Difficult
Points:
1.
2.
mechanism of action in receptor theories
The parameters(pA2) of competitive antagonism
Evaluation
methods
Evaluation from students
References
1..Rang and Dale’s Pharmacology 6th edition Rang HP, Dall MM,
Ritter JM, Flower RJ , Churchill Livingstong, Elsevier, 2007
2.Golan DE， et al. Principle of Pharmacology, The pathophysiologic
basis of drug therepy 2nd ed. 2008
3.Farrell SE, Priciples of Pharmacology, Workbook 2nd ed, 2008
Lippincott.
4.Finlel R.,et al. eds, Lippincott’s Illustrated Reviews: Pharmacology
4th ed. Lippincott 2009
5. 杨世杰主编《药理学》（8 年制规划教材），人民卫生出版社，2005
年
6. 张德昌主编《医学药理学》中国协和医科大学出版社 1998 年
2
Teaching
aims
Comprehend
Master
Master
Master
Master
Comprehend
Comprehend
Contents
Methods
Chapter
2
PHAMACODYNAMICS
Overview
Conception
of
pharmacodynamics
Basic Action of Drug:
Excitation
and
Inhibition；Local action
and general action ；
Selectivity ； therapeutic
action and untoward
reaction.
Conception and curve of
graded
and
quantal
response
Parameter of graded and
quantal response
Conception
of
mechanism of action of
drugs
Drug receptor conception
TimeRemarks
assignment
5 min
5 min
40 min
Media mix,
explanation,
question-raising
and discussion
case study
15 min
15 min
10 min
10 min
Comprehend
Theory and parameter of
drug-receptor interaction
20 min
Master
The conception of
competitive antagonism
10 min
Master
Interaction and
15 min
parameters of
competitive antagonism
The summary and review
5 min
What is bioavailability? What is first-pass effect? What is Css, T1/2?
Reflection
questions
References
1..Rang and Dale’s Pharmacology 6th edition Rang HP, Dall MM,
Ritter JM, Flower RJ , Churchill Livingstong, Elsevier, 2007
2.Golan DE ，
et al. Principle of Pharmacology, The
pathophysiologic basis of drug therepy 2nd ed. 2008
3.Farrell SE, Priciples of Pharmacology, Workbook 2nd ed, 2008
Lippincott.
4.Finlel R.,et al. eds, Lippincott’s Illustrated Reviews: Pharmacology
4th ed. Lippincott 2009
5. 杨世杰主编《药理学》（8 年制规划教材），人民卫生出版社，
2005 年
6. 张德昌主编《医学药理学》中国协和医科大学出版社 1998 年
3
Chapter 2 PHAMACODYNAMICS
ⅠDefinition:
1. etiological treatment：
symptomatic treatment：
2. adverse reaction：
1）side reaction：
2）toxic reaction：
3）residual effect：
4）withdrawl reaction：
5）allergic reaction：
6）Idiosyncratic reaction：
Ⅱconcentration-effect relationship:
1. graded resonse：
2. all-or-none response：
3. Therapeutic index (TI)
TI = LD50/ED50, LD5/ED95
Dose-response of drug action:
4. receptor and drug interaction
affinity:
intrinsic activity:
5. Agonist, Antagonist, Partial Agonist
4