Download 415 MT2

CLS 415 virology
Mid term 2
----------------------------------------------------------------------------------------------------------1- Which of the following laboratory tests can be used to make a specific diagnosis of
current hepatitis A virus (HAV) infection?
A. Elevated levels of serum aminotransferase enzyme
B. High titer of IgG anti –HAV in serum.
C. High titer of IgM anti-HAV in serum.
D. Detection of HBsAg in serum.
E. Detection of anti-HBsAg in serum.
2- All of the following statements about viral hepatitis are true EXCEPT:
A. Hepatitis A virus is most commonly associated with acute, self –limiting disease and
low mortality.
B. Hepatitis A virus is commonly transmitted parenterally and blood-bank workers are at
increased risk of disease.
C. Hepatitis B virus may be sexually transmitted
D. Liver cancer has been associated with Hepatitis B virus
E. Hepatitis B virus & Hepatitis C virus are more likely to produce chronic infections
than hepatitis A virus
3- The following are characteristic of Epstein – Barr virus infection EXCEPT :
A. primary infection causes infectious mononucleosis
B. congenital infection leads to early B – cell lymphoma
C. leads to cervical carcinoma
D. virus replicates in pharyngeal epithelial cells
E. high Ig A titer are seen in persons with nasopharyngeal carcinoma
4- Which of the following is NOT a characterisitic of cytomegalovirus infection :
A. CMV infections may be identified histologically by the presence of both intracellular
& cytoplasmic inclusions
B. cytotoxic T – cell response are lower in immunocomprised patients , and those with
the lowest response are at the greatest risk of CMV reactivation
C. antiviral chemotherapy has reduced the frequency of CMV pneumonia after
transplantation in transplant recipient who receive organs from CMV seropositive donors
D. persons who are seropositive for CMV no longer secrete virus
E. congenital CMV infection can be indolent & can be responsible for hearing loss
5- Which one of the following statements concerning hepatitis A and hepatitis B viruses
is true?
A. both viruses have single stranded RNA chromosomes.
B. both viruses commonly produce carrier states and chronic disease .
C. many infections with either virus are asymptomatic.
D. both viruses are associated with hepatocelluar carcinoma.
E. there are no vaccines for either virus.
6-The following statements pertaining to Cytomegalovirus are true EXCEPT :
A. prevention of CMV infections can be achieved by administering blood products &
organs only from CMV seronegative donors to organ transplant patients who are CMV
seronegative
B. Infectious mononucleosis caused by CMV is heterophil antibody test positive
C. The isolation of CMV from a broncheoalveolar lavage specimen in a bone marrow
transplant recipient requires therapy with the antiviral agent ganciclovir
D. The isolation of CMV from the urine of a newborn suggests congenital CMV infection
7-The following statements are TRUE about Hepatitis B virus EXCEPT :
A. both double stranded & single strand DNA are found in the virion
B. chronic carriers possess Ab to the core Ag
C. screening of all potential blood donors for the Hepatitis B surface Ag & Ab to the
hepatitis B core Ag has eliminated hepatitis associated with blood transfusion
D. HBs Ag free in serum is the infectious form of HBV
8- From the following circulating B virus markers , which one is found in all patient who
are chronic carriers ?
A. HBs Ag
B. HBc Ag
C. HBe Ag
D. Anti- HBs
E. Anti- HBe
9- Which of the following is NOT a characteristic of hepatitis C ?
A. Most infections occur from nonparenteral source
B. virus can be transmitted via organ donation
C. Ag varitation within the envelope gene is a mechanism by which the virus persists
D. strains resistant to interferon have been described
E. the envelope gene of hepatitis C appear to be necessary for the efficient replication of
hepatitis D virus
10- Adenoviruses causes :
A. respiratory infections
B. gastroenteritis
C. acute hemorrhagic cystitis
D. conjunctivitis
E. all of the above
11- Which of the following viuses has a DNA genome?
A. adenovirus.
B. astrovirus.
C. influenza virus.
D. HCV
E. HGV
12- The causative agent of molluscum contagiosum is a:
A. parvovirus
B. poxvirus
C. herpesvirus
D. adenovirus
E. rhinovirus
13- Certain genotypes of human papilloma virus are associated with which of the
following malignancies
A. Burkitt's lymphoma.
B. cervical carcinoma.
C. hepatocellular carcinoma.
D. kaposi's sarcoma.
E. non-hodgkin's lymphoma.
14- Which viral agent was the first to be eradicated?
A. Polio
B. Measles
C. Smallpox
D. Rift Valley Fever
E. Scrapie
15- A concern if it infects a pregnant women in the first trimester :
A. HHV - 6
B. HHV – 7
C. HHV – 8
D. Coxsackie B – 4 Virus
E. Parvovirus B – 19
16- Associated with Kaposi sarcoma in Ungandan children :
A. HHV - 6
B. HHV – 7
C. HHV – 8
D. Coxsackie B – 4 Virus
E. Parvovirus B – 19
17-. The major etiologic agent of roseola infectiousum :
A. HHV – 6
B. HHV – 7
C. HHV – 8
D. Coxsackie B – 4 Virus
E. Parvovirus B – 19
18- concern if it infects a child with sickle cell anemia :
A. HHV - 6
B. HHV – 7
C. HHV – 8
D. Coxsackie B – 4 Virus
E. Parvovirus B – 19
19- Characteristics of varicalla zoster virus include all of the following Except:
A. common childhood illness with vesicular lesions that are clustered in the face and
neck area of children.
B. can be found latent in thoracic nerve root ganglia.
C. initial infection of the mother in pregnancy can result in congenital infection in the
infant .
D. reactivation can cause painful skin lesions which may persist for extended time
periods in patients with AIDS .
E. all the above are correct.
20- HSV -1 and HSV-2 share the following characteristics except :
A. Ag
B. DNA
C. Mode of transmission
D. site of latency in nerve ganglia
E. all the above are correct.
True or false :
1.
2.
3.
4.
All herpes viruses can be isolated in tissue culture
In EBV infectious mononucleosis many large atypical lymphocytes are found.
All hepatitis viruses are enveloped (ether sensitive)
HGV require HBV for its replication.
5. RIBA is used for diagnosis HCV infection during the early seronegative phase
and in infants .
6. Adenovirus have tendency to become latent in lymphoid & nerve tissues .
7. Papova virus can be isolated in tissue culture cells
8. JC virus causes cystitis, nephropathy and severe renal allograft dysfunction
9. Polyoma virus causes hemorrhagic cystitis
10. HDV vaccine is effective for HBV also