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Neuro: 1:00 - 2:00 Scribe: Brittney Wise Monday, April 6, 2009 Proof: Laura Adams Dr. Zehren Structures of the Cardiovascular System Page 1 of 14 NOTE: The notes that are found under the slide in the power point have been copied and pasted under each slide in the transcript (they are italicized). I. II. III. IV. V. Introduction [S1]: [S2] General Remarks [S3] Components of the Cardiovascular System - Includes heart, arteries, vein, and capillaries. [S4] Pattern of Blood Flow Through Heart - Not going to discuss this right now. He will cover this in the next hour. [S5] Arteries carry blood away from the heart a. Arteries are defined as vessels carrying blood away from the heart. Although they usually carry oxygen/nutrient rich blood, this is not always the case. The pulmonary arteries would be a major exception (shown in blue). Pulmonary arteries carry blood away from the heart but they have unoxygenated blood. b. Arteries are said to branch. The lumen/diameter of the vessel gets smaller as you get to the level of the arterioles which leads into the capillary beds. c. 1. Arteries are defined as vessels carrying blood away from the heart. Arteries progressively branch into smaller and smaller vessels. Note that although most arteries carry O2 rich blood to the tissues of the body, the pulmonary trunk and arteries carry O2 poor blood to the lungs. VI. [S6] Veins carry blood toward the heart a. Veins are defined as vessels carrying unoxygenated blood toward the heart. The pulmonary veins are carrying oxygenated blood back to the heart. b. Veins have tributaries not branches and they get larger and larger as they get closer to the heart. c. Veins in the limbs are characterized by the presence of valves which ensure that blood only flows to the heart. Other veins, like the hepatic portal vein for example, has no valves in it. So, veins may or may not have valves, it depends on whether or not the venous flow has to work against gravity. d. 1. Veins are vessels that carry blood toward the heart. Veins have tributaries (not branches). Like the tributary system of a river, small veins unite to form larger veins, which unite to form still larger veins, etc. Although most veins carry O2 poor blood back to the heart, the pulmonary veins (not labelled) are an exception. VII. [S7] Structure of Blood Vessels VIII. [S8] Distinguishing Arteries from Veins a. All blood vessels (with the exception of capillaries) have 3 layers in their walls. If we look at an artery and a vein of about equal diameter we see that each has i. Tunica intima (tunica = coat) 1. the innermost coat and is primarily endothelium 2. the integrity of this endothelium is important; if it’s torn that will interrupt blood flow and can lead to a clot/thrombus formation ii. Tunica media (middle layer) is smooth muscle which controls the diameter of the lumen and therefore the blood pressure and the amount of peripheral blood reaching some area iii. Tunica adventitia (outermost coat) is a connective tissue coat 1. In this layer there are both vessels and nerves 2. Many of the vessels that are here are going to the smooth muscle of the tunica media, making these autonomic fibers controlling the tone in that muscle 3. There are also blood vessels in the tunica adventitia which supply the vessels itself. Unless the vessel has an extremely thin wall like a capillary where it can get its own oxygen and nutrients directly from the blood, vessels need their own blood supply and that is called the vasa vasorum (this is an important term that means vessels of the vessel) b. The thickness of the tunica media is the easy way that you can tell arteries and veins apart. Arteries have a thicker tunica media than veins which gives them a much more rigid wall. c. Capillaries are the vessels that unite the smallest arteries (arterioles) and the smallest veins (venules). d. Capillaries only have a tunica intima, only an endothelial coat, which facilitates the exchange of oxygen and nutrients. The exchange occurs at the level of the capillary beds. They form networks or a capillary bed (shown in the diagram). 1. Arteries and veins have three coats or tunics: Tunica intima – consists of an endothelium (lining of flattened cells) and a thin layer of connective tissue. The integrity of the endothelium is essential to normal blood flow; if injured blood cells stick at site of injury and form a clot. Tunica media – consists of a layer of smooth (involuntary) muscle. Contraction of the smooth muscle regulates the size of the lumen of the vessel and helps determine blood pressure and blood flow. Tunica adventitia – consists of a layer of connective tissue. Adventitia contains nerves that innervate the smooth muscle and small vessels (vasa vasorum) that supply the cells of the vessel wall which are too far removed from blood in the vessel itself to receive nutrition. Neuro: 1:00 - 2:00 Scribe: Brittney Wise Monday, April 6, 2009 Proof: Laura Adams Dr. Zehren Structures of the Cardiovascular System Page 2 of 14 2. The structural difference between arteries and veins is primarily the degree of development of the tunica media. For any given size, the tunica media in an artery is thicker than in a vein. (The more rigid wall of an artery compared to the thinner, more collapsed wall of a vein usually makes it easy to distinguish arteries from veins in the lab.) 3. In addition to arteries and veins, there are capillaries which unite the smallest arteries (arterioles) with the smallest veins (venules). Capillaries form interconnecting networks (capillary beds) where O2 and nutrients leave the blood stream and enter the extracellular spaces to supply tissues, and where CO2 and wastes from the tissues enter the blood stream. Capillaries consist only of the tunica intima in order to allow this interchange to occur. 4. Arterioles are the most important factor in regulating peripheral blood flow (their tunica media is composed almost entirely of smooth muscle and so they are particularly contractile). If too many arterioles are contracted (or so diseased that they can’t relax), there is an increase in blood pressure; if too many are relaxed, there is a decrease in blood pressure. 5. Can discussion the significance of arteriovenous anastomoses (not shown) at this point. An arteriovenous anastomoses consists of a vessel which directly connects an arteriole w/ a venule. This shunting vessel is equipped w/ a well-developed muscular wall which is capable of completely closing this channel, thereby forcing blood to pass through the capillary bed, or, contrarily, of opening wide and short-circuiting the capillary bed. These anastomoses are functionally useful b/c they provide a means whereby a part of the body can receive the proper amount of blood needed at a particular time (for example, during a meal the anastomoses are closed, allowing increased blood flow to the capillary beds of the GI tract so nutrients can be absorbed, but between meals the anastomoses are open, thus diverting blood to other areas where it may be needed more (eg, muscles). IX. [S9] Arterial System X. [S10] Head and Neck a. With regard to the head and neck the chief arteries are the common carotids and the vertebral arteries. Remember that the right common carotid and the right subclavian artery branch off the brachiocephalic artery or trunk which itself comes from the aortic arch. b. On the left side the common carotid and subclavian arteries are independent branches that branch directly off the aortic arch. XI. [S11] Common Carotid Arteries and Vertebral Arteries a. If we go and look at the distribution of the internal carotid arteries and vertebral arteries they are mainly involved in supplying the brain. b. Both the ICA’s and the vertebral arteries will come together at the base of the brain and form the arterial Circle of Willis and this is what supplies the brain. i. ICA - branches off and goes up through the temporal bone of the skull ii. Vertebral arteries - branch off of the subclavian artery, pass through the transverse foramina of the cervical vertebrae, merge from the uppermost cervical vertebrae, and pass into the skull through the foramen magnum c. The ICA has no branches in the neck and the only branch it has that distributes outside the head is the opthalamic artery. d. 1. The head & neck receives its blood supply primarily from the two common carotid aa and the two vertebral aa. 2. On the right side of the body, the common carotid a. arises from the brachiocephalic trunk (which itself arises from the aortic arch in the thorax). On the left side, the common carotid a. arises independently from the aortic arch. 3. Likewise, the right subclavian a. (which supplies the upper limb) arises from the brachiocephalic trunk whereas the left subclavian a. arises independently from the aortic arch. XII. [S12] Blood Supply to the Brain – (shared most of its information with slide 11) a. 1. The brain receives its arterial blood from the two internal carotid arteries (ICA) and the two vertebral arteries. 2. The ICAs arise from the common carotid aa. and have no branches in the neck. The ICAs enter the skull through the carotid canals in the petrous temporal bones. 3. The vertebral arteries arise from the subclavian aa. in the root of the neck. They enter the skull through the foramen magnum. 4. At the base of the brain the ICAs and vertebral arteries are involved in the formation of the arterial circle (of Willis), which supplies the brain. XIII. [S13] External Carotid Artery and It’s Branches (“SALFOPSM”) a. This has 8 branches in the neck and gets its name because it supplies to the outside of the skull. b. You remember the names of these branches (SALFOPSM). Remember to look at these on your own again. Neuro: 1:00 - 2:00 Scribe: Brittney Wise Monday, April 6, 2009 Proof: Laura Adams Dr. Zehren Structures of the Cardiovascular System Page 3 of 14 c. 1. The COMMON CAROTID A. splits into int. and ext. carotid aa. at the superior border of the thyroid cartilage (CV4). 2. The EXT. CAROTID A. distributes primarily to the outside of the skull. It lies anterior to the internal carotid a. 3. The ext. carotid a. has 8 branches . The mnemonic (nonsensical, but perhaps useful) for remembering these branches is S. A. L. F. O. P. S. M. --1. Superior thyroid a. 2. Ascending pharyngeal a. 3. Lingual a. 4. Facial a. 5. Occipital a. 6. Posterior auricular a. 7. Superficial temporal a. 8. Maxillary a. (Whew !). These arteries distribute to the areas their names suggest. XIV. [S14] Upper Limb XV. [S15] Subclavian Artery and It’s Continuation a. The chief artery of the upper limb is going to be the subclavian artery (artery shown in blue). The subclavian artery will arch over the 1st rib (it is directly against the rib and can be compressed against it) and past the 1 st rib it changes names and becomes the axillary artery. b. The axillary artery has numerous branches that we won’t name that supply the axillary or armpit region. It then continues until it reaches the lower border of this muscle, the teres major muscle, and it will change its name again and will become the brachial artery because now it’s in the arm or brachium. i. The brachial artery also has many branches and the only one that we will point out is the profunda brachii artery or deep brachial artery. This is a fairly large artery that winds around behind the humorous and supplies the posterior compartment of the arm, the muscles, and so forth. Since it is directly against the bone it can easily be injured if you shatter your humorous at the mid-shaft level. c. 1. The subclavian a. (BLUE) is the chief artery supplying the upper limb. (x)On the R side it arises from the brachiocephalic trunk; on the left side from the aortic arch. 2. The subclavian a. arches over the 1st rib (on both sides) to become the axillary a., which lies in the axilla (armpit). At the lower border of the teres major m., the axillary a. changes its name to brachial a. (brachium = arm). The brachial a. descends in the arm until it reaches the cubital fossa in front of the elbow, where it divides into radial and ulnar aa. 3. The subclavian a. gives branches to the scapular (shoulder) region; namely the transverse cervical and suprascapular aa. The axillary a. also gives branches to the scapular region; namely the subscapular a. Since these branches of the subclavian and axillary aa. anastomose in the scapular region, they provide a collateral circulation to the upper limb should the main arterial trunk become blocked between the thyrocervical trunk of the subclavian a. and the origin of the subscapular a. 4. The brachial a. gives off several named branches, the largest of which is the profunda brachii a. (= deep brachial a.). This artery supplies the posterior compartment of the arm. (x)The brachial a. also gives off branches involved in the anastomoses around the elbow joint, as mentioned earlier. XVI. [S16] Radial and Ulnar Arteries a. The brachial artery will continue down in front of the elbow in the cubital fossa region where it will divide into 2 terminal branches, the radial and the ulnar. The radius is the bone on the lateral side of the forearm and the ulna on the medial side. i. Both of these have branches that will supply structures in the forearm. ii. They both enter the palm of the hand and in the palm of the hand they form 2 arches: 1. The superficial palmar arch which is formed primarily by the ulnar artery. 2. The deep palmar arch which is formed primarily from the radial artery. iii. From these arches precede other arteries that supply the digits. b. 1. The radial and ulnar arteries are terminal branches of the brachial a. The radial and ulnar aa. descend on the radial (thumb side) and ulnar (little finger side) of the forearm to reach the hand. (x)(Note that the common interosseous a., a branch of the ulnar a., splitting into ant. and post. interosseous aa. which supply the ant. and post. compartments of the forearm.) 2. In the hand, the radial and ulnar aa. anastomose with each other to form the superficial and deep palmar arches. From these arches proceed branches which supply the digits. XVII. [S17] Thorax XVIII. [S18] Blood Supply to Thoracic Wall a. The thoracic wall itself is supplied by the intercostal arteries. These arteries run between the ribs. Neuro: 1:00 - 2:00 Scribe: Brittney Wise Monday, April 6, 2009 Proof: Laura Adams Dr. Zehren Structures of the Cardiovascular System Page 4 of 14 i. Posterior intercostal arteries mostly come directly off the thoracic aorta as segmental branches that run laterally and supply the tissues of the thoracic wall. ii. The anterior intercostals arteries arise from the internal thoracic that comes off the subclavian. b. The upper intercostal spaces receive their anterior intercostal arteries directly off the internal thoracic. c. Lower down in the thorax, the lower intercostal spaces get their anterior intercostal arteries from a branch of the thoracic called the musculophrenic. d. What’s important to notice is that these anterior and posterior intercostals arteries anastomose with each other in the intercostal space. e. THE BLOOD SUPPLY TO THE THORACIC WALL IS CHIEFLY BY THE ANT. & POST. INTERCOSTAL AA. Most of the POST. INTERCOSTAL AA. arise as direct segmental branches of the descending thoracic aorta. The ANT. INTERCOSTAL AA. to the upper intercostal spaces originate from the int. thoracic a.; those to the lower spaces originate from the musculophrenic a. The ant. and post. intercostal aa. ANASTOMOSE in an intercostal space. This is clinically important (see later slide re: coarctation of aorta). XIX. [S19] Coarctation of Aorta a. This is a condition where the aorta is severely constructed just beyond the point where the left subclavian branched off. b. It’s a congenital deformity. c. You see the severe constriction and you might ask if this is compatible with life and it is. The reason that it is, is because you have collateral circulation, essentially a bypass around that obstruction. i. What happens over time is that the subclavian arteries begin to enlarge, the internal thoracic arteries which are branches off the subclavian begin to enlarge, and the anterior and posterior intercostal arteries begin to enlarge; the flow in the anterior intercostals arteries is lateral, away from the sternum (which is a normal pattern of blood flow), but then when they anastomose with the posterior intercostals there is a reverse blood flow in the posterior intercostal arteries. ii. The posterior intercostals carry the blood back to the aorta distal to where the occlusion is, so there is just a bypass to the point of obstruction allowing the lower part of the body to get adequate blood supply. Over time these intercostal arteries get so large that they can be palpated on the chest wall and the pulsations of those intercostal arteries can be felt and they can also erode the ribs as they get larger. iii. Eventually this can be corrected surgically but a person can live for a number of years with this condition. d. 1. In COARCTATION OF THE AORTA, a congenital condition in which the aortic arch is severly constricted, the intercostal aa. may become greatly enlarged and provide for a collateral circulation to the body distal to the point of constriction. 2. This type of coarctation is compatible w/many years of life b/c the collateral circulation carries blood to the thoracic aorta inferior to the stenosis. The collateral vessels may become so large that they cause notable pulsation in the intercostal spaces and erode the adjacent surfaces of the ribs, which is visible in chest x-rays. (COA, 5th ed., p. 175). XX. [S20] Blood Supply to Heart (Coronary Arteries) a. We will talk about the details of this in the next hour (so you can skip this slide and come back to it next hour). XXI. [S21] Pulmonary Trunk and Arteries a. He wanted to reiterate that there are 2 pulmonary arteries that spring from the pulmonary trunk which comes off the heart. The right and left pulmonary arteries divide sort of like a “T” just below the concavity of the aortic arch, going into the hialis (spelling?) of the lung on either side. b. 1. The pulmonary trunk arises from the R ventricle and divides beneath the aortic arch into R and L pulmonary aa. 2. The pulmonary arteries carry UNOXYGENATED blood to the lungs (thus shown in blue). XXII. [S22] Intrapulmonary Blood Circulation a. If you look at a close up view, these little sac like structures are the alveoli where gas exchange occurs. They are extremely thin walled. At each alveolus there is a capillary plexus aka an alveolar plexus. You can see that the pulmonary artery carries unoxygenated blood to the alveoli. b. After oxygenation the blood is collected via tributaries to the pulmonary veins which then return blood to the heart. c. These alveoli appear on what are called respiratory bronchioles. Proximal to the respiratory bronchioles where there are no alveoli, those parts of the lung receive their own special blood supply. There is a special bronchial circulation in addition to pulmonary circulation. d. So, the non-respiratory parts of the lung, that is that parts that don’t have alveoli, need their own nourishment and oxygen supply and that is supplied by the bronchial arteries which carry O2/nutrient rich blood to them and bronchial veins which return that blood back to the systemic circulation. e. 1. Branches of pulmonary a. (blue) carry unoxygenated blood to the capillary plexuses on the alveoli. Neuro: 1:00 - 2:00 Scribe: Brittney Wise Monday, April 6, 2009 Proof: Laura Adams Dr. Zehren Structures of the Cardiovascular System Page 5 of 14 2. The CAPILLARY PLEXUSES ON THE ALVEOLI are where gas exchange occurs. Oxygenated blood is returned to the heart via pulmonary vv. (red) 3. The nonrespiratory tissues of the lung (parts of lung that don’t have alveoli) are supplied by the bronchial vessels (note bronchial a., bronchial v. not shown). XXIII. [S23]Abdomen XXIV. [S24] Arteries of Anterior Abdominal Wall a. The vessels of the abdominal wall: there are 4 major arteries that supply the anterior abdominal wall and they are shown here. i. The 2 terminal branches of the internal thoracic called the superior epigastric and the musculophrenic arteries that are coming in from above. ii. Coming in from below there is an inferior epigastric and a deep circumflex iliac artery which are both branches of the external iliac. b. Again, these anastomose with each other in the anterior abdominal wall. c. 1. The chief arterial supply to the anterior abdominal wall is the superior epigastric a. and musculophrenic a. (both brs. of the int. thoracic a.), and the inferior epigastric a. and deep circumflex iliac a. (both brs. of the ext. iliac a.). 2. Lesser contributions come from the lower intercostal aa., subcostal a., and lumbar aa. (shown in the flank region but not labeled). XXV. [S25] Arteries of Posterior Abdominal Wall a. We see here the major vessel is the abdominal aorta which continues from the thoracic aorta. b. It ends about the L4 vertebral level by dividing into the 2 common iliac arteries. c. The branches of the abdominal aorta are usually classified as either being paired or unpaired, and either parietal or visceral. i. Parietal just means the same thing as somatic; it means that it supplies a structure on the body wall. Visceral means that it goes to an organ. d. The chief parietal branches of the abdominal aorta would be the inferior phrenic arteries, which come off almost immediately as it enters the abdomen and supply the diaphragm, and then 4 pairs of lumbar arteries. These lumbar arteries are segmental branches which are serially homologous with the intercostal arteries at a higher level and they run laterally and supply the posterior abdominal wall. e. The visceral arteries of the abdominal aorta, the paired visceral arteries, would include the renal arteries which are going to the kidneys, and just below the renal arteries there is this pair of very slender arteries termed the gonadal arteries (also known as the testicular or ovarian arteries). These gonadal arteries either descend to the scrotum to supply the testis or to the ovus, (where they supply the ovaries. These gonadal arteries arise high up on the posterior abdominal wall because during development the gonads descend and they drag their nerve and blood supply with them (this is the reason for the high origin of these vessels). f. There is one other pair of visceral arteries that arise directly from the abdominal aorta and they are known as the middle suprarenal arteries. i. These are small arteries and they go to the suprarenal gland which is an endocrine gland and it has a tremendously rich blood supply. ii. The middle suprarenal artery is just one of many suprarenal arteries. There are a whole series of superior renal arteries which come off the inferior phrenic and there are usually a couple of inferior suprarenal arteries which come off the renal artery. iii. So, the superior and inferior suprarenal arteries supplement the middle suprarenal artery, but only the middle suprarenal is the correct branch off the aorta. g. 1. The BRANCHES OF THE ABDOMINAL AORTA MAY BE CLASSIFIED as paired vs. unpaired and parietal vs. visceral. The PAIRED PARIETAL BRANCHES include the inf. phrenic aa. (to diaphragm, the roof of the abdomen) and the first four pairs of lumbar aa. (to post. abdominal wall). (X)The subcostal aa. also supply the post. abdominal wall, but they arise from the thoracic aorta. 2. The only UNPAIRED PARIETAL BRANCH is the median sacral a. (shown but not labelled). 3. The PAIRED VISCERAL BRANCHES supply viscera that lie on (or began their embryological development on) the posterior abdominal wall. They include the middle suprarenal aa., the renal aa. and the "gonadal" aa. (either testicular or ovarian). The gonadal aa. are slender branches which descend to reach the ovaries (in the pelvis) or the testes (in the scrotum). (x) The high origin of the gonadal aa. from the aorta is due to the fact that embryologically the gonads begin development in the upper lumbar region and later descend to their final position, dragging their blood supply with them. In addition to the middle suprarenal a., each suprarenal gland receives numerous sup. suprarenal aa. (from the inf. phrenic a.) and one or more inf. suprarenal aa. (from the renal a.). A rich blood supply is characteristic of endocrine glands. 4. The UNPAIRED VISCERAL BRANCHES are the celiac trunk, sup. mesenteric a. and inf. mesenteric a. (shown but not labelled). These arteries supply the gastrointestinal tract. Neuro: 1:00 - 2:00 Scribe: Brittney Wise Monday, April 6, 2009 Proof: Laura Adams Dr. Zehren Structures of the Cardiovascular System Page 6 of 14 5. THE AORTA TERMINATES AT THE LEVEL OF THE FOURTH LUMBAR VERTEBRA BY DIVIDING INTO THE TWO COMMON ILIAC AA. (x)(This division is at the highest level of the iliac crests, or ~ 2.5 cm inferior to the umbilicus.) XXVI. [S26] Arteries of Gastrointestinal Tract a. In addition to all these arteries, we have 3 unpaired visceral arteries that come right off the front of the aorta. These are the arteries that supply the GI tract: i. celiac artery ii. superior mesenteric artery (SMA) iii. inferior mesenteric artery (IMA). 1. These are all unpaired and they all go to the GI tract. b. Developmentally, the gut tube is divided into 3 parts (foregut, hindgut, and midgut) and each of these arteries is associated with the foregut, midgut, and hindgut. c. When we take up the GI tract we will go into the branches of all of these arteries and the exact areas that they supply but right now just appreciate that there are 3 visceral arteries supplying the different parts of the embryonic gut. d. 1. The arteries supplying the GI tract are the three unpaired visceral branches of the abdominal aorta; namely the celiac trunk, the SMA and the IMA. Each of these arteries supplies a portion of the embryonic gut tube. 2. The celiac trunk supplies derivatives of the embryonic foregut; (x) namely the abdominal pt. of the esophagus, the stomach, the proximal part of the duodenum, the liver and gall bladder, the pancreas, and the spleen (not part of the foregut, however). 3. The SMA supplies the derivatives of the embryonic midgut; (x) namely the distal part of the duodenum, the jejunum and ileum (parts of the small instestine), the cecum and appendix, the ascending colon, and most of the transverse colon. 4. The IMA supplies the derivatives of the embryonic hindgut; (X) namely the distal part of the transverse colon, the descending and sigmoid colon, and the superior part of the rectum. XXVII. [S27] Pelvis and Perineum XXVIII. [S28] Arteries of Pelvis (Internal Iliac Artery) a. The chief artery of the pelvis and perineum is the internal iliac artery which is a branch of the common iliac artery (there is an internal and an external branch of the common iliac artery). b. The internal iliac has numerous branches. This is a very variable system in terms of the pattern of branching. Woodburn’s Anatomy book says that the internal iliac system is the most variable system in the entire body. c. There are differences (not that many) between males and females. i. Basically re: branches of the internal iliac, whether they are direct branches off the internal iliac or indirect, we have some that supply the pelvic viscera that would include arteries such as the … 1. Superior vesical arteries, (vesical in the pelvis means bladder) that supply the upper surface of the bladder 2. Inferior vesical artery which is only found in males; this artery supplies among the prostate gland below the bladder and the seminal vesicle behind the bladder 3. In the female, there are vaginal and uterine arteries 4. Both sexes have a middle rectal artery which goes to the mid part of the rectum d. All of these are pelvic organs that are receiving their blood supply from the internal iliac. e. However, this artery is much more extensive than just the pelvic viscera: i. It has an obturator artery branch which leaves the pelvis and enters the thigh and supplies the medial part of the thigh. ii. It has 2 gluteal arteries (a superior and an inferior) which leave the pelvis and supply the buttocks area, the hip region. iii. There is an Iliolumbar artery which runs back up to supply the lower posterior abdominal wall. iv. There is a lateral sacral artery which gives off branches to supply the contents of the sacral canal v. Finally, is this internal pudendal artery that leaves the pelvis and enters the perineum which is an area between the medial thighs that contains the external genitalia. So, internal pudendal is the chief artery of the perineum having numerous branches itself which are not shown. f. Note that although a male pelvis is shown here, arteries in the female pelvis are, for the most part, similar. 1. The chief artery of the pelvis in both the male and female is the internal iliac a. The internal iliac a. originates from the common iliac a. and descends into the pelvis, where it typically divides into anterior and posterior divisions (shown but not labeled). The branching pattern of the internal iliac a. is very variable. 2. Branches (direct or indirect) of the int. iliac a. that supply pelvic viscera include the superior vesical aa. (to superior aspect of bladder), inferior vesical a. (males only, to fundus of bladder, seminal vesicles, prostate), middle rectal a. (rectum), and uterine and vaginal aa. (females only). Neuro: 1:00 - 2:00 Scribe: Brittney Wise Monday, April 6, 2009 Proof: Laura Adams Dr. Zehren Structures of the Cardiovascular System Page 7 of 14 3. In addition, the int. iliac a. is the chief a. of the perineum (area between the thighs) by means of the internal pudendal a. The internal pudendal a. supplies the erectile tissues of the penis and clitoris as well as other branches. 4. The int. iliac a. also supplies the gluteal region by means of the superior and inferior gluteal aa., the medial aspect of the thigh by means of the obturator a., and the lower part of the posterior abdominal wall by means of the iliolumbar a. Finally, the lateral sacral a. (or aa.) give off spinal branches that supply the contents of the sacral canal and emerge on the dorsum of the sacrum to supply muscles and skin. XXIX. [S29] Lower Limb XXX. [S30] Femoral Artery a. The femoral artery is the major artery of the lower limb. You can see that this is actually a continuation of the external iliac artery. Once the external iliac artery crosses this boundary which is defined by the inguinal ligament (fibrous tissue in the groin area) and passes posterior to that inguinal ligament it changes its name and is now in the thigh and is called the femoral artery. b. The femoral artery has a number of important branches, one is the deep femoral or profunda femoris artery which parallels the femoral artery and gives off these perforating branches. These are arteries which run posteriorly behind the femur and supply the muscles in the posterior compartment of the thigh, mainly the hamstring muscles. c. The other 2 branches of the femoral which are quite important are the medial femoral circumflex or medial circumflex femoral and the lateral circumflex femoral. These arteries encircle the neck of the femur and anastomose with each other. The medial femoral circumflex is of particular importance because the branches coming off of it supply the head and neck of the femur. d. If the neck of the femur is broken, there is a very good chance that the blood supply to the head and neck will be compromised. This can lead to what’s called avascular necrosis of the head and neck of the femur. This is a very common problem in elderly people, especially women with osteoporosis who have weak bones. This is what happens when you hear of elderly people falling and breaking their hip. i. This is somewhat misleading because what usually happens that the neck of the femur brakes first (not the hip bone) and then they fall. Usually (unless the person is lucky) these vessels off the medial circumflex artery that supply the neck and head of the femur will be torn and without adequate blood supply to the head and neck they will become necrotic and this results in a necessary hip replacement. e. 1. The femoral a. is the chief a. supplying the lower limb. It arises as a continuation of the external iliac a., which passes posterior to the inguinal ligament to enter the anterior aspect of the thigh. The femoral a. gives off a large branch, the profunda femoris a. (= deep femoral a.) early in its course. 2. The profunda femoris a. has several branches, including perforating aa. which pass to the back of the thigh to supply the hamstring mm. It also gives off the medial and lateral circumflex femoral aa., which anastomose around the neck of the femur. The circumflex femoral aa. (esp. the medial a.) are the principal blood supply to the head and neck of the femur. When the neck of the femur fractures (common in elderly females “broken hip”), the blood supply to the head of the femur may be compromised and lead to avascular necrosis. XXXI. [S31] Popliteal Artery (Posterior View) a. The femoral artery will continue into the back of the knee joint. It pierces a muscle called the adductor magnus (there is an opening or a hiatus) and it changes its name again and now it is called the popliteal artery. Poplitieal refers to the back of the knee. b. There are also several (4) genicular arteries that come off by the knee joint. c. 1. The popliteal a. lies posterior to the knee joint (in the popiteal fossa). It is a continuation of the femoral a. as it passes through the hiatus in the adductor magnus m. 2. The popliteal a. gives off two medial and two lateral genicular aa. which supply the knee joint. 3. The popliteal a. terminates at the lower border of the popliteus m. by dividing into ant. and post. tibial aa. XXXII. [S32] Arteries of the Leg and Foot a. The popliteal artery will enter the leg and terminate by dividing into anterior and posterior tibial arteries. b. These arteries simply descend in the posterior compartment of the leg or the anterior compartment of the leg and supply the muscles in those 2 compartments. c. The posterior tibial artery will enter the sole of the foot and divide and divide into 2 plantar arteries. Plantar is a term that means sole of the foot. You can see that the lateral plantar artery actually forms a deep arch in the sole of the foot similar to the deep palmar arch in the hand. d. The anterior tibial artery continues in front of the ankle joint and will become the dorsal artery of the foot or the dorsalis pedis artery. e. Often time clinicians will take a pulse of the dorsalis pedis artery to see if the anterior tibial is patent. If it is patent then you should get a good pulse. Neuro: 1:00 - 2:00 Scribe: Brittney Wise Monday, April 6, 2009 Proof: Laura Adams Dr. Zehren Structures of the Cardiovascular System Page 8 of 14 f. 1. The anterior and posterior tibial arteries are terminal branches of the popliteal a. in the popliteal fossa. The anterior tibial a. pierces intraosseous membrane to reach anterior compartment of the leg; posterior tibial a. descends in posterior compartment of leg to supply it. 2. Fibular artery is a branch of the posterior tibial a.; although it remains in the posterior compartment it is the chief blood supply to the lateral compartment of the leg. 3. The dorsalis pedis a. (=dorsal a. of the foot) is the principal a. supplying the dorsum of the foot. It is a continuation of the anterior tibial a. as the latter passes in front of the ankle joint. 4. The medial and lateral plantar aa. supply the sole of the foot. They are the terminal branches of the posterior tibial a. Note that the lateral plantar a. forms an arterial arch deep in the sole. XXXIII. [S33] Venous System XXXIV. [S34] Head and Neck XXXV. [S35] Dural Venous Sinuses a. The cranial cavity is primarily drained by these dural venous sinuses that are embedded in the dura mater. Remember that all these venous sinuses are valveless and they are connected, at least some of them, with veins outside the skull by means of emissary veins, which are tiny veins that penetrate the skull. Like the venous sinuses, the emissary veins are valveless which allows a route for infection to spread from outside the skull to the inside via these emissary veins. b. Eventually this blood will accumulate at the base of the skull and be drained via the IJV. c. Make sure to review this slide on your own. d. 1. The DURAL SINUSES are veins (paired and unpaired) inside the cranial cavity which are embedded in the dura mater. (The dura is shown in green, and is one of the layers that surrounds and protects the brain). They are also valveless. The dural sinuses collect blood from the brain, dura and skull bones and transport this blood toward the jugular foramen (IJV). 2. Note also the emissary vein connecting sup. sag. sinus w/ superficial vein of scalp. (EMISSARY VEINS are those which pass through the skull and connect the dural venous sinuses with extracranial veins . ) Emissary vv. are valveless; hence blood can flow in either direction depending on the pressure gradient. Emissary vv. are clinically significant because they are routes for infection to spread into the cranial cavity and because they provide alternate routes for blood to escape from the cranial cavity. Some emissary vv. are not always present. XXXVI. [S36] Internal Jugular Vein (IJV) and Tributaries a. This shows you the IJV as it descends in the neck. It is the largest veins in the neck. It begins as a continuation of the sigmoid sinus and it ends at the root of the neck by uniting with the subclavian vein. So it’s logical to call that larger vein formed by the junction of the subclavian vein and the IJV the brachiocephalic vein . i. brachio = arm and cephalic=head ii. The brachiocephalic vein drains the upper limb and head on that side. iii. The 2 brachiocephalic veins unite to form the superior vena cava. b. Again there are numerous tributaries of the IJV that you can review on your own. c. The INT. JUGULAR V. (IJV) is the largest vein of the head and neck. It begins at the jugular f. as a continuation of the sigmoid venous sinus inside the skull. It ends at the root of the neck by uniting with the subclavian v. to form the brachiocephalic v. The IJV receives numerous tributaries as it descends. (X) These include the inferior petrosal sinus (which, like the sigmoid sinus, drains the brain), facial v., lingual v., sup. and mid. thyroid vv., pharyngeal vv. and sometimes the occipital v. (as shown here). XXXVII. [S37] Superficial Veins of Head and Neck a. The main ones here would be the facial vein, the anterior jugular vein (draining the front of the neck), and the external jugular vein (has a wide area of distribution. b. The EJV will drain the scalp area, the deep infratemporal area, and even drain the shoulder area via these tributaries it receives down here. c. It finally terminates in the subclavian vein. d. 1. The facial v. is the chief vein draining the face. It usually ends (indirectly) in the IJV. 2. The anterior jugular vv. (paired) descend near the midline of the neck. They end in the ext. jugular vv. 3. The ext. jugular v. descends superficially across the surface of the SCM muscle (the IJV descends deep to the SCM). It drains a wide area including the scalp (superficial temporal v. and posterior auricular v.), infratemporal fossa (maxillary v.), front of the neck (ant. jugular v.) and shoulder (transverse cervical v. and suprscapular v.) The ext. jugular v. ends in the subclavian v. (Note: just name areas drained by EJV but not specific names of tributaries). (x) Optional: 4. Prominence of EJV. The EJV may serve as an “internal barometer”. When venous pressure is in the normal range, the EJV is usually visible above the clavicle for only a short distance. However, when venous pressure rises (e.g., heart failure), the EJV is prominent throughout its course. Thus, observation of EJV during physical Neuro: 1:00 - 2:00 Scribe: Brittney Wise Monday, April 6, 2009 Proof: Laura Adams Dr. Zehren Structures of the Cardiovascular System Page 9 of 14 exam may give diagnostic sign of heart failure, SVC obstruction, enlarged supraclavicular lymph nodes, or increased intrathoracic pressure. 5. Severance of EJV. If the EJV is severed where it pierces the roof of the posterior triangle, its lumen is held open by the investing layer of deep cervical fascia, and the negative intrathoracic pressure will suck air into the vein. A venous air embolism produced in this way will fill the right side of he heart w/ froth, which nearly stops blood flow through it, resulting in dyspnea and cyanosis. The application of firm pressure to the severed EJV until it can be sutured will prevent this. XXXVIII. [S38] Upper Limb XXXIX. [S39] Superficial Veins of Upper Limb a. There are 3 superficial veins of the upper limb that you should know: i. Basilic vein – begins on the dorsum (back) of the wrist; this vein ascends on the medial or ulnar side; tends to remain superficial (in the superficial fascia just deep to the skin); this vein remains superficial until about the mid-arm level and then it goes deep and continues up and eventually becomes continuous with the axillary vein ii. Cephalic vein – begins on the dorsum (back) of the wrist; this vein ascends on the lateral side of the upper limb (the radial side); tends to remain superficial (in the superficial fascia just deep to the skin); the cephalic remains superficial all the way up to the shoulder area and finally goes deep and terminates in the axillary vein iii. Median capital vein – connecting the basilic and cephalic vein; it connects them in front of the elbow; this oblique cross channel is called the median cubital vein (look at the slide for a good visual) b. Origin, course & termination of cephalic and basilic vv. c. Median cubital vein used in venipuncture (more later). XL. [S40] Axillary and Subclavian Veins a. This slide is just showing you that there are deeper veins in the upper limb as well, and these veins usually accompany the deeper artery. For example, the brachial artery which is deeply placed has a pair of deep veins running with it called deep brachial veins or just brachial veins. You can see that they are joining the basilic vein right here to form the axillary vein. b. Here again you can see the termination of the cephalic vein going deep and ending in the axillary vein. c. The axillary vein becomes the subclavian vein at the outer border of the 1st rib just like the artery. d. So we have these deeper veins in the upper limb as well as the superficial veins. e. 1. Begin by mentioning that veins accompany the deep arteries in the upper limb; eg, the brachial vv. (shown here). 2. The brachial vv. ascend w/ the brachial a. and join w/ the basilic v. to form the axillary v. 3. The axillary v. crosses the outer border of rib 1 to become the subclavian v., which terminates in the brachiocephalic v. XLI. [S41] Median Cubital Vein and Venipuncture a. This is the vein that connects the basilic vein with the cephalic vein in front of the elbow. Either this vein or the cephalic or basilic, any of these veins can be used for venipuncture. They can be used for blood transfusions, administration of drugs, or taking a blood sample. b. It’s important to realize that there are some pretty important structures related to these veins that can cause some complications. In particular, if you look at this slide you can see that there are some cutaneous nerves. c. There is a nerve here that runs parallel with the cephalic vein and is called the lateral cutaneous nerve of the forearm and on the medial side there is a medial cutaneous nerve to the forearm that accompanies the basilic vein. If a person is giving a venipuncture and should hit one of those nerves the patient is going to have a lot of severe burning pain in the region of distribution of those cutaneous nerves. This is called paresthesia, meaning an abnormal sensation (burning, tingling, that sort of thing). d. Even more serious, if the needle goes to deep, there is a fibrous structure just deep to the medial cubital vein called the bicipital aponeurosis (an aponeurosis is a flat tendon). The tendon of the biceps muscle is inserting into the radius right about this region, but before it inserts it gives off this fibrous expansion called the bicipital aponeurosis. That is all that separates this vein from these deeper structures namely the brachial artery and the median nerve. These are 2 very important structures. If you were to damage the median nerve you would have both sensory and motor problems with the forearm and hand because it’s a mixed nerve. If you hit the artery, besides getting just hemorrhage, if you inject a drug into an artery that can have very serious consequences. It can cause the artery to spasm and potentially you could lose your blood supply to the forearm and hand if a clot formed or it if had a big enough spasm (this could result in necrosis). e. This can also be called this the grace of God tendon, because the median nerve and the brachial artery are spared/protected by this tendon when you give a venipuncture. f. 1. Veins in cubital fossa are commonly used for taking blood samples, blood transfusions, and injecting drugs. Usually the median cubital or basilic veins are used. Neuro: 1:00 - 2:00 Scribe: Brittney Wise Monday, April 6, 2009 Proof: Laura Adams Dr. Zehren Structures of the Cardiovascular System Page 10 of 14 2. A number of complications can arise during these procedures: a. The medial and lateral cutaneous nerves of the forearm accompany the basilic and cephalic vv. and could be injured, producing paresthesia. b. Injecting the needle too deeply could penetrate the bicipital aponeurosis, which is all that separates the median cubital v. from the brachial a. and median n. Optional: Injecting irritating drugs into an artery can cause thrombosis and spasm, w/ subsequent gangrene of the tissues supplied. If the drug is an anesthetic, a lethal overdose could be given (b/c intra-arterial anesthesia is delayed relative to direct IV anesthesia.) COA (5th ed., p. 799) notes that the bicipital aponeurosis is also known as the grace Deux tendon (Fr. grace of God tendon), by the grace of which arterial hemorrhage is usually avoided. XLII. [S42] Thorax XLIII. [S43] Veins of Thoracic Wall a. The veins draining the thoracic wall usually parallel the arteries. b. You have anterior and posterior intercostals veins and the anterior intercostal veins are either direct or indirect tributaries to the internal thoracic vein which goes to the brachiocephalic vein and back to the superior vena cava. c. The posterior intercostal veins, those on the right side of the body, most of them drain directly into this un-paired vein called the azygos vain. You can see the azygos vein as it ascends along the vertebral column, and then arches forward and empties its blood into the superior vena cava. d. On the left side the drainage is a little more indirect. The posterior intercostal veins on the left side of the body, drain first into either the accessory hemiazygos or the hemiazygos veins. Both of those veins themselves cross the midline and empty into the azygos vein. So, ultimately, all the venous blood from the thoracic wall gets into the superior vena cava and back to the heart. e. 1. The thoracic wall is drained by anterior and posterior intercostal vv. 2. The anterior intercostal vv. are tribuataries (direct or indirect) of the internal thoracic vv. 3. Each int. thoracic v. drains into its corresponding brachiocephalic v. 4. The POST. INTERCOSTAL VV. drain the post. thoracic wall. Most of those on the RIGHT SIDE drain into the AZYGOS V. The azygos v. empties its blood into the sup. vena cava which then enters the heart. Most of the post. intercostal vv. on the LEFT SIDE drain into the ACCESSORY HEMIAZYGOS V. and the HEMIAZYGOS V. Both the accessory hemiazygos and the hemiazygos vv. cross the midline to empty into the azygos v. XLIV. [S44] Veins of Heart (Cardiac Veins) (Anterior View) a. We will take these up next hour. XLV. [S45] Pulmonary Veins a. Just know that there are 4 of them: 2 on each side, superior and inferior. These are also valveless veins that are returning oxygenated blood from the lungs to the left atrium of the heart (the base of the heart). b. The FOUR PULMONARY VV. (superior and inferior veins from each lung) carry OXYGENATED blood from the lungs back to the L atrium of the heart. (X) The pulmonary vv. are valveless. XLVI. [S46] Abdomen XLVII. [S47] Veins of Anterior Abdominal Wall a. Again the veins typically parallel the arteries. You have musculophrenic and superficial or superior epigastric veins which are tributaries to the internal thoracic. We also have inferior epigastric and deep circumflex iliac veins which drain to the external iliac. So, again there are veins corresponding to their arteries. b. There are also superficial veins in the anterior abdominal wall just beneath the skin. Some of them around the umbilicus anastomose with deeper veins, in particular what are called paraumbilical veins. He is going to come back to this point later because it is of some importance (the anastomoses of the superficial veins of the abdominal vein in the region of the umbilicus and the paraumbilical veins. c. 1. The veins of the anterior abdominal wall largely correspond with the arteries supplying it. Thus, there are superior and inferior epigastric veins as well as tributaries of the musculophrenic and deep circumflex iliac veins. There are several superficial veins in the anterior abdominal wall that are noteworthy. Among these is the thoracoepigastric v. which connects with the lateral thoracic v. (above) and with the superficial epigastric vein (below). 2. The anastomoses between the sup. and inf. epigastric vv., and between the lateral thoracic and superficial epigastric vv., provide collateral routes for venous blood to reach the heart should the SVC or IVC become blocked (COA, 5th ed., p. 210). 3. The clinical significance of the anastomoses between the veins around the umbilicus with the paraumbilical vv. along the round lig. of the liver will become apparent later. XLVIII. [S48] Veins of Posterior Abdominal Wall a. The major vein here is the IVC (Inferior vena cava; aka “big blue”). Neuro: 1:00 - 2:00 Scribe: Brittney Wise Monday, April 6, 2009 Proof: Laura Adams Dr. Zehren Structures of the Cardiovascular System Page 11 of 14 b. This is the largest vein in the body in terms of its diameter. It begins just a little more inferior than the aorta about the L5 vertebral level and you can see it is formed by the union of the common iliac veins, the right and left. c. The IVC ascends on the posterior abdominal wall just to the right of the aorta. It finally penetrates the diaphragm around the level of the 8th vertebra. It’s quite long and then immediately it enters the heart. d. On its course in the abdomen the inferior vena cava receives a number of tributaries (listed below): i. Inferior phrenic veins draining the diaphragm ii. 4 pairs of lumbar veins from the posterior abdominal wall iii. It also receives veins from the viscera lying on the posterior abdominal wall like the … 1. pararenal veins (you can see the long left renal vein crossing the midline and you can see the shorter right renal vein) 2. the right gonadal vein (direct tributary to IVC) 3. the right suprarenal vein (direct tributary to IVC) 4. On the left side there is some asymmetry; the left suprarenal vein and the left gonadal vein don’t drain directly into the IVC they go 1st into the left renal vein and then over to the IVC e. 1. The veins draining the roof of the abdomen (ie, diaphragm) are the inferior phrenic vv., whereas those draining the posterior abdominal wall proper are the lumbar vv. The inferior phrenic vv. and lumbar vv. are tributaries of the IVC. 2. The IVC is the largest (widest) vein in the body. It begins by the union of the R and L common iliac vv. at the level of LV5. The IVC ascends retroperitoneally to the right of the aorta, finally piercing the diaphragm at vertebral level TV8 to enter the heart. (X) Except for a non-functional valve at the entrance of the IVC into the heart, the IVC has no valves. 3. The IVC receives (directly or indirectly) tributaries that drain organs lying on the posterior abdominal wall, or which began their development on the post. abdominal wall. Thus, the IVC receives the R and L renal vv., and the R suprarenal v. and R “gonadal” v. as direct tributaries (the L suprarenal v. and L gonadal v. first drain into the L renal v.) . 4. Note the increased length of the L renal v. and L common iliac v. w/respect to those on the R side. XLIX. [S49] Veins of Gastrointestinal Tract (Hepatic Portal Vein) a. There is another very important vein in the abdomen and this is the hepatic portal vein. b. This carries blood from the GI tract including the pancreas, gall bladder, and the spleen. c. The entire GI tract’s (plus the spleen’s) collected venous blood is transported to the liver via the hepatic portal vein. d. A portal vein is defined as a vein that begins in capillaries and ends in capillaries before the blood goes back to the heart. The hepatic portal vein is collecting the blood from the capillary beds in the GI tract and it’s transporting that venous blood to the liver, and in the liver that hepatic portal vein will break up into smaller veins which at the capillary level are called hepatic sinusoids. e. The blood then from the liver is then re-collected by hepatic veins which then empty directly into the vena cava. So the vena cava doesn’t receive this blood from the GI tract directly, it has to go first through the liver via the hepatic portal vein. f. This is a huge system of veins. It’s estimated that about 1/3 of the total volume of blood in your body lies in this hepatic portal system. g. The 2 main tributaries of this are the splenic vein, which drains the spleen and the spleen itself is very vascular organ, and the superior mesenteric vein. These 2 veins unite behind the pancreas to form the hepatic portal vein. As you can see there are numerous tributaries draining into this portal system. h. So, this blood, after you have eaten a meal all the products of digestion, other than fats which are absorbed in the lymphatics, are carried to the liver via the hepatic portal vein so that he cells in the liver can metabolize those products of digestion. i. 1. A portal vein is a vein which begins and ends in capillaries (or capillary-like structures) before its blood reaches the heart. 2. THE (HEPATIC) PORTAL V. IS A LARGE VEIN WHICH DRAINS BLOOD FROM THE GI TRACT AS WELL AS FROM THE SPLEEN, PANCREAS & GALLBLADDER. It transports this blood to the porta hepatis of the liver, where it divides into right and left branches. The blood eventually passes through the liver sinusoids (capillary-like structures) before being collected by several large hepatic veins which empty into the IVC. The portal vein carries the products of digestion ( (X) breakdown products of carbohydrates and proteins) to the liver where they are metabolized. (X) Fats are absorbed into the lymphatic system and ultimately reach the thoracic duct. The portal vein and its tributaries constitute a very large system, and it has been stated that this system may contain ONE-THIRD of the volume of blood in the body ! Neuro: 1:00 - 2:00 Scribe: Brittney Wise Monday, April 6, 2009 Proof: Laura Adams Dr. Zehren Structures of the Cardiovascular System Page 12 of 14 3. The PORTAL V. IS FORMED BY THE UNION OF THE SPLENIC V. & THE SUP. MESENTERIC V. posterior to the pancreas. The inf. mesenteric v. is usually a tributary of the splenic v. (X) Both the sup. and inf. mesenteric vv. receive tributaries corresponding to the branches of their respective arteries. L. [S50] Hepatic Veins a. Here you see the hepatic portal vein (a very large vein lying directly in front of the IVC) and it’s entering the liver and branching and ultimately forms these liver sinusoids (capillary like structures in the liver), the blood is then recollected by 2 or 3 large hepatic veins which drain the liver and empty directly into the IVC. b. So, the hepatic portal vein carries blood to the liver and the hepatic vein carries blood away from the liver. c. 1. Note the hepatic portal v. carrying blood to the liver sinusoids. Three large hepatic vv. drain blood from the liver to the IVC just before it pierces the diaphragm. LI. [S51] Portal – Systemic Anastomoses a. There are points where tributaries of the hepatic portal vein will anastomose with tributaries of either the superior or inferior vena cava. These points of anastomoses are called portacaval or portal - systemic anastomoses. These are important clinically. b. The hepatic portal vein along with some of its tributaries are shown here on the slide in deep blue. Systemic veins would be the superior vena cava and the inferior vena cava and their tributaries. c. At various points there are areas where these tributaries anastomose. i. For example, on the lower end of the esophagus right here you see that’s this tributary to the portal vein anastomoses with this tributary of the azygos vein which itself drains to the superior vena cava. So, here is one portacaval anastomoses on the lower esophagus. d. Another one is down here on the rectum. The superior rectal vein which is a tributary of the portal system, anastomoses with the middle and inferior rectal veins which are tributaries to the inferior vena cava. e. There is another one around the umbilicus where the paraumbilical vein, a tributary to the portal vein, anastomoses with the veins of the abdominal wall. f. This is important clinically because when someone has portal hypertension, which means increased blood pressure in the portal system (this can be due to liver disease, say cirrhosis of the liver which destroys the liver tissue and makes blood flow through the liver difficult). Since the hepatic portal vein is valveless, the blood backs up into the portal vein and all of it’s tributaries and can become greatly engorged, that blood tries to get back to the heart via another route because it can’t get through the liver because it’s blocked. So, these small anastomoses will enlarge and they may rupture causes severe bleeding. This can all be a consequence of portal hypertension. i. When these esophageal veins become enlarged and rupture it’s called esophageal varices and if they rupture the person will vomit blood and this is critical because the person can lose a lot of blood. ii. Rectal veins can also become enlarged and this is what hemorrhoids are. iii. The veins around the umbilicus can enlarge. What happens here can be seen on the next slide. g. 1. SOME OF THE TRIBUTARIES OF THE PORTAL V. (DARK BLUE) ANASTOMOSE WITH TRIBUTARIES OF EITHER THE SVC OR IVC (LIGHT BLUE). THESE ARE TERMED PORTACAVAL (PORTAL – SYSTEMIC) ANASTOMOSES. 2. FOUR SITES OF PORTACAVAL ANASTOMOSES ARE: ( 1) on the lower end of the esophagus where twigs of the L gastric v. (portal) anastomose with twigs of the azygos v. (SVC) 2) around the umbilicus where the paraumbilical vv. (portal) anastomose with veins of the ant. abdominal wall (SVC & IVC) 3) on the rectum where the sup. rectal v. (portal) anastomoses with the middle and inf. rectal vv. (IVC) and (X) 4) on the posterior abdominal wall where twigs of the L colic v. and splenic v. (portal) anastomose with retroperitoneal vv. of the posterior abdominal wall (IVC). 3. The portacaval anastomoses are clinically important because they allow portal venous blood to enter the caval system if blood flow through the liver is obstructed. Liver disease (eg., alcoholic cirrhosis) may cause such an obstruction. Since the portal venous system is valveless blood "backs up" and attempts to get into the caval system via the anastomoses. The anastomotic veins may become engorged with blood and even rupture. Enlarged veins on the lower esophagus are termed ESOPHAGEAL VARICES. Enlarged veins which radiate out from the umbilicus are called CAPUT MEDUSAE (because they resemble the snakes which came out of the head (caput) of Medusa, a character in Greek mythology). When the rectal veins become engorged the condition is known as HEMORRHOIDS. LII. [S52] Caput Medusae a. In Greek or Latin, caput means head and medusa was a character in Greek mythology and was the lady with snakes coming out of her head. This resembles the head of medusa with these enlarge veins radiating out from the umbilicus looking like snakes coming out of the head of the medusa. It could be the result of portal hypertension which causes the veins to back up and try to get into the superior or inferior vena cava through these anastomoses. Neuro: 1:00 - 2:00 Scribe: Brittney Wise Monday, April 6, 2009 Proof: Laura Adams Dr. Zehren Structures of the Cardiovascular System Page 13 of 14 b. 1. Enlarged veins which radiate out from the umbilicus are called CAPUT MEDUSAE (because they resemble the snakes which came out of the head (caput) of Medusa, a character in Greek mythology). LIII. [S53] Portal – Systemic Shunts a. What can be done in portal hypertension, surgically, is you can take the portal vein since it is right in front of the vena cava, and they perform a side to side anastomoses. You take the portal vein and anastomose it with the IVC and that blood can get direct backflow into the IVC. This is called a portacaval shunt. b. Another thing that can be done is to remove the spleen, take the splenic vein and anastomose or suture it into the left renal vein which is a tributary to the vena cava. c. 1. In cases where the buildup of pressure in the portal venous system (PORTAL HYPERTENSION) due to liver disease is severe surgical intervention may be required. One way to accomplish a reduction in portal hypertension is to SURGICALLY ANASTOMOSE THE PORTAL V. WITH THE IVC (these two veins are close to one another being separated only by the epiploic foramen). Another is to perform a SPLENO-RENAL SHUNT in which the splenic v. is joined to the L renal v. (again, these two veins are in close proximity). (Note: spleen removed prior to doing this shunt). LIV. [S54] Pelvis and Perineum LV. [S55] Veins of Pelvis and Perineum a. The internal iliac vein and likely the internal iliac artery is the chief vein draining the pelvis and perineum. b. Many of the pelvic viscera have venous plexuses around them like the prostatic plexus. Although these venous plexuses do drain to the internal iliac, they also communicate with veins in the vertebral canal (the internal vertebral plexus). i. This is important because these plexuses and these communications with the internal vertebral plexuses are valveless. This means that if these pelvic organs become cancerous (like prostate cancer) if those malignant cells enter the venous system they can metastasize via the venous system into the vertebral canal and become embedded in the vertebral column or sometimes they can go all the way up into the skull because the internal vertebral plexus communicates at the foramen magnum with the dural sinuses. So, you can get prostatic cancer spreading up into the brain via this pathway. c. Internal pudendal vein is one of the major tributaries of the internal iliac and this one drains the perineum. d. 1. The internal iliac v. is the chief vein draining the pelvis & perineum. It receives tributaries which largely correspond to the branches of the internal iliac a. 2. Many of the pelvic viscera have venous plexuses closely associated with them (vesical and rectal plexuses around the bladder and rectum), prostatic plexus (in male) and uterine and vaginal plexuses (in female). These plexuses interconnect w/each other, and although they drain primarily into the internal iliac v., they communicate w/ the internal vertebral venous plexus inside the vertebral canal as well. This is important b/c it forms a possible route for pelvic cancers to metastasize to the vertebral canal. 3. The internal pudendal v. drains the perineum and ends in the internal iliac v. A major exception, however, is that the deep dorsal v. of the penis (or clitoris), which drains the glans and corpora cavernosa, ends in the prostatic plexus (male) or vesical plexus (female). LVI. [S56] Lower Limb LVII. [S57] Superficial Veins of Lower Limb a. Like in the case of the upper limb, you have superficial and deep veins. b. There are 2 major superficial veins in the lower limb and they are called the great and the small saphenous veins. (saphenous means “easily seen”). i. Both of these veins begin on the dorsum of the foot. ii. The great saphenous starts at the medial side of the foot and ascends along the medial side of the lower limb all the way up to the groin area where it finally goes deep and empties into the femoral vein. iii. The small saphenous vein begins on the lateral side of the foot and ascends in the back of the calf and then goes deep and ends in the popliteal vein. c. Both of these superficial veins have numerous valves to prevent backflow of blood working against gravity. d. These superficial veins are also connected with deep veins of the leg via perforating veins. e. 1. Origin, course and termination of the great and small saphenous vv. 2. Superficial vv. have valves only permitting flow of blood toward heart. LVIII. [S58] Deep Veins of Lower Limb a. The deep veins of the lower limb are again veins that go along with the deep arteries in the leg. We have a pair of anterior and posterior tibial veins which drain the front and back of the leg. These veins unite in the knee region forming the single popliteal vein which is quite large and very deeply placed. The popliteal vein ascends through the adductor hiatus and becomes the femoral vein in the thigh and the femoral vein receives near it’s termination the deep femoral vein and then it becomes the external iliac vein once it crosses behind the inguinal ligament. So, pretty much this is just a reverse with what we saw with the arteries. Neuro: 1:00 - 2:00 Scribe: Brittney Wise Monday, April 6, 2009 Proof: Laura Adams Dr. Zehren Structures of the Cardiovascular System Page 14 of 14 b. 1. The deep veins of the leg are the anterior tibial vv., posterior tibial vv., and the fibular vv. (These are the venae comitantes of the similarly named aa.). These deep leg veins unite in the popliteal fossa (concavity behind the knee) to form a single popliteal v. The popliteal v. continues through the adductor hiatus (not shown) to become the femoral v. The femoral v. ascends in the thigh, and in the proximal thigh it receives the deep v. of the thigh. The femoral v. ends by passing behind the inguinal ligament to become the external iliac v. 2. The femoral v. is quite superficial in the proximal thigh, and can be used to insert catheters, etc., if necessary. 3. Deep veins of lower limb also have valves (more numerous than in superfical veins). (COA, 5 th ed., p. 580). LIX. [S59] End of Lecture LX. [S60] The Renal Arteries … (answer is in bold) a. assist in the supply of the suprarenal glands b. are branches of the celia trunk c. are branches of the superior mesenteric artery d. are classified as paired parietal branches e. none of the above is correct LXI. [S61] The brachiocephalic vein is formed by the junction of the … (answer is in bold) a. Internal and external jugular veins b. External jugular and subclavian veins c. Internal jugular and subclavian veins d. Internal jugular and axillary veins e. External jugular and axillary veins LXII. [S62] The inferior vena cava … (answer is in bold) a. Begins at vertebral level L5 b. Pierces the diaphragm at vertebral level T12 c. Lies to the left of the abdominal aorta d. Receives the hepatic portal vein as a direct tributary e. Contains numerous valves [end 48:44 min]