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Cellular and Molecular Biology, Block 1 Weekly Formative Questions
Week 4 (September 14-September 18, 2009)
Dr. Manning Pentose Phosphate Pathway
1.
Which one of the following statements is INCORRECT? Glucose 6-phosphate
A.
B.
C.
D.
E.
2.
is oxidized by the enzyme glucose 6-phosphate dehydrogenase;
(G-6-PD).
yields the compounds 6-phosphogluconolactone and NADPH in the first
step in its oxidation.
has an increased rate of oxidation in G-6-PD deficiency.
is hydrolyzed to glucose and orthophosphate by the cytoplasmic enzyme
glucose 6-phosphatase.
is synthesized from ATP and glucose by the enzyme hexokinase.
Which one of the following statements does NOT apply to the pentose phosphate
pathway?
A.
B.
C.
D.
E.
Ribulose 5-phosphate and ribose 5-phosphate are produced
All of the carbon atoms are shunted back into the glycolytic
pathways
NADPH is produced
It involves the formation of C3, C4, C5, C6 and C7 sugars
It occurs in red blood cells
Dr. Manning Interconversion of Hexoses
For Questions 3 and 4, match the following characteristics or symptoms to the correct
disorder.
A.
B.
C.
D.
E.
Glucose-6-phosphate dehydrogenase deficiency
Wernicke-Korsakoff syndrome
Hereditary fructose intolerance
Diabetes mellitus
Classic galactosemia
3.
This disorder is treated by a diet devoid of milk products.
4.
An infant being weaned off breast milk begins to exhibit poor
health when fruit juice and sweets are introduced into its diet.
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Cellular and Molecular Biology, Block 1 Weekly Formative Questions
Week 4 (September 14-September 18, 2009)
Dr. Chiaia Muscle 2 and 3
5.
Cardiac muscle tissue is characterized by
A.
B.
C.
D.
E.
6.
Which of the following statement(s) concerning muscle is (are) CORRECT?
A.
B.
C.
D.
7.
A triad consists of two T-tubules and a centrally located terminal cisterna
of the sarcoplasmic reticulum
At the myoneural junction, acetylcholine is released by axon terminals
Both A and B are correct
Neither A nor B is correct
The sarcolemmal specialization found at the neuromuscular junction designed to
increase surface area of the junction is known as a
A
B.
C.
D.
E.
8.
a nucleus (1 or 2) located in the center of the cell.
is striated involuntary muscle.
intercalated discs which hold cardiac cells together at their adjacent ends.
branching fibers consisting of cells tightly adherent to one another at their
adjacent ends.
All of the above are correct.
myocisternae.
junctional folds.
motor endplate.
Z-line.
motor tubule.
Individual muscle fibers are enclosed by a connective tissue covering termed the
A.
B.
C.
D.
E.
endomysium.
myomysium.
intermysium.
epimysium.
perimysium.
Dr. Chiaia Structure of Neurons and Glia
9.
Which of the following cells makes the myelin sheath found within the CNS?
A.
B.
C.
D.
E.
Microglia
Protoplasmic astrocyte
Satellite cell
Schwann cell
Oligodendrocyte
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Cellular and Molecular Biology, Block 1 Weekly Formative Questions
Week 4 (September 14-September 18, 2009)
Dr. Chiaia Structure of Neurons and Glia cont
10.
Nissl substance or bodies actually is the light microscope version of what?
A.
B.
C.
D.
E.
Golgi apparatus
Synaptic vesicles
RER and polysome areas
Groups of neurofilament
The Axon hillock
Dr. Maltese Lipids 1: Beta Oxidation
11.
The enzyme that utilizes coenzyme A as one of its substrates in the beta
oxidation cycle of fatty acids is
A.
B.
C.
D.
12.
acyl dehydrogenase.
enoyl-CoA hydratase.
L-hydroxyacyl-CoA dehydrogenase.
thiolase.
Choose the expression that describes myristate.
A.
B.
C.
D.
E.
cis,cis-9,12-octadecadienoate
cis-9-octadecenoate
n-hexadecanoate
cis-9-hexadecenoate
n-tetradecanoate
Dr. Maltese Lipids 2: Fatty Acid Synthesis
13.
During synthesis of fatty acids, which of the following compounds is consumed?
A.
B.
C.
D.
E.
14.
beta-ketoacyl-CoA
acetoacetate
fatty acyl-CoA
NADPH
FADH2
The enzyme reaction catalyzed by acetyl-CoA carboxylase
A.
B.
C.
D.
E.
produces butyryl-CoA.
is inhibited by phosphorylation of the enzyme.
requires oxaloacetate.
requires NADPH.
is inhibited by aggregation of the enzyme.
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Cellular and Molecular Biology, Block 1 Weekly Formative Questions
Week 4 (September 14-September 18, 2009)
Dr. Maltese Lipids 3: Triacylglycerols
15.
Which of the following events would occur in an untreated diabetic (low insulin)?
A.
B.
C.
D.
E.
16.
Decreased production of malonyl-CoA.
Increased synthesis of triglycerides.
Decreased uptake of fatty acids into the mitochondria.
Decreased fatty acid oxidation.
Decreased amount of acetyl-CoA diverted to acetoacetate.
In liver ketogenesis the immediate precursor of acetoacetate is
A.
B.
C.
D.
E.
beta-hydroxy butyrate.
acetoacetyl-CoA.
beta-hydroxy butyryl-CoA.
mevalonic acid.
beta-hydroxy-3-methyglutaryl-CoA.
Dr. A. Lee Muscle 4
17.
Following statements are related to descriptions of muscle mechanics. All are
true except
A.
B.
C.
D.
E.
18.
Muscle torque generation will increase as the velocity of movement
increases.
Muscle force generation with isolated muscle preparation is greatest at an
optimal resting length (2-2.2 um).
Muscle power increases as the velocity of movement increases to a
certain point, thereafter, decreases with a further increase in movement
velocity.
A muscle that consists predominantly of fast twitch muscle fibers will
generate greater torque than does a muscle that consists predominantly of
slow twitch muscle fibers at a given velocity of movement.
All above are correct
Which one of the following is involved in signal transduction for exercise traininginduced mitochondrial biogenesis in skeletal muscles?
A.
B.
C.
D.
AMPK
Calcineurin
IGF-1
mTOR
(See next page for answers)
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Cellular and Molecular Biology, Block 1 Weekly Formative Questions
Week 4 (September 14-September 18, 2009)
Instructor
Dr. Manning
Dr. Chiaia
Dr. Maltese
Dr. A. Lee
Question
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
5
Answer
C
B
E
C
E
B
B
A
E
C
D
E
D
B
A
E
A
A