Download Intro to Virology: March 15 2009

Intro to Virology: March 15 2009
1. viruses go through interactions w/ various cells in various ways.
2. books open university world of attackers
high level–3. fields virology
4. principles of virology by flint
5. wagner basic virology
6. virus= latin for poison
7. The History of Virology:
1884 Charles Chamberland invents chamberland filters: very small filters used till today.
1892 Dimitri Iwanowski extracts disease from tobbaco plants using chamberland filters
uses the filters and transfers disease to healthy plants understands that the disease is
transferred by poison (virus).
1898: Beijerinck the transmitted agents propogate in the host: makes the extract and
dilutes it to make the infected tobbacco plants still so dealing w/ very small things that
procreate,
foot and mouth disease in cattle: Loffler and Frosch
1909 Landsteiner and Popper poliomyelitis caused by filterable agent first human disease
recognised as being caused by a virus the polio virus that later got a vaxine by using
spinal fluid and brain fluid and made 2 rabbits and turtles and monkeys only the monkeys
developed the polio.
1910 Rous: identified the first oncogenic virus: avian flu he tested on birds and saw
cancerous growths as a result he won a nobel prize for his discovery 50 years later
1915 Twort and dHerell identify bacteriophages viruses that infect bacteria
1935 Wendell Stanley crystalised tobbacco mosaic virus learned about the form and
shape of the virus.
Present: geonomic analyses, virus host interactions, genetic manipulations treatment and
prevention fall short.
8. Sars disease is a good example of the no cure issue all that could be done was
quarentine and isolating people who had it.
9. Mosaic Tobacco Virus: it infects tobacco plants with polkadot like spots on the leaves
and renders the leaves useless but peopled used the viruses to get prettier flowers out of
the plant.
10. first images of polio and tobacco viruses made by the first electronic microscope in
1935 show the differences in shape of the different viruses.
11. Virus is a particle w/ a nucleic acid and a protein membrane
or a nucleic acid w/ bad news around it Peter Medawar 1960
or a virus is a parasite that needs a living cell host to procreate
or a thing (is it living or dead) that has genetic information.
12. living organism can use its genetic information and translate it but a virus cant do it
alone they need to use a living organism to translate its genetic info.
13. We don’t know where viruses came from. But we assume that they are ancient
beings. There is no consensis on theyre origin. The three theories are one: regresives
theory a microorganism that lost some of its makeup hardware. Two: progressive theory
which is harder to accept since we know where all nucleic acids are made up of. Three:
they evoluted the same as we did and were made by proteins and such.
14. There is a consensis that they were made a few times from no specific one father.
15. You can classify viruses by the cotings: ones that attack prokariotes and ones that
attack eyokariotic cells in these lecters we will deal with eyokariotic attackers.
16. us and viruses: public health, plant viruses, bio warfare, basic research and genetic
ripui (hebrew)