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Biology Midterm Review Chapter 1 Introduction to Biology Vocabulary: biosphere ecosystem dependent variable biodiversity homeostasis constant species evolution theory biology adaptation microscope organism observation gene cell data molecular genetics metabolism hypothesis genomics DNA experiment biotechnology system independent variable transgenic 1.1 KEY CONCEPT Biologists study life in all its forms. Biology is the scientific study of all forms of life. Living things are found almost everywhere on Earth, from very hot environments to very cold environments and from the dry deserts to the ocean floor. The types of living things found in a particular region depend on which can survive there. Those living things that can survive in an environment can differ greatly in size and shape. All of the living things on Earth, and all of the places in which they live, make up the biosphere. The variety of living things in a certain area, or across the entire biosphere, is called biodiversity. Biodiversity can be measured in terms of the number of species in an area or across the biosphere. Although there are several definitions of the term species, you can think of a species as a certain type of living things that can reproduce by interbreeding. At least two million species exist on Earth. Each individual living thing, no matter the species, is an organism. Every organism, from any species, shares certain characteristics of life. • All organisms are made of one or more cells. A cell is the basic unit of life on Earth. • All organisms need chemical energy to carry out all of their cell functions. Energy is used for metabolism, which is all of the chemical processes that build up or break down materials. • All organisms respond to physical factors, or stimuli, in their environment. • Members of a species must be able to reproduce so that the species will survive. When organisms reproduce they pass on their genetic material, which is called DNA, to their offspring. 1.2 KEY CONCEPT Unifying themes connect concepts from many fields of biology Several major concepts run through all of biology. These underlying ideas, or unifying themes, demonstrate the relationships among all organisms and help to connect one f ield of biology to others. • Systems: A system is a group of related parts that interact to form a whole. Groups of molecules can interact to form the cellular machinery for a particular process. Groups of cells can interact to form an organ, such as the heart. Groups of organisms can interact within an ecosystem. An ecosystem is a certain area in which living and nonliving things interact. • Structure and Function: The biological function of a part of an organism is directly related to that part’s structure. This relationship is found in molecules within cells, among different types of cells, and across different species. Different organisms have different specialized structures that perform functions specialized to that species. • Homeostasis: All organisms must keep their internal conditions stable in order to stay alive. Homeostasis is the maintenance of these conditions. Homeostasis is necessary because the cells of all organisms function best within a particular range of conditions. If conditions vary too far from the ideal set, cells will not be able to function normally. When internal conditions change, a negative feedback system often acts to return the condition to normal. • Evolution: Evolution is the process by which the genetic makeup of a population changes over time. One way in which evolution occurs is through the natural selection of genetic traits that give an individual an advantage in a particular environment. Individuals with these advantageous traits, or adaptations, are more likely to survive and reproduce. 1.3 KEY CONCEPT Science is a way of thinking, questioning, and gathering evidence. Scientists do not use one scientific method, but all science is based on the same principles: curiosity, critical and logical evaluation of evidence, and the open and honest exchange of data. In any scientif ic inquiry, scientists • Make observations: Scientists use their senses and various measurement tools to collect information, or make observations, about the world. • Form hypotheses: Scientists propose answers to scientific questions, or form hypotheses, based on observations they, or other scientists, made. • Test hypotheses: Scientists devise methods of observing and experimenting to test their predictions. • Analyze data: Scientists use statistics to analyze data. This analysis tells a scientist whether a hypothesis is supported or not supported by the data. • Evaluate results: Scientists evaluate both their own results and the results from other scientists. Scientists use experiments to test hypotheses. A scientific experiment uses tightly controlled conditions to test a possible cause-and-effect relationship between variables. In an experiment, there are constants and two types of variables: the independent variable and dependent variables. • Independent variables: An independent variable is a condition that is manipulated by a scientist to determine its effect on a dependent variable. An independent variable is the “cause.” • Dependent variables: A dependent variable is measured by a scientist to study the effect of the independent variable. It is the “effect” and depends on the independent variable. • Constants: Factors that are controlled so that they do not change are constants. A hypothesis is a proposed explanation for a single observation. A scientific theory, however, is a proposed explanation for a wide range of observations and experimental results, and is supported by a wide range of evidence. Chapter 2 CHEMISTRY OF LIFE Vocabulary atom adhesion carbohydrate bond energy element solution lipid equilibrium compound solvent fatty acid activation energy ion solute protein exothermic ionic bond acid amino acid endothermic covalent bond base nucleic acid catalyst molecule pH chemical reaction enzyme hydrogen bond monomer reactant substrate cohesion polymer product 2.1 KEY CONCEPT All living things are based on atoms and their interactions All matter, whether living or nonliving, is made of the same tiny building blocks, called atoms. An atom is the smallest basic unit of matter. All atoms have the same basic structure, composed of three smaller particles. • Protons: A proton is a positively charged particle in an atom’s nucleus. The nucleus is the dense center of an atom. • Neutrons: A neutron has no electrical charge, has about the same mass as a proton, and is also found in an atom’s nucleus. • Electrons: An electron is a negatively charged particle found outside the nucleus. Electrons are much smaller than either protons or neutrons. Different types of atoms are called elements, which cannot be broken down by ordinary chemical means. Which element an atom is depends on the number of protons in the atom’s nucleus. For example, all hydrogen atoms have one proton, and all oxygen atoms have 16 protons. Only about 25 different elements are found in organisms. Atoms of different elements can link, or bond, together to form compounds. Atoms form bonds in two ways. • Ionic bonds: An ion is an atom that has gained or lost one or more electrons. Some atoms form positive ions, which happens when an atom loses electrons. Other atoms form negative ions, which happens when an atom gains electrons. An ionic bond forms through the electrical force between oppositely charged ions. • Covalent bonds: A covalent bond forms when atoms share one or more pairs of electrons. A molecule is two or more atoms that are held together by covalent bonds. 2.2 KEY CONCEPT Water’s unique properties allow life to exist on Earth. The structure of the water molecule gives water unique properties. Water is a polar molecule, which means that it has a region with a slight negative charge (the oxygen atom), and a region with a slight positive charge (the hydrogen atoms). The oppositely charged regions of water molecules interact to form hydrogen bonds. A hydrogen bond is an attraction between a slightly positive hydrogen atom and a slightly negative atom. Hydrogen bonds are responsible for several important properties of water. • High specific heat: Water resists changes in temperature; it must absorb a large amount of heat energy to increase in temperature. • Cohesion: The attraction among molecules of a substance is called cohesion. Cohesion due to hydrogen bonds makes water molecules “stick” together. • Adhesion: The attraction among molecules of different substances is called adhesion. Water molecules “stick” to many other materials because of hydrogen bonds. Many compounds that are important for life dissolve in water. Water is the largest component of cells’ interiors, and chemical reactions in the cell take place in this water. When one substance dissolves in another, a solution is formed. The substance present in the greatest amount is called the solvent. Substances that are present in lower amounts and dissolve in the solvent are called solutes. Polar solvents, such as water, dissolve polar molecules and ions. When some substances dissolve in water they break up into ions. A compound that releases a hydrogen ion (a proton) when it dissolves in water is an acid. Bases are compounds that remove, or accept, hydrogen ions. A solution’s acidity, or its hydrogen ion concentration, is measured on the pH scale. An acid has a low pH (pH below 7) and a high hydrogen ion concentration. A base has a high pH (pH above 7) and a low hydrogen ion concentration. Organisms must maintain a stable pH. Even a small change in pH can disrupt many biological processes. 2.3 KEY CONCEPT Carbon-based molecules are the foundation of life. Carbon atoms are the basis of most molecules that make up living things. Many carbon-based molecules are large molecules called polymers that are made of many smaller, repeating molecules called monomers. There are four main types of carbon-based molecules in living things. • Carbohydrates include sugars and starches, and are often broken down as a source of chemical energy for cells. Some carbohydrates are part of cell structure, such as cellulose, which makes up plant cell walls. • Lipids include fats and oils and, like carbohydrates, are often broken down as a source of chemical energy for cells. One type of lipid, called a phospholipid, makes up most of all cell membranes. • Proteins have a large number of structures and functions. Some proteins are needed for muscle movement; another protein, called hemoglobin, transports oxygen in blood. Another type of proteins, called enzymes, speed up chemical reactions in cells. • Nucleic acids are molecules that store genetic information and build proteins. DNA stores genetic information in cells, and RNA helps to build the proteins for which DNA codes. 2.4 KEY CONCEPT Life depends on chemical reactions. At the most fundamental level, every process that takes place in an organism depends on chemical reactions. In a chemical reaction, substances are changed into different substances by the breaking and forming of chemical bonds. The substances that are present at the start of a chemical reaction, and are changed by the reaction, are called reactants. The substances that are formed by a chemical reaction are the products. Chemical bonds must be broken in the reactants and new ones must be formed in the products. Energy must be added to break chemical bonds. In contrast, energy is always released when new bonds form. The amount of energy needed to break a bond, or the amount of energy released when a bond forms, is called bond energy. All chemical reactions require the input of at least a small amount of energy in order for bonds to break in the reactants and for the reaction to start. The energy needed to start a chemical reaction is the activation energy. In general, there are two types of energy changes that can occur during a chemical reaction. • Exothermic reaction: An exothermic chemical reaction releases more energy than it absorbs. The bonds that are broken in the reactants of an exothermic reaction have a higher bond energy than the new bonds that form in the products. Energy is usually released as heat or light. • Endothermic reaction: An endothermic chemical reaction absorbs more energy than it releases. The bonds that are broken in the reactants of an endothermic reaction have a lower bond energy than the new bonds that form in the products. The energy that is absorbed makes up for the difference. Chapter 3 CELL STRUCTURE AND FUNCTION Vocabulary cell theory vacuole concentration gradient cytoplasm lysosome osmosis organelle centriole isotonic prokaryotic cell cell wall hypertonic eukaryotic cell chloroplast hypotonic cytoskeleton cell membrane facilitated diffusion nucleus phospholipid active transport endoplasmic reticulum fluid mosaic model endocytosis ribosome selective permeability phagocytosis Golgi apparatus receptor exocytosis vesicle passive transport mitochondrion diffusion 3.1 KEY CONCEPT Cells are the basic unit of life. The invention of the microscope in the late 1500s revealed to early scientists a whole new world of tiny cells. Most cells are so small that they cannot be seen without a microscope. The discoveries of scientists from the 1600s through the 1800s led to the cell theory, which is a unifying concept of biology. The cell theory has three major principles: • All organisms are made of cells. • All existing cells are produced by other living cells. • The cell is the most basic unit of life. All cells can be divided into two major groups: prokaryotic cells or eukaryotic cells. The main differences between the two kinds of cells are in their structure: • Eukaryotic cells have a nucleus defined by a membrane, while prokaryotic cells have no nucleus. • In eukaryotic cells, the DNA, or genetic information, is found in the nucleus. In prokaryotic cells, the DNA is found in the cytoplasm, the jellylike substance that fills both types of cells. • Eukaryotic cells have organelles, structures that perform jobs for a cell. Most organelles are surrounded by membranes. Prokaryotic cells do not have organelles surrounded by membranes. Prokaryotic cells make up organisms called prokaryotes. All prokaryotes are tiny and consist of single cells. Bacteria are prokaryotic cells. Eukaryotic cells make up eukaryotes. You are a eukaryote, as are plants and some types of single-celled organisms. All multicellular organisms, or organisms that have many cells, are eukaryotes. 3.2 KEY CONCEPT Eukaryotic cells share many similarities Plants, animals, and some single-celled organisms are eukaryotes. Eukaryotic cells have an organized internal structure and organelles that are surrounded by membranes. Organelles look different from each other and have different functions. Several have a specific job in making and processing proteins so that a cell can live, function, and reproduce. Plant and animal cells have a lot of the same parts, but a few of their parts are different. The list below tells you what each cell part does. Part nucleus endoplasmic reticulum (ER) ribosomes Golgi apparatus vesicles mitochondria centrioles vacuoles cell walls chloroplasts cytoplasm cell membrane lysosomes Job and Description double membrane layer that stores and protects DNA; includes the nucleolus, a dense region where ribosomes are assembled. network of thin folded membranes that help produce proteins and lipids; two kinds of ER: smooth and rough tiny round organelles that link amino acids together to form proteins; may be in the cytoplasm or on the ER, which makes it look rough stacked layers of membranes that sort, package, and deliver proteins little sacs that carry different molecules where they’re needed; made and broken down as needed by the cell bean-shaped organelles that release energy from sugars for the cell found in animal cells; organize microtubules to form cilia and flagella sacs that store materials for the cell; the materials might be water, food molecules, ions, and enzymes strong layer that protects, supports, and gives shape to plant cells; not found in animal cells change energy from the sun into chemical energy for the plant; not found in animal cells jellylike substance that fills a cell double-layer of phospholipids that forms a boundary between a cell and its surrounding environment membrane-bound organelles that contain enzymes 3.3 KEY CONCEPT The cell membrane is a barrier that separates a cell from the external environment. The cell membrane forms a boundary that separates the inside of a cell from the outside environment. It plays an active role by controlling the passage of materials into and out of a cell and by responding to signals. The membrane is made of molecules called phospholipids, which consist of three parts: (1) a charged phosphate group; (2) glycerol; (3) two fatty acid chains. The structure of phospholipids gives them distinct chemical properties. The phosphate group and glycerol form a polar “head.” The fatty acid chains form a nonpolar “tail.” Cells are both surrounded by water and contain water. In the cell membrane, phospholipids form a double layer, or bilayer. In this way, the polar heads interact with the polar water molecules outside and inside a cell. The nonpolar tails are sandwiched together inside the bilayer, away from the water. The cell membrane also includes a variety of molecules that give the membrane properties it would not otherwise have. • Cholesterol molecules make the membrane stronger. • Proteins help molecules and ions cross the membrane and can act as receptors, proteins that detect a signal and respond by performing an action. • Carbohydrates help cells distinguish one cell type from another. The fluid mosaic model describes the characteristics and makeup of the cell membrane. The phospholipids can slip past each other like a fluid. The membrane is made up of many different molecules, like a mosaic. The cell membrane has a property called selective permeability, which means that it allows some molecules to cross but blocks others. Selective permeability helps a cell maintain homeostasis. Cells have receptors both in the cell membrane and inside the cell. Receptors help cells communicate with other cells and respond to the environment. • Membrane receptors bind to signals that cannot cross the cell membrane. They cross the membrane and transmit a message inside the cell by changing shape. • Intracellular receptors are located inside a cell and bind to molecules that can cross the cell membrane. They may interact with DNA to control certain genes. 3.4 KEY CONCEPT Materials move across membranes because of concentration differences. Cells are continuously exchanging materials with their environment across the cell membrane. Passive transport is the movement of molecules across a cell membrane that does not require energy input by the cell. Diffusion, a type of passive transport, is the movement of molecules from an area of higher concentration to an area of lower concentration. This difference in concentration from one area to another is called a concentration gradient. When a molecule diffuses, it can be described as moving down its concentration gradient. Not all molecules can cross the cell membrane. Facilitated diffusion is the diffusion of molecules across a membrane through transport proteins, proteins that form channels across the membrane. Diffusion is a result of the natural energy of molecules. When molecules are in solution, they collide and scatter. Over time, these molecules will become evenly spread throughout the solution, which means that the molecules have reached dynamic equilibrium. The molecules continue to move, but their concentration remains equal. Water also moves from a higher water concentration to a lower water concentration. The diffusion of water is called osmosis. The higher the concentration of dissolved particles that are in a solution, the lower the concentration of water molecules. The reverse is also true. That is, the lower the concentration of dissolved particles that are in a solution, the higher the concentration of water molecules. Scientists have developed terms to compare the concentration of solutions with some reference point. Here, our reference point is the concentration of particles in a cell. • An isotonic solution has the same concentration of dissolved particles as a cell. A cell in an isotonic solution will not change. • A hypertonic solution has a higher concentration of dissolved particles than a cell. A cell in a hypertonic solution will shrivel. • A hypotonic solution has a lower concentration of dissolved particles than a cell. A cell in a hypotonic solution will swell. 3.5 KEY CONCEPT Cells use energy to transport materials that cannot diffuse across the membrane. Cells use active transport to obtain materials they need that they could not get by means of diffusion or facilitated diffusion. Active transport is the movement of a substance against its concentration gradient by the use of transport proteins embedded in the cell membrane and chemical energy. The transport proteins used in active transport are often called pumps. Most often, the chemical energy that is used comes from breakdown of a molecule called ATP. A cell may use this energy directly or indirectly. • The sodium-potassium pump directly uses energy from the breakdown of ATP to pump two potassium ions into a cell for every three sodium ions it removes from the cell. • The proton pump indirectly uses energy from the breakdown of ATP to remove hydrogen ions (protons) from a cell. This action creates a charge gradient, which is a form of stored energy. This charge gradient can then be used to drive other pumps to transport molecules such as sucrose. Some molecules are too large to be transported through proteins. These molecules can be moved in vesicles, so they never actually have to cross the membrane. The movement of these vesicles also requires energy from a cell. • Endocytosis is the process of taking liquids or large molecules into a cell by engulfing them in a vesicle. During endocytosis, the cell membrane makes a pocket around the material to be brought in. The pocket pinches together around the material and breaks off, forming a vesicle, inside the cell. This vesicle then joins with a lysosome, which breaks down the contents if needed and recycles the vesicle. Phagocytosis is a type of endocytosis and means “cell eating.” • Exocytosis is the process of releasing materials from a cell by fusion of a vesicle with the cell membrane. In this process, a vesicle forms around select materials. The vesicle is moved to the cell surface, and it fuses with the cell membrane, releasing the contents. Exocytosis plays an important role in releasing hormones and digestive enzymes and in transmitting nerve impulses. Chapter 5 CELL GROWTH AND DIVISION Vocabulary cell cycle prophase metastasize mitosis metaphase carcinogen cytokinesis anaphase asexual reproduction chromosome telophase binary fission histone growth factor tissue chromatin apoptosis organ chromatid cancer organ system centromere benign cell differentiation telomere malignant stem cell 5.1 KEY CONCEPT Cells have distinct phases of growth, reproduction, and normal functions. Cells have a regular pattern of growth, DNA duplication, and division that is called the cell cycle. In eukaryotic cells, the cell cycle consists of four stages: gap 1 (G1), synthesis (S), gap 2 (G2), and mitosis (M). G1, S, and G2 are collectively called interphase. • During gap 1 (G1), a cell carries out its normal functions. Cells may also increase in size and duplicate their organelles during this stage. Cells must pass a checkpoint before they can progress to the S stage. • During synthesis (S), cells duplicate their DNA. At the end of the S stage, a cell contains two complete sets of DNA. • During gap 2 (G2), a cell continues to grow and carry out its normal functions. Cells must pass a checkpoint before they can progress to the M stage. • The mitosis (M) stage consists of two processes. Mitosis divides the cell nucleus, creating two nuclei that each have a full set of DNA. Cytokinesis divides the cytoplasm and organelles, resulting in two separate cells. Cells divide at different rates to accommodate the needs of an organism. For example, cells that receive a lot of wear and tear, such as the skin, have a life span of only a few days. Cells making up many of the internal organs have a life span of many years. Cells tend to stay within a certain size range. To maintain a suitable size range, cell growth must be coordinated with cell division. Cell volume increases much faster than cell surface area for most cells. All materials that a cell takes in or secretes enter and exit through the membrane. The cell’s surface area must be large enough relative to its overall volume in order for the cell to get its necessary materials. Therefore, most cells tend to be very small. 5.2 KEY CONCEPT Cells divide during mitosis and cytokinesis. During interphase, a cell needs access to its DNA to make use of specific genes and to copy the DNA. During mitosis, however, the DNA must be condensed and organized so that it can be accurately divided between the two nuclei. DNA is a long polymer made of repeating subunits called nucleotides. Each long continuous thread of DNA is called a chromosome, and each chromosome has many genes. During interphase, DNA wraps around organizing proteins called histones and is loosely organized as chromatin, which looks sort of like spaghetti. As a cell prepares for mitosis, however, the DNA and histones start to coil more and more tightly until they form condensed chromosomes. Each half of the duplicated chromosome is called a chromatid. Both chromatids together are called sister chromatids, which are attached at a region called the centromere. The ends of DNA molecules form telomeres, structural units that do not code for proteins. Telomeres help prevent chromosomes from sticking to each other. Mitosis is a continuous process, but scientists have divided it into phases for easier discussion. • During prophase the chromatin condenses into chromosomes, the nuclear envelope breaks down, and spindle fibers start to assemble. • During metaphase spindle fibers align the chromosomes along the middle of the cell. • During anaphase spindle fibers pull the sister chromatids away from each other and toward opposite sides of the cell. • During telophase, the nuclear membranes start to form around each set of chromosomes, the chromosomes start to uncoil, and the spindle fibers fall apart. • Cytokinesis divides the cytoplasm into two separate cells. In animal cells, the cell membrane pinches together. In plant cells, a cell plate forms between the two nuclei. It will eventually form new cell membranes for the cells and a new cell wall. 5.3 KEY CONCEPT Cell cycle regulation is necessary for healthy growth. The cell cycle is regulated by both external and internal factors. External factors come from outside the cell. These include cell–cell contact, which prevents further growth of normal cells, and chemical signals called growth factors. Growth factors stimulate cells to divide. Most cells respond to a combination of growth factors, not just one. Some growth factors affect many different types of cells. Others specifically affect one cell type. Internal factors come from inside the cell. Very often, an external factor triggers the activation of an internal factor. A cyclin is a type of internal factor. It activates kinases, which in turn, add a phosphate group to other molecules that help drive the cell cycle forward. Cells not only regulate growth, but also death. Apoptosis is programmed cell death. Apoptosis plays important roles in development and metamorphosis. When a cell loses control over its cycle of growth and division, cancer may result. Cancer cells can continue to divide despite cell–cell contact or a lack of growth factors. Cancer cells form disorganized clumps of cells called tumors. Benign tumors tend to remain clumped together and may be cured by removal. Malignant tumors have cells that break away, or metastasize, and spread to other parts of the body, forming new tumors. Malignant tumors are more difficult to treat than benign tumors. Radiation therapy and chemotherapy are common treatments for cancer. However, both treatments kill healthy cells as well as cancer cells. Cancer cells can arise from normal cells that have experienced damage to their genes involved in cell cycle regulation. Damage may arise from inherited errors in genes, from mutations carried by viruses, and from carcinogens. Carcinogens are substances known to produce or promote the development of cancer. These include substances such as tobacco smoke and other air pollutants. 5.4 KEY CONCEPT Cells work together to carry out complex functions. Your body began as a single fertilized egg. Since that time, your cells have not only gone through millions of cell divisions, but those cells have also undergone the process of cell differentiation by which unspecialized cells develop into their mature form and function. Groups of cells that work together to perform a similar function make up tissues. Groups of tissues that work together to perform a similar function make up organs. Groups of organs that carry out related functions make up organ systems. The interaction of multiple organ systems working together helps organisms maintain homeostasis. An organism’s body plan is established in the very earliest stages of embryonic development. In both animals and plants, a cell’s location within the embryo helps determine how that cell will differentiate. In animals, cells migrate to specific areas that will determine how they specialize. Plant cells cannot readily migrate because of their cell walls. However, the cells remain very adaptable throughout the life of the plant. Stem cells are a unique type of body cell characterized by three features: • They divide and renew themselves for long periods of time. • They remain undifferentiated in form. • They can develop into a variety of specialized cell types. Because of their ability to develop into other types of cells, stem cells offer great hope for curing damaged organs and currently untreatable diseases. However, they also raise many ethical concerns. Stem cells can be categorized by their developmental potential, as totipotent, pluripotent, or multipotent. Stem cells can also be classified by origin, as adult or embryonic. Chapter 6 Vocabulary: somatic cell egg genotype gamete polar body phenotype homologous chromosome trait dominant autosome genetics recessive sex chromosome purebred Punnett square sexual reproduction cross monohybrid cross fertilization law of segregation testcross diploid gene dihybrid cross haploid allele law of independent assortment meiosis homozygous probability gametogenesis heterozygous crossing over sperm genome genetic linkage 6.1 KEY CONCEPT Gametes have half the number of chromosomes that body cells have. Your body is made of two basic cell types. One basic type are somatic cells, also called body cells, which make up almost all of your tissues and organs. The second basic type are germ cells, which are located in your reproductive organs. They are the cells that will undergo meiosis and form gametes. Gametes are sex cells. They include eggs and sperm cells. Each species has a characteristic number of chromosomes per cell. Body cells are diploid, which means that each cell has two copies of each chromosome, one from each parent. Gametes are haploid, which means that each cell has one copy of each chromosome. Gametes join together during fertilization, which is the actual fusion of egg and sperm, and restores the diploid number. The diploid chromosome number in humans is 46. Your cells need both copies of each chromosome to function properly. Each pair of chromosomes is called homologous. Homologous chromosomes are a pair of chromosomes that have the same overall appearance and carry the same genes. One comes from the mother, and one comes from the father. Thus, one chromosome from a pair of homologous chromosomes might carry a gene that codes for green eye color, while the other carries a gene that codes for brown eye color. For reference, each pair of homologous chromosomes has been numbered, from largest to smallest. Chromosome pairs 1 through 22 are autosomes. Autosomes are chromosomes that contain genes for characteristics not directly related to sex. The two other chromosomes are sex chromosomes, chromosomes that directly control the development of sexual characteristics. In humans, a woman has two X chromosomes, and a man has an X and a Y chromosome. The Y chromosome is very small and carries few genes. Meiosis is a form of nuclear division that reduces chromosome number from diploid to haploid. Each haploid cell produced by meiosis has 22 autosomes and 1 sex chromosome. 6.2 KEY CONCEPT During meiosis, diploid cells undergo two cell divisions that result in haploid cells. Meiosis occurs after a cell has already duplicated its DNA. Cells go through two rounds of cell division during meiosis. During the first round, meiosis I, homologous chromosomes separate from each other. During the second round, meiosis II, sister chromatids separate from each other. Meiosis produces genetically unique haploid cells that will go through more steps to form mature gametes. Meiosis is a continuous process, but scientists have divided it into phases. • Prophase I: The nuclear membrane breaks down, and the spindle fibers assemble. The duplicated chromosomes condense, and homologous chromosomes pair up. The sex chromosomes also pair together. • Metaphase I: The homologous chromosome pairs randomly line up along the middle of the cell. Because this is random, there are a mixture of chromosomes from both parents on each side of the cell equator. • Anaphase I: The paired homologous chromosomes separate from each other and move to opposite sides of the cell. • Telophase I: The nuclear membrane forms in some species, the spindle fibers break apart, and the cell undergoes cytokinesis. Each cell has 23 duplicated chromosomes. • Prophase II: The nuclear membrane breaks down if necessary and the spindle fibers assemble again. • Metaphase II: The chromosomes line up along the middle of the cell. • Anaphase II: The sister chromatids are pulled apart from each other and move to opposite sides of the cell. • Telophase II: The nuclear membranes form again, the spindle fibers break apart, and the cell undergoes cytokinesis. The haploid cells produced by meiosis are not capable of fertilization. They must undergo additional steps to form mature gametes. During gametogenesis, sperm cells—the male gametes—and eggs—the female gametes—become specialized to carry out their functions. Sperm cells lose much of their cytoplasm and develop a tail. Eggs receive almost all of the cytoplasm during the divisions in meiosis. This is necessary for an embryo to have all the materials needed to begin life after fertilization. The smaller cells produced by meiosis in the female are called polar bodies, and they are eventually broken down. 6.3 KEY CONCEPT Mendel’s research showed that traits are inherited as discrete units. Traits are inherited characteristics, and genetics is the study of the biological inheritance of traits and variation. Gregor Mendel, an Austrian monk, first recognized that traits are inherited as discrete units. We call these units genes. Mendel conducted his experiments with pea plants, which were an excellent choice because they are easily manipulated, produce large numbers of offspring, and have a short life cycle. Mendel made three important decisions that helped him to see patterns in the resulting offspring. • Use of purebred plants: Mendel used pea plants that had self-pollinated for so long that they had become genetically uniform, or purebred. This meant that the offspring looked like the parent plant. Because of this characteristic, Mendel knew that any differences he observed in the offspring were the result of his experiments. • Control over breeding: At the start of his experiments, Mendel removed the male flower parts from the pea plants. He then pollinated the female flower part with pollen from a plant of his choosing, which produced offspring referred to as the F1 generation. • Observation of “either-or” traits: Mendel studied seven traits that appeared in only two forms. For example, flowers were white or purple; peas were wrinkled or round. Mendel observed that when he mated, or crossed, a purple-flowered plant with a white-flowered plant, for example, all of the F1 offspring had purple flowers. Mendel next allowed the F1 offspring to self-pollinate; that is, the plant mated with itself. In the resulting offspring, the F2 generation, approximately three-fourths of the flowers were purple and one-fourth were white. Mendel continued to find this 3:1 ratio for each of his crosses, regardless of the specific trait he was examining. Based on his results, Mendel concluded that traits are inherited as discrete units. He also developed what is known as Mendel’s first law, or the law of segregation. This law states the following: • Organisms inherit two copies of each unit (gene), one from each parent. • The two copies separate, or segregate, during gamete formation. As a result, organisms donate only one copy of each unit (gene) in their gametes. 6.4 KEY CONCEPT Genes encode proteins that produce a diverse range of traits. A gene is a segment of DNA that tells the cell how to make a particular polypeptide. The location of a gene on a chromosome is called a locus. A gene has the same locus on both chromosomes in a pair of homologous chromosomes. In genetics, scientists often focus on a single gene or set of genes. Genotype typically refers to the genetic makeup of a particular set of genes. Phenotype refers to the physical characteristics resulting from those genes. An alternative form of a gene is an allele. The pea plants that Mendel worked with had two alleles for each gene. For example, there was an allele for round peas and an allele for wrinkled peas. Genes are not limited to two alleles, however. Some genes are found in many different forms throughout a population. Your cells have two alleles for each gene regardless of how many alleles are present in a population. Suppose there were 64 alleles of a hair color gene present in the human population. Your cells would only have two of those alleles, one from your mother and one from your father. If the two alleles are the same, they are homozygous. If the two alleles are different, they are heterozygous. Some alleles are dominant over others. • A dominant allele is expressed when two different alleles or two dominant alleles are present. Therefore, both homozygous dominant and heterozygous genotypes can produce the dominant phenotype. • A recessive allele is expressed only when both alleles are recessive. Therefore, only the homozygous recessive genotype can produce the recessive phenotype. Alleles may be represented using letters. Uppercase letters represent dominant alleles. Lowercase letters represent recessive alleles. 6.5 KEY CONCEPT The inheritance of traits follows the rules of probability. The possible genotypes resulting from a cross can be predicted using a Punnett square. A Punnett square is a grid. The axes are labeled with the alleles of each parent organism. The grid boxes show all of the possible genotypes of the offspring resulting from those two parents. A monohybrid cross is used when studying only one trait. A cross between a homozygous dominant organism and a homozygous recessive organism produces offspring that are all heterozygous and have the dominant phenotype. A cross between two heterozygous organisms results in a 3:1 phenotypic ratio in the offspring, where three-fourths have the dominant phenotype and one-fourth have the recessive phenotype. The genotypic ratio resulting from this cross is 1:2:1 of homozygous dominant:heterozygous:homozygous recessive. A testcross is a cross between an organism with an unknown genotype (dominant phenotype) and an organism with the recessive phenotype. If the organism with the unknown genotype is homozygous dominant, the offspring will all have the dominant phenotype. If it is heterozygous, half the offspring will have the dominant phenotype, and half will have the recessive phenotype. A dihybrid cross is used when studying the inheritance of two traits. Mendel’s dihybrid crosses helped him develop the law of independent assortment, which basically states that different traits are inherited separately. When two organisms that are heterozygous for both traits are crossed, the resulting phenotypic ratio is 9:3:3:1. Probability is the likelihood that a particular event, such as the inheritance of a particular allele, will happen. The events of meiosis and fertilization are random, so hereditary patterns can be calculated with probability. 6.6 KEY CONCEPT Independent assortment and crossing over during meiosis result in genetic diversity. In organisms that reproduce sexually, the independent assortment of chromosomes during meiosis and the random fertilization of gametes creates a lot of new genetic combinations. In humans, for example, there are over 64 trillion different possible combinations of chromosomes. Sexual reproduction creates genetically unique offspring that have a combination of both parents’ traits. This uniqueness increases the likelihood that some organisms will survive or even flourish in changing conditions. Genetic diversity is further increased through crossing over. Crossing over is the exchange of segments of chromosomes between homologous chromosomes. It happens during prophase I of meiosis I when homologous chromosomes pair up with each other and come into very close contact. At this stage, the chromosomes have already been duplicated. Part of a chromatid from each homologous chromosome may break off and reattach to the other chromosome. Crossing over is more likely to occur between genes that are far apart from each other on a chromosome. The likelihood that crossing over will happen is much less if two genes are located close together. Thus, genes that are located close together on a chromosome have a tendency to be inherited together, which is called genetic linkage. Most of the traits that Mendel studied were located on separate chromosomes, and so they assorted independently. When genes are on the same chromosome, however, their distance from each other is a large factor in how they assort. If they are far apart, crossing over is likely to occur between them and so they will assort independently. If they are close together, they are unlikely to be separated by crossing over and so they will not assort independently. Chapter 7 Vocabulary carrier incomplete dominance sex-linked gene codominance pedigree X chromosome inactivation polygenic trait karyotype 7.1 KEY CONCEPT The chromosomes on which genes are located can affect the expression of traits. There are two types of chromosomes: autosomes and sex chromosomes. Genes on the sex chromosomes determine an organism’s sex. Autosomes are all of the other chromosomes, and they do not directly affect sex determination. Gene expression can differ depending on the type of chromosome on which a gene is located. • Autosomal genes: There are two copies of each autosome, which means that there are two copies of each autosomal gene. However, the two copies of a gene may be different alleles. Both copies of a gene can affect phenotype. Much of what has been learned about human genes comes from studies of genetic disorders. Many genetic disorders are caused by recessive alleles on autosomes. People who have one dominant allele and one recessive, disorder-causing allele, do not have the disorder, but can pass it on because they are carriers of the disorder. • Sex-linked genes: Genes on the sex-chromosomes (the X and Y chromosomes in many species) are sex-linked genes. In mammals, including humans, and some other animals, XX individuals are female and XY individuals are male. Because males have only one copy of each sex chromosome, all of the genes on each chromosome will be expressed. Expression of sex-linked genes in females is similar to the expression of autosomal genes: two copies of each gene can affect phenotype. However, one X chromosome in each cell is randomly turned off by a process called X chromosome inactivation. 7.2 KEY CONCEPT Phenotype is affected by many different factors. Although some genetic traits are produced by one gene with dominant and recessive alleles, most genetic traits are the result of more complex relationships among genes and alleles. In many cases phenotype comes from more than just one gene, and many genes have more than just two alleles. • Incomplete dominance: In incomplete dominance, neither of two alleles is completely dominant or completely recessive. Instead, the alleles show incomplete dominance, where the heterozygous phenotype is somewhere between the homozygous dominant and homozygous recessive phenotypes. The heterozygous phenotype is a third, distinct phenotype. • Codominance: In codominance, two alleles of a gene are completely and separately expressed, and both phenotypes are also completely expressed. Human blood type is an example of both codominance and a multiple allele trait. The alleles for blood types A and B are codominant, which can be expressed as an AB blood type. The allele for type O blood is recessive to the other two alleles. • Polygenic traits: Traits that are produced by two or more genes are polygenic traits. Because many different gene interactions can occur with polygenic traits, these traits often have a wide, continuous range of phenotypes. • Epistasis: An epistatic gene is a gene that can affect the expression of all of the other genes that affect a trait. The environment can influence gene expression, which then affects phenotype. Human height is a trait that is partially due to environment. Another example is how temperature affects sex determination of sea turtles. 7.4 KEY CONCEPT A combination of methods is used to study human genetics. The patterns of inheritance in humans are the same as the patterns of inheritance in other sexually reproducing organisms. Phenotypes are often the result of varying degrees of dominance, several genes, multiple alleles, or sex-linked genes. Only females can be carriers of sex-linked disorders. Females, who have an XX genotype for their sex chromosomes, must have two recessive alleles to show a recessive phenotype, such as for a recessive sex-linked disorder. Males, on the other hand, have an XY genotype. They will show all of the phenotypes from the genes on their X chromosome, even the recessive alleles, because they cannot have a second, dominant allele that could mask the recessive allele. The potential for a genetic disorder to be passed on through a family can be studied using pedigree analysis. A pedigree is a chart that is used to trace phenotypes and genotypes within a family. It can help show whether someone in a family may have recessive alleles that cause a genetic disorder. In addition to pedigrees, other methods of studying human genetics are used. Karyotypes, for example, are pictures of all of a person’s chromosomes that can show any large changes in the chromosomes. Chapter 8 Vocabulary nucleotide RNA polymerase mutagen messenger RNA (mRNA) mutation double helix ribosomal RNA (rRNA) point mutation base pairing rules transfer RNA (tRNA) frameshift mutation replication translation DNA polymerase codon central dogma stop codon RNA start codon transcription anticodon 8.2 KEY CONCEPT DNA structure is the same in all organisms. DNA is a chain of nucleotides. In DNA, each nucleotide is made of a phosphate group, a sugar called deoxyribose, and one of four nitrogen-containing bases. These four bases are cytosine (C), thymine (T), adenine (A), and guanine (G). Two of the bases, C and T, have a single-ring structure. The other two bases, A and G, have a double-ring structure. Although scientists had a good understanding of the chemical structure of DNA by the 1950s, they did not understand its three-dimensional structure. The contributions of several scientists helped lead to this important discovery. • Erwin Chargaff analyzed the DNA from many different organisms and realized that the amount of A is equal to the amount of T, and the amount of C is equal to the amount of G. This A = T and C = G relationship became known as Chargaff ’s rules. • Rosalind Franklin and Maurice Wilkins studied DNA structure using x-ray crystallography. Franklin’s data suggested that DNA is a helix consisting of two strands that are a regular, consistent width apart. James Watson and Francis Crick applied Franklin’s and Chargaff ’s data in building a three-dimensional model of DNA. They confirmed that DNA is a double helix in which two strands of DNA wind around each other like a twisted ladder. The sugar and phosphate molecules form the outside strands of the helix, and the bases pair together in the middle, forming hydrogen bonds that hold the two sides of the helix together. A base with a double ring pairs with a base with a single ring. Thus, in accordance with Chargaff ’s rules, they realized that A pairs with T, and C pairs with G. The bases always pair this way, which is called the base pairing rules. 8.3 KEY CONCEPT DNA replication copies the genetic information of a cell. Every cell needs its own complete set of DNA, and the discovery of the three-dimensional structure of DNA immediately suggested a mechanism by which the copying of DNA, or DNA replication, could occur. Because the DNA bases pair in only one way, both strands of DNA act as templates that direct the production of a new, complementary strand. DNA replication takes place during the S stage of the cell cycle. The process of DNA replication is very similar in both eukaryotes and prokaryotes, but we will focus on eukaryotes. • During the S stage of the cell cycle, the DNA is loosely organized in the nucleus. Certain enzymes start to unzip the double helix at places called origins of replication. The double helix unzips in both directions along the strand. Eukaryotic chromosomes are very long, so they have many origins of replication to help speed the process. Other proteins hold the two strands apart. • The unzipping exposes the bases on the DNA strands and enables free-floating nucleotides to pair up with their complementary bases. DNA polymerases bond the nucleotides together to form new strands that are complementary to the original template strands. • The result is two identical strands of DNA. DNA replication is described as semiconservative because each DNA molecule has one new strand and one original strand. DNA polymerase not only bonds nucleotides together. It also has a proofreading function. It can detect incorrectly paired nucleotides, clip them out, and replace them with the correct nucleotides. Uncorrected errors are limited to about one per 1 billion nucleotides. 8.4 KEY CONCEPT Transcription converts a gene into a single-stranded RNA molecule. DNA provides the instructions needed by a cell to make proteins. But the instructions are not made directly into proteins. First, a DNA message is converted into RNA in a process called transcription. Then, the RNA message is converted into proteins in a process called translation. The relationship between these molecules and processes is summed up in the central dogma, which states that information flows in one direction, from DNA to RNA to proteins. Like DNA, RNA is a nucleic acid. It is made of nucleotides that consist of a phosphate group, a sugar, and a nitrogen-containing base. However, RNA differs in important ways from DNA: (1) RNA contains the sugar ribose, not deoxyribose; (2) RNA is made up of the nucleotides A, C, G, and uracil, U, which forms base pairs with A; (3) RNA is usually single-stranded. This single-stranded structure enables RNA to fold back on itself into specific structures that can catalyze reactions, much like an enzyme. During transcription, a gene is transferred into RNA. Specific DNA sequences and a combination of accessory proteins help RNA polymerase recognize the start of a gene. RNA polymerase is a large enzyme that bonds nucleotides together to make RNA. RNA polymerase, in combination with the other proteins, forms a large transcription complex that unwinds a segment of the DNA molecule. Using only one strand of DNA as a template, RNA polymerase strings together a complementary RNA strand that has U in place of T. The DNA strand zips back together as the transcription complex moves forward along the gene. Transcription makes three main types of RNA. • Messenger RNA (mRNA) is the intermediate message between DNA and proteins. It is the only type of RNA that will be translated to form a protein. • Ribosomal RNA (rRNA) forms a significant part of ribosomes. • Transfer RNA (tRNA) carries amino acids from the cytoplasm to the ribosome during translation. The DNA of a cell therefore has genes that code for proteins, as well as genes that code for rRNA and tRNA. 8.5 KEY CONCEPT Translation converts an mRNA message into a polypeptide, or protein. Translation is the process that converts an mRNA message into a polypeptide, or protein. An mRNA message is made up of combinations of four nucleotides, whereas proteins are made up of twenty types of amino acids. The mRNA message is read as a series of non-overlapping codons, a sequence of three nucleotides that code for an amino acid. Many amino acids are coded for by more than one codon. In general, codons that code for the same amino acid share the same first two nucleotides. Three codons, called stop codons, signal the end of the polypeptide. There is also a start codon, which both signals the start of translation and codes for the amino acid methionine. This genetic code is the same in almost all organisms, so it is sometimes called the universal genetic code. Although tRNA and rRNA are not translated into proteins, they play key roles in helping cells translate mRNA into proteins. Each tRNA molecule folds up into a characteristic L shape. One end has three nucleotides called an anticodon, which recognize and bind to a codon on the mRNA strand. The other end of the tRNA molecule carries a specific amino acid. A combination of rRNA and proteins make up the ribosome. Ribosomes consist of a large and small subunit. The large subunit has binding sites for tRNA. The small subunit binds to the mRNA strand. At the start of translation, a small subunit binds to an mRNA strand. Then the large subunit joins. A tRNA molecule binds to the start codon. Another tRNA molecule binds to the next codon. The ribosome forms a bond between the two amino acids carried by the tRNA molecules and pulls the mRNA strand by the length of one codon. This causes the first tRNA molecule to be released and opens up a new codon for binding. This process continues to be repeated until a stop codon is reached and the ribosome falls apart. 8.7 KEY CONCEPT Mutations are changes in DNA that may or may not affect phenotype. A mutation is a change in an organism’s DNA. Although a cell has mechanisms to deal with mutations, exposure to mutagens may cause mutations to happen more quickly than the body can repair them. Mutagens are agents in the environment that can change DNA. Some occur naturally, such as UV light from the Sun. Many other mutagens are industrial chemicals. Mutations may affect individual genes or an entire chromosome. Gene mutations include point mutations and frameshift mutations. • A point mutation is a substitution in a single nucleotide. • A frameshift mutation involves the insertion or deletion of a nucleotide or nucleotides. It throws off the reading frame of the codons that come after the mutation. Chromosomal mutations include gene duplications and translocations. Gene duplication is the result of improper alignment during crossing over. It results in one chromosome having two copies of certain genes, and the other chromosome having no copies of those genes. Translocation is the movement of a piece of one chromosome to another, nonhomologous chromosome. Mutations may or may not affect phenotype. Chromosomal mutations affect many genes and tend to have a large effect on an organism. They may also cause breaks in the middle of a gene, causing that gene to no longer function or to make a hybrid with a new function. The effect of a gene mutation can also vary widely. For example, a point mutation may occur in the third nucleotide of a codon and have no effect on the amino acid coded for. Or the mutation may occur in an intron and thus have no effect. However, the mutation might result in the incorporation of an incorrect amino acid that messes up protein folding and function. Or it might code for a premature stop codon. Even mutations that occur in noncoding regions of DNA can have significant effects if they disrupt a splice site or a DNA sequence involved in gene regulation. For a mutation to affect offspring, it must occur in an organism’s germ cells. Chapter 10 Vocabulary evolution variation fitness species adaptation biogeography fossil artificial selection homologous structure catastrophism heritability analogous structure gradualism natural selection vestigial structure uniformitarianism population 10.1 KEY CONCEPT There were theories of biological and geologic change before Darwin. Evolution is the process of biological change by which descendants come to differ from their ancestors. Charles Darwin was not the first scientist to share his ideas about evolution and how it occurs. • Carolus Linnaeus proposed that plant varieties, or species—a group of organisms so similar to one another that they can reproduce and have fertile offspring—can be crossed to create new species. • Georges Buffon proposed that species shared ancestors instead of arising separately, the common thought of the time. • Erasmus Darwin, Charles Darwin’s grandfather, noted that more-complex forms of life seemed to arise from less-complex forms. • Jean-Baptiste Lamarck recognized that changes in physical characteristics could be passed on to offspring and were driven by environmental changes over time. Although Lamarck had ideas that influenced Darwin’s thinking, his explanation of how organisms evolve was flawed. He thought, for example, that the long necks of giraffes evolved as generations of giraffes reached for leaves higher in the trees. This idea, which was later discredited, is known as the inheritance of acquired characteristics. The field of geology also offered insights into evolution. Geologists noted that fossils—traces of organisms that existed in the past—in deeper layers of rock were quite different than those found in the upper layers. There were several ideas proposed to explain how such changes occur. • The theory of catastrophism states that natural disasters such as floods and volcanic eruptions have happened often during Earth’s long history. These events shaped landforms and caused species to become extinct in the process. • The principle of gradualism states that changes in landforms result from slow changes over a long period of time. • The theory of uniformitarianism states that the geologic processes that shape Earth are uniform through time. The theory of uniformitarianism, proposed by geologist Charles Lyell, combines gradualism with the observation that changes on Earth have occurred at a constant rate and are ongoing. The concept of uniformitarianism greatly affected Darwin’s thinking. 10.2 KEY CONCEPT Darwin’s voyage provided insights into evolution. Darwin traveled aboard the ship HMS Beagle to map the coast of South America and the Pacific Islands in 1831. He observed variation—the difference in the physical traits of an individual from those of other individuals in the same population—between island species on his voyage. The differences were especially noticeable on the Galápagos Islands off of South America. Some differences seemed well-suited to the animals’ environments and diets. He noticed that species have adaptations, or features that allow them to better survive in their environments. Adaptations can lead to genetic change in a population over time. • Saddle-backed tortoises, which have long necks and legs, lived in areas with a lot of tall plants. Domed tortoises, with their shorter necks and legs, lived in wet areas rich in mosses and short plants. • Finches with strong, thick beaks lived in areas with a lot of large, hard-shelled nuts. Species of finch with more delicate beaks were found where insects or fruits were widely available. On his voyage, Darwin also saw fossil evidence of species changing over time. • He found fossils of huge animals, such as Glyptodon, a giant armadillo. He recognized that these fossils looked like living species, which suggested to him that modern animals might have some relationship to fossil forms. • He observed fossil shells of marine organisms high up in the mountains. Later, Darwin experienced an earthquake and saw firsthand the result: land that had been underwater was moved above sea level. Darwin realized that over long periods of time, gradual geologic or biological processes can add up to great change. 10.3 KEY CONCEPT Darwin proposed natural selection as a mechanism for evolution. Darwin’s ideas about evolution were influenced by many different sources. One important influence was the work of farmers and breeders. Artificial selection, the process by which humans change a species by breeding it for certain traits, provided Darwin with some important insights. He noticed that breeders could produce a great amount of diversity through selection of certain traits. In order for artificial selection to occur, the trait must be heritable. Heritability is the ability of a trait to be inherited, or passed down, from one generation to the next. Darwin extended the ideas he gained from studying artificial selection to his theory of natural selection. Natural selection is a mechanism by which individuals that have inherited beneficial adaptations produce more offspring on average than do other individuals. Unlike artificial selection, where humans do the selecting of traits, in natural selection the environment is the selective agent. Natural selection is based upon four principles: • Overproduction: producing more offspring than are likely to survive • Variation: the heritable differences that exist in every population • Adaptation: a certain characteristic that allows an individual to survive better than other individuals it competes against for resources • Descent with modification: the spread of an adaptation throughout new generations Natural selection works on physical traits rather than genetic material itself. New traits are not made by natural selection. Natural selection can act only on traits that already exist in a population. 10.4 KEY CONCEPT Evidence of common ancestry among species comes from many sources. Darwin found evidence supporting evolution from a wide range of sources. The most important and convincing support came from fossils, geography, embryology, and anatomy. • The fossil is a record of change in a species over time. Geologists found that fossil organisms on the bottom, or older, layers were more primitive than those in the upper, or newer, layers. These findings supported Darwin’s concept of descent with modification. • Biogeography, the study of the distribution of organisms around the world, reveals a pattern of evolution of organisms. Darwin’s observations on the Galapagos islands, for instance, demonstrated that species can adapt to different environments and evolve into separate populations or species over time. • Embryology, the study of embryo development, reveals that even organisms that are very different from each other in their adult forms can have similar patterns of development. Two species that exhibit similar traits during development are likely to have a common ancestor. • Anatomy also provides insight into evolution. Homologous structures are features that are similar in structure but appear in different organisms and have different functions. Vestigial structures are remnants of organs or structures that had a function in an early ancestor. Both homologous structures and vestigial structures point to a shared ancestry among organisms that share them.