Repolarization reserve, arrhythmia and new drug development
... It recently has been reported that other currents also contribute to repolarization reserve. Several studies indicated that late sodium current (INa,L) was up-regulated by various factors and represented a functional reserve under disease conditions. Augmentation of INa,L by gene mutations or polymo ...
... It recently has been reported that other currents also contribute to repolarization reserve. Several studies indicated that late sodium current (INa,L) was up-regulated by various factors and represented a functional reserve under disease conditions. Augmentation of INa,L by gene mutations or polymo ...
Pericardial Disease: Etiology, Pathophysiology
... Echocardiography is, without doubt, the best tool for establishing the presence of pericardial effusion. Not only can the presence or absence of pericardial effusion be established with remarkable certainty33 (Fig. 68.1), but, in addition, one can make a reliable estimate as to whether the effusion ...
... Echocardiography is, without doubt, the best tool for establishing the presence of pericardial effusion. Not only can the presence or absence of pericardial effusion be established with remarkable certainty33 (Fig. 68.1), but, in addition, one can make a reliable estimate as to whether the effusion ...
Title Page - Adolescent Health
... •Prodromal symptoms (dizzy, visual, auditory changes, nausea, diaphoresis) •Trigger event •Vasovagal more likely if standing for long time ...
... •Prodromal symptoms (dizzy, visual, auditory changes, nausea, diaphoresis) •Trigger event •Vasovagal more likely if standing for long time ...
digoxin delusions - UCSF | Department of Medicine
... • There was increased mortality in the digoxin group when serum digoxin levels exceed 1.2 ng/ml. The upper limit of normal in most labs is 2.0 ng/ml. In fact, at digoxin levels of 0.9 ng/ml or higher, there is no benefit to giving digoxin. • Bottom line: if you are going to use digoxin in your heart ...
... • There was increased mortality in the digoxin group when serum digoxin levels exceed 1.2 ng/ml. The upper limit of normal in most labs is 2.0 ng/ml. In fact, at digoxin levels of 0.9 ng/ml or higher, there is no benefit to giving digoxin. • Bottom line: if you are going to use digoxin in your heart ...
Print - Circulation
... To evaluate this problem in the diseased heart we simulated an LVAD in the operating room by bypassing and unloading the left ventricle with the heart-lung machine before routine open heart surgery. Right ventricular function was assessed in 12 patients with preoperative left ventricular ejection fr ...
... To evaluate this problem in the diseased heart we simulated an LVAD in the operating room by bypassing and unloading the left ventricle with the heart-lung machine before routine open heart surgery. Right ventricular function was assessed in 12 patients with preoperative left ventricular ejection fr ...
cardio i - jan 2015
... Are P waves present? Are the P waves regular? Is there one P wave for each QRS complex? Are the P waves upright or inverted? Do all the P waves look alike? ...
... Are P waves present? Are the P waves regular? Is there one P wave for each QRS complex? Are the P waves upright or inverted? Do all the P waves look alike? ...
Risk prediction and prognosis following cardiac surgery
... disease alone is responsible for about 24%, which makes it the leading cause of death 1. Various surgical and medical treatment strategies are available for a broad variety of cardiovascular diseases, including both ischemic heart disease and heart valve diseases. Worldwide, the first records of hea ...
... disease alone is responsible for about 24%, which makes it the leading cause of death 1. Various surgical and medical treatment strategies are available for a broad variety of cardiovascular diseases, including both ischemic heart disease and heart valve diseases. Worldwide, the first records of hea ...
Increased plasma arginine vasopressin levels in patients
... Patient selection. Thirty-one patients with clear evidence of congestive heart failure on the basis of typical history and physical findings formed the basic study population . All had supporting noninvasive evidence for the syndrome including an enlarged heart on chest X-ray examination and either ...
... Patient selection. Thirty-one patients with clear evidence of congestive heart failure on the basis of typical history and physical findings formed the basic study population . All had supporting noninvasive evidence for the syndrome including an enlarged heart on chest X-ray examination and either ...
Solutions for Electrocardiograph and Heart Rate Monitor Applications
... • Atrial systole: Atria contract and eject blood to the ventricles in a passive way. Once the blood has been expelled from the atria, atrioventricular valves (located between atria and ventricles) are closed to avoid blood return. • Ventricular systole: The ventricles contract, ejecting blood toward ...
... • Atrial systole: Atria contract and eject blood to the ventricles in a passive way. Once the blood has been expelled from the atria, atrioventricular valves (located between atria and ventricles) are closed to avoid blood return. • Ventricular systole: The ventricles contract, ejecting blood toward ...
Analysis of the Heart Sounds and Murmurs of Fetuses - REAL-PhD
... Cardiac auscultation is one of the oldest examination methods. Despite the development of modern imaging techniques the stethoscope is still considered a symbol of the doctor’s profession. At the beginning of the 21th century auscultation has found its main role in primary and in home health care wh ...
... Cardiac auscultation is one of the oldest examination methods. Despite the development of modern imaging techniques the stethoscope is still considered a symbol of the doctor’s profession. At the beginning of the 21th century auscultation has found its main role in primary and in home health care wh ...
2012 focused update of the ESC Guidelines
... and a three-fold incidence of congestive heart failure, and higher mortality. Hospitalization of patients with AF is also very common. This arrhythmia is a major cardiovascular challenge in modern society and its medical, social and economic aspects are all set to worsen over the coming decades. For ...
... and a three-fold incidence of congestive heart failure, and higher mortality. Hospitalization of patients with AF is also very common. This arrhythmia is a major cardiovascular challenge in modern society and its medical, social and economic aspects are all set to worsen over the coming decades. For ...
2012 focused update of the ESC Guidelines for the management of
... and a three-fold incidence of congestive heart failure, and higher mortality. Hospitalization of patients with AF is also very common. This arrhythmia is a major cardiovascular challenge in modern society and its medical, social and economic aspects are all set to worsen over the coming decades. For ...
... and a three-fold incidence of congestive heart failure, and higher mortality. Hospitalization of patients with AF is also very common. This arrhythmia is a major cardiovascular challenge in modern society and its medical, social and economic aspects are all set to worsen over the coming decades. For ...
Focused update 2012 on atrial fibrillation
... and a three-fold incidence of congestive heart failure, and higher mortality. Hospitalization of patients with AF is also very common. This arrhythmia is a major cardiovascular challenge in modern society and its medical, social and economic aspects are all set to worsen over the coming decades. For ...
... and a three-fold incidence of congestive heart failure, and higher mortality. Hospitalization of patients with AF is also very common. This arrhythmia is a major cardiovascular challenge in modern society and its medical, social and economic aspects are all set to worsen over the coming decades. For ...
Water and sodium regulation in chronic heart failure: the role of
... atrium is positively correlated with mean right atrial pressure and ANP mRNA in subjects undergoing cardiac surgery, which has led to the suggestion that atrial pressure may also be an important regulatory mechanism [63]. Much less is known regarding the haemodynamic factors responsible for CNP rele ...
... atrium is positively correlated with mean right atrial pressure and ANP mRNA in subjects undergoing cardiac surgery, which has led to the suggestion that atrial pressure may also be an important regulatory mechanism [63]. Much less is known regarding the haemodynamic factors responsible for CNP rele ...
Running head: ATRIAL FIBRILLATION
... Flaker, 2005). Atrial pacing prevents bradycardia, synchronizes the atria, and reduces the dispersion of refractoriness thus reducing the incidence of atrial fibrillation (Khaja & Flaker, 2005). An additional benefit of atrial pacing is that it synchronizes the atria thus reducing conduction delay ( ...
... Flaker, 2005). Atrial pacing prevents bradycardia, synchronizes the atria, and reduces the dispersion of refractoriness thus reducing the incidence of atrial fibrillation (Khaja & Flaker, 2005). An additional benefit of atrial pacing is that it synchronizes the atria thus reducing conduction delay ( ...
experiments on the origin of auricular flutter and fibrillation
... during the stimulation. The form of the wave is compatible with flutter despite the presence of isoelectric lines between the single auricular waves. The contiguity of the waves need not be present, at least in some leads, in flutter. Against the diagnosis of auricular paroxysmal tachycardia due to ...
... during the stimulation. The form of the wave is compatible with flutter despite the presence of isoelectric lines between the single auricular waves. The contiguity of the waves need not be present, at least in some leads, in flutter. Against the diagnosis of auricular paroxysmal tachycardia due to ...
2012 focused update of the ESC Guidelines for the management of
... and a three-fold incidence of congestive heart failure, and higher mortality. Hospitalization of patients with AF is also very common. This arrhythmia is a major cardiovascular challenge in modern society and its medical, social and economic aspects are all set to worsen over the coming decades. For ...
... and a three-fold incidence of congestive heart failure, and higher mortality. Hospitalization of patients with AF is also very common. This arrhythmia is a major cardiovascular challenge in modern society and its medical, social and economic aspects are all set to worsen over the coming decades. For ...
cardiovascular magnetic resonance in the prediction of outcome
... immediate predecessor as research fellow, and he devised the CMR-TSI technique with Dr Leyva and Dr Stegemann. My work followed on from Dr Chalil’s original work and naturally developed from the work already undertaken. Dr Chalil analysed the original 20 controls and 77 patients undergoing CRT. He a ...
... immediate predecessor as research fellow, and he devised the CMR-TSI technique with Dr Leyva and Dr Stegemann. My work followed on from Dr Chalil’s original work and naturally developed from the work already undertaken. Dr Chalil analysed the original 20 controls and 77 patients undergoing CRT. He a ...
- Korean Circulation Journal
... study. Patients who were <19 years of age, were diagnosed with an infectious disease, had experienced allograft rejection or heart failure symptoms, were not in the normal sinus rhythm, or had a pacemaker, were excluded from the study. The study consisted of two series. The first series was a post-H ...
... study. Patients who were <19 years of age, were diagnosed with an infectious disease, had experienced allograft rejection or heart failure symptoms, were not in the normal sinus rhythm, or had a pacemaker, were excluded from the study. The study consisted of two series. The first series was a post-H ...
Early right ventricular fibrosis and reduction in - AJP
... of adipose tissue and fibrosis such that most patients are nonambulatory by their teenage years (11). As the disease progresses, the muscles of respiration are increasingly affected resulting in significant respiratory insufficiency (4, 31, 42). This respiratory failure is a leading cause of death i ...
... of adipose tissue and fibrosis such that most patients are nonambulatory by their teenage years (11). As the disease progresses, the muscles of respiration are increasingly affected resulting in significant respiratory insufficiency (4, 31, 42). This respiratory failure is a leading cause of death i ...
Genetics - Circulation
... to which genetic modifiers contribute to incomplete penetrance and phenotypic variability as observed in humans might only be appreciated, however, in a much larger study. In this regard, the diverse anatomic phenotypes described in association with Nkx2-5 mutation offer a foothold into the genetic ...
... to which genetic modifiers contribute to incomplete penetrance and phenotypic variability as observed in humans might only be appreciated, however, in a much larger study. In this regard, the diverse anatomic phenotypes described in association with Nkx2-5 mutation offer a foothold into the genetic ...
Arrhythmia ToolBox Resources
... Content Course I: AACN - Basic ECG Interpretation by American Association of Critical-Care Nurses (ACCN) is designed to provide knowledge and enhance skills in adult ECG interpretation basics including rhythm categories of sinus, atrial, junctional, ventricular, and heart blocks, cardiac anatomy and ...
... Content Course I: AACN - Basic ECG Interpretation by American Association of Critical-Care Nurses (ACCN) is designed to provide knowledge and enhance skills in adult ECG interpretation basics including rhythm categories of sinus, atrial, junctional, ventricular, and heart blocks, cardiac anatomy and ...
Influence of pacing site on canine left ventricular contraction
... and right ventricular free wall pacing were compared. At a given volume, the peak isovolumic pressure was determined while pacing from each site. The volume was then changed in a random manner, and the pacing site variation was repeated. In each heart studied, the volume was varied between approxima ...
... and right ventricular free wall pacing were compared. At a given volume, the peak isovolumic pressure was determined while pacing from each site. The volume was then changed in a random manner, and the pacing site variation was repeated. In each heart studied, the volume was varied between approxima ...
Myocardial infarction
Myocardial infarction (MI) or acute myocardial infarction (AMI), commonly known as a heart attack, occurs when blood flow stops to a part of the heart causing damage to the heart muscle. The most common symptom is chest pain or discomfort which may travel into the shoulder, arm, back, neck, or jaw. Often it is in the center or left side of the chest and lasts for more than a few minutes. The discomfort may occasionally feel like heartburn. Other symptoms may include shortness of breath, nausea, feeling faint, a cold sweat, or feeling tired. About 30% of people have atypical symptoms, with women more likely than men to present atypically. Among those over 75 years old, about 5% have had an MI with little or no history of symptoms. An MI may cause heart failure, an irregular heartbeat, or cardiac arrest.Most MIs occur due to coronary artery disease. Risk factors include high blood pressure, smoking, diabetes, lack of exercise, obesity, high blood cholesterol, poor diet, and excessive alcohol intake, among others. The mechanism of an MI often involves the rupture of an atherosclerotic plaque, leading to complete blockage of a coronary artery. MIs are less commonly caused by coronary artery spasms, which may be due to cocaine, significant emotional stress, and extreme cold, among others. A number of tests are useful to help with diagnosis, including electrocardiograms (ECGs), blood tests, and coronary angiography. An ECG may confirm an ST elevation MI if ST elevation is present. Commonly used blood tests include troponin and less often creatine kinase MB.Aspirin is an appropriate immediate treatment for a suspected MI. Nitroglycerin or opioids may be used to help with chest pain; however, they do not improve overall outcomes. Supplemental oxygen should be used in those with low oxygen levels or shortness of breath. In ST elevation MIs treatments which attempt to restore blood flow to the heart are typically recommended and include angioplasty, where the arteries are pushed open, or thrombolysis, where the blockage is removed using medications. People who have a non-ST elevation myocardial infarction (NSTEMI) are often managed with the blood thinner heparin, with the additional use angioplasty in those at high risk. In people with blockages of multiple coronary arteries and diabetes, bypass surgery (CABG) may be recommended rather than angioplasty. After an MI, lifestyle modifications, along with long term treatment with aspirin, beta blockers, and statins, are typically recommended.Worldwide, more than 3 million people have ST elevation MIs and 4 million have NSTEMIs each year. STEMIs occur about twice as often in men as women. About one million people have an MI each year in the United States. In the developed world the risk of death in those who have had an STEMI is about 10%. Rates of MI for a given age have decreased globally between 1990 and 2010.