Subcellular Calcium Content in Cardiomyopathic Hamster Hearts In
... Hamsters were anesthetized by intraperitoneal injection of Inactin (80-90 mg/kg body wt) and then taped, dorsal side down, to a board supported over a water bath. Animals were tracheotomized and ventilated with room air at 80-90 breaths/min, with a tidal volume of 1-1.2 ml. To ensure that the ventil ...
... Hamsters were anesthetized by intraperitoneal injection of Inactin (80-90 mg/kg body wt) and then taped, dorsal side down, to a board supported over a water bath. Animals were tracheotomized and ventilated with room air at 80-90 breaths/min, with a tidal volume of 1-1.2 ml. To ensure that the ventil ...
NIH Public Access
... mammals and birds, Tbx5 mRNA and protein are highly enriched in the prospective LV (Fig. 2b,c and Supplementary Fig. 5)8,9. At looping heart tube stages, Tbx5 was broadly expressed throughout the embryonic turtle and anole hearts (Fig. 2a,d), similar to Xenopus Tbx5 (Ref 13), but unlike its early re ...
... mammals and birds, Tbx5 mRNA and protein are highly enriched in the prospective LV (Fig. 2b,c and Supplementary Fig. 5)8,9. At looping heart tube stages, Tbx5 was broadly expressed throughout the embryonic turtle and anole hearts (Fig. 2a,d), similar to Xenopus Tbx5 (Ref 13), but unlike its early re ...
The Sequence of Retrograde Atrial Activation in the Canine Heart
... bath, and blood from the bath was gently poured over the atria at appropriate intervals to prevent any drying of the atrial tissue. In three additional experiments, the study heart was exposed through a right thoracotomy, and the heart was then perfused in situ. This in situ study allowed the record ...
... bath, and blood from the bath was gently poured over the atria at appropriate intervals to prevent any drying of the atrial tissue. In three additional experiments, the study heart was exposed through a right thoracotomy, and the heart was then perfused in situ. This in situ study allowed the record ...
Mitochondria in the diabetic heart
... in several subsequent studies.2,3 Other studies have shown that the increased risk for developing heart failure persists in diabetic patients after adjusting for age, blood pressure, weight, cholesterol, and coronary artery disease.4,5 These observations led to the introduction of the term ‘diabetic ...
... in several subsequent studies.2,3 Other studies have shown that the increased risk for developing heart failure persists in diabetic patients after adjusting for age, blood pressure, weight, cholesterol, and coronary artery disease.4,5 These observations led to the introduction of the term ‘diabetic ...
In utero pulmonary artery and aortic growth and potential for
... lesion (5) or in the presence of tricuspid valve disease and tricuspid insufficiency (6,7). Knowledge of the in utero natural history and potential for progression of cardiac defects is important not only for our understanding of the determinants of postnatally encountered disease, but also for appr ...
... lesion (5) or in the presence of tricuspid valve disease and tricuspid insufficiency (6,7). Knowledge of the in utero natural history and potential for progression of cardiac defects is important not only for our understanding of the determinants of postnatally encountered disease, but also for appr ...
Obstructive Sleep Apnea and Cardiovascular Disease
... (i.e., age, sex, race, smoking, alcohol consumption, body mass index, and the presence or absence of diabetes mellitus, dyslipidemia, atrial fibrillation, and hypertension).5 This finding is consistent with a cross-sectional study showing that patients with an apnea hypopnea index (AHI) ≥ 20 had sig ...
... (i.e., age, sex, race, smoking, alcohol consumption, body mass index, and the presence or absence of diabetes mellitus, dyslipidemia, atrial fibrillation, and hypertension).5 This finding is consistent with a cross-sectional study showing that patients with an apnea hypopnea index (AHI) ≥ 20 had sig ...
Haemodynamics in Essential Hypertension
... & Gajendragadkar, 1979). Only two include strictly untreated patients and have been performed with the same experimental conditions at both studies. In our series (Lund-Johansen, 1977, 1979a) 77 patients who had been investigated haemodynamically in 1964-1966 were restudied clinically, and 33 of the ...
... & Gajendragadkar, 1979). Only two include strictly untreated patients and have been performed with the same experimental conditions at both studies. In our series (Lund-Johansen, 1977, 1979a) 77 patients who had been investigated haemodynamically in 1964-1966 were restudied clinically, and 33 of the ...
CPR for the Healthcare Provider
... The second link in the chain is early CPR. CPR is most effective when started immediately after the collapse. The patient is twice as likely to have a successful resuscitation when bystanders perform CPR before EMS providers arrive on the scene. However, in most cases of out-of-hospital cardiac arre ...
... The second link in the chain is early CPR. CPR is most effective when started immediately after the collapse. The patient is twice as likely to have a successful resuscitation when bystanders perform CPR before EMS providers arrive on the scene. However, in most cases of out-of-hospital cardiac arre ...
Full Text
... of tachycardia were demonstrated during the course of electrophysiologic studies: AVNRT induced at baseline and VT, the same as the clinically documented arrhythmia. One unique feature of our case is the demonstration of the interrelationships of 2 different types of tachycardia. VT was initiated by ...
... of tachycardia were demonstrated during the course of electrophysiologic studies: AVNRT induced at baseline and VT, the same as the clinically documented arrhythmia. One unique feature of our case is the demonstration of the interrelationships of 2 different types of tachycardia. VT was initiated by ...
Definitions for a Common Standard for 2D Speckle Tracking
... Figure 3 Schematic diagram of the different LV segmentation models. Left panel: 16-segment model. Central panel: 17-segment model. Right panel: 18-segment model. In all diagrams, the outer circle represents the basal segments, the mid one the segments at the mid-papillary muscle level, and the inner ...
... Figure 3 Schematic diagram of the different LV segmentation models. Left panel: 16-segment model. Central panel: 17-segment model. Right panel: 18-segment model. In all diagrams, the outer circle represents the basal segments, the mid one the segments at the mid-papillary muscle level, and the inner ...
Introduction: Left ventricular (LV) twist and untwisting rate (LV twist
... structural or functional myocardial abnormalities were suspected using echocardiography, 2) were known or suspected to have any underlying medical conditions e.g. systematic diseases, high blood pressure, and 3) were currently smoking during the past 6 months. An a priori sample size calculation sug ...
... structural or functional myocardial abnormalities were suspected using echocardiography, 2) were known or suspected to have any underlying medical conditions e.g. systematic diseases, high blood pressure, and 3) were currently smoking during the past 6 months. An a priori sample size calculation sug ...
TNF-α and IL-10 Modulate CK and CK
... in various organs and tissues, such as bone marrow, lymph nodes, spleen, liver and skin, in addition the cardiac muscle. Cardiac muscle lesions provide the substances release, among which we can mention the creatine kinase (CK), its MB subunit (CK-MB) and troponin. The changes that cause these injur ...
... in various organs and tissues, such as bone marrow, lymph nodes, spleen, liver and skin, in addition the cardiac muscle. Cardiac muscle lesions provide the substances release, among which we can mention the creatine kinase (CK), its MB subunit (CK-MB) and troponin. The changes that cause these injur ...
The effects of 48 hours fasting at cardio
... membrane en open them, thus potassium permeability is increased. As a result, heart rate will decrease due to an efflux of potassium ions because the cellular membrane becomes more polarized. This hyperpolarization makes the generation of action potential more difficult, and thus slowing the rate of ...
... membrane en open them, thus potassium permeability is increased. As a result, heart rate will decrease due to an efflux of potassium ions because the cellular membrane becomes more polarized. This hyperpolarization makes the generation of action potential more difficult, and thus slowing the rate of ...
Isolated Heart Perfusion Systems
... tubing. This is accomplished by the use of the patented membrane afterload resistor and built-in compliance membranes which faithfully reproduce physiological peripheral and lung resistances and compliances. The system is also based on our Solid State Physiological Perfusion Circuit technology provi ...
... tubing. This is accomplished by the use of the patented membrane afterload resistor and built-in compliance membranes which faithfully reproduce physiological peripheral and lung resistances and compliances. The system is also based on our Solid State Physiological Perfusion Circuit technology provi ...
Heart Sounds Detecting and Analyzing Heart Murmurs
... • B) a saturation of 89% in an otherwise asymptomatic child with no murmurs • C) poor pulses and mottled skin in a distressed infant with no murmurs Which is least likely to have hemodynamically significant cardiac disease? ...
... • B) a saturation of 89% in an otherwise asymptomatic child with no murmurs • C) poor pulses and mottled skin in a distressed infant with no murmurs Which is least likely to have hemodynamically significant cardiac disease? ...
Evaluation of Syncope
... usually accompanied by falling, and with spontaneous recovery. Syncope must be carefully differentiated from other conditions that may cause a loss of consciousness or falling. Syncope can be classified into four categories: reflex mediated, cardiac, orthostatic, and cerebrovascular. A cardiac cause ...
... usually accompanied by falling, and with spontaneous recovery. Syncope must be carefully differentiated from other conditions that may cause a loss of consciousness or falling. Syncope can be classified into four categories: reflex mediated, cardiac, orthostatic, and cerebrovascular. A cardiac cause ...
Using a human cardiovascular-respiratory model to characterize
... Cardiac tamponade is a condition whereby the accumulation of fluid in the pericardial sac causes a hemodynamically significant in the intra-pericardial pressure (PPERI) which is conventionally defined as a liquid pressure. In a healthy subject, PPERI is approximately equal to the pleural pressure (P ...
... Cardiac tamponade is a condition whereby the accumulation of fluid in the pericardial sac causes a hemodynamically significant in the intra-pericardial pressure (PPERI) which is conventionally defined as a liquid pressure. In a healthy subject, PPERI is approximately equal to the pleural pressure (P ...
Relation of Ultrastructure to Function in the Intact Heart: Sarcomere
... preparation was perfused with fixative through the previously cannulated left coronary artery, employing glutaraldehyde, 6.25%, in phosphate buffer, pH 7.6. Previous studies have shown that this fixative does not change resting muscle tension9 and does not significantly alter filament dimensions or ...
... preparation was perfused with fixative through the previously cannulated left coronary artery, employing glutaraldehyde, 6.25%, in phosphate buffer, pH 7.6. Previous studies have shown that this fixative does not change resting muscle tension9 and does not significantly alter filament dimensions or ...
Aortic Stenosis: Pathophysiology, Diagnosis, and Medical Management of
... decade) than does tricuspid valve stenosis (seventh to eighth decade) because 2 cusps, instead of 3, are forced to absorb the shearing stress of blood flow leaving the left ventricle.7 The most common cause of aortic stenosis is valve calcification, termed calcific aortic valve disease (CAVD), which ...
... decade) than does tricuspid valve stenosis (seventh to eighth decade) because 2 cusps, instead of 3, are forced to absorb the shearing stress of blood flow leaving the left ventricle.7 The most common cause of aortic stenosis is valve calcification, termed calcific aortic valve disease (CAVD), which ...
Cortisol and Testosterone in Hair as Biological Markers of Systolic
... Heart failure is a progressive disease that occurs when the heart is unable to eject sufficient blood to meet the metabolic demands of the body. There are approximately 500,000 Canadians living with heart failure and 50,000 new patients are diagnosed each year (Ross et al. 2006). There are two main ...
... Heart failure is a progressive disease that occurs when the heart is unable to eject sufficient blood to meet the metabolic demands of the body. There are approximately 500,000 Canadians living with heart failure and 50,000 new patients are diagnosed each year (Ross et al. 2006). There are two main ...
Optimal pacing strategies for coming off CPB
... sufficient in pt with normal systolic or diastolic function, in the hemodynamically compromised patients, adjustment of the AV delay to a real-time measure of cardiac output (such as Doppler time-velocity integral at the aortic valve, pulse contour analysis CO, or the mixed venous oxygen saturation) ...
... sufficient in pt with normal systolic or diastolic function, in the hemodynamically compromised patients, adjustment of the AV delay to a real-time measure of cardiac output (such as Doppler time-velocity integral at the aortic valve, pulse contour analysis CO, or the mixed venous oxygen saturation) ...
AUTONOMIC FUNCTION TESTING Clinical Applications and
... Loss of quality of life (eating, sleep, voiding, sex) ...
... Loss of quality of life (eating, sleep, voiding, sex) ...
Aalborg Universitet Quality Assessment of Coronary Artery Bypass Graft Surgery
... vessel lumen is reduced a mismatch between oxygen demand and requirement occurs. The reduced perfusion of the myocardium can trigger ischemia, which is more distinct during exercise and can cause angina pectoris. [2, 16] The plaque content is protected by a fibrotic cap, which prevents thrombosis fo ...
... vessel lumen is reduced a mismatch between oxygen demand and requirement occurs. The reduced perfusion of the myocardium can trigger ischemia, which is more distinct during exercise and can cause angina pectoris. [2, 16] The plaque content is protected by a fibrotic cap, which prevents thrombosis fo ...
Myocardial infarction
Myocardial infarction (MI) or acute myocardial infarction (AMI), commonly known as a heart attack, occurs when blood flow stops to a part of the heart causing damage to the heart muscle. The most common symptom is chest pain or discomfort which may travel into the shoulder, arm, back, neck, or jaw. Often it is in the center or left side of the chest and lasts for more than a few minutes. The discomfort may occasionally feel like heartburn. Other symptoms may include shortness of breath, nausea, feeling faint, a cold sweat, or feeling tired. About 30% of people have atypical symptoms, with women more likely than men to present atypically. Among those over 75 years old, about 5% have had an MI with little or no history of symptoms. An MI may cause heart failure, an irregular heartbeat, or cardiac arrest.Most MIs occur due to coronary artery disease. Risk factors include high blood pressure, smoking, diabetes, lack of exercise, obesity, high blood cholesterol, poor diet, and excessive alcohol intake, among others. The mechanism of an MI often involves the rupture of an atherosclerotic plaque, leading to complete blockage of a coronary artery. MIs are less commonly caused by coronary artery spasms, which may be due to cocaine, significant emotional stress, and extreme cold, among others. A number of tests are useful to help with diagnosis, including electrocardiograms (ECGs), blood tests, and coronary angiography. An ECG may confirm an ST elevation MI if ST elevation is present. Commonly used blood tests include troponin and less often creatine kinase MB.Aspirin is an appropriate immediate treatment for a suspected MI. Nitroglycerin or opioids may be used to help with chest pain; however, they do not improve overall outcomes. Supplemental oxygen should be used in those with low oxygen levels or shortness of breath. In ST elevation MIs treatments which attempt to restore blood flow to the heart are typically recommended and include angioplasty, where the arteries are pushed open, or thrombolysis, where the blockage is removed using medications. People who have a non-ST elevation myocardial infarction (NSTEMI) are often managed with the blood thinner heparin, with the additional use angioplasty in those at high risk. In people with blockages of multiple coronary arteries and diabetes, bypass surgery (CABG) may be recommended rather than angioplasty. After an MI, lifestyle modifications, along with long term treatment with aspirin, beta blockers, and statins, are typically recommended.Worldwide, more than 3 million people have ST elevation MIs and 4 million have NSTEMIs each year. STEMIs occur about twice as often in men as women. About one million people have an MI each year in the United States. In the developed world the risk of death in those who have had an STEMI is about 10%. Rates of MI for a given age have decreased globally between 1990 and 2010.