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Packer -PARADIGM - Clinical Trial Results
Packer -PARADIGM - Clinical Trial Results

... The sample size of the trial was determined by effect on cardiovascular mortality, not the primary endpoint The Data Monitoring Committee was allowed to stop the trial only for a compelling effect on cardiovascular mortality (in addition to the primary endpoint) Difference in cardiovascular mortalit ...
Let`s Talk About: Atrial Fibrillation
Let`s Talk About: Atrial Fibrillation

... The St. Paul's Hospital Atrial Fibrillation Clinic established in November 2009 was the first of its kind in BC. The program now has about 900 enrolled patients and is one of the fastest growing specialized clinics of Providence Health Care. The UBC Division of Cardiac Electrophysiology has been in ...
Update on Global Heart Failure Program
Update on Global Heart Failure Program

... the funding requirements for the program. The growing body of clinical evidence validates our strong conviction in the potential of our product candidate MPC-150-IM to change the way that advanced heart failure is treated. We thank our partner Teva for having brought our Phase 3 heart failure progra ...
The Physiology of Deep Water Running
The Physiology of Deep Water Running

...  RER = (volume of CO2)/(volume of O2)  DeMaere and Ruby (1997)  DWR induced a higher RER ration indicating an increased reliance of carbohydrate oxidation and ...
Q1. In which patient is an implantable cardioverter defibrillator (ICD
Q1. In which patient is an implantable cardioverter defibrillator (ICD

... Q4. A patient is admitted for an acute anterior myocardial infarction and underwent emergent percutaneous coronary revascularization. His LVEF was estimated at 25%, and runs of asymptomatic non-sustained VT were observed on telemetry at day 3. Which of the following should be considered : A. B. C. D ...
Dronedarone for the treatment of atrial fibrillation and atrial flutter
Dronedarone for the treatment of atrial fibrillation and atrial flutter

... of Sinus Rhythm), ATHENA (A placebocontrolled, double-blind parallel arm Trial to assess the efficacy of dronedarone 400mg bid for the prevention of cardiovascular Hospitalisation or death from any cause in patiENts with Atrial fibrillation/atrial flutter) and DIONYSOS (Efficacy and Safety of Droned ...
ESC Guidelines 2008
ESC Guidelines 2008

... Angiotension-converting enzyme inhibitors Angiotensin receptor blockers Aldosterone antagonists Left ventricular assist device ...
Title of Presentation
Title of Presentation

... • May improve CO in some patient and hence increase effective renal perfusion • ACEI may lower BP to the point where effective renal perfusion is impaired • With chronic renal disease, there is hyperfiltration in the remaining nephrons. ACEI decreases efferent arteriole constriction and hence decrea ...
Reversing heart failure by CRT: how long do the effects last?
Reversing heart failure by CRT: how long do the effects last?

... adverse clinical events.13 The presence of an ICM, male sex, and a narrow QRS width (,140 ms) were predictors for non-response. Thus, a close look at the morphological changes in each individual patient and in particular in the ICM patients and in those who experience adverse clinical events such as ...
Electron Beam Tomography EBT - Oregon Institute of Technology
Electron Beam Tomography EBT - Oregon Institute of Technology

... CAD in the US For 450,000 Americans each year the very first symptom of a heart problem is a sudden heart attack. For one-third of them, that first attack is fatal. That's what makes an EBT imaging study so valuable. It is the first and only screening test approved by the Food and Drug Administrati ...
File - A. Hammond Biology
File - A. Hammond Biology

... Cardiac muscle is said to be myogenic. This means that, unlike striated muscle, cardiac muscle is selfexciting. Cardiac muscle cells beat continuously contracting on their own. The heartbeat can be changed by nervous or hormonal influences. Cardiac muscle never tires. The heartbeat is initiated in a ...
Tina`s 12 Lead Class Notes
Tina`s 12 Lead Class Notes

... Basic 12 Lead EKGs Review Pathological Q-waves are greater than 0.04 seconds in duration and/or at least one-third the amplitude of the R-wave. U-waves (if seen) should be low and have the same deflection as the T-wave. S-T segment J-point is located at the end of the QRS where the T-wave begins. It ...
Chapter 8 - Delmar Cengage Learning
Chapter 8 - Delmar Cengage Learning

... • Veins are blood vessels that carry blood toward the heart – Combining forms for vein are ven/o and phleb/o ...
8 Cardio Exam
8 Cardio Exam

... Shortly after S2, the closing of the semilunar valves, the AV valves open and diastole begins. Diastole is itself further divided into several stages, the first being that of rapid filling, where 80% of the blood stored in the atria during systole is transferred to the ventricles. At the end of this ...
Cardiac Cycle - WordPress.com
Cardiac Cycle - WordPress.com

... systems in the body while the right ventricle receives deoxygenated (oxygen-poor) blood from the right atrium. The left and right ventricles pump the • EFFORT There is also a difference between the effort ...
667 - جامعة المنيا
667 - جامعة المنيا

... alcohol ( 15 %) daily by orogastric tube, and group (3) which received cilostazol in a dose of 6.2 mg/animal/day dissolved in 1ml. (15%) benzyl alcohol also administered by the orogastric infusion method. The experiment continued for 3 months then the whole animals were anaesthetized through intrape ...
From cardiac output to blood flow auto
From cardiac output to blood flow auto

... the tissues, resulting in cellular dysoxia and organ failure. In this process, the factors that govern the circulation at a haemodynamic level and oxygen delivery at a microcirculatory level play a major role. This manuscript aims to review the blood flow regulation from macro- and micro-haemodynami ...
AusPAR Attachment 1: Product Information for Lucassin (Terlipressin)
AusPAR Attachment 1: Product Information for Lucassin (Terlipressin)

... pressure (MAP), normalisation of endogenous vasoconstrictor systems (renin-angiotensinaldosterone and sympathetic nervous system), and an increase in renal blood flow. The therapeutic rationale for treatment of HRS with terlipressin is that these effects may result in improved renal function. Pharma ...
Document
Document

... •Modifiable risk factors for atherosclerosis: smoking, diabetes mellitus, hypertension, dyslipidemia, obesity •New and other risk factors for atherosclerosis: elevated homocysteine levels, male pattern baldness, sedentary lifestyle and/or lack of exercise, psychosocial stress, presence of peripheral ...
Blood transfusion
Blood transfusion

... some may tolerate very low Hb< 6-8 g/dl in the perioperative period without an incresae in mortality ...
Antianginal (Anti-ischaemic) Drugs
Antianginal (Anti-ischaemic) Drugs

Anatomy Blood Vessels
Anatomy Blood Vessels

... smooth muscle cells (tunica media); regulate blood flow to tissues & affect arterial blood pressure  Venules – endothelium (tunica interna) + thin layer of CT (tunica externa) ...
Acute right ventricular failure
Acute right ventricular failure

... volume-dependent, optimizing pre-load is very important. However, too much pre-load will decrease ...
Automated External Defibrillation
Automated External Defibrillation

... machine called a defibrillator. The likelihood of successful defibrillation decreases by 7% - 10% with each minute following a SCA. It is therefore unlikely that early CPR and defibrillation will be successful after 10 minutes. Over the years defibrillator technology has changes, and now it easier f ...
Anesthesia for the Patient with Congenital Heart Disease
Anesthesia for the Patient with Congenital Heart Disease

... • Adverse maternal events, although rare, may be associated with left ventricular dysfunction, severe pulmonary HTN, and severe PR with RV ...
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Antihypertensive drug



Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34%, of ischaemic heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease. There are many classes of antihypertensives, which lower blood pressure by different means. Among the most important and most widely used drugs are thiazide diuretics, calcium channel blockers, ACE inhibitors, angiotensin II receptor antagonists (ARBs), and beta blockers.Which type of medication to use initially for hypertension has been the subject of several large studies and resulting national guidelines. The fundamental goal of treatment should be the prevention of the important endpoints of hypertension, such as heart attack, stroke and heart failure. Patient age, associated clinical conditions and end-organ damage also play a part in determining dosage and type of medication administered. The several classes of antihypertensives differ in side effect profiles, ability to prevent endpoints, and cost. The choice of more expensive agents, where cheaper ones would be equally effective, may have negative impacts on national healthcare budgets. As of 2009, the best available evidence favors the thiazide diuretics as the first-line treatment of choice for high blood pressure when drugs are necessary. Although clinical evidence shows calcium channel blockers and thiazide-type diuretics are preferred first-line treatments for most people (from both efficacy and cost points of view), an ACE inhibitor is recommended by NICE in the UK for those under 55 years old.
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