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262 Cardiovascular System - Jordan University of Science and
262 Cardiovascular System - Jordan University of Science and

... Explain the mechanism of endothelial deriving relaxing factor (EDRF), the nitric oxide (NO). Discuss the changes that can develop in long-term regulation, including tissue vascularity, angiogenesis and collateral circulation. Discuss humoral regulation of blood flow, by vasoconstrictor and vasodilat ...
262 Cardiovascular System - Jordan University of Science and
262 Cardiovascular System - Jordan University of Science and

... Explain the mechanism of endothelial deriving relaxing factor (EDRF), the nitric oxide (NO). Discuss the changes that can develop in long-term regulation, including tissue vascularity, angiogenesis and collateral circulation. Discuss humoral regulation of blood flow, by vasoconstrictor and vasodilat ...
HAPPY HEARTS CLASSES 2016 Summer
HAPPY HEARTS CLASSES 2016 Summer

... to anyone who wants to maintain a healthy level of fitness. Happy Hearts was primarily for Phase IV Cardiac Rehabilitation patients, but due to the connections with other medical conditions it is now open to anyone of any age that may have a medical condition or just feel the need to get fit, althou ...
prompt diagnosis and management of acute heart failure syndrome
prompt diagnosis and management of acute heart failure syndrome

... compliance or increase ventricular filling pressure. Because this extra sound is low pitch, using the bell of stethoscope with patient slight left lateral decubitus will ease to find this.11 Elevated jugular venous pressure (JVP) is perhaps the most useful clinical finding for detecting AHF especial ...
HEART FAILURE WITH PRESERVED
HEART FAILURE WITH PRESERVED

... cardiac preload and afterload and improve myocardial relaxation and compliance. Improvements in LV filling and reduction in BP are associated with improved exercise tolerance and quality of life.6 Data demonstrating beneficial effects of these agents on mortality are limited. A retrospective trial i ...
Management of Blood Loss and Hypovolemic Shock
Management of Blood Loss and Hypovolemic Shock

... – Systemic vascular resistance rises – Maintain systemic pressure to perfuse heart and brain at expense of muscle, skin and GI tract – 2/3 of circulating blood is contained in the venous system • Cardiovascular – Increased heart rate to maintain cardiac output in setting of decreased stroke volume ...
Resting heart rate and cardiovascular events: time for a new crusade?
Resting heart rate and cardiovascular events: time for a new crusade?

... which can be summarized by plaque growth. During this period the plaque evolves gradually from the ‘fatty streak’ to the advanced plaque under the influence of the risk factors fighting against protective mechanisms. Since the first Framingham study launched in 1948,1,2 several modifiable risk facto ...
METASTATIC CARCINOMA OF THE HEART Metastasis to the heart
METASTATIC CARCINOMA OF THE HEART Metastasis to the heart

... Nicholls, A. G.: Secondary carcinoma implanted on the endocardium of the right ventricle, Canad. M. A. J. 17: 798, 19'27. Morris, Laird M.: Metastasis to the heart from malignant tumors, Am. Heart J. ...
Acute Pericarditis
Acute Pericarditis

... Answer: ...
ENHANCE Trial
ENHANCE Trial

... ♦ FH 1 in 500 people : most 45yo patients have been on lipid meds for 1 or 2 decades – recent theory suggests that plaques stabilize with continued lipidlowering therapy, thus are not easily reduced with progressive treatment2. Conversely, studies have shown that statins alone slow or even ↓ IMT2. ♦ ...
The Heart - csfcbiology
The Heart - csfcbiology

... pulmonary valve is open because the blood pushes the cusps out of the way. After contracting, the ventricles begin to relax and the pulmonary valve closes and prevents backflow (called regurgitation) of blood into the ventricle. ...
Vessels
Vessels

... taking pulse and blood pressure measurements  Vital signs – pulse and blood pressure, along with respiratory rate and body temperature  Pulse – pressure wave caused by the expansion and recoil of elastic arteries  Radial pulse (taken on the radial artery at the wrist) is routinely used  Varies w ...
Haemodynamic Effects of RapidDigitalization Following Acute
Haemodynamic Effects of RapidDigitalization Following Acute

... Digitalis is known to increase cardiac contractile force and to result in an increased cardiac output in subjects with heart failure (Goodman and Gilman, 1965). Our patients all had evidence of poor left ventricular function, but were not in cardiogenic shock and did not have congestive cardiac fail ...
AFFIRM Trial
AFFIRM Trial

... (HR 1.49), which was due to non-cardiovascular causes, while the presence of SR was associated with a significant reduction in mortality (HR 0.53). A similar benefit from being in sinus rhythm (relative risk 0.44) was noted in the DIAMOND trial that compared dofetilide to placebo in patients with re ...
Cardiomyopathy and anaesthesia
Cardiomyopathy and anaesthesia

... been shown to improve mortality, and is well established. In patients undergoing surgery and considered at high risk of coronary events, b-blockers have been shown to improve outcomes.7 There is, however, no evidence that they improve perioperative outcome in patients with acute heart failure. ...
Using a heart simulator for optimal therapy
Using a heart simulator for optimal therapy

... more effective: doctors will be able to test medicines and surgical techniques on the computer heart and determine the most effective therapy. Olaf Dössel, director of the Institute of Biomedical Engineering at the Karlsruhe Institute of Technology, believes that his team's heart model is among the ...
Cardiovascular System
Cardiovascular System

... ( It is almost the diameter of a garden hose.) It extends upward from the left ventricle, arches over the heart to the left and descends just anterior and to the left of the vertebral column.  You have an ascending and a descending aorta.  It takes blood away from the heart. ...
I began my Cholesterol Report by documenting beginning figures
I began my Cholesterol Report by documenting beginning figures

... If diet and exercise don’t work or if the cholesterol is at a life threatening level then doctors may choose to use drugs. The most widely used drugs are the “Statin” drugs. They have a great impact with minimal side effects. These drugs include Mevacor, Lescol, Pravachol, Zocor, Baycol, and Lipitor ...
Chapter 10 - Vascular Physiology
Chapter 10 - Vascular Physiology

... MAP = CO  TPR Arteriole resistance is greatest because they have the smallest diameter Capillary BP is reduced because of the total cross-sectional area 3 most important variables are HR, SV, and TPR Increase in each of these will result in an increase in BP BP can be regulated by: Kidney and sympa ...
4- Cardiac output, exercise and cardiac hypertrophy
4- Cardiac output, exercise and cardiac hypertrophy

... Because there is a correlation between resting cardiac output (COP) and surface area of the body, it is important to find some mean by which COP of different sized people can be compared with one another. The COP is frequently stated in term of the cardiac index, which is the cardiac output /minute ...
The Cardiovascular System
The Cardiovascular System

... Hypotension Low systolic (below 110 mmHG) Often associated with illness Hypertension ...
Blood - Haiku Learning
Blood - Haiku Learning

... 3. Ventricles contract a fraction of a second after the atria to complete one full heartbeat a) average of 70 beats per minute 4. Systole: phase one of the heartbeat when ventricles contract, closing the AV valves and opening the SL valves to pump blood to the vessels 5. Diastole: phase two when th ...
Lung Volumes - CIM
Lung Volumes - CIM

... vasodilator metabolites (lactate, potassium, adenosine). This is called metabolic vasodilation, and it is the dominant control mechanism in skeletal muscle during exercise. Because this vasodilation improves the delivery of oxygen, more oxygen can be extracted and utilized by the contracting muscle. ...
- European Medical Journal
- European Medical Journal

... hyperkalaemia from the trial population. The trial was stopped early due to the significant benefits demonstrated by ARNi, both for cardiovascular mortality (HR: 0.80, 95% CI: 0.71–0.89; p<0.001) and HF hospitalisations (HR: 0.79, 95% CI: 0.71– 0.89; p<0.001).43 This treatment gave incremental benef ...
Criteria for “making the cut” as an enduring concept: Used often
Criteria for “making the cut” as an enduring concept: Used often

... this is called spinal (or a type of distributive) shock. If you have a rip-roaring infection, your immune system can explode and unleash an inflammatory storm. Part of your body’s response to this, for reasons that are not at all clear even now, is to dilate your blood vessels. (Perhaps the body’s w ...
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Antihypertensive drug



Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34%, of ischaemic heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease. There are many classes of antihypertensives, which lower blood pressure by different means. Among the most important and most widely used drugs are thiazide diuretics, calcium channel blockers, ACE inhibitors, angiotensin II receptor antagonists (ARBs), and beta blockers.Which type of medication to use initially for hypertension has been the subject of several large studies and resulting national guidelines. The fundamental goal of treatment should be the prevention of the important endpoints of hypertension, such as heart attack, stroke and heart failure. Patient age, associated clinical conditions and end-organ damage also play a part in determining dosage and type of medication administered. The several classes of antihypertensives differ in side effect profiles, ability to prevent endpoints, and cost. The choice of more expensive agents, where cheaper ones would be equally effective, may have negative impacts on national healthcare budgets. As of 2009, the best available evidence favors the thiazide diuretics as the first-line treatment of choice for high blood pressure when drugs are necessary. Although clinical evidence shows calcium channel blockers and thiazide-type diuretics are preferred first-line treatments for most people (from both efficacy and cost points of view), an ACE inhibitor is recommended by NICE in the UK for those under 55 years old.
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