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Modern methods in Molecular Pathology
Modern methods in Molecular Pathology

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... Look at the uses of atomic science and see what I mean. In 1944, while at Columbia University in New York City, I began my investigations into the composition of DNA. I collaborated with fellow scientists and biochemists there, as I had when a student at Yale University. By 1950 I had experimentally ...
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DNA supercoil



DNA supercoiling refers to the over- or under-winding of a DNA strand, and is an expression of the strain on that strand. Supercoiling is important in a number of biological processes, such as compacting DNA. Additionally, certain enzymes such as topoisomerases are able to change DNA topology to facilitate functions such as DNA replication or transcription. Mathematical expressions are used to describe supercoiling by comparing different coiled states to relaxed B-form DNA.As a general rule, the DNA of most organisms is negatively supercoiled.
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