Direct visualization of protein interactions in plant cells
... interactions among protein pairs and of allosteric transitions in membrane-associated receptors in living mammalian cells. Furthermore, dose dependence was demonstrated to be consistent with the known pharmacological responses for induced protein–protein interactions13,14. Other techniques to detect ...
... interactions among protein pairs and of allosteric transitions in membrane-associated receptors in living mammalian cells. Furthermore, dose dependence was demonstrated to be consistent with the known pharmacological responses for induced protein–protein interactions13,14. Other techniques to detect ...
fulltext
... Tardigrades are known for being resistant to extreme conditions, including tolerance to ionising and UV radiation in both the hydrated and the dehydrated state. It is known that these factors may cause damage to DNA. It has recently been shown that single and double DNA strand breaks occur when tard ...
... Tardigrades are known for being resistant to extreme conditions, including tolerance to ionising and UV radiation in both the hydrated and the dehydrated state. It is known that these factors may cause damage to DNA. It has recently been shown that single and double DNA strand breaks occur when tard ...
Beta-Glucan - Human Nature Natural Health
... action, including activation of macrophages, neutrophils, and T-cell–mediated immunity.[3,8,9] Orally administered yeast beta-glucan is processed by macrophages—the first line of defense in cellular immunity[8]—with subsequent increases in phagocytosis, selective cytokine release, and ...
... action, including activation of macrophages, neutrophils, and T-cell–mediated immunity.[3,8,9] Orally administered yeast beta-glucan is processed by macrophages—the first line of defense in cellular immunity[8]—with subsequent increases in phagocytosis, selective cytokine release, and ...
Distinct cytokine profiles define clinical immune response to
... blood mononuclear cells (PBMC) [21]. Elevated IL-10 levels have been found in severe malaria patients [8, 22, 23], suggesting its role in regulating Th1 cytokine-associated pathology. The cytokine profile that regulates an individual’s humoral and cell-mediated immune responses, and their acquisitio ...
... blood mononuclear cells (PBMC) [21]. Elevated IL-10 levels have been found in severe malaria patients [8, 22, 23], suggesting its role in regulating Th1 cytokine-associated pathology. The cytokine profile that regulates an individual’s humoral and cell-mediated immune responses, and their acquisitio ...
Biogenesis and significance of lipofuscin in the equine thyroid gland
... showed the same ultrastructure as in situ. The protein content ranged from 15% to 77% w/w (mean = 36%). In contrast, the amino acid composition was constant and similar to that of thyroglobulin. The most distinctive feature of lipofuscin protein was the presence of four proteins of 14-18 kDa. The ha ...
... showed the same ultrastructure as in situ. The protein content ranged from 15% to 77% w/w (mean = 36%). In contrast, the amino acid composition was constant and similar to that of thyroglobulin. The most distinctive feature of lipofuscin protein was the presence of four proteins of 14-18 kDa. The ha ...
Axonal Transport of Monoclonal Antibodies
... Three monoclonal antibodies against rat brain synaptosomes, produced by conventional hybridoma techniques, were screened for their ability to undergo uptake and axonal transport in viva Injections of ascitic fluid or of purified immunoglobulin G (IgG) were made into the vitreal chamber of the eye in ...
... Three monoclonal antibodies against rat brain synaptosomes, produced by conventional hybridoma techniques, were screened for their ability to undergo uptake and axonal transport in viva Injections of ascitic fluid or of purified immunoglobulin G (IgG) were made into the vitreal chamber of the eye in ...
Exploiting Amoeboid and Non-Vertebrate Animal Model Systems to Study the
... transitions to hyphal forms only occur at 37 8C, but they can occur at ambient temperatures in the presence of the invertebrate hosts. Given that there are many thousands of species that are microherbivores, it is likely that the ability of fungi to interconvert between yeast and hyphal forms provid ...
... transitions to hyphal forms only occur at 37 8C, but they can occur at ambient temperatures in the presence of the invertebrate hosts. Given that there are many thousands of species that are microherbivores, it is likely that the ability of fungi to interconvert between yeast and hyphal forms provid ...
The interleukin-23 axis in intestinal inflammation
... (11, 16). The small and large intestines also contain forkhead box protein 3 (Foxp3)1 regulatory T cells (Tregs) that contribute to the maintenance of intestinal homeostasis (17). Adaptive responses are initiated within the associated organized lymphoid structures. Some of these are contained within ...
... (11, 16). The small and large intestines also contain forkhead box protein 3 (Foxp3)1 regulatory T cells (Tregs) that contribute to the maintenance of intestinal homeostasis (17). Adaptive responses are initiated within the associated organized lymphoid structures. Some of these are contained within ...
Medical Virology of Hepatitis B: how it began and where we are now
... genetic markers for susceptibility to certain illnesses, especially cancer, and had gathered serum samples world-wide from a wide variety of ethnic sources in the 1950′s and 60′s. The possibilities for recognizing genetic differences with laboratory methods were very limited at that time. Blumberg u ...
... genetic markers for susceptibility to certain illnesses, especially cancer, and had gathered serum samples world-wide from a wide variety of ethnic sources in the 1950′s and 60′s. The possibilities for recognizing genetic differences with laboratory methods were very limited at that time. Blumberg u ...
Unit 30C Cell Division, Genetics, and Molecular
... of breast cancer. People at risk of developing this form of breast cancer have a mutation in a particular gene, which in turn directs the production of a mutant protein. Dr. Glover’s group created the first three-dimensional model of the part of this protein that is involved in cancer development. T ...
... of breast cancer. People at risk of developing this form of breast cancer have a mutation in a particular gene, which in turn directs the production of a mutant protein. Dr. Glover’s group created the first three-dimensional model of the part of this protein that is involved in cancer development. T ...
A plant dialect of the histone language
... considerable research interest because it is associated with transcriptional regulation and methyl transferases contain well conserved domains among different organisms. In contrast to other modifications, no histone demethylases have thus far been identified, although theoretical studies recently p ...
... considerable research interest because it is associated with transcriptional regulation and methyl transferases contain well conserved domains among different organisms. In contrast to other modifications, no histone demethylases have thus far been identified, although theoretical studies recently p ...
Licentiate thesis from the Department of Immunology,
... at the infant and adult ages. We also examined whether the rHBHA protein could boost BCG-mediated protective immunity. Cellular immune responses and protection as measured by control of bacterial growth in the lungs of the treated animals were followed. Our results showed an improved effect of BCG-p ...
... at the infant and adult ages. We also examined whether the rHBHA protein could boost BCG-mediated protective immunity. Cellular immune responses and protection as measured by control of bacterial growth in the lungs of the treated animals were followed. Our results showed an improved effect of BCG-p ...
6- review article Tolou.indd
... divided on the basis of their function and biochemistry into class I and class II. Class I MHC molecules are required for antigen presentation to CD8+ T-cells, can be recognised directly as antigen presentation to CD4+ T-cells and are also potent allogeneic antigens. Class I MHC molecules can bind e ...
... divided on the basis of their function and biochemistry into class I and class II. Class I MHC molecules are required for antigen presentation to CD8+ T-cells, can be recognised directly as antigen presentation to CD4+ T-cells and are also potent allogeneic antigens. Class I MHC molecules can bind e ...
Construction of a new peptide insertion site in the top
... aggregation into VP7 crystalline structures. In the second stage of the investigation, a twenty-five amino acid sequence of a VP2 neutralising epitope (Venter et al. , 2000; Bentley et al. , 2000; Martinez-Torrecuadrada et al. , 2001) was chosen to insert into the created site at position 144. This ...
... aggregation into VP7 crystalline structures. In the second stage of the investigation, a twenty-five amino acid sequence of a VP2 neutralising epitope (Venter et al. , 2000; Bentley et al. , 2000; Martinez-Torrecuadrada et al. , 2001) was chosen to insert into the created site at position 144. This ...
The Disadvantage Being Homozygous
... • Plays a key role in immune response (navel of the immune world) and in some other things ...
... • Plays a key role in immune response (navel of the immune world) and in some other things ...
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... Although such experimental studies have improved our understanding of temporary immunity and viral interference, the underlying mechanisms of how a virus is controlled and cleared by the immune system are still not fully understood. In particular, the re-exposure experimental data revealed a number ...
... Although such experimental studies have improved our understanding of temporary immunity and viral interference, the underlying mechanisms of how a virus is controlled and cleared by the immune system are still not fully understood. In particular, the re-exposure experimental data revealed a number ...
SMAD proteins of oligodendroglial cells regulate transcription of JC
... JCV E gene transcription in KG-1 cells We compared the effects of expressed, transfected pTat with those of purified Tat added exogenously to the culture medium. Importation of such Tat could mimic the transmigration of Tat in the brain. It was thus important to determine the concentrations of exoge ...
... JCV E gene transcription in KG-1 cells We compared the effects of expressed, transfected pTat with those of purified Tat added exogenously to the culture medium. Importation of such Tat could mimic the transmigration of Tat in the brain. It was thus important to determine the concentrations of exoge ...
A robust, high-throughput assay to determine the phagocytic activity
... In addition to their role in neutralization, antibodies are able to mediate a number of additional functions including the recruitment of innate immune responses to eliminate antibody-opsonized material. Among these additional antibody mediated functions, antibodies are able to promote phagocytosis, ...
... In addition to their role in neutralization, antibodies are able to mediate a number of additional functions including the recruitment of innate immune responses to eliminate antibody-opsonized material. Among these additional antibody mediated functions, antibodies are able to promote phagocytosis, ...
Plasmacytoid Dendritic Cells and the Control of Herpesvirus Infections
... the unique ability to rapidly recognize herpesviruses for consecutive high level production of IFNI [36,37]. We reported the first evidence that pDCs actually constitute the major source of systemic IFN-I production during a viral infection in vivo using MCMV as a model [12,32]. To the best of our k ...
... the unique ability to rapidly recognize herpesviruses for consecutive high level production of IFNI [36,37]. We reported the first evidence that pDCs actually constitute the major source of systemic IFN-I production during a viral infection in vivo using MCMV as a model [12,32]. To the best of our k ...
HLA-A*02 AND ITS PROGNOSTIC TRAITS IN CANCER.
... representation of HLA alleles in EOC compared to healthy Swedish bone-marrow donors where HLA-A*02 was overrepresented, also HLA-A*02 homozygotes were two-fold higher among EOC patients. The frequency of HLA-A*01 was also increased whereas HLA-A*03 was decreased. Combinations of A*02 with B*05, B*15 ...
... representation of HLA alleles in EOC compared to healthy Swedish bone-marrow donors where HLA-A*02 was overrepresented, also HLA-A*02 homozygotes were two-fold higher among EOC patients. The frequency of HLA-A*01 was also increased whereas HLA-A*03 was decreased. Combinations of A*02 with B*05, B*15 ...
DNA vaccination
DNA vaccination is a technique for protecting an animal against disease by injecting it with genetically engineered DNA so cells directly produce an antigen, resulting in a protective immunological response. Several DNA vaccines have been released for veterinary use, and there has been promising research using the vaccines for viral, bacterial and parasitic diseases, as well as to several tumour types. Although only one DNA vaccine has been approved for human use, DNA vaccines may have a number of potential advantages over conventional vaccines, including the ability to induce a wider range of immune response types.