Analysis of Cross Sequence Similarities for Multiple - PolyU
... Abstract: Current DNA compression algorithms rely on finding repetitions within the DNA sequence so that similar subsequences can be encoded by referencing to each other. We explore similarities between different chromosomes of the sequence ‘Saccharomyces cerevisiae’. These similarities are characte ...
... Abstract: Current DNA compression algorithms rely on finding repetitions within the DNA sequence so that similar subsequences can be encoded by referencing to each other. We explore similarities between different chromosomes of the sequence ‘Saccharomyces cerevisiae’. These similarities are characte ...
No Slide Title
... Cyclin-cdks are themselves regulated by phosphorylation of the cdk • Cyclin associated cdk is still inactive as a kinase • Threonine at position 160 (T160) of cdk2 has to be phosphorylated for the kinase to be active. The cdk activating kinase (CAK) is actually cyclin H-cdk7 • Threonine at position ...
... Cyclin-cdks are themselves regulated by phosphorylation of the cdk • Cyclin associated cdk is still inactive as a kinase • Threonine at position 160 (T160) of cdk2 has to be phosphorylated for the kinase to be active. The cdk activating kinase (CAK) is actually cyclin H-cdk7 • Threonine at position ...
NUCLEIC ACID ECONOMY IN BACTERIA INFECTED WITH
... DNA begins to accumulate. Since no phage particles are finished during the first 10 minutes, the cytosineless DNA formed up to this time consists of unidentiffed DNA. Mter 10 minutes, the amount of unidentified DNA remains roughly constant, and most of the further increase in cytosineless DNA can be ...
... DNA begins to accumulate. Since no phage particles are finished during the first 10 minutes, the cytosineless DNA formed up to this time consists of unidentiffed DNA. Mter 10 minutes, the amount of unidentified DNA remains roughly constant, and most of the further increase in cytosineless DNA can be ...
Replication timing and transcriptional control: beyond
... There are only two mammalian loci for which both replication-timing switches and origin localization have been studied. At the mouse immunoglobulin IgH locus, new origins are activated in pre-B cells when the promoter region of this locus becomes transcriptionally active and switches from late to ea ...
... There are only two mammalian loci for which both replication-timing switches and origin localization have been studied. At the mouse immunoglobulin IgH locus, new origins are activated in pre-B cells when the promoter region of this locus becomes transcriptionally active and switches from late to ea ...
Nanopore Unzipping of Individual DNA Hairpin Molecules
... duplex region sequence, and that the intercept depends strongly on the duplex region energy. We also present the first nanopore dynamic force measurements (time varying force). Our results are in agreement with the ~log(V_ ) dependence at high V_ (where V_ is the loading rate) observed by other metho ...
... duplex region sequence, and that the intercept depends strongly on the duplex region energy. We also present the first nanopore dynamic force measurements (time varying force). Our results are in agreement with the ~log(V_ ) dependence at high V_ (where V_ is the loading rate) observed by other metho ...
Get - Wiley Online Library
... five-membered furanose ring by the bond from C1’ of the sugar to the base. 3. Phosphate ester: Phosphate groups are attached to the sugar as esters, with the most common site of esterification in natural compounds being via the hydroxyl at the C5’. Typically, one, two or three phosphates are joined, p ...
... five-membered furanose ring by the bond from C1’ of the sugar to the base. 3. Phosphate ester: Phosphate groups are attached to the sugar as esters, with the most common site of esterification in natural compounds being via the hydroxyl at the C5’. Typically, one, two or three phosphates are joined, p ...
Statistical analysis of simple repeats in the human genome
... F. Piazza, P. Liò / Physica A ] (]]]]) ]]]–]]] ...
... F. Piazza, P. Liò / Physica A ] (]]]]) ]]]–]]] ...
The genomic landscape of meiotic crossovers and gene
... eLife digest Most living organisms package their DNA into bundles called chromosomes. These chromosomes generally form pairs, with each chromosome in the pair containing the same number of genes. The genes also come in the same order, but the exact sequence of DNA bases within the genes can be diffe ...
... eLife digest Most living organisms package their DNA into bundles called chromosomes. These chromosomes generally form pairs, with each chromosome in the pair containing the same number of genes. The genes also come in the same order, but the exact sequence of DNA bases within the genes can be diffe ...
INFINITI CYP450 2C19+ Assay
... for DNA analysis. The layers have been designed to provide a versatile surface to enhance test performance. The microarrays are designed to be assay specific. The INFINITI CYP450 2C19+ Assay uses a microarray chip (RChip) which contains unused capture probes which could potentially be used for certa ...
... for DNA analysis. The layers have been designed to provide a versatile surface to enhance test performance. The microarrays are designed to be assay specific. The INFINITI CYP450 2C19+ Assay uses a microarray chip (RChip) which contains unused capture probes which could potentially be used for certa ...
Molecular insights into RNA and DNA helicase evolution from the
... region called the ‘helicase core’, but they work in different ways. For example, some move along the DNA or RNA strand whilst they unwind it, while others can unwind RNA without moving. It remains unclear how these helicases have evolved different ways to unwind DNA and RNA structures using the same ...
... region called the ‘helicase core’, but they work in different ways. For example, some move along the DNA or RNA strand whilst they unwind it, while others can unwind RNA without moving. It remains unclear how these helicases have evolved different ways to unwind DNA and RNA structures using the same ...
Bacteriophage A cloning system for the construction of
... phosphatase to ensure high insertion rates would be unnecessary. (iv) DNA inserts can be cloned in a known orientation relative to vector-encoded expression signals. The cloning vector XORF8 possesses a multiple cloning site (MCS) containing single recognition sequences for the restriction enzymes B ...
... phosphatase to ensure high insertion rates would be unnecessary. (iv) DNA inserts can be cloned in a known orientation relative to vector-encoded expression signals. The cloning vector XORF8 possesses a multiple cloning site (MCS) containing single recognition sequences for the restriction enzymes B ...
Replication timing as an epigenetic mark
... a few dozen individual gene loci using molecular approaches, with the finding that early replicating genes could be either expressed or silent, while late replicating genes were almost always silent, leading to the hypothesis that early replication is necessary for transcriptional competence but is ...
... a few dozen individual gene loci using molecular approaches, with the finding that early replicating genes could be either expressed or silent, while late replicating genes were almost always silent, leading to the hypothesis that early replication is necessary for transcriptional competence but is ...
... tissues. (A) Genomic organization of the Kcnq1 region scanned in this study, spanning 387 kb. Dark boxes in the Kcnq1 gene are exons. Arrows show direction of transcription; maternal-specific and paternal-specific expression is indicated above and below the line. Reactivated Kcnq1 expression is depi ...
Document
... Mendel’s Law of Segregation A. Law of Segregation states that a pair of factors (alleles) is segregated, or separated, during the formation of gametes (reproductive cells) (1) When two gametes combine during fertilization, the offspring have two factors controlling a specific trait (Gg) ...
... Mendel’s Law of Segregation A. Law of Segregation states that a pair of factors (alleles) is segregated, or separated, during the formation of gametes (reproductive cells) (1) When two gametes combine during fertilization, the offspring have two factors controlling a specific trait (Gg) ...
Read the Nobel Lecture
... First we needed an assay – a way to detect if telomere elongation was happening. The first assay we tried explored whether a piece of DNA that included a telomere would incorporate DNA precursors more readily than a piece of DNA containing non-telomeric sequences. The idea was that if there was an ...
... First we needed an assay – a way to detect if telomere elongation was happening. The first assay we tried explored whether a piece of DNA that included a telomere would incorporate DNA precursors more readily than a piece of DNA containing non-telomeric sequences. The idea was that if there was an ...
Recognition of Nucleic Acid Bases and Base
... donates two hydrogen bonds to the O6 and N7 acceptor groups of guanine and a second in which the carboxamide group of Asn (or Gln) hydrogen bonds to the N7 acceptor and N6 donor groups of adenine. These interactions are indeed the most commonly observed in protein –DNA complexes,4,7 – 9 and the impo ...
... donates two hydrogen bonds to the O6 and N7 acceptor groups of guanine and a second in which the carboxamide group of Asn (or Gln) hydrogen bonds to the N7 acceptor and N6 donor groups of adenine. These interactions are indeed the most commonly observed in protein –DNA complexes,4,7 – 9 and the impo ...
345 - Timstar
... genes, the noncoding sequences of genes, or regions in-between genes (the intergenic regions). When an SNP falls within a coding sequence, that alteration may not necessarily change the amino acid sequence of the subsequent protein produced due to degeneracy of the genetic code. On the other hand, S ...
... genes, the noncoding sequences of genes, or regions in-between genes (the intergenic regions). When an SNP falls within a coding sequence, that alteration may not necessarily change the amino acid sequence of the subsequent protein produced due to degeneracy of the genetic code. On the other hand, S ...
The Histone Variant H2A.W Defines Heterochromatin and Promotes
... their own N-terminal tails. For example, H3.3 tends to be associated with H3K4me2/3, whereas H3.1 tends to be enriched at heterochromatin marked by H3K9me2 (Loyola and Almouzni, 2007). Although H2A.Z and H3.3 are predominantly linked to transcriptional activation, they are also associated with heter ...
... their own N-terminal tails. For example, H3.3 tends to be associated with H3K4me2/3, whereas H3.1 tends to be enriched at heterochromatin marked by H3K9me2 (Loyola and Almouzni, 2007). Although H2A.Z and H3.3 are predominantly linked to transcriptional activation, they are also associated with heter ...
USMLE Step 1 - Becker Professional Education
... of State Medical Boards (FSMB) and National Board of Medical Examiners® (NBME®). United States Medical Licensing Examination, USMLE, National Board of Medical Examiners, and NBME are registered trademarks of the National Board of Medical Examiners. The National Board of Medical Examiners does not sp ...
... of State Medical Boards (FSMB) and National Board of Medical Examiners® (NBME®). United States Medical Licensing Examination, USMLE, National Board of Medical Examiners, and NBME are registered trademarks of the National Board of Medical Examiners. The National Board of Medical Examiners does not sp ...
The Ph1 Locus Suppresses Cdk2-Type Activity during Premeiosis
... that Cdk-type phosphorylation affects chromosome pairing. This raises the question of whether it is possible to demonstrate that Ph1 actually suppresses Cdk-type activity, and, if so, whether this suppression is specifically of Cdk2-type activity. Mammalian Cdk2 phosphorylates many substrates, inclu ...
... that Cdk-type phosphorylation affects chromosome pairing. This raises the question of whether it is possible to demonstrate that Ph1 actually suppresses Cdk-type activity, and, if so, whether this suppression is specifically of Cdk2-type activity. Mammalian Cdk2 phosphorylates many substrates, inclu ...
Prediction and investigation of novel proteins in DNA double
... DSBs are primarily repaired by two independent and highly conserved pathways: homologous recombination (HR) and non-homologous end joining (NHEJ). HR requires a homologous sequence to repair DNA breaks, whereas NHEJ repair is achieved through direct ligation of the broken ends of DNA. The process of ...
... DSBs are primarily repaired by two independent and highly conserved pathways: homologous recombination (HR) and non-homologous end joining (NHEJ). HR requires a homologous sequence to repair DNA breaks, whereas NHEJ repair is achieved through direct ligation of the broken ends of DNA. The process of ...
Figures and figure supplements
... shown. Underlying colors indicate the similarity between the different datasets. Note that H3K36me3 was flagged for low signal to noise, potentially explaining the somewhat high correlation with H3K27me3 (see Figure 1—source data 4). However, this does not affect the conclusions of the paper in any ...
... shown. Underlying colors indicate the similarity between the different datasets. Note that H3K36me3 was flagged for low signal to noise, potentially explaining the somewhat high correlation with H3K27me3 (see Figure 1—source data 4). However, this does not affect the conclusions of the paper in any ...
Evaluation of genomic DNA from paraffin
... Dogs that are clinically diagnosed with DCM reveal two distinct histological forms of DCM. Cardiomyopathy of Boxers and Doberman Pinschers are called “fatty infiltration-degenerative” type and in many giant, large- and medium-sized breeds DCM can be classified as “attenuated wavy fiber” type. Attenu ...
... Dogs that are clinically diagnosed with DCM reveal two distinct histological forms of DCM. Cardiomyopathy of Boxers and Doberman Pinschers are called “fatty infiltration-degenerative” type and in many giant, large- and medium-sized breeds DCM can be classified as “attenuated wavy fiber” type. Attenu ...
Compaction of Duplex Nucleic Acids upon Native
... > 12-d100 (supporting Figure S14), in line with the relative gas-phase kinetic stabilities in tandem mass spectrometry.11-14 When LC models are used, the T-REMD final structures depend significantly on the choice of charge location (Figure S17, S19—S21). For example, for [12d100]5-, a first model (F ...
... > 12-d100 (supporting Figure S14), in line with the relative gas-phase kinetic stabilities in tandem mass spectrometry.11-14 When LC models are used, the T-REMD final structures depend significantly on the choice of charge location (Figure S17, S19—S21). For example, for [12d100]5-, a first model (F ...
Nucleosome
A nucleosome is a basic unit of DNA packaging in eukaryotes, consisting of a segment of DNA wound in sequence around eight histone protein cores. This structure is often compared to thread wrapped around a spool.Nucleosomes form the fundamental repeating units of eukaryotic chromatin, which is used to pack the large eukaryotic genomes into the nucleus while still ensuring appropriate access to it (in mammalian cells approximately 2 m of linear DNA have to be packed into a nucleus of roughly 10 µm diameter). Nucleosomes are folded through a series of successively higher order structures to eventually form a chromosome; this both compacts DNA and creates an added layer of regulatory control, which ensures correct gene expression. Nucleosomes are thought to carry epigenetically inherited information in the form of covalent modifications of their core histones.Nucleosomes were observed as particles in the electron microscope by Don and Ada Olins and their existence and structure (as histone octamers surrounded by approximately 200 base pairs of DNA) were proposed by Roger Kornberg. The role of the nucleosome as a general gene repressor was demonstrated by Lorch et al. in vitro and by Han and Grunstein in vivo.The nucleosome core particle consists of approximately 147 base pairs of DNA wrapped in 1.67 left-handed superhelical turns around a histone octamer consisting of 2 copies each of the core histones H2A, H2B, H3, and H4. Core particles are connected by stretches of ""linker DNA"", which can be up to about 80 bp long. Technically, a nucleosome is defined as the core particle plus one of these linker regions; however the word is often synonymous with the core particle. Genome-wide nucleosome positioning maps are now available for many model organisms including mouse liver and brain.Linker histones such as H1 and its isoforms are involved in chromatin compaction and sit at the base of the nucleosome near the DNA entry and exit binding to the linker region of the DNA. Non-condensed nucleosomes without the linker histone resemble ""beads on a string of DNA"" under an electron microscope.In contrast to most eukaryotic cells, mature sperm cells largely use protamines to package their genomic DNA, most likely to achieve an even higher packaging ratio. Histone equivalents and a simplified chromatin structure have also been found in Archea, suggesting that eukaryotes are not the only organisms that use nucleosomes.