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No Slide Title - University of Warwick
No Slide Title - University of Warwick

... Deregulated expression of the c-myc (cellular Myelocytomatosis) protooncogene is seen in a large number of human cancers. [1] The protein product is a transcription factor that forms a heterodimeric complex with Max to promote a variety of tumour related biological functions; cell cycle progression ...
DNA - 長庚大學生物醫學系
DNA - 長庚大學生物醫學系

... ribozyme (ribonucleic acid enzyme) is an RNA molecule that is capable of catalyzing specific biochemical reactions, similar to the action of protein enzymes. The 1982 discovery of ribozymes demonstrated that RNA can be both genetic material (like DNA) and a biological catalyst (like protein enzymes) ...
Genetics - Mrs. Yu`s Science Classes
Genetics - Mrs. Yu`s Science Classes

...  Nucleosome packing influences whether a section of DNA will be transcribed.  DNA segments are tightly packed by methylation (addition of methyl groups) of histones, making transcription more difficult.  In contrast, acetylation (addition of acetyl groups) of histones allows uncoiling and transcr ...
DNA
DNA

... DNA has several level of compactization to form chromatin. ...
Central Dogma of Genetics
Central Dogma of Genetics

... • Process by which the genetic information is conveyed from a double stranded DNA molecule to a single stranded RNA molecule. • Only one strand of DNA serves as a template: – this is the transcribed or anti-sense strand. ...
Foundations of Biology
Foundations of Biology

... Eukaryotic genes are controlled individually and each gene has specific control sequences preceding the transcription start site In addition to controlling transcription, there are additional ways in which expression can be controlled in eukaryotes ©2000 Timothy G. Standish ...
31_operons
31_operons

... In bacteria, genes are often clustered into operons Operons have: 1. Several genes for metabolic enzymes 2. One promoter 3. An operator, or control site (“on-off” switch) ...
Poster Patrocles_V3
Poster Patrocles_V3

... Using positional cloning, we have recently identified the mutation responsible for muscular phenotype of the Texel sheep. It is located in the 3’UTR of the GDF8 gene - a known developmental repressor of muscle growth - and creates an illegitimate target site for miRNA expressed in the same tissue. T ...
GENE REGULATION
GENE REGULATION

... Linear sequence of exons maintained in both alternates In most cases, the alternative versions of a protein will have similar functions, because much of their amino acid sequences will be identical to each other Nevertheless, alternative splicing produces differences in amino acid sequences that wil ...
video slide - Greensburg
video slide - Greensburg

... • In prokaryotes, mRNA produced by transcription is immediately translated without more processing • In a eukaryotic cell, the nuclear envelope separates transcription from translation • Eukaryotic RNA transcripts are modified through RNA processing to yield finished mRNA • Cells are governed by a ...
Table S1
Table S1

... Subunit of DNA polymerase delta holoenzyme complex C3H8.09c RNA-binding protein, involved in packaging pre-mRNAs into ribonucleoprotein structures C25D12.06 RNA helicase ATP-dependent C660.10 Protein containing an elongation factor Tu GTP binding domain Othersc C18H10.11c C1635.01 mrs2 C1071.02 ...
Supplementary Methods
Supplementary Methods

... For sscDNA generation, each sample was mixed with 2 μl 500 μM random primer (5’phosphate-N7-OH-3’; Integrated DNA Technologies, Coralville, IA), incubated at 70oC for 10 minutes and immediately transferred to ice for 2 minutes. Subsequently, the RNA was reverse transcribed in a total volume of 20 μl ...
anti-codon
anti-codon

Document
Document

... RbcS and rbcL mRNAs are not associated with polysomes in D plants Regulation in response to light occurs at the level of translation initiation ...
notes pdf - Auburn University
notes pdf - Auburn University

... the aminoacyl-tRNA coding for the next codon in the mRNA then binds to the A site of the ribosome ...
PowerPoint
PowerPoint

... GENE REGULATION 11.1 Proteins interacting with DNA turn prokaryotic genes on or off in response to environmental changes • Early understanding of gene control ...
Dysregulation of CD69 in Dcr  /   CD4+CD8+ (DP) thymocytes
Dysregulation of CD69 in Dcr / CD4+CD8+ (DP) thymocytes

... Q2 ’07 cash of ~$195M; Y-E ’07 cash >$435M ~$1.25B market cap ...
C. elegans
C. elegans

... genes, analogous to the operons of bacteria. The genes in these operons are of course transcribed together as a polycistronic transcript and hence are coordinately expressed, but the downstream genes are translated as a result of a trans-splicing event in which a short RNA leader is spliced onto the ...
DNA
DNA

... DNA Synthesis The synthesis of new DNA strands complementary to both strands of the parental molecule posed an important problem to understanding the biochemistry of DNA replication. Since the two strands of double-helical DNA run in opposite (antiparallel) directions, continuous synthesis of two ...
Biological information flow
Biological information flow

... and GC boxes & other cisacting elements are recognized by proteins other than RNA polymerase. ...
lecture9 - Stanford AI Lab
lecture9 - Stanford AI Lab

Gene7-05
Gene7-05

... region controls mRNA stability. ...
Ch. 17 From Gene to Protein
Ch. 17 From Gene to Protein

... has three binding sites for tRNA  The P site ...
RNA-based life forms
RNA-based life forms

... that RNA could act not only as a carrier of genetic information, but also as a catalyst. This hypothesis was not conclusively proven until the 1980s when Sidney Altman’s work on ribonuclease P (RNase P) 2,3 and Thomas Cech’s work on RNA from T. thermophila4 showed that RNA could catalyse both self-s ...
ICLAL ARGUC, Sabanci University Senior Technology Transfer
ICLAL ARGUC, Sabanci University Senior Technology Transfer

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RNA silencing

RNA silencing (associated with the concept of post-transcriptional gene silencing or RNA interference) refers to a family of gene silencing effects by which the expression of one or more genes is downregulated or entirely suppressed by non-coding RNAs, particularly small RNAs. It may also refer to the introduction of a synthetic antisense RNA molecule used in scientific experiments on gene expression. RNA silencing may also be defined as sequence-specific regulation of gene expression triggered by double-stranded RNA (dsRNA). RNA silencing mechanisms are highly conserved in most eukaryotes. The most common and well-studied example is RNA interference (RNAi), in which endogenously expressed microRNA (miRNA) or exogenously derived small interfering RNA (siRNA) induces the degradation of complementary messenger RNA. Other classes of small RNA have been identified, including piwi-interacting RNA (piRNA) and its subspecies repeat associated small interfering RNA (rasiRNA).
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