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The Autonomic Nervous System
The Autonomic Nervous System

Lecture 19
Lecture 19

NERVOUS SYSTEM REVIEW
NERVOUS SYSTEM REVIEW

Independent Functions of Slit–Robo Repulsion and Netrin– Frazzled
Independent Functions of Slit–Robo Repulsion and Netrin– Frazzled

Case Study 29 - University of Pittsburgh
Case Study 29 - University of Pittsburgh

Florence Bareyre - scientia.global
Florence Bareyre - scientia.global

Nerve activates contraction
Nerve activates contraction

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Nervous System Organization and Components

... Both systems integrate and coordinate activities to assure proper body function. These systems allow for communication and control of body functions to maintain homeostasis of the body. Now we will consider the nervous system, next semester you will study the endocrine system. II. General Plan of th ...
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Ch. 3 S. 1
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Chapter 16: Autonomic Nervous System
Chapter 16: Autonomic Nervous System

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... Neurotransmitters are involved in _____________________ people do. Whenever a person waves a hand, yawns, or thinks about a friend, neurotransmitters are involved. Some diseases and psychological disorders may also be caused by the presence of too much or too little of various neurotransmitters. Res ...
Use of lipophilic dyes in studies of axonal pathfinding in vivo
Use of lipophilic dyes in studies of axonal pathfinding in vivo

... During the development of the nervous system, axons have to navigate through the preexisting tissue and to establish correct connections with their targets. For this purpose, the axon has a highly motile structure at its tip that acts as a sensor for guidance cues presented by the environment (Vogt ...
Spinal Cord Tutorial 101
Spinal Cord Tutorial 101

... approximately 100 billion neurons in the brain and spinal cord combined. As many as 10,000 different subtypes of neurons have been identified, each specialized to send and receive certain types of information. Each neuron is made up of a cell body, which houses the nucleus. Axons and dendrites form ...
Ch. 2 - WordPress.com
Ch. 2 - WordPress.com

Axon = short Dendrite = long Axon = long or short Dendrite = short
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Distribution of Calbindin D28k-like lmmunoreactivity (LI)

RIKEN Center for Developmental Biology (CDB)
RIKEN Center for Developmental Biology (CDB)

... odor molecules in the air; odorants inspired into the nasal cavity contact odorant receptors (ORs) expressed by olfactory sensory neurons (OSNs) of the olfactory epithelium, and the OSNs then relay the information via the glomeruli in the olfactory bulb (OB) to the mitral and tufted cells, the secon ...
Document
Document

Neuroscience
Neuroscience

... Netrin-1 is a guidance molecule that triggers either attraction or repulsion effects on migrating axons of neurons, interacting with the receptors DCC or UNC5 (A to D). It has been proposed that DCC and UNC5 are dependence receptors that, in the absence of netrin-1, promote apoptosis. This pro-apopt ...
Spinal Cord and Spinal Nerves
Spinal Cord and Spinal Nerves

Curriculum Vitae
Curriculum Vitae

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Neuronal Cytoskeleton14

... immature neurons, glial cells • (53); Myocytes • (51); Astroglial cells • (57); PNS neurons • (68); Neurons • (145); Neurons • (200); Neurons • (66); CNS neurons • (66-72); All cells • (240); CNS neural stem cells ...
sensory1
sensory1

... • Graded potentials are the result of transduction within a receptor. Transduction produces a receptor potential • Amplitude is usually in proportion to the stimulus intensity • Specialty receptor cells with no axon (visual, gustatory, auditory, and vestibular systems). The graded receptor potential ...
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Netrin



Netrins are a class of proteins involved in axon guidance. They are named after the Sanskrit word ""netr"", which means ""one who guides."" Netrins are genetically conserved across nematode worms, fruit flies, frogs, mice, and humans. Structurally, netrin resembles the extracellular matrix protein laminin.Netrins are chemotropic; a growing axon will either move towards or away from a higher concentration of netrin. Though the detailed mechanism of axon guidance is not fully understood, it is known that netrin attraction is mediated through UNC-40/DCC cell surface receptors and repulsion is mediated through UNC-5 receptors. Netrins also act as growth factors, encouraging cell growth activities in target cells. Mice deficient in netrin fail to form the hippocampal comissure or the corpus callosum.A proposed model for netrin activity in the spinal column of developing human embryos is that netrins are released by the floor plate and then are picked up by receptor proteins embedded in the growth cones of axons belonging to neurons in the developing spinal column. The bodies of these neurons remain stationary while the axons follow a path defined by netrins, eventually connecting to neurons inside the embryonic brain by developing synapses. Research supports that new axons tend to follow previously traced pathways, rather than being guided by netrins or related chemotropic factors.
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