Testing of the predictive power and robustness
... Adverse outcome (AO): change in morphology or physiology of an organism or system that results in impairment of the functional capacity or the capacity to compensate for ...
... Adverse outcome (AO): change in morphology or physiology of an organism or system that results in impairment of the functional capacity or the capacity to compensate for ...
The evolutionary causes and consequences of sex
... expression but may be a result of another correlated feature, such as expression breadth (that is, the number of different tissues in which the gene is expressed). Indeed, many sex-biased genes tend to have a low expression breadth (often restricted to the testes or ovaries), and it is known that ge ...
... expression but may be a result of another correlated feature, such as expression breadth (that is, the number of different tissues in which the gene is expressed). Indeed, many sex-biased genes tend to have a low expression breadth (often restricted to the testes or ovaries), and it is known that ge ...
FURTHER CONSIDERATION OF A MOUSE MODEL MALIGNANT PHEOCHROMOCYTOMA FOR Review Article
... Eight genes were upregulated in liver tumors, 15 in subcutaneous tumors and seven in both compared to the cultured cells. Using quantitative real-time PCR, expression of five genes (Metap2, Reck, S100a4, Timp2, and Timp3) was verified as significantly lower in liver tumors than in subcutaneous tumor ...
... Eight genes were upregulated in liver tumors, 15 in subcutaneous tumors and seven in both compared to the cultured cells. Using quantitative real-time PCR, expression of five genes (Metap2, Reck, S100a4, Timp2, and Timp3) was verified as significantly lower in liver tumors than in subcutaneous tumor ...
DmTTF, a novel mitochondrial transcription termination factor that
... termination factor. FlyBase GadFly Genome Annotation Database reports that the DmTTF gene is 1587 bp long; it is composed of three exons and two introns and generates a transcript of 1468 nt. The cDNA of DmTTF was cloned by means of PCR on a cDNA library of D.melanogaster. The sequence of the ORF (a ...
... termination factor. FlyBase GadFly Genome Annotation Database reports that the DmTTF gene is 1587 bp long; it is composed of three exons and two introns and generates a transcript of 1468 nt. The cDNA of DmTTF was cloned by means of PCR on a cDNA library of D.melanogaster. The sequence of the ORF (a ...
Week 8 - GEA
... • The program uses an underlying database (MSigDB) of about 11,000 gene sets that include KEGG, BIOCARTA pathways, curated sets from disease states, etc. ...
... • The program uses an underlying database (MSigDB) of about 11,000 gene sets that include KEGG, BIOCARTA pathways, curated sets from disease states, etc. ...
Word file (37 KB )
... The average number of reporters from these 78 classifiers is 238+/-23. Figure S4 presents the frequency of the original 231 genes and the union of other genes found in these 78 classifiers. We found that the vast majority of the original 231 reporter genes is commonly shared by the 78 classifiers. I ...
... The average number of reporters from these 78 classifiers is 238+/-23. Figure S4 presents the frequency of the original 231 genes and the union of other genes found in these 78 classifiers. We found that the vast majority of the original 231 reporter genes is commonly shared by the 78 classifiers. I ...
Genomic structure and mutational analysis of the human
... structure of the human KIF1Bß gene, which was found to be a homologue of the murine Kif1bß, and demonstrated that the human KIF1Bß is a causative gene of Charcot-Marie-Tooth disease type 2A although we did not prove that it is a tumor suppressor gene of neuroblastoma. Here, we identified another iso ...
... structure of the human KIF1Bß gene, which was found to be a homologue of the murine Kif1bß, and demonstrated that the human KIF1Bß is a causative gene of Charcot-Marie-Tooth disease type 2A although we did not prove that it is a tumor suppressor gene of neuroblastoma. Here, we identified another iso ...
slides pdf - Auburn University
... promoters vary between genes; this is the main means for controlling which genes are transcribed at a given time ...
... promoters vary between genes; this is the main means for controlling which genes are transcribed at a given time ...
Biol 1020: Genes and how they work
... promoters vary between genes; this is the main means for controlling which genes are transcribed at a given time ...
... promoters vary between genes; this is the main means for controlling which genes are transcribed at a given time ...
Gene expression in early and progression phases of autosomal
... improved disease model. Several distinct early expression signatures of differentially expressed genes with potential roles in cystogenesis were identified. These genes are involved in several pathways including cell proliferation, apoptosis, transport, and immune defenses. A variety of biochemical ...
... improved disease model. Several distinct early expression signatures of differentially expressed genes with potential roles in cystogenesis were identified. These genes are involved in several pathways including cell proliferation, apoptosis, transport, and immune defenses. A variety of biochemical ...
PDF
... The precision measures the accuracy in identifying the co-regulated genes, and the recall measures the percentage of co-regulated genes that are correctly identified. P W F 1 combines these two factors by their harmonic mean. Note that neither the precision nor the recall alone is appropriate for ev ...
... The precision measures the accuracy in identifying the co-regulated genes, and the recall measures the percentage of co-regulated genes that are correctly identified. P W F 1 combines these two factors by their harmonic mean. Note that neither the precision nor the recall alone is appropriate for ev ...
Conservation, relocation and duplication in genome evolution
... with the immune system, which might be under directional selection. Another apparent confirmation is that yeast deletion mutations have more severe effects on growth rate the greater their similarity to their best-matching coding sequence in the nematode, Caenorhabditis elegans [29]. This was contes ...
... with the immune system, which might be under directional selection. Another apparent confirmation is that yeast deletion mutations have more severe effects on growth rate the greater their similarity to their best-matching coding sequence in the nematode, Caenorhabditis elegans [29]. This was contes ...
A candidate region for Asperger syndrome defined by two
... Figure 2 Fluorescent in situ hybridisation of the BAC clones (red signals) and to metaphase chromosomes from the patients. (A) Hybridisation of the BAC clone RP11-81A22 to chromosomes from the patient with t(17;19). The clone is detected on the native chromosome 17 and chromosome 19 derivative (arro ...
... Figure 2 Fluorescent in situ hybridisation of the BAC clones (red signals) and to metaphase chromosomes from the patients. (A) Hybridisation of the BAC clone RP11-81A22 to chromosomes from the patient with t(17;19). The clone is detected on the native chromosome 17 and chromosome 19 derivative (arro ...
Ramamoorthy, Krithika : Critical Review of Methods available for Microarray Data Analysis
... have increased levels of the experimental and control sample respectively. Black spots correspond to genes that are not differentially expressed, while red spots indicate upregulation of the gene (increase in expression levels) and green spots indicate downregulation (7). Software is available to fo ...
... have increased levels of the experimental and control sample respectively. Black spots correspond to genes that are not differentially expressed, while red spots indicate upregulation of the gene (increase in expression levels) and green spots indicate downregulation (7). Software is available to fo ...
Chapter 15: The Chromosomal Basis of Inheritance - AP
... blindness, but who is not color-blind, mates with a male who has normal color vision. What is the probability that they will have a son who is color-blind? A Punnett square to use for this problem is shown in the following figure. See page 291 of your text for the labeled figure. If a carrier mates ...
... blindness, but who is not color-blind, mates with a male who has normal color vision. What is the probability that they will have a son who is color-blind? A Punnett square to use for this problem is shown in the following figure. See page 291 of your text for the labeled figure. If a carrier mates ...
Closely related proteins MBD2 and MBD3 play distinctive but
... 1999). As methylation is associated with gene silencing, a demethylase would be expected to act as a transcriptional activator. Contrary to this expectation, MBD2 was subsequently found to repress transcription through the recruitment of histone deacetylases (Ng et al. 1999). Further, both MBD2 and ...
... 1999). As methylation is associated with gene silencing, a demethylase would be expected to act as a transcriptional activator. Contrary to this expectation, MBD2 was subsequently found to repress transcription through the recruitment of histone deacetylases (Ng et al. 1999). Further, both MBD2 and ...
Independent specialization of the human and mouse X
... were averaged, it was important to rule out the possibility that only one family member was actively transcribed in the testis—which we did by scrutinizing the testis mRNA-seq data for sequence variants that differentiated members of a gene family (Supplementary Table 9). The testis-predominant expr ...
... were averaged, it was important to rule out the possibility that only one family member was actively transcribed in the testis—which we did by scrutinizing the testis mRNA-seq data for sequence variants that differentiated members of a gene family (Supplementary Table 9). The testis-predominant expr ...
Abstract - BioPublisher
... Abstract Genomic imprinting is an important mechanism of epigenetic regulation. It only expresses the genetic information one of the parent, the other part is silence. Numerous studies have shown that Imprinted Genes play an important role in regulating the growth and development of mammals, and its ...
... Abstract Genomic imprinting is an important mechanism of epigenetic regulation. It only expresses the genetic information one of the parent, the other part is silence. Numerous studies have shown that Imprinted Genes play an important role in regulating the growth and development of mammals, and its ...
Sex Chromosomes and Sex
... 2) Single X chromosome is maternal in origin in 70–80%; thus, the paternallytransmitted sex chromosome is lacking 3) Associated with the Turner phenotype of webbed neck, shield chest, coarctation of the aorta, short stature and renal malformations. 4) Associated with gonadal dysgenesis, a process of ...
... 2) Single X chromosome is maternal in origin in 70–80%; thus, the paternallytransmitted sex chromosome is lacking 3) Associated with the Turner phenotype of webbed neck, shield chest, coarctation of the aorta, short stature and renal malformations. 4) Associated with gonadal dysgenesis, a process of ...
in trans
... Local eQTL: “near” the affected gene Distant eQTL: “far” from the affected gene cis effect: often taken to mean on the DNA molecule affected trans effect: often taken to mean takes effect through the protein/RNA PHYSIOLOGY ...
... Local eQTL: “near” the affected gene Distant eQTL: “far” from the affected gene cis effect: often taken to mean on the DNA molecule affected trans effect: often taken to mean takes effect through the protein/RNA PHYSIOLOGY ...
THE SEX CHROMOSOMES AND THEIR ABNORMALITIES
... Upon fertilization of the two ova by two sperm cells (one carrying an X and the other carrying a Y chromosome), the two fertilized ova are then fused together resulting in a person having dual genitalial, gonadal and genetic sex. ...
... Upon fertilization of the two ova by two sperm cells (one carrying an X and the other carrying a Y chromosome), the two fertilized ova are then fused together resulting in a person having dual genitalial, gonadal and genetic sex. ...
Sequence Alignment - Bilkent University
... spliced internal exons from chromosome 22 (Hide et al. 2001), which occur in the proteincoding region, are presented as reference (darker shaded bars). Exons were considered as domain adding if their length was a multiple of three, and there was no in-frame stop codon within them. Exons were conside ...
... spliced internal exons from chromosome 22 (Hide et al. 2001), which occur in the proteincoding region, are presented as reference (darker shaded bars). Exons were considered as domain adding if their length was a multiple of three, and there was no in-frame stop codon within them. Exons were conside ...