Gene Section TTL (twelve-thirteen translocation leukemia) Atlas of Genetics and Cytogenetics
... The other transcript, TTL/ETV6, comprises 5' TTL exons 1 to 5 or to 8a, fused to ETV6 from exon 2. The predicted 530 amino acids fusion protein consists mostly of ETV6 with both HLH and ETS domains, and could have modified transcriptional activities. On the other hand, a loss of function of ETV6 and ...
... The other transcript, TTL/ETV6, comprises 5' TTL exons 1 to 5 or to 8a, fused to ETV6 from exon 2. The predicted 530 amino acids fusion protein consists mostly of ETV6 with both HLH and ETS domains, and could have modified transcriptional activities. On the other hand, a loss of function of ETV6 and ...
Introduction to Molecular Biology and Genomics
... • Gene expression database mining is used to identify intrinsic patterns and relationships in gene expression data. • Traditionally molecular biology has concentrated on a study of a single or very few genes in research projects. • With genomes being sequenced, this is now changing into so-called sy ...
... • Gene expression database mining is used to identify intrinsic patterns and relationships in gene expression data. • Traditionally molecular biology has concentrated on a study of a single or very few genes in research projects. • With genomes being sequenced, this is now changing into so-called sy ...
Leukaemia Section t(2;11)(q31;p15) NUP98/HOXD13 t(2;11)(q31;p15) NUP98/HOXD11 Atlas of Genetics and Cytogenetics
... NUP98 gene, located on chromosome 11p15, encodes a 98-KD protein a component of nuclear pore complex (NPC). NUP98 is found in the nucleoplasmic and cytoplasmic domains of the NPC, and functions as a transport co-factor of RNA and protein between the nucleus and cytoplasm. In addition, NUP98 appear t ...
... NUP98 gene, located on chromosome 11p15, encodes a 98-KD protein a component of nuclear pore complex (NPC). NUP98 is found in the nucleoplasmic and cytoplasmic domains of the NPC, and functions as a transport co-factor of RNA and protein between the nucleus and cytoplasm. In addition, NUP98 appear t ...
HW10 Answer Key
... their binding to/assembly on DNA. The lac repressor is prevented from binding by the presence of lactose, which causes the lac repressor to change structure and become unable to bind to the operator DNA sequence. The presence of nucleosomes is regulated by "chromatin remodelling" proteins that act i ...
... their binding to/assembly on DNA. The lac repressor is prevented from binding by the presence of lactose, which causes the lac repressor to change structure and become unable to bind to the operator DNA sequence. The presence of nucleosomes is regulated by "chromatin remodelling" proteins that act i ...
Regulatory mechanism of membrane protein production in an EPA
... EPA biosynthesis and found that the levels of the outer membrane porin homolog, Omp417, were markedly decreased in the EPA-less mutant (ΔEPA). To examine the effects of EPA on the folding of Omp417, in vitro refolding of recombinant Omp417 was carried out with liposomes in the presence or absence of ...
... EPA biosynthesis and found that the levels of the outer membrane porin homolog, Omp417, were markedly decreased in the EPA-less mutant (ΔEPA). To examine the effects of EPA on the folding of Omp417, in vitro refolding of recombinant Omp417 was carried out with liposomes in the presence or absence of ...
Lecture I
... organisms: dividing fibroblasts for instance give rise to new fibroblasts even though their genome is identical to that of all other cells. Epigenetic transmission of traits also occurs from one generation to the next in some organisms, though it is comparatively rare. It has first been observed in ...
... organisms: dividing fibroblasts for instance give rise to new fibroblasts even though their genome is identical to that of all other cells. Epigenetic transmission of traits also occurs from one generation to the next in some organisms, though it is comparatively rare. It has first been observed in ...
Tumor-Suppressor Genes
... The Roles of Transcription Factors • To initiate transcription, eukaryotic RNA polymerase requires the assistance of proteins called transcription factors • General transcription factors are essential for the transcription of all protein-coding genes • In eukaryotes, high levels of transcription of ...
... The Roles of Transcription Factors • To initiate transcription, eukaryotic RNA polymerase requires the assistance of proteins called transcription factors • General transcription factors are essential for the transcription of all protein-coding genes • In eukaryotes, high levels of transcription of ...
Special topics in electrical and systems engineering: Systems Biology
... arrows depict the synthesis of the gene products from the two-component regulatory genes. The red and blue letters represent RRs and the genes induced under anaerobic conditions, respectively. For simplicity not all the target genes for each two-component system are shown, nor the interaction betwee ...
... arrows depict the synthesis of the gene products from the two-component regulatory genes. The red and blue letters represent RRs and the genes induced under anaerobic conditions, respectively. For simplicity not all the target genes for each two-component system are shown, nor the interaction betwee ...
You may not start to read the questions printed on the subsequent
... unambiguously aligned to one or other terminal repeat. (ii) Outline the method by which you would identify the locations at which variation is occurring. ...
... unambiguously aligned to one or other terminal repeat. (ii) Outline the method by which you would identify the locations at which variation is occurring. ...
Control of Gene Expression
... either increase or decrease their activity, for example by preventing an mRNA from producing a protein. RNA interference has an important role in defending cells against parasitic nucleotide sequences – viruses and transposons – but also in directing development as well as gene expression in general ...
... either increase or decrease their activity, for example by preventing an mRNA from producing a protein. RNA interference has an important role in defending cells against parasitic nucleotide sequences – viruses and transposons – but also in directing development as well as gene expression in general ...
No Slide Title
... is known to be heterozygous for all three traits. Nothing is known about the arrangement of the mutant alleles on the paternal and maternal homologs of this heterozygote, the sequence of the genes, or the map distances between the genes. What genotype must the ...
... is known to be heterozygous for all three traits. Nothing is known about the arrangement of the mutant alleles on the paternal and maternal homologs of this heterozygote, the sequence of the genes, or the map distances between the genes. What genotype must the ...
Integrated analysis of regulatory and metabolic networks
... regulation could be found in the literature, and they were assumed to be constitutively expressed in all environmental conditions. – The third layer: the gene–protein–reaction associations that encode the relationship between gene expression and presence/absence of a particular reaction in the netwo ...
... regulation could be found in the literature, and they were assumed to be constitutively expressed in all environmental conditions. – The third layer: the gene–protein–reaction associations that encode the relationship between gene expression and presence/absence of a particular reaction in the netwo ...
ppt - people.vcu.edu
... different samples. Expression levels for each gene are normalized across the samples such that the mean is 0 and the standard deviation is 1. Expression levels greater than the mean are shaded in red, and those below the mean are shaded in blue. The scale indicates standard deviations above or below ...
... different samples. Expression levels for each gene are normalized across the samples such that the mean is 0 and the standard deviation is 1. Expression levels greater than the mean are shaded in red, and those below the mean are shaded in blue. The scale indicates standard deviations above or below ...
Olivier Pourquie. 2003. The Segmentation Clock: Converting
... activation of new sets of genes such as paraxis, thus ensuring a perfect match between segment in cells that are not related to the paraxial the down-regulation of posterior genes such as boundary position and future regional identity of mesoderm, thus raising the possibility that the Brachyury, and ...
... activation of new sets of genes such as paraxis, thus ensuring a perfect match between segment in cells that are not related to the paraxial the down-regulation of posterior genes such as boundary position and future regional identity of mesoderm, thus raising the possibility that the Brachyury, and ...
Presentation Title Goes Here
... One thousand gene expression data sets containing EH were simulated, tested, and ranked for differential expression as detailed in Simulated Examples. (A) A boxplot of the standard deviation of the ranks of each gene for differential expression over repeated simulated studies. Results are shown for ...
... One thousand gene expression data sets containing EH were simulated, tested, and ranked for differential expression as detailed in Simulated Examples. (A) A boxplot of the standard deviation of the ranks of each gene for differential expression over repeated simulated studies. Results are shown for ...
File
... (a) In the absence of a functional testosterone receptor, Tfm individuals, even though XY, form a testis and secrete testosterone, but they cannot respond to the testosterone signal. Because the testosterone receptor is a transcription factor that is necessary to activate male-specific gene transcri ...
... (a) In the absence of a functional testosterone receptor, Tfm individuals, even though XY, form a testis and secrete testosterone, but they cannot respond to the testosterone signal. Because the testosterone receptor is a transcription factor that is necessary to activate male-specific gene transcri ...
Responses to Editor
... One reason for the confusion about the figure 2b was an editing error on our side which put some of the wrong numbers into the table. We have carefully corrected these numbers in figure 2b. Also, as noted above, for the Spellman and DeRisi datasets we are referring to expression fluctuations, not ab ...
... One reason for the confusion about the figure 2b was an editing error on our side which put some of the wrong numbers into the table. We have carefully corrected these numbers in figure 2b. Also, as noted above, for the Spellman and DeRisi datasets we are referring to expression fluctuations, not ab ...
Document
... splicing sites. Mouse has a second promoter that has not been found in other Xist/XIST genes analysed to date. Extensive alternative splicing of the human gene has been described yielding isoforms that lack exon 4, half of exon6, exon7 or include the last two introns. ...
... splicing sites. Mouse has a second promoter that has not been found in other Xist/XIST genes analysed to date. Extensive alternative splicing of the human gene has been described yielding isoforms that lack exon 4, half of exon6, exon7 or include the last two introns. ...
Slide 1
... through changes in genetic regulatory regions that can be detected through gene expression studies and bioinformatics analyses. Coexpressed genes are commonly identified by global analyses of large sets of expression experiments and data from several expression platforms are available. To assess the ...
... through changes in genetic regulatory regions that can be detected through gene expression studies and bioinformatics analyses. Coexpressed genes are commonly identified by global analyses of large sets of expression experiments and data from several expression platforms are available. To assess the ...
Trinucleotide repeats (TNRs)
... FRDA is caused by a large intronic GAA repeat expansion located on chromosome 9 (Gene:X25/Potein: frataxin) which leads to reduced gene expression The expanded AT-rich sequence most probably causes self-association of the GAA/TTC tract, which stabilizes the DNA in a triplex structure ...
... FRDA is caused by a large intronic GAA repeat expansion located on chromosome 9 (Gene:X25/Potein: frataxin) which leads to reduced gene expression The expanded AT-rich sequence most probably causes self-association of the GAA/TTC tract, which stabilizes the DNA in a triplex structure ...
