Identification of Transcription Factor Binding Sites
... Using AlignACE 18 motifs from 12 clusters were found. 7 of the found motifs were identified experimentally ...
... Using AlignACE 18 motifs from 12 clusters were found. 7 of the found motifs were identified experimentally ...
Ditto Chapter 15 Chromosomes
... 8. About 5% of individuals with Down Syndrome are the result of a chromosomal ...
... 8. About 5% of individuals with Down Syndrome are the result of a chromosomal ...
Rethinking Gene Expression and Evolution (Nobel Lecture)
... suggests how the genetic material can be replicated. They stated in their famously brief paper in Nature[1] that, “It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.” The DNA strands are wrapped aroun ...
... suggests how the genetic material can be replicated. They stated in their famously brief paper in Nature[1] that, “It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.” The DNA strands are wrapped aroun ...
Gene Enrichment Analysis
... This lecture introduces the notion of enrichment analysis, where one wishes to assign biological meaning to some group of genes. Whereas in the past each gene product was studied individually to assign it functions and roles in biological processes, there now exist tools that allow this process to b ...
... This lecture introduces the notion of enrichment analysis, where one wishes to assign biological meaning to some group of genes. Whereas in the past each gene product was studied individually to assign it functions and roles in biological processes, there now exist tools that allow this process to b ...
Mom and Dad are Fighting
... allowing the father’s genes to act without any restraint. Children with Angelman try to nurse more than average children do. The smiles and laughter that are associated with Angelman may also come from attention-grabbing strategies encoded by paternal genes. Prader-Willi emerges from an opposite bre ...
... allowing the father’s genes to act without any restraint. Children with Angelman try to nurse more than average children do. The smiles and laughter that are associated with Angelman may also come from attention-grabbing strategies encoded by paternal genes. Prader-Willi emerges from an opposite bre ...
The importance ofRNA
... that compose it, while deoxyribonucleic acid (DNA) does not. This seemingly minor difference makes RNA much more flexible than DNA, resulting in a molecule that can adopt many different structures and acquire an array of functions. At the same time, RNA can in some cases use these hydroxyl groups to ...
... that compose it, while deoxyribonucleic acid (DNA) does not. This seemingly minor difference makes RNA much more flexible than DNA, resulting in a molecule that can adopt many different structures and acquire an array of functions. At the same time, RNA can in some cases use these hydroxyl groups to ...
Solid Tumour Section t(4;22)(q35;q12) in embryonal rhabdomyo-sarcoma (ERMS) Atlas of Genetics and Cytogenetics
... DUX4 Location 4q35 Protein DUX4 (double homeobox, chromosome 4) contains two homeodomains (about 60 amino acids, involved in DNA-binding), each similar in sequence to PAX3 and PAX7 homeodomains. It is a transcription factor DUX4 is involved in myogenic differentiation and cell-cycle control (Dixit e ...
... DUX4 Location 4q35 Protein DUX4 (double homeobox, chromosome 4) contains two homeodomains (about 60 amino acids, involved in DNA-binding), each similar in sequence to PAX3 and PAX7 homeodomains. It is a transcription factor DUX4 is involved in myogenic differentiation and cell-cycle control (Dixit e ...
Dosage compensation: do birds do it as well?
... obviously contains many genes. For one of the nine genes analysed by quantitative RT–PCR, ScII, expression levels were consistently twice as high in males as in females [4]. This might suggest that some avian Z-linked genes escape dosage compensation in a similar manner to about 10% of X-linked huma ...
... obviously contains many genes. For one of the nine genes analysed by quantitative RT–PCR, ScII, expression levels were consistently twice as high in males as in females [4]. This might suggest that some avian Z-linked genes escape dosage compensation in a similar manner to about 10% of X-linked huma ...
Methods S1.
... fresh MS medium or MS supplemented with 200 mM NaCl. For kinetics of stress-mediated STRS relocalization, 10 day-old seedlings grown upon mesh on MS medium were transferred to a cover slip chamber (Nalge Nunc International) and flushed with liquid MS or MS supplemented with 200 mM NaCl, 500 mM manni ...
... fresh MS medium or MS supplemented with 200 mM NaCl. For kinetics of stress-mediated STRS relocalization, 10 day-old seedlings grown upon mesh on MS medium were transferred to a cover slip chamber (Nalge Nunc International) and flushed with liquid MS or MS supplemented with 200 mM NaCl, 500 mM manni ...
Lecture 5 pdf
... Phenotype is result of complex, integrated pattern of reactions under control of more than one gene and the environment. 1. Epistasis (true non-allelic interaction) - expression of a single trait depends on interaction between 2 or more genes examples: comb shape in chickens ...
... Phenotype is result of complex, integrated pattern of reactions under control of more than one gene and the environment. 1. Epistasis (true non-allelic interaction) - expression of a single trait depends on interaction between 2 or more genes examples: comb shape in chickens ...
A Mini-Review
... protein is stabilized and regulated by nuclear lamina interactions [8]. Hence, the altered cell-cycle regulation observed in HGPS cells is probably due to an impaired function of the retinoblastoma protein network. Moreover, two recent in silico ceRNA and interactome analyses [9, 10] pointed to seve ...
... protein is stabilized and regulated by nuclear lamina interactions [8]. Hence, the altered cell-cycle regulation observed in HGPS cells is probably due to an impaired function of the retinoblastoma protein network. Moreover, two recent in silico ceRNA and interactome analyses [9, 10] pointed to seve ...
Supplementary information
... studied. Similarly, specific mouse mRNA species were measured relative to Pmm1 expression using mouse specific gene primers, listed in Supplementary Table 2. Invasion assays. MC38 cells were serum starved in 1% FBS media for 5 hrs prior to invasion assay. For invasion assays, 40l of 2 mg/ml matrige ...
... studied. Similarly, specific mouse mRNA species were measured relative to Pmm1 expression using mouse specific gene primers, listed in Supplementary Table 2. Invasion assays. MC38 cells were serum starved in 1% FBS media for 5 hrs prior to invasion assay. For invasion assays, 40l of 2 mg/ml matrige ...
Chem 465 Biochemistry II Hour Exam 3
... 1. Back in Chapter 24 it was stated that up to 45% of the human genome is made up of transposons. What is a transposon? How are simple and complex transposons different? What is the difference between direct transposition and replicative transposition? And, finally How are Eukaryotic transposons dif ...
... 1. Back in Chapter 24 it was stated that up to 45% of the human genome is made up of transposons. What is a transposon? How are simple and complex transposons different? What is the difference between direct transposition and replicative transposition? And, finally How are Eukaryotic transposons dif ...
The Murine Interleukin-3 Receptor a Subunit Gene
... under the same condition except for annealing temperature at 55°C. The final amplified product was treated with T4 DNA polymerase to create blunt ends. After heat inactivation of polymerase, the DNA was cleaved with EcoRI, as the anchor sequence includes an EcoRI site. The resultant DNA fragments we ...
... under the same condition except for annealing temperature at 55°C. The final amplified product was treated with T4 DNA polymerase to create blunt ends. After heat inactivation of polymerase, the DNA was cleaved with EcoRI, as the anchor sequence includes an EcoRI site. The resultant DNA fragments we ...
Microarray
... Hypothesis testing is a common form of inferential statistics. A null hypothesis is stated, such as: “There is no difference in signal intensity for the gene expression measurements in normal and diseased samples.” The alternative hypothesis is that there is a difference. We use a test statistic to ...
... Hypothesis testing is a common form of inferential statistics. A null hypothesis is stated, such as: “There is no difference in signal intensity for the gene expression measurements in normal and diseased samples.” The alternative hypothesis is that there is a difference. We use a test statistic to ...
Identification of porcine Lhx3 and SF1 as candidate genes for QTL
... reactions (Neg) with no input cDNA also are shown. The assays for each stage were performed at least three times; a representative gel is shown. ...
... reactions (Neg) with no input cDNA also are shown. The assays for each stage were performed at least three times; a representative gel is shown. ...
Widespread Organ Expression of the Rat Proenkephalin Gene
... skeletal muscle is greater than that observed in neonatal brain (Fig. 2). Transcript abundance in muscle shows a steady several-fold decline during the first 2 weeks after birth and falls below the limits of detection in the adult (Fig. 3). In contrast, both brain and heart exhibited the opposite pa ...
... skeletal muscle is greater than that observed in neonatal brain (Fig. 2). Transcript abundance in muscle shows a steady several-fold decline during the first 2 weeks after birth and falls below the limits of detection in the adult (Fig. 3). In contrast, both brain and heart exhibited the opposite pa ...
Document
... transcription and -10 and -35 boxes for this promoter are indicated in red above the sequence. P2 denotes the downstream promoter, recognized by σ E; the start of transcription and -10 and -35 boxes for this promoter are indicated in blue below the sequence. ...
... transcription and -10 and -35 boxes for this promoter are indicated in red above the sequence. P2 denotes the downstream promoter, recognized by σ E; the start of transcription and -10 and -35 boxes for this promoter are indicated in blue below the sequence. ...
TimeClust: a clustering tool for gene expression
... give indication about the optimal number of clusters thus the choice has to be quite arbitrary. BC, being a model-based evolution of the HC explicitly designed to consider the specific nature of temporal data, represents the most suitable algorithm for this kind of data. It is quite robust and compu ...
... give indication about the optimal number of clusters thus the choice has to be quite arbitrary. BC, being a model-based evolution of the HC explicitly designed to consider the specific nature of temporal data, represents the most suitable algorithm for this kind of data. It is quite robust and compu ...
portable document (.pdf) format
... a similar definition as univariate ranking (UR) as in Golub et al. (1999). Recently, Tomlins et al. (2005) introduced a method called “cancer outlier profile analysis” (COPA) for detecting “oncogene outliers.” Those genes show systematically increased expressions in disease samples, but only for a s ...
... a similar definition as univariate ranking (UR) as in Golub et al. (1999). Recently, Tomlins et al. (2005) introduced a method called “cancer outlier profile analysis” (COPA) for detecting “oncogene outliers.” Those genes show systematically increased expressions in disease samples, but only for a s ...